메뉴 건너뛰기




Volumn 314, Issue 13, 2008, Pages 2434-2447

Telomere dysfunction in human keratinocytes elicits senescence and a novel transcription profile

Author keywords

DNA damage; Keratinocyte; Microarray; Senescence; Telomere; TRF2

Indexed keywords

BETA GALACTOSIDASE; PROTEIN P53; TELOMERIC REPEAT BINDING FACTOR 2;

EID: 47549100990     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2008.05.007     Document Type: Article
Times cited : (11)

References (70)
  • 1
    • 33846090789 scopus 로고    scopus 로고
    • Accumulation of senescent cells in mitotic tissue of aging primates
    • Jeyapalan J.C., Ferreira M., Sedivy J.M., and Herbig U. Accumulation of senescent cells in mitotic tissue of aging primates. Mech. Ageing Dev. 128 (2007) 36-44
    • (2007) Mech. Ageing Dev. , vol.128 , pp. 36-44
    • Jeyapalan, J.C.1    Ferreira, M.2    Sedivy, J.M.3    Herbig, U.4
  • 2
    • 33750030758 scopus 로고    scopus 로고
    • The regulation of INK4/ARF in cancer and aging
    • Kim W.Y., and Sharpless N.E. The regulation of INK4/ARF in cancer and aging. Cell 127 (2006) 265-275
    • (2006) Cell , vol.127 , pp. 265-275
    • Kim, W.Y.1    Sharpless, N.E.2
  • 4
    • 0031715965 scopus 로고    scopus 로고
    • Altered stem cell regeneration in irradiated intestinal crypts of senescent mice
    • Martin K., Potten C.S., Roberts S.A., and Kirkwood T.B. Altered stem cell regeneration in irradiated intestinal crypts of senescent mice. J. Cell Sci. 111 Pt 16 (1998) 2297-2303
    • (1998) J. Cell Sci. , vol.111 , Issue.PART 16 , pp. 2297-2303
    • Martin, K.1    Potten, C.S.2    Roberts, S.A.3    Kirkwood, T.B.4
  • 5
    • 34447623393 scopus 로고    scopus 로고
    • Epidermal stem cells are resistant to cellular aging
    • Stern M.M., and Bickenbach J.R. Epidermal stem cells are resistant to cellular aging. Aging. Cell 6 (2007) 439-452
    • (2007) Aging. Cell , vol.6 , pp. 439-452
    • Stern, M.M.1    Bickenbach, J.R.2
  • 6
    • 0036288508 scopus 로고    scopus 로고
    • A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status
    • Rheinwald J.G., Hahn W.C., Ramsey M.R., Wu J.Y., Guo Z., Tsao H., De Luca M., Catricala C., and O'Toole K.M. A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol. Cell. Biol. 22 (2002) 5157-5172
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5157-5172
    • Rheinwald, J.G.1    Hahn, W.C.2    Ramsey, M.R.3    Wu, J.Y.4    Guo, Z.5    Tsao, H.6    De Luca, M.7    Catricala, C.8    O'Toole, K.M.9
  • 7
    • 33744732501 scopus 로고    scopus 로고
    • A keratinocyte hypermotility/growth-arrest response involving laminin 5 and p16INK4A activated in wound healing and senescence
    • Natarajan E., Omobono II J.D., Guo Z., Hopkinson S., Lazar A.J., Brenn T., Jones J.C., and Rheinwald J.G. A keratinocyte hypermotility/growth-arrest response involving laminin 5 and p16INK4A activated in wound healing and senescence. Am. J. Pathol. 168 (2006) 1821-1837
    • (2006) Am. J. Pathol. , vol.168 , pp. 1821-1837
    • Natarajan, E.1    Omobono II, J.D.2    Guo, Z.3    Hopkinson, S.4    Lazar, A.J.5    Brenn, T.6    Jones, J.C.7    Rheinwald, J.G.8
  • 9
    • 0035960043 scopus 로고    scopus 로고
    • The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
    • Vulliamy T., Marrone A., Goldman F., Dearlove A., Bessler M., Mason P.J., and Dokal I. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature 413 (2001) 432-435
    • (2001) Nature , vol.413 , pp. 432-435
    • Vulliamy, T.1    Marrone, A.2    Goldman, F.3    Dearlove, A.4    Bessler, M.5    Mason, P.J.6    Dokal, I.7
  • 11
    • 0025029030 scopus 로고
    • Hypervariable ultra-long telomeres in mice
    • Kipling D., and Cooke H.J. Hypervariable ultra-long telomeres in mice. Nature 347 (1990) 400-402
    • (1990) Nature , vol.347 , pp. 400-402
    • Kipling, D.1    Cooke, H.J.2
  • 12
    • 0029827128 scopus 로고    scopus 로고
    • Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex
    • Luderus M.E., van Steensel B., Chong L., Sibon O.C., Cremers F.F., and de Lange T. Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex. J. Cell Biol. 135 (1996) 867-881
    • (1996) J. Cell Biol. , vol.135 , pp. 867-881
    • Luderus, M.E.1    van Steensel, B.2    Chong, L.3    Sibon, O.C.4    Cremers, F.F.5    de Lange, T.6
  • 13
    • 24944460598 scopus 로고    scopus 로고
    • Shelterin: the protein complex that shapes and safeguards human telomeres
    • de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 19 (2005) 2100-2110
    • (2005) Genes Dev. , vol.19 , pp. 2100-2110
    • de Lange, T.1
  • 17
    • 0037102234 scopus 로고    scopus 로고
    • Different telomere damage signaling pathways in human and mouse cells
    • Smogorzewska A., and de Lange T. Different telomere damage signaling pathways in human and mouse cells. EMBO J. 21 (2002) 4338-4348
    • (2002) EMBO J. , vol.21 , pp. 4338-4348
    • Smogorzewska, A.1    de Lange, T.2
  • 18
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
    • Greider C.W., and Blackburn E.H. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43 (1985) 405-413
    • (1985) Cell , vol.43 , pp. 405-413
    • Greider, C.W.1    Blackburn, E.H.2
  • 22
    • 0029973653 scopus 로고    scopus 로고
    • Regulation of telomerase activity in immortal cell lines
    • Holt S.E., Wright W.E., and Shay J.W. Regulation of telomerase activity in immortal cell lines. Mol. Cell. Biol. 16 (1996) 2932-2939
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2932-2939
    • Holt, S.E.1    Wright, W.E.2    Shay, J.W.3
  • 24
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • Takai H., Smogorzewska A., and de Lange T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 13 (2003) 1549-1556
    • (2003) Curr. Biol. , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    de Lange, T.3
  • 25
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel B., Smogorzewska A., and de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell 92 (1998) 401-413
    • (1998) Cell , vol.92 , pp. 401-413
    • van Steensel, B.1    Smogorzewska, A.2    de Lange, T.3
  • 26
    • 0037148277 scopus 로고    scopus 로고
    • Protection of mammalian telomeres
    • de Lange T. Protection of mammalian telomeres. Oncogene 21 (2002) 532-540
    • (2002) Oncogene , vol.21 , pp. 532-540
    • de Lange, T.1
  • 27
    • 0033605145 scopus 로고    scopus 로고
    • p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
    • Karlseder J., Broccoli D., Dai Y., Hardy S., and de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283 (1999) 1321-1325
    • (1999) Science , vol.283 , pp. 1321-1325
    • Karlseder, J.1    Broccoli, D.2    Dai, Y.3    Hardy, S.4    de Lange, T.5
  • 29
    • 0345304888 scopus 로고    scopus 로고
    • Senescing oral dysplasias are not immortalized by ectopic expression of hTERT alone without other molecular changes, such as loss of INK4A and/or retinoic acid receptor-beta: but p53 mutations are not necessarily required
    • Muntoni A., Fleming J., Gordon K.E., Hunter K., McGregor F., Parkinson E.K., and Harrison P.R. Senescing oral dysplasias are not immortalized by ectopic expression of hTERT alone without other molecular changes, such as loss of INK4A and/or retinoic acid receptor-beta: but p53 mutations are not necessarily required. Oncogene 22 (2003) 7804-7808
    • (2003) Oncogene , vol.22 , pp. 7804-7808
    • Muntoni, A.1    Fleming, J.2    Gordon, K.E.3    Hunter, K.4    McGregor, F.5    Parkinson, E.K.6    Harrison, P.R.7
  • 30
    • 0021682474 scopus 로고
    • Polycyclic aromatic hydrocarbon mutagenesis of human epidermal keratinocytes in culture
    • Allen-Hoffmann B.L., and Rheinwald J.G. Polycyclic aromatic hydrocarbon mutagenesis of human epidermal keratinocytes in culture. Proc. Natl. Acad. Sci. U. S. A. 81 (1984) 7802-7806
    • (1984) Proc. Natl. Acad. Sci. U. S. A. , vol.81 , pp. 7802-7806
    • Allen-Hoffmann, B.L.1    Rheinwald, J.G.2
  • 31
    • 0028978505 scopus 로고
    • Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss
    • Edington K.G., Loughran O.P., Berry I.J., and Parkinson E.K. Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss. Mol. Carcinog. 13 (1995) 254-265
    • (1995) Mol. Carcinog. , vol.13 , pp. 254-265
    • Edington, K.G.1    Loughran, O.P.2    Berry, I.J.3    Parkinson, E.K.4
  • 32
    • 0035858987 scopus 로고    scopus 로고
    • Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres
    • Munro J., Steeghs K., Morrison V., Ireland H., and Parkinson E.K. Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres. Oncogene 20 (2001) 3541-3552
    • (2001) Oncogene , vol.20 , pp. 3541-3552
    • Munro, J.1    Steeghs, K.2    Morrison, V.3    Ireland, H.4    Parkinson, E.K.5
  • 33
    • 0037102370 scopus 로고    scopus 로고
    • Molecular changes associated with oral dysplasia progression and acquisition of immortality: potential for its reversal by 5-azacytidine
    • McGregor F., Muntoni A., Fleming J., Brown J., Felix D.H., MacDonald D.G., Parkinson E.K., and Harrison P.R. Molecular changes associated with oral dysplasia progression and acquisition of immortality: potential for its reversal by 5-azacytidine. Cancer Res. 62 (2002) 4757-4766
    • (2002) Cancer Res. , vol.62 , pp. 4757-4766
    • McGregor, F.1    Muntoni, A.2    Fleming, J.3    Brown, J.4    Felix, D.H.5    MacDonald, D.G.6    Parkinson, E.K.7    Harrison, P.R.8
  • 34
    • 0031828021 scopus 로고    scopus 로고
    • Optimised retroviral infection of human epidermal keratinocytes: long-term expression of transduced integrin gene following grafting on to SCID mice
    • Levy L., Broad S., Zhu A.J., Carroll J.M., Khazaal I., Peault B., and Watt F.M. Optimised retroviral infection of human epidermal keratinocytes: long-term expression of transduced integrin gene following grafting on to SCID mice. Gene Ther. 5 (1998) 913-922
    • (1998) Gene Ther. , vol.5 , pp. 913-922
    • Levy, L.1    Broad, S.2    Zhu, A.J.3    Carroll, J.M.4    Khazaal, I.5    Peault, B.6    Watt, F.M.7
  • 35
    • 0034716904 scopus 로고    scopus 로고
    • Identification of human Rap1: implications for telomere evolution
    • Li B., Oestreich S., and de Lange T. Identification of human Rap1: implications for telomere evolution. Cell 101 (2000) 471-483
    • (2000) Cell , vol.101 , pp. 471-483
    • Li, B.1    Oestreich, S.2    de Lange, T.3
  • 36
    • 0037316303 scopus 로고    scopus 로고
    • A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    • Bolstad B.M., Irizarry R.A., Astrand M., and Speed T.P. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics (Oxford, England) 19 (2003) 185-193
    • (2003) Bioinformatics (Oxford, England) , vol.19 , pp. 185-193
    • Bolstad, B.M.1    Irizarry, R.A.2    Astrand, M.3    Speed, T.P.4
  • 38
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher V.G., Tibshirani R., and Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. U. S.A. 98 (2001) 5116-5121
    • (2001) Proc. Natl. Acad. Sci. U. S.A. , vol.98 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 39
  • 42
    • 0032485213 scopus 로고    scopus 로고
    • Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
    • Robles S.J., and Adami G.R. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene 16 (1998) 1113-1123
    • (1998) Oncogene , vol.16 , pp. 1113-1123
    • Robles, S.J.1    Adami, G.R.2
  • 43
    • 0018902467 scopus 로고
    • Serial cultivation of normal human epidermal keratinocytes
    • Rheinwald J.G. Serial cultivation of normal human epidermal keratinocytes. Methods Cell Biol. 21A (1980) 229-254
    • (1980) Methods Cell Biol. , vol.21 A , pp. 229-254
    • Rheinwald, J.G.1
  • 44
    • 0028199026 scopus 로고
    • Measurement of DNA double-strand breaks in mammalian cells by pulsed-field gel electrophoresis: a new approach using rarely cutting restriction enzymes
    • Lobrich M., Ikpeme S., and Kiefer J. Measurement of DNA double-strand breaks in mammalian cells by pulsed-field gel electrophoresis: a new approach using rarely cutting restriction enzymes. Radiat. Res. 138 (1994) 186-192
    • (1994) Radiat. Res. , vol.138 , pp. 186-192
    • Lobrich, M.1    Ikpeme, S.2    Kiefer, J.3
  • 45
    • 11144268164 scopus 로고    scopus 로고
    • Significant role for p16INK4a in p53-independent telomere-directed senescence
    • Jacobs J.J., and de Lange T. Significant role for p16INK4a in p53-independent telomere-directed senescence. Curr. Biol. 14 (2004) 2302-2308
    • (2004) Curr. Biol. , vol.14 , pp. 2302-2308
    • Jacobs, J.J.1    de Lange, T.2
  • 46
    • 0033979731 scopus 로고    scopus 로고
    • Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics
    • Dickson M.A., Hahn W.C., Ino Y., Ronfard V., Wu J.Y., Weinberg R.A., Louis D.N., Li F.P., and Rheinwald J.G. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol. Cell. Biol. 20 (2000) 1436-1447
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1436-1447
    • Dickson, M.A.1    Hahn, W.C.2    Ino, Y.3    Ronfard, V.4    Wu, J.Y.5    Weinberg, R.A.6    Louis, D.N.7    Li, F.P.8    Rheinwald, J.G.9
  • 47
    • 0029666504 scopus 로고    scopus 로고
    • Association of CDKN2A/p16INK4A with human head and neck keratinocyte replicative senescence: relationship of dysfunction to immortality and neoplasia
    • Loughran O., Malliri A., Owens D., Gallimore P.H., Stanley M.A., Ozanne B., Frame M.C., and Parkinson E.K. Association of CDKN2A/p16INK4A with human head and neck keratinocyte replicative senescence: relationship of dysfunction to immortality and neoplasia. Oncogene 13 (1996) 561-568
    • (1996) Oncogene , vol.13 , pp. 561-568
    • Loughran, O.1    Malliri, A.2    Owens, D.3    Gallimore, P.H.4    Stanley, M.A.5    Ozanne, B.6    Frame, M.C.7    Parkinson, E.K.8
  • 48
  • 49
    • 27144549704 scopus 로고    scopus 로고
    • Co-regulation of p16INK4A and migratory genes in culture conditions that lead to premature senescence in human keratinocytes
    • Darbro B.W., Schneider G.B., and Klingelhutz A.J. Co-regulation of p16INK4A and migratory genes in culture conditions that lead to premature senescence in human keratinocytes. J. Invest. Dermatol. 125 (2005) 499-509
    • (2005) J. Invest. Dermatol. , vol.125 , pp. 499-509
    • Darbro, B.W.1    Schneider, G.B.2    Klingelhutz, A.J.3
  • 52
    • 1642355129 scopus 로고    scopus 로고
    • Normal human fibroblasts are resistant to RAS-induced senescence
    • Benanti J.A., and Galloway D.A. Normal human fibroblasts are resistant to RAS-induced senescence. Mol. Cell. Biol. 24 (2004) 2842-2852
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 2842-2852
    • Benanti, J.A.1    Galloway, D.A.2
  • 54
    • 33646181086 scopus 로고    scopus 로고
    • Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus
    • Jung D., Giallourakis C., Mostoslavsky R., and Alt F.W. Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu. Rev. Immunol. 24 (2006) 541-570
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 541-570
    • Jung, D.1    Giallourakis, C.2    Mostoslavsky, R.3    Alt, F.W.4
  • 55
    • 0011478490 scopus 로고
    • Three clonal types of keratinocyte with different capacities for multiplication
    • Barrandon Y., and Green H. Three clonal types of keratinocyte with different capacities for multiplication. Proc. Natl. Acad. Sci. U. S. A. 84 (1987) 2302-2306
    • (1987) Proc. Natl. Acad. Sci. U. S. A. , vol.84 , pp. 2302-2306
    • Barrandon, Y.1    Green, H.2
  • 56
    • 0034256009 scopus 로고    scopus 로고
    • In vitro replication and differentiation of normal human oral keratinocytes
    • Kang M.K., Bibb C., Baluda M.A., Rey O., and Park N.H. In vitro replication and differentiation of normal human oral keratinocytes. Exp. Cell Res. 258 (2000) 288-297
    • (2000) Exp. Cell Res. , vol.258 , pp. 288-297
    • Kang, M.K.1    Bibb, C.2    Baluda, M.A.3    Rey, O.4    Park, N.H.5
  • 57
    • 24644518976 scopus 로고    scopus 로고
    • Id2 protein is selectively upregulated by UVB in primary, but not in immortalized human keratinocytes and inhibits differentiation
    • Simbulan-Rosenthal C.M., Trabosh V., Velarde A., Chou F.P., Daher A., Tenzin F., Tokino T., and Rosenthal D.S. Id2 protein is selectively upregulated by UVB in primary, but not in immortalized human keratinocytes and inhibits differentiation. Oncogene 24 (2005) 5443-5458
    • (2005) Oncogene , vol.24 , pp. 5443-5458
    • Simbulan-Rosenthal, C.M.1    Trabosh, V.2    Velarde, A.3    Chou, F.P.4    Daher, A.5    Tenzin, F.6    Tokino, T.7    Rosenthal, D.S.8
  • 59
    • 24144473952 scopus 로고    scopus 로고
    • Effectors of mammalian telomere dysfunction: a comparative transcriptome analysis using mouse models
    • Franco S., Canela A., Klatt P., and Blasco M.A. Effectors of mammalian telomere dysfunction: a comparative transcriptome analysis using mouse models. Carcinogenesis 26 (2005) 1613-1626
    • (2005) Carcinogenesis , vol.26 , pp. 1613-1626
    • Franco, S.1    Canela, A.2    Klatt, P.3    Blasco, M.A.4
  • 62
    • 0037974865 scopus 로고    scopus 로고
    • Identification of a novel homeobox-containing gene, LAGY, which is downregulated in lung cancer
    • Chen Y., Petersen S., Pacyna-Gengelbach M., Pietas A., and Petersen I. Identification of a novel homeobox-containing gene, LAGY, which is downregulated in lung cancer. Oncology 64 (2003) 450-458
    • (2003) Oncology , vol.64 , pp. 450-458
    • Chen, Y.1    Petersen, S.2    Pacyna-Gengelbach, M.3    Pietas, A.4    Petersen, I.5
  • 68
    • 33748754731 scopus 로고    scopus 로고
    • Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1
    • Severa M., Coccia E.M., and Fitzgerald K.A. Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1. J. Biol. Chem. 281 (2006) 26188-26195
    • (2006) J. Biol. Chem. , vol.281 , pp. 26188-26195
    • Severa, M.1    Coccia, E.M.2    Fitzgerald, K.A.3
  • 69
    • 33747816716 scopus 로고    scopus 로고
    • SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells
    • Sprangers M., Feldhahn N., Liedtke S., Jumaa H., Siebert R., and Muschen M. SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells. Oncogene 25 (2006) 5180-5186
    • (2006) Oncogene , vol.25 , pp. 5180-5186
    • Sprangers, M.1    Feldhahn, N.2    Liedtke, S.3    Jumaa, H.4    Siebert, R.5    Muschen, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.