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Volumn 10, Issue 4, 2007, Pages 420-426

Gene-environment interactions in the pathogenesis of type 2 diabetes and metabolism

Author keywords

Behaviour; Diet; Genetics; Lifestyle; Lipid; Obesity

Indexed keywords

APOLIPOPROTEIN A5; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN; TRANSCRIPTION FACTOR 7 LIKE 2; UNCLASSIFIED DRUG;

EID: 34250616639     PISSN: 13631950     EISSN: 15353885     Source Type: Journal    
DOI: 10.1097/MCO.0b013e3281e2c9ab     Document Type: Review
Times cited : (47)

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    • Florez JC, Jablonski AK, Sun MW. Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone. J Clin Endocrinol Metab 2007; 92:1502-1509. A large-scale intervention study of type 2 diabetes including more than 3500 participants with impaired glucose tolerance. No interaction of PPARG Pro12Ala genotype with lifestyle intervention or medical treatment on progression to type 2 diabetes is observed.
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    • de Rooij SR, Painter RC, Phillips DI, et al. Impaired insulin secretion after prenatal exposure to the Dutch famine. Diabetes Care 2006; 29:1052-1057. A most interesting study of a unique birth cohort exposed to prenatal famine during World War II. The paper shows that the effect of PPARG Pro12Ala genotype on type 2 diabetes and insulin secretion is modulated by prenatal exposure to famine during mid-gestation.
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    • Grant SF, Thorleifsson G, Reynisdottir I, et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006; 38:320-323. The original paper from deCODE genetics describing the observation of TCF7L2 as a type 2 diabetes susceptibility gene. Includes independent replication of significant findings.
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    • Groves CJ, Zeggini E, Minton J, et al. Association analysis of 6 736 U. K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes 2006; 55:2640-2644.
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    • Helgason A, Palsson S, Thorleifsson G, et al. Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet 2007; 39:218-225. An interesting study refining the association of variation in TCF7L2 with type 2 diabetes.
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    • Florez JC, Jablonski AK, Bayley N, et al. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl JMed 2006; 355:241-250. A large-scale intervention study of type 2 diabetes including more than 3500 participants with impaired glucose tolerance. Describes the relationship between lifestyle intervention, TCF7L2 genotypes and progression to type 2 diabetes.
    • Florez JC, Jablonski AK, Bayley N, et al. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl JMed 2006; 355:241-250. A large-scale intervention study of type 2 diabetes including more than 3500 participants with impaired glucose tolerance. Describes the relationship between lifestyle intervention, TCF7L2 genotypes and progression to type 2 diabetes.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.