Mice lacking the Nkx6.2 (Gtx) homeodomain transcription factor develop and reproduce normally

Molecular and Cellular Biology

Volumn 21, Issue 13, 2001, Pages 4399-4403

  Cai, J ^a   Qi, Y ^a   Wu, R ^a   Modderman, G ^a   Fu, H ^a   Liu, R ^a   Qiu, M ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ARTICLE; CELL DIFFERENTIATION; CELL SPECIFICITY; CENTRAL NERVOUS SYSTEM; DEVELOPMENT; EMBRYONAL TISSUE; GENE EXPRESSION; GENE TARGETING; HISTOLOGY; HOMEOBOX; IMMUNOHISTOCHEMISTRY; MOUSE; NEURAL TUBE; NONHUMAN; NULL CELL; OLIGODENDROGLIA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; TESTIS;

ANIMALS; AVIAN PROTEINS; CELL DIFFERENTIATION; CENTRAL NERVOUS SYSTEM; DOPAMINE; GENE TARGETING; GENES, HOMEOBOX; HOMEODOMAIN PROTEINS; IMMUNOHISTOCHEMISTRY; MICE; MICE, KNOCKOUT; MYELIN SHEATH; NEURONS; OLIGODENDROGLIA; PHENOTYPE; REPRODUCTION; SEROTONIN; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 0034973592     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.13.4399-4403.2001     Document Type: Article

References (18)

1. Evidence that the homeodomain protein Gtx is involved in the regulation of oligodendrocytes myelination
2. Gtx, an oligodendrocyte-specific homeodomain protein, has repressor activity
3. Homeobox gene Nkx-2.2 and specification of neuronal identity by graded sonic hedgehog signaling
4. Expression and regulation of the chicken Nkx6.2 homeobox gene suggest its possible involvement in the ventral neural patterning and cell fate specification
5. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
6. Control of neuronal diversity by the floor plate: Contact-mediated induction of midbrain dopaminergic neurons
7. Specification of dopaminergic and serotonergic neurons in the vertebrate CNS
8. Gtx: A novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter
9. Nkx-2.9 is a novel homeobox transcription factor which demarcates ventral domains in the developing mouse CNS
10. Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain
11. Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development
12. Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeobox genes during brain and ear development
13. A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: In situ hybridization using digoxigenin-labeled cRNA probes
14. Longitudinal organization of the anterior neural plate and neural tube
15. The re-expression of the homeodomain transcription factor gtx during remyelination of experimentally induced demyelinating lesions in young and old rat brain
16. Specification of motor neuron identity by the MNR2 homeodomain protein
17. Selective expression of Nkx-2.2 transcription factor in the migratory chicken oligodendrocyte progenitor cells and implications for the embryonic origin of oligodendrocytes
18. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate