Cross talk between the insulin and Wnt signaling pathways: Evidence from intestinal endocrine L cells

Endocrinology

Volumn 149, Issue 5, 2008, Pages 2341-2351

  Yi, Fenghua ^a   Sun, Jane ^b   Lim, Gareth E ^b   Fantus, I George ^a,b   Brubaker, Patricia L ^b   Jin, Tianru ^a,b,c  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; GLUCAGON LIKE PEPTIDE 1; INCRETIN; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROGLUCAGON; PROTEIN KINASE B; T CELL FACTOR PROTEIN; T CELL FACTOR PROTEIN 4; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENDOCRINE CELL; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION; INTESTINE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RAT;

ANIMALS; BETA CATENIN; BINDING SITES; CELLS, CULTURED; CRICETINAE; ENHANCER ELEMENTS (GENETICS); ENTEROENDOCRINE CELLS; FEMALE; INSULIN; MICE; PREGNANCY; PROGLUCAGON; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTOR CROSS-TALK; RNA, MESSENGER; SIGNAL TRANSDUCTION; TCF TRANSCRIPTION FACTORS; WNT PROTEINS;

EID: 42449134942     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-1142     Document Type: Article

References (60)

1. Kinzler KW, Vogelstein B 1996 Lessons from hereditary colorectal cancer. Cell 87:159-170
2. Kinzler KW, Nilbert MC, Su LK, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hedge P, McKechnie D, Finniear R, Markhan A. Groffen J, Boguski MS, Altschul SF, Horii A, Ando H, Miyoshi Y, Miki Y, Nishisho I, Nakamura Y 1991 Identification of FAP locus genes from chromosome 5q21. Science 253:661-665
3. van Es JH, Barker N, Clevers H 2003 You Wnt some, you lose some: oncogenes in the Wnt signaling pathway. Curr Opin Genet Dev 13:28-33
4. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW 1998 Identification of c-MYC as a target of the APC pathway. Science 281:1509-1512
5. Khor TO, Gul YA, Ithnin H, Seow HF 2006 A comparative study of the expression of Wnt-1, WISP-1, survivin and cyclin-D1 in colorectal carcinoma. Int J Colorectal Dis 21:291-300
6. He X, Saint-Jeannet JP, Woodgett JR, Varmus HE, Dawid IB 1995 Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. Nature 374:617-622
7. Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, Kinzler KW 1997 Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 275:1787-1790
8. Yi F, Brubaker PL, Jin T 2005 TCF-4 mediates cell type-specific regulation of proglucagon gene expression by β-catenin and glycogen synthase kinase-3β. J Biol Chem 280:1457-1464
9. Doble BW, Woodgett JR 2003 GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci 116:1175-1186
10. Zeng X, Tamai K, Doble B, Li S, Huang H, Habas R, Okamura H, Woodgett J, He X 2005 A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature 438:873-877
11. Stambolic V, Ruel L, Woodgett JR 1996 Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol 6:1664-1668
12. Kieffer TJ 2004 Gastro-intestinal hormones GIP and GLP-1. Ann Endocrinol (Paris) 65:13-21
13. Drucker DJ 2002 Biological actions and therapeutic potential of the glucagon-like peptides. Gastroenterology 122:531-544
14. Bell GI, Sanchez-Pescador R, Laybourn PJ, Najarian RC 1983 Exon duplication and divergence in the human preproglucagon gene. Nature 304:368-371
15. Bell GI, Santerre RF, Mullenbach GT 1983 Hamster preproglucagon contains the sequence of glucagon and two related peptides. Nature 302:716-718
16. Heinrich G, Gros P, Lund PK, Bentley RC, Habener JF 1984 Pre-proglucagon messenger ribonucleic acid: nucleotide and encoded amino acid sequences of the rat pancreatic complementary deoxyribonucleic acid. Endocrinology 115:2176-2181
17. Brubaker PL, Drucker DJ 2004 Minireview: glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology 145:2653-2659
18. Meeran K, O'Shea D, Edwards CM, Turton MD, Heath MM, Gunn I, Abusnana S, Rossi M, Small CJ, Goldstone AP, Taylor GM, Sunter D, Steere J, Choi SJ, Ghatei MA, Bloom SR 1999 Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9 -39) alters body weight in the rat. Endocrinology 140:244-250
19. Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CM, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JP, Smith DM, Ghatei MA, Herbert J, Bloom SR 1996 A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379:69-72
20. Talsania T, Anini Y, Siu S, Drucker DJ, Brubaker PL 2005 Peripheral exendin-4 and peptide YY(3-36) synergistically reduce food intake through different mechanisms in mice. Endocrinology 146:3748-3756
21. Drucker DJ, Erlich P, Asa SL, Brubaker PL 1996 Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc Natl Acad Sci USA 93:7911-7916
22. Lovshin J, Estall J, Yusta B, Brown TJ, Drucker DJ 2001 Glucagon-like peptide (GLP)-2 action in the murine central nervous system is enhanced by elimination of GLP-1 receptor signaling. J Biol Chem 276:21489-21499
23. Wojdemann M, Wettergren A, Hartmann B, Holst JJ 1998 Glucagon-like peptide-2 inhibits centrally induced antral motility in pigs. Scand J Gastroenterol 33:828-832
24. Estall JL, Koehler JA, Yusta B, Drucker DJ 2005 The glucagon-like peptide-2 receptor C terminus modulates β-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation. J Biol Chem 280:22124-22134
25. Ni Z, Anini Y, Fang X, Mills G, Brubaker PL, Jin T 2003 Transcriptional activation of the proglucagon gene by lithium and β-catenin in intestinal endocrine L cells. J Biol Chem 278:1380-1387
26. Philippe J 1989 Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line. J Clin Invest 84:672-677
27. Philippe J 1991 Insulin regulation of the glucagon gene is mediated by an insulin-responsive DNA element. Proc Natl Acad Sci USA 88:7224-7227
28. Lu F, Jin T, Drucker DJ 1996 Proglucagon gene expression is induced by gastrin-releasing peptide in a mouse enteroendocrine cell line. Endocrinology 137:3710-3716
29. Jin T, Drucker DJ 1996 Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3. Mol Cell Biol 16:19-28
30. Jin T, Trinh DK, Wang F, Drucker DJ 1997 The caudal homeobox protein cdx-2/3 activates endogenous proglucagon gene expression in InR1-G9 islet cells. Mol Endocrinol 11:203-209
31. Kolligs FT, Hu G, Dang CV, Fearon ER 1999 Neoplastic transformation of RK3E by mutant β-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression. Mol Cell Biol 19:5696-706
32. Morin PJ, Vogelstein B, Kinzler KW 1996 Apoptosis and APC in colorectal tumorigenesis. Proc Natl Acad Sci USA 93:7950-7954
33. -/- colon carcinoma. Science 275:1784-1787
34. Liu S, Yu S, Hasegawa Y, Lapushin R, Xu HJ, Woodgett JR, Mills GB, Fang X 2004 Glycogen synthase kinase 3β is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase. J Biol Chem 279:51075-51081
35. Fernandez AM, Kim JK, Yakar S, Dupont J, Hernandez-Sanchez C, Castle AL, Filmore J, Shulman GI, Le Roith D 2001 Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes. Genes Dev 15:1926-1934
36. Asghar Z, Yau D, Chan F, Leroith D, Chan CB, Wheeler MB 2006 Insulin resistance causes increased β-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes. Diabetologia 49:90-99
37. Anini Y, Hansotia T, Brubaker PL 2002 Muscarinic receptors control postprandial release of glucagon-like peptide-1: in vivo and in vitro studies in rats. Endocrinology 143:2420-2426
38. Drucker DJ, Jin T, Asa SL, Young TA, Brubaker PL 1994 Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line. Mol Endocrinol 8:1646-1655
39. Rindi G, Grant SG, Yiangou Y, Ghatei MA, Bloom SR, Bautch VL, Solcia E, Polak JM 1990 Development of neuroendocrine tumors in the gastrointestinal tract of transgenic mice. Heterogeneity of hormone expression. Am J Pathol 136:1349-1363
40. Takaki R, Ono J, Nakamura M, Yokogawa Y, Kumae S, Hiraoka T, Yamaguchi K, Hamaguchi K, Uchida S 1986 Isolation of glucagon-secreting cell lines by cloning insulinoma cells. In Vitro Cell Dev Biol 22:120-126
41. Chen L, Wang P, Andrade CF, Zhao IY, Dube PE, Brubaker PL, Liu M, Jin T 2005 PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AMP. FEBS J 272:2746-2759
42. Jamieson CH, Ailles LE, Dylla SJ, Muijtjens M, Jones C, Zehnder JL, Gotlib J, Li K, Manz MG, Keating A, Sawyers CL, Weissman IL 2004 Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med 351:657-667
43. Lim GE, Brubaker, PL 2006 Glucagon-like peptide 1 secretion by the L-cell. The View from within. Diabetes 55:S70-S77
44. Schinner S, Barthel A, Dellas C, Grzeskowiak R, Sharma SK, Oetjen E, Blume R, Knepel W 2005 Protein kinase B activity is sufficient to mimic the effect of insulin on glucagon gene transcription. J Biol Chem 280:7369-7376
45. Nusse R 1997 A versatile transcriptional effector of Wingless signaling. Cell 89:321-323
46. Ding VW, Chen RH, McCormick F 2000 Differential regulation of glycogen synthase kinase 3β by insulin and Wnt signaling. J Biol Chem 275:32475-32481
47. Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR 2000 Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation. Nature 406:86-90
48. Fu P, Arcasoy MO 2007 Erythropoietin protects cardiac myocytes against anthracycline-induced apoptosis. Biochem Biophys Res Commun 354:372-378
49. Murtaugh LC, Law AC, Dor Y, Melton DA 2005 β-Catenin is essential for pancreatic acinar but not islet development. Development 132:4663-4674
50. Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PI, Shuldiner AR, Knowler WC, Nathan DM, Altshuler D 2006 TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 355:241-250
51. Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K 2006 Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38:320-323
52. Lyssenko V, Lupi R, Marchetti P, Del Guerra S, Orho-Melander M, Almgren P, Sjogren M, Ling C, Eriksson KF, Lethagen AL, Mancarella R, Berglund G, Tuomi T, Nilsson P, Del Prato S, Groop L 2007 Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117:2155-2163
53. Desbois-Mouthon C, Cadoret A, Blivet-Van Eggelpoel MJ, Bertrand F, Cherqui G, Perret C, Capeau J 2001 Insulin and IGF-1 stimulate the β-catenin pathway through two signalling cascades involving GSK-3β inhibition and Ras activation. Oncogene 20:252-259
54. Verras M, Sun Z 2005 β-Catenin is involved in insulin-like growth factor 1-mediated transactivation of the androgen receptor. Mol Endocrinol 19:391-398
55. Tian Q, Feetham MC, Tao WA, He XC, Li L, Aebersold R, Hood L 2004 Proteomic analysis identifies that 14-3-3ζ interacts with β-catenin and facilitates its activation by Akt. Proc Natl Acad Sci USA 101:15370-15375
56. Wilker E, Lu J, Rho O, Carbajal S, Beltran L, DiGiovanni J 2005 Role of PI3K/Akt signaling in insulin-like growth factor-1 (IGF-1) skin tumor promotion. Mol Carcinog 44:137-145
57. Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC 2005 Erk associates with and primes GSK-3β for its inactivation resulting in upregulation of β-catenin. Mol Cell 19:159-170
58. Satyamoorthy K, Li G, Vaidya B, Patel D, Herlyn M 2001 Insulin-like growth factor-1 induces survival and growth of biologically early melanoma cells through both the mitogen-activated protein kinase and β-catenin pathways. Cancer Res 61:7318-7324
59. Desbois-Mouthon C, Blivet-Van Eggelpoel MJ, Beurel E, Boissan M, Delelo R, Cadoret A, Capeau J 2002 Dysregulation of glycogen synthase kinase-3β signaling in hepatocellular carcinoma cells. Hepatology 36:1528-1536
60. Zhang Q, Adiseshaiah P, Kalvakolanu DV, Reddy SP 2006 A phosphatidylinositol 3-kinase-regulated Akt-independent signaling promotes cigarette smoke-induced FRA-1 expression. J Biol Chem 281:10174-10181