메뉴 건너뛰기




Volumn 52, Issue 2, 2003, Pages 425-433

Pax-6 activates endogenous proglucagon gene expression in the rodent gastrointestinal epithelium

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; GLUCAGON LIKE PEPTIDE; GLUCAGON LIKE PEPTIDE 1; LUCIFERASE; PROGLUCAGON; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CDX 3; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR PAX6; UNCLASSIFIED DRUG;

EID: 0037312830     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.2.425     Document Type: Article
Times cited : (39)

References (44)
  • 1
    • 0023008693 scopus 로고
    • Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing
    • Mojsov S, Heinrich G, Wilson IB, Ravazzola M, Orci L, Habener JF: Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem 261:11880-11889, 1986
    • (1986) J Biol Chem , vol.261 , pp. 11880-11889
    • Mojsov, S.1    Heinrich, G.2    Wilson, I.B.3    Ravazzola, M.4    Orci, L.5    Habener, J.F.6
  • 2
    • 0035106978 scopus 로고    scopus 로고
    • The glucagon-like peptides
    • Drucker DJ: The glucagon-like peptides. Endocrinology 142:521-527, 2001
    • (2001) Endocrinology , vol.142 , pp. 521-527
    • Drucker, D.J.1
  • 3
    • 0033175006 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 (GLP-1): An intestinal hormone, signalling nutritional abundance, with an unusual therapeutic potential
    • Holst JJ: Glucagon-like peptide 1 (GLP-1): an intestinal hormone, signalling nutritional abundance, with an unusual therapeutic potential. Trends Endocrinol Metab 10:229-235, 1999
    • (1999) Trends Endocrinol Metab , vol.10 , pp. 229-235
    • Holst, J.J.1
  • 5
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide-1 agonists stimulate expression of homeodomain protein IDX-1 and increase β-cell mass in mouse pancreas
    • Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Egan JM, Bonner-Weir S, Habener JF: Insulinotropic glucagon-like peptide-1 agonists stimulate expression of homeodomain protein IDX-1 and increase β-cell mass in mouse pancreas. Diabetes 49:741-748, 2000
    • (2000) Diabetes , vol.49 , pp. 741-748
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3    Drucker, D.J.4    Egan, J.M.5    Bonner-Weir, S.6    Habener, J.F.7
  • 6
  • 7
    • 0031936954 scopus 로고    scopus 로고
    • The glucagon-like peptides
    • Drucker DJ: The glucagon-like peptides. Diabetes 47:159-169, 1998
    • (1998) Diabetes , vol.47 , pp. 159-169
    • Drucker, D.J.1
  • 8
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study
    • Zander M, Madsbad S, Madsen JL, Holst JJ: Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. Lancet 359:824-830, 2002
    • (2002) Lancet , vol.359 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3    Holst, J.J.4
  • 9
    • 0036189831 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men
    • Agerso H, Jensen LB, Elbrond B, Rolan P, Zdravkovic M: The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men. Diabetologia 45:195-202, 2002
    • (2002) Diabetologia , vol.45 , pp. 195-202
    • Agerso, H.1    Jensen, L.B.2    Elbrond, B.3    Rolan, P.4    Zdravkovic, M.5
  • 10
    • 0023723641 scopus 로고
    • Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins
    • Philippe J, Drucker DJ, Knepel W, Jepeal L, Misulovin Z, Habener JF: Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins. Mol Cell Biol 8:4877-4888, 1988
    • (1988) Mol Cell Biol , vol.8 , pp. 4877-4888
    • Philippe, J.1    Drucker, D.J.2    Knepel, W.3    Jepeal, L.4    Misulovin, Z.5    Habener, J.F.6
  • 11
    • 0024334030 scopus 로고
    • Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line
    • Philippe J: Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line. J Clin Invest 84:672-677, 1989
    • (1989) J Clin Invest , vol.84 , pp. 672-677
    • Philippe, J.1
  • 12
    • 0028280977 scopus 로고
    • Glucagon gene expression is negatively regulated by hepatocyte nuclear factor 3β
    • Philippe J, Morel C, Prezioso VR: Glucagon gene expression is negatively regulated by hepatocyte nuclear factor 3β. Mol Cell Biol 14:3514-3523, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 3514-3523
    • Philippe, J.1    Morel, C.2    Prezioso, V.R.3
  • 13
    • 0028873948 scopus 로고
    • Islet-specific proteins interact with the insulin-response element of the glucagon gene
    • Philippe J, Morel C, Cordier-Bussat M: Islet-specific proteins interact with the insulin-response element of the glucagon gene. J Biol Chem 270:3039-3045, 1995
    • (1995) J Biol Chem , vol.270 , pp. 3039-3045
    • Philippe, J.1    Morel, C.2    Cordier-Bussat, M.3
  • 14
    • 0033548148 scopus 로고    scopus 로고
    • Pax-6 and Cdx-2/3 interact to activate glucagon gene expression on the G1 control element
    • Ritz-Laser B, Estreicher A, Klages N, Saule S, Philippe J: Pax-6 and Cdx-2/3 interact to activate glucagon gene expression on the G1 control element. J Biol Chem 274:4124-4132, 1999
    • (1999) J Biol Chem , vol.274 , pp. 4124-4132
    • Ritz-Laser, B.1    Estreicher, A.2    Klages, N.3    Saule, S.4    Philippe, J.5
  • 15
    • 0025935925 scopus 로고
    • The pancreatic islet-specific glucagon G3 transcription factors recognize control elements in the rat somatostatin and insulin-I genes
    • Knepel W, Vallejo M, Chafitz JA, Habener JF: The pancreatic islet-specific glucagon G3 transcription factors recognize control elements in the rat somatostatin and insulin-I genes. Mol Endocrinol 5:1457-1466, 1991
    • (1991) Mol Endocrinol , vol.5 , pp. 1457-1466
    • Knepel, W.1    Vallejo, M.2    Chafitz, J.A.3    Habener, J.F.4
  • 16
    • 0030712878 scopus 로고    scopus 로고
    • POU domain transcription factor brain 4 confers pancreatic a-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element
    • Hussain MA, Lee J, Miller CP, Habener JF: POU domain transcription factor brain 4 confers pancreatic a-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element. Mol Cell Biol 17:7186-7194, 1997
    • (1997) Mol Cell Biol , vol.17 , pp. 7186-7194
    • Hussain, M.A.1    Lee, J.2    Miller, C.P.3    Habener, J.F.4
  • 17
    • 0029655778 scopus 로고    scopus 로고
    • Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3
    • Jin T, Drucker DJ: Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3. Mol Cell Biol 16:19-28, 1996
    • (1996) Mol Cell Biol , vol.16 , pp. 19-28
    • Jin, T.1    Drucker, D.J.2
  • 18
    • 0031016385 scopus 로고    scopus 로고
    • The caudal homeobox protein cdx-2/3 activates endogenous proglucagon gene expression in InR1-G9 islet cells
    • Jin T, Trinh DKY, Wang F, Drucker DJ: The caudal homeobox protein cdx-2/3 activates endogenous proglucagon gene expression in InR1-G9 islet cells. Mol Endocrinol 11:203-209, 1997
    • (1997) Mol Endocrinol , vol.11 , pp. 203-209
    • Jin, T.1    Trinh, D.K.Y.2    Wang, F.3    Drucker, D.J.4
  • 19
    • 0033305721 scopus 로고    scopus 로고
    • Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription
    • Hill ME, Asa SL, Drucker DJ: Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription. Mol Endocrinol 13:1474-1486, 1999
    • (1999) Mol Endocrinol , vol.13 , pp. 1474-1486
    • Hill, M.E.1    Asa, S.L.2    Drucker, D.J.3
  • 21
    • 0030914931 scopus 로고    scopus 로고
    • Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas
    • St-Onge L, Sosa-Pineda B, Chowdhury K, Mansouri A, Gruss P: Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas. Nature 387:406-409, 1997
    • (1997) Nature , vol.387 , pp. 406-409
    • St-Onge, L.1    Sosa-Pineda, B.2    Chowdhury, K.3    Mansouri, A.4    Gruss, P.5
  • 23
    • 0028575660 scopus 로고
    • Activation of proglucagon gene transcription by protein kinase A in a novel mouse enteroendocrine cell line
    • Drucker DJ, Jin T, Asa SL, Young TA, Brubaker PL: Activation of proglucagon gene transcription by protein kinase A in a novel mouse enteroendocrine cell line. Mol Endocrinol 8:1646-1655, 1994
    • (1994) Mol Endocrinol , vol.8 , pp. 1646-1655
    • Drucker, D.J.1    Jin, T.2    Asa, S.L.3    Young, T.A.4    Brubaker, P.L.5
  • 24
    • 0023226168 scopus 로고
    • Fetal rat intestinal cells in monolayer culture: A new in vitro system to study the glucagon-like immunoreactive peptides
    • Brubaker PL, Vranic M: Fetal rat intestinal cells in monolayer culture: a new in vitro system to study the glucagon-like immunoreactive peptides. Endocrinology 120:1976-1985, 1987
    • (1987) Endocrinology , vol.120 , pp. 1976-1985
    • Brubaker, P.L.1    Vranic, M.2
  • 26
    • 0023787950 scopus 로고
    • Glucagon gene expression in vertebrate brain
    • Drucker DJ, Asa S: Glucagon gene expression in vertebrate brain. J Biol Chem 263:13475-13478, 1988
    • (1988) J Biol Chem , vol.263 , pp. 13475-13478
    • Drucker, D.J.1    Asa, S.2
  • 27
    • 0024332336 scopus 로고
    • Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine
    • Drucker DJ, Brubaker PL: Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine. Proc Natl Acad Sci 86:3953-3957, 1989
    • (1989) Proc Natl Acad Sci , vol.86 , pp. 3953-3957
    • Drucker, D.J.1    Brubaker, P.L.2
  • 28
    • 0032877154 scopus 로고    scopus 로고
    • Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator
    • Hussain MA, Habener JF: Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator. J Biol Chem 274:28950-28957, 1999
    • (1999) J Biol Chem , vol.274 , pp. 28950-28957
    • Hussain, M.A.1    Habener, J.F.2
  • 29
    • 0029826459 scopus 로고    scopus 로고
    • The caudal-related homeodomain protein Cdx-2/3 regulates glucagon gene expression in islet cells
    • Laser B, Meda P, Constant I, Philippe J: The caudal-related homeodomain protein Cdx-2/3 regulates glucagon gene expression in islet cells. J Biol Chem 271:28984-28994, 1996
    • (1996) J Biol Chem , vol.271 , pp. 28984-28994
    • Laser, B.1    Meda, P.2    Constant, I.3    Philippe, J.4
  • 30
    • 0033605281 scopus 로고    scopus 로고
    • Identification of domains mediating transcriptional activation and cytoplasmic export in the caudal homeobox protein Cdx-3
    • Trinh KY, Jin T, Drucker DJ: Identification of domains mediating transcriptional activation and cytoplasmic export in the caudal homeobox protein Cdx-3. J Biol Chem 274:6011-6019, 1999
    • (1999) J Biol Chem , vol.274 , pp. 6011-6019
    • Trinh, K.Y.1    Jin, T.2    Drucker, D.J.3
  • 31
    • 1842330860 scopus 로고    scopus 로고
    • Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development
    • Sander M, Neubuser A, Kalamaras J, Ee HC, Martin GR, German MS: Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev 11:1662-1673, 1997
    • (1997) Genes Dev , vol.11 , pp. 1662-1673
    • Sander, M.1    Neubuser, A.2    Kalamaras, J.3    Ee, H.C.4    Martin, G.R.5    German, M.S.6
  • 32
    • 0029998610 scopus 로고    scopus 로고
    • Regulation of sucrase and lactase in Caco-2 cells: Relationship to nuclear factors SIF-1 and NF-LPH-1
    • Olsen WA, Lloyd M, Korsmo H, He YZ: Regulation of sucrase and lactase in Caco-2 cells: relationship to nuclear factors SIF-1 and NF-LPH-1. Am J Physiol 271:G707-G713, 1996
    • (1996) Am J Physiol , vol.271
    • Olsen, W.A.1    Lloyd, M.2    Korsmo, H.3    He, Y.Z.4
  • 33
  • 34
    • 0029047865 scopus 로고
    • The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription
    • Wang M, Drucker DJ: The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription. J Biol Chem 270:12646-12652, 1995
    • (1995) J Biol Chem , vol.270 , pp. 12646-12652
    • Wang, M.1    Drucker, D.J.2
  • 35
    • 0033557490 scopus 로고    scopus 로고
    • Inactivation of the winged helix transcription factor HNF3α affects glucose homeostasis and islet glucagon gene expression in vivo
    • Kaestner KH, Katz J, Liu Y, Drucker DJ, Schutz G: Inactivation of the winged helix transcription factor HNF3α affects glucose homeostasis and islet glucagon gene expression in vivo. Genes Dev 13:495-504, 1999
    • (1999) Genes Dev , vol.13 , pp. 495-504
    • Kaestner, K.H.1    Katz, J.2    Liu, Y.3    Drucker, D.J.4    Schutz, G.5
  • 36
    • 0034693046 scopus 로고    scopus 로고
    • The paired homeodomain transcription factor Pax-2 is expressed in the endocrine pancreas and transactivates the glucagon gene promoter
    • Ritz-Laser B, Estreicher A, Gauthier B, Philippe J: The paired homeodomain transcription factor Pax-2 is expressed in the endocrine pancreas and transactivates the glucagon gene promoter. J Biol Chem 275:32708-32715, 2000
    • (2000) J Biol Chem , vol.275 , pp. 32708-32715
    • Ritz-Laser, B.1    Estreicher, A.2    Gauthier, B.3    Philippe, J.4
  • 37
    • 0036165598 scopus 로고    scopus 로고
    • The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6
    • Ritz-Laser B, Estreicher A, Gauthier BR, Mamin A, Edlund H, Philippe J: The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6. Diabetologia 45:97-107, 2002
    • (2002) Diabetologia , vol.45 , pp. 97-107
    • Ritz-Laser, B.1    Estreicher, A.2    Gauthier, B.R.3    Mamin, A.4    Edlund, H.5    Philippe, J.6
  • 38
    • 0027373934 scopus 로고
    • Transcription of the rat glucagon gene by the cyclic AMP response element-binding protein CREB is modulated by adjacent CREB-associated proteins
    • Miller CP, Lin JC, Habener JF: Transcription of the rat glucagon gene by the cyclic AMP response element-binding protein CREB is modulated by adjacent CREB-associated proteins. Mol Cell Biol 13:7080-7090, 1993
    • (1993) Mol Cell Biol , vol.13 , pp. 7080-7090
    • Miller, C.P.1    Lin, J.C.2    Habener, J.F.3
  • 41
    • 0031721136 scopus 로고    scopus 로고
    • Peroral gene therapy of lactose intolerance using an adeno-associated virus vector
    • During MJ, Xu R, Young D, Kaplitt MG, Sherwin RS, Leone P: Peroral gene therapy of lactose intolerance using an adeno-associated virus vector. Nat Med 4:1131-1135, 1998
    • (1998) Nat Med , vol.4 , pp. 1131-1135
    • During, M.J.1    Xu, R.2    Young, D.3    Kaplitt, M.G.4    Sherwin, R.S.5    Leone, P.6
  • 43
    • 0030039456 scopus 로고    scopus 로고
    • Gene therapy in gastroenterology
    • Pandha HS, Lemoine NR: Gene therapy in gastroenterology. Gut 38:161-165, 1996
    • (1996) Gut , vol.38 , pp. 161-165
    • Pandha, H.S.1    Lemoine, N.R.2
  • 44
    • 0025025628 scopus 로고
    • Use of reverse transcriptase polymerase chain reaction to monitor expression of intronless genes
    • Grillo M, Margolis FL: Use of reverse transcriptase polymerase chain reaction to monitor expression of intronless genes. Biotechniques 9:262-268, 1990
    • (1990) Biotechniques , vol.9 , pp. 262-268
    • Grillo, M.1    Margolis, F.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.