Conserved regulation of the hansenula polymorpha MOX promoter in Saccharomyces cerevisiae reveals insights in the transcriptional activation by Adr1p

European Journal of Biochemistry

Volumn 238, Issue 1, 1996, Pages 181-191

  Pereira, Gonçalo G ^a   Hollenberg, Cornelis P ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Adr1p; Glucose repression; Methanol oxidase; Yeast

Indexed keywords

TRANSCRIPTION FACTOR;

ARTICLE; CONTROLLED STUDY; DNA BINDING; GENE EXPRESSION REGULATION; GENE TRANSFER; HANSENULA POLYMORPHA; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION;

EID: 0030002498     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1996.0181q.x     Document Type: Article

References (51)

1. Harder, W. & Veenhuis, M. (1989) Metabolism of one carbon compound, in The yeasts (Rose, A. H. & Harrison, J. R., eds) pp. 289-316, Academic Press Inc., London.
2. Veenhuis, M., Van Dijken, J. P. & Harder. W. (1983) The significance of peroxisomes in the metabolism of one carbon compound in yeast, Adv. Microb. Physiol. 24, 1-82.
3. Sahm, H. (1977) Metabolism of methanol by yeast, Adv. Biochem. Eng. 6, 77-103.
4. Van der Klei, I. J., Sulter, G. J., Harder, W. & Veenhuis, M. (1991) Assembly of alcohol oxidase in the cytosol of a peroxisome-deficient mutant of Hansenula polymorpha: properties of the protein and architecture of the crystals, Yeast 7, 15-24.
5. Roggenkamp, R., Janowicz, Z., Stanikowski, B. & Hollenberg, C. P. (1984) Biosynthesis and regulation of the peroxisomal methanol oxidase from the methylotrophic yeast Hansenula polymorpha, Mol. & Gen. Genet. 194, 489-493.
6. Giuseppin, M. L. F., Van Eijk, H. M. J. & Bes, B. C. M. (1988) Molecular regulation of methanol oxidase in continuous culture of Hansenula polymorpha, Biotechnol. Bioeng. 32, 577-583.
7. Van der Klei, I. J., Harder, W. & Veenhuis, M. (1991) Biosynthesis and assembly of alcohol oxidase, a peroxisomal matrix protein in methylotrophic yeasts: a review. Yeast 7, 195-209.
8. Gödecke, S., Eckart, M., Janowicz, Z. A. & Hollenberg, C. P. (1994) Identification of sequences responsible for transcriptional regulation of the strongly expressed methanol oxidase-encoding gene in Hansenula polymorpha, Gene (Amst.) 139, 35-42.
9. Veenhuis, M., Mateblowski, M., Kunau, W. H. & Harder, W. (1987) Proliferation of microbodies in Saccharomyces cerevisiae, Yeast 3, 77-84.
10. Simon, M., Adam, G., Rapatz, W., Spevak, W. & Ruis, H. (1991) The Saccharomyces cerevisiae ADR1 gene is a positive regulator of transcription of genes encoding peroxisomal proteins, Mol. Cell. Biol. 11, 699-704.
11. Simon, M., Binder, M., Adam, G., Hartig, A. & Ruis, H. (1992) Control of peroxisome proliferation in Saccharomyces cerevisiae by ADR1, SNF1 (CAT1, CCR1) and SNF4 (CAT3). Yeast 8, 303-309.
12. Navarro, B. & Igual, J. C. (1994) ADR1 and SNF1 mediate different mechanisms in transcriptional regulation of yeast POT1 gene, Biochem. Biophys. Res. Commun. 202, 960-966.
13. Ciriacy, M. (1975) Genetics of alcohol dehydrogenase in Saccharomyces cerevisiae. II. Two loci controlling synthesis of the glucose-repressible ADH2, Mol. & Gen. Genet. 138, 157-164.
14. Denis, C. L., Ciriacy, M. & Young, E. T. (1981) A positive regulatory gene is required for accumulation of the functional mRNA for the glucose-repressible alcohol dehydrogenase from Saccharomyces cerevisiae, J. Mol. Biol. 148, 355-368.
15. Thukral, S. K., Tavianini, M. A., Blumberg, H. & Young, E. T. (1989) Localization of a minimal binding domain and activation regions in yeast regulatory protein ADR1, Mol. Cell. Biol. 9, 2360-2369.
16. Eisen, A., Taylor, W. E., Blumberg, H. & Young, E. T. (1988) The yeast regulatory protein ADR1 binds in a zinc-dependent manner to the upstream activating sequence of ADH2, Mol. Cell. Biol. 8, 4552-4556.
17. Taylor, W. K. & Young, E. T. (1990) cAMP-dependent phosphorylation and inactivation of yeast transcription factor ADR1 does not affect DNA binding, Proc. Natl Acad. Sci. USA 87, 4098-4102.
18. Thukral, S. K., Eisen, A. & Young, H. T. (1991) Two monomers of yeast transcription factor ADR1 hind a palindromic sequence symmetrically to activate ADH2 expression, Mol. Cell. Biol. 11, 1566-1577.
19. Thukral, S. K., Morrison, M. L. & Young, E. T. (1992) Mutations in the zinc fingers of ADR1 that change the specificity of DNA binding and transactivation, Mol. Cell. Biol. 12, 2784-2792.
20. Bemis, L. T. & Denis, C. L. (1988) Identification of functional regions in the yeast transcriptional activator ADR1, Mol. Cell. Biol. 8, 2125-2131.
21. Pavlik, P., Simon, M., Schuster, T. & Ruis, H. (1993) The glycerol kinase (GUT1) gene of Saccharomyces cerevisiae: cloning and characterization, Curr. Genet. 24, 21-25.
22. Cheng, C., Kacherovsky, N., Dombek, K. M., Camier, S., Thukral, S. K., Rhim, E. & Young, E. T. (1994) Identification of potential target genes for Adr1p through characterization of essential nucleotides in UAS1, Mol. Cell. Biol. 14, 3842-3852.
23. Vallari, R. C., Cook, W. J., Audino, D. C., Morgan, M. J., Jensen, D. E., Laudano, A. P. & Denis, C. E. (1992) Glucose repression of the yeast ADH2 gene occurs through multiple mechanisms, including control of the protein synthesis of its transcriptional activator, ADR1, Mol. Cell. Biol. 12, 1663-1673.
24. Denis, C. L., Fontaine, S. C., Chase, D., Kemp, B. E. & Bemis, L. T. (1992) ADR1 mutations enhance the ability of ADR1 to activate transcription by a mechanism that is independent of effects on cyclic AMP-dependent protein kinase phosphorylation of Ser-230, Mol. Cell. Biol. 12, 1507-1514.
25. Cook, W. J., Chase, D., Audino, D. C. & Denis, C. L. (1944) Dissection of the ADR1 protein reveals multiple, functionally redundant activation domains interspersed with inhibitory regions: evidence for a repressor binding to the ADR1-c region, Mol. Cell. Biol. 14, 629-640.
26. Yu, J., Donoviel, M. S. & Young, E. T. (1989) Adjacent upstream activation sequence elements synergistically regulate transcription of ADH2 in Saccharomyces cerevisiae. Mol. Cell. Biol. 9, 34-42.
27. Donoviel, M. S., Kacherovsky, N. & Young, E. T. (1995) Synergistic activation of ADH2 expression is sensitive to upstream activation sequence 2 (UAS2) orientation, copy number, and UAS1-UAS2 helical phasing, Mol. Cell. Biol. 15, 3442-3449.
28. Sherman, F., Fink, F. & Lawrence, C. (1983) Methods in yeast genetics, Cold Spring Harbor Laboratory, Cold Spring Harbor N. Y.
29. Denis, C. L. & Young, E. T. (1983) Isolation and characterization of the positive regulator gene ADR1 from Saccharomyces cerevisiae, Mol. Cell. Biol. 3, 360-370.
30. Myers, A. M., Tzagoloff, A., Kinney, D. M. & Lusty, C. J. (1986) Yeast shuttle and integrative vectors with multiple cloning sites suitable for construction of lacZ fusions, Gene (Amst.) 45, 299-310.
31. Guarente, L. & Ptashne, M. (1981) Fusion of Escherichia coli lacZ to the cytochrome c gene of Saccharomyces cerevisiae, Proc. Natl Acad. Sci. USA 78, 2199-2203.
32. Dohmen, R. J., Strasser, A. W. M., Höner, C. B. & Hollenberg, C. P. (1991) An efficient transformation procedure enabling long-term storage of competent cells of various yeast genera. Yeast 7, 691-692.
33. Bradford, M. M. (1976) A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
34. Roggenkamp, R., Kustermann-Kuhn, B. & Hollenberg, C. P. (1981) Expression and processing of bacterial β-lactamase in the yeast Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA 78, 4466-4470.
35. Miller, J. H. (1972) Experiments in molecular genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor NY.
36. Sahm, H. & Wagner, F. (1973) Microbial assimilation of methanol. The ethanol and methanol oxidizing enzymes of the yeast Candida boidinii, Eur. J. Biochem. 36, 250-256.
37. Marinius, M. G. & Morris, N. R. (1973) Isolation of desoxyribonucleic acid methylase mutants of Escherichia coli K-12, J. Bacteriol. 114, 1143-1150.
38. Ausubel, F. M., Brent, R., Kingston, R. K., Moore, D. D., Seidman, J. G., Smith, J. A. & Struhl, K. (1990) Current protocols in molecular biology, Wiley Interscience, New York.
39. Breunig, K. & Kuger, P. (1987) Functional homology between the yeast regulatory protein GAL4 and LAC9: LAC9 mediated transcriptional activation in Kluyveromyces lactis involves protein binding to a regulatory sequence homologous to GAL4 protein binding site, Mol. Cell. Biol. 7, 4400-4406.
40. Keegan, L., Gill, G. & Ptashne, M. (1986) Separation of DNA binding from transcription-activating function of a eukaryotic regulatory protein, Science 233, 699-704.
41. Negri, R., Constanzo, G. & Di Mauro, E. (1991) A single reaction method for DNA sequence determination. Anal. Biochem. 197, 389-395.
42. Roggenkamp, R., Didion, T. & Kowallik, K. V. (1989) Formation of irregular giant peroxisomes by overproduction of the crystalloid core protein methanol oxidase in the methylotrophic yeast Hansenula polymorphic, Mol. Cell. Biol. 9, 988-994.
43. Einerhand, A. W. C., Kos, W. T., Distel, B. & Tabak, H. F. (1993) Characterization of a transcriptional control element involved in proliferation of peroxisomes in yeast in response to oleate, Eur. J. Biochem. 214, 323-331.
44. Einerhand, A. W. C., Van der Leij, I., Kos, W. T., Distel, B. & Tabak, H. F. (1992) Transcriptional regulation of genes encoding proteins involved in biogenesis of peroxisomes in Saccharomyces cerevisiae, Cell Biochem. Funct. 10, 185-191.
45. Thukral, S. K., Morrison, M. L. & Young, H. T. (1991) Alanine scanning site-directed mutagenesis of the zinc fingers of transcription factor ADR1: residues that contact DNA and that transactivate, Proc. Natl Acad. Sci. USA 88, 9188-9192.
46. Constanzo, G., Di Mauro, E., Negri, R., Pereira, G. A. G & Hollenberg, C. P. (1995) Multiple overlapping positions of nucleosomes with single rotational setting in the Hansenula polymorpha MOX promoter, J. Biol. Chem. 270, 11 091-11 097.
47. Filipits, M., Simon, M., Rapatz, W., Hamilton, B. & Ruis, H. (1993) A Saccharomyces cerevisiae upstream activating sequence mediates induction of peroxisomes proliferation by fatty acids. Gene (Amst.) 132, 49-55.
48. Denis, C. L. (1987) The effects of ADR1 and CCR1 gene dosage on the regulation of the glucose-repressible alcohol dehydrogenase from Saccharomyces cerevisiae. Mol. & Gen. Genet. 208, 101-106.
49. Dombek, K. M., Camier, S. & Young, E. T. (1993) ADH2 expression is repressed by REG1 independently of mutations that alter the phosphorylation of the yeast transcription factor ADR1, Mol. Cell. Biol. 13, 4391-4399.
50. Camier, S., Kacherovsky, N. & Young, E. T. (1992) A mutation outside the two zinc fingers of ADR1 can suppress defects in either finger, Mol. Cell. Biol. 12, 5758-5767.
51. Shain, D. H., Salvadore, C. & Denis, C. L. (1992) Evolution of the alcohol dehydrogenase (ADH) genes in yeast: characterization of a fourth ADH in Kluyveromyces lactis, Mol. & Gen. Genet. 232, 479-488.