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Molecular motors and mechanisms of directional transport in neurons
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Vale R.D. The molecular motor toolbox for intracellular transport. Cell 112 (2003) 467-480
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Duncan J.E., and Goldstein L.S. The genetics of axonal transport and axonal transport disorders. PLoS Genet 2 (2006) e124
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Zhang F., Strom A.L., Fukada K., Lee S., Hayward L.J., and Zhu H. Interaction between familial amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants and the dynein complex. J Biol Chem 282 (2007) 16691-16699
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Interaction of tau protein with the dynactin complex
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Magnani E., Fan J., Gasparini L., Golding M., Williams M., Schiavo G., Goedert M., Amos L.A., and Spillantini M.G. Interaction of tau protein with the dynactin complex. EMBO J 26 (2007) 4546-4554
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Magnani, E.1
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6
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39749165656
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Differential regulation of dynein and kinesin motor proteins by tau
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Using in vitro motility assays and GFP-tagged dynein and kinesin, the authors demonstrated that kinesin motor activity was affected at tau concentrations 10-fold lower than dynein, suggesting that kinesin-dependent transport is more sensitive to MT-binding proteins. The accumulation of tau in the soma of neurons in Alzheimer's disease may therefore inhibit kinesin-dependent transport and lead to neurodegeneration.
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Dixit R., Ross J.L., Goldman Y.E., and Holzbaur E.L. Differential regulation of dynein and kinesin motor proteins by tau. Science 319 (2008) 1086-1089. Using in vitro motility assays and GFP-tagged dynein and kinesin, the authors demonstrated that kinesin motor activity was affected at tau concentrations 10-fold lower than dynein, suggesting that kinesin-dependent transport is more sensitive to MT-binding proteins. The accumulation of tau in the soma of neurons in Alzheimer's disease may therefore inhibit kinesin-dependent transport and lead to neurodegeneration.
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Science
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Dixit, R.1
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Message in a bottle: long-range retrograde signaling in the nervous system
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Ibanez C.F. Message in a bottle: long-range retrograde signaling in the nervous system. Trends Cell Biol 17 (2007) 519-528
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Ibanez, C.F.1
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Nerve growth factor-mediated neurite outgrowth via regulation of Rab5
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Liu J., Lamb D., Chou M.M., Liu Y.J., and Li G. Nerve growth factor-mediated neurite outgrowth via regulation of Rab5. Mol Biol Cell 18 (2007) 1375-1384
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Liu, J.1
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The small GTPase Rab7 controls the endosomal trafficking and neuritogenic signaling of the nerve growth factor receptor TrkA
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Saxena S., Bucci C., Weis J., and Kruttgen A. The small GTPase Rab7 controls the endosomal trafficking and neuritogenic signaling of the nerve growth factor receptor TrkA. J Neurosci 25 (2005) 10930-10940
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Saxena, S.1
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One at a time, live tracking of NGF axonal transport using quantum dots
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Cui B., Wu C., Chen L., Ramirez A., Bearer E.L., Li W.P., Mobley W.C., and Chu S. One at a time, live tracking of NGF axonal transport using quantum dots. Proc Natl Acad Sci U S A 104 (2007) 13666-13671
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Cui, B.1
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12
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Trk-signaling endosomes are generated by Rac-dependent macroendocytosis
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Valdez G., Philippidou P., Rosenbaum J., Akmentin W., Shao Y., and Halegoua S. Trk-signaling endosomes are generated by Rac-dependent macroendocytosis. Proc Natl Acad Sci U S A 104 (2007) 12270-12275
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Valdez, G.1
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13
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33749620373
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Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway
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The binding fragment of tetanus toxin coupled to magnetic nanobeads was utilised to isolate axonal retrograde carriers used by this toxin, neurotrophins and their receptors to travel back to the soma in primary motor neurons. This strategy enabled the identification of Rab7 as a key component of these structures. The activity of Rab7 was shown to be essential for axonal retrograde transport.
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Deinhardt K., Salinas S., Verastegui C., Watson R., Worth D., Hanrahan S., Bucci C., and Schiavo G. Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway. Neuron 52 (2006) 293-305. The binding fragment of tetanus toxin coupled to magnetic nanobeads was utilised to isolate axonal retrograde carriers used by this toxin, neurotrophins and their receptors to travel back to the soma in primary motor neurons. This strategy enabled the identification of Rab7 as a key component of these structures. The activity of Rab7 was shown to be essential for axonal retrograde transport.
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Neuron
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Deinhardt, K.1
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Verastegui, C.3
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Hanrahan, S.6
Bucci, C.7
Schiavo, G.8
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Rab conversion as a mechanism of progression from early to late endosomes
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Rink J., Ghigo E., Kalaidzidis Y., and Zerial M. Rab conversion as a mechanism of progression from early to late endosomes. Cell 122 (2005) 735-749
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Cell
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Rink, J.1
Ghigo, E.2
Kalaidzidis, Y.3
Zerial, M.4
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15
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33644764063
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Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes
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This study reported on a new pre-early endosomal sorting mechanism occurring during cargo progression along the endocytic pathway in cultured cells. A dynamic population of Rab5 endosomes was shown to sort selective cargoes, such as LDL and influenza virus, towards late and degradative endosomes whereas transferrin was also delivered to a distinct pool of static early endosomes. Disruption of MT and knockdown of the clathrin adaptor AP2 were shown to impair this pre-early endosome sorting.
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Lakadamyali M., Rust M.J., and Zhuang X. Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Cell 124 (2006) 997-1009. This study reported on a new pre-early endosomal sorting mechanism occurring during cargo progression along the endocytic pathway in cultured cells. A dynamic population of Rab5 endosomes was shown to sort selective cargoes, such as LDL and influenza virus, towards late and degradative endosomes whereas transferrin was also delivered to a distinct pool of static early endosomes. Disruption of MT and knockdown of the clathrin adaptor AP2 were shown to impair this pre-early endosome sorting.
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Cell
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Lakadamyali, M.1
Rust, M.J.2
Zhuang, X.3
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33845905221
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Dynein is required for receptor sorting and the morphogenesis of early endosomes
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Driskell O.J., Mironov A., Allan V.J., and Woodman P.G. Dynein is required for receptor sorting and the morphogenesis of early endosomes. Nat Cell Biol 9 (2007) 113-120
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Driskell, O.J.1
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17
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33847003020
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Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued, ORP1L, and the receptor betalll spectrin
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Johansson M., Rocha N., Zwart W., Jordens I., Janssen L., Kuijl C., Olkkonen V.M., and Neefjes J. Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued, ORP1L, and the receptor betalll spectrin. J Cell Biol 176 (2007) 459-471
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Johansson, M.1
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Olkkonen, V.M.7
Neefjes, J.8
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18
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40849116519
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The somatodendritic endosomal regulator NEEP21 facilitates axonal targeting of L1/NgCAM
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This study uncovers the molecular mechanisms controlling the axonal targeting of L1/NgCAM. This adhesion molecule uses a somato-dendritic compartment regulated by the neuronal specific endosomal protein NEEP21 to access the axonal plasma membrane. Live cell experiments showed a preferential axonal anterograde transport of NgCAM-containing small vesicles. NEEP21 knockdown causes missorting of L1/NgCAM to dendrites owing to the impairment of its progression through the early endosomal compartment and axonal recycling.
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Yap C.C., Wisco D., Kujala P., Lasiecka Z.M., Cannon J.T., Chang M.C., Hirling H., Klumperman J., and Winckler B. The somatodendritic endosomal regulator NEEP21 facilitates axonal targeting of L1/NgCAM. J Cell Biol 180 (2008) 827-842. This study uncovers the molecular mechanisms controlling the axonal targeting of L1/NgCAM. This adhesion molecule uses a somato-dendritic compartment regulated by the neuronal specific endosomal protein NEEP21 to access the axonal plasma membrane. Live cell experiments showed a preferential axonal anterograde transport of NgCAM-containing small vesicles. NEEP21 knockdown causes missorting of L1/NgCAM to dendrites owing to the impairment of its progression through the early endosomal compartment and axonal recycling.
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J Cell Biol
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Yap, C.C.1
Wisco, D.2
Kujala, P.3
Lasiecka, Z.M.4
Cannon, J.T.5
Chang, M.C.6
Hirling, H.7
Klumperman, J.8
Winckler, B.9
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19
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38349160161
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The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis
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Gitler A.D., Bevis B.J., Shorter J., Strathearn K.E., Hamamichi S., Su L.J., Caldwell K.A., Caldwell G.A., Rochet J.C., McCaffery J.M., et al. The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proc Natl Acad Sci U S A 105 (2008) 145-150
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Gitler, A.D.1
Bevis, B.J.2
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Hamamichi, S.5
Su, L.J.6
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McCaffery, J.M.10
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20
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33746533924
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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
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Cooper A.A., Gitler A.D., Cashikar A., Haynes C.M., Hill K.J., Bhullar B., Liu K., Xu K., Strathearn K.E., Liu F., et al. Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 313 (2006) 324-328
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Science
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Cooper, A.A.1
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Liu, K.7
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Liu, F.10
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21
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33750312943
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Charcot-Marie-Tooth disease due to a de novo mutation of the RAB7 gene
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Meggouh F., Bienfait H.M., Weterman M.A., de Visser M., and Baas F. Charcot-Marie-Tooth disease due to a de novo mutation of the RAB7 gene. Neurology 67 (2006) 1476-1478
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22
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33745473350
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Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities
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Devon R.S., Orban P.C., Gerrow K., Barbieri M.A., Schwab C., Cao L.P., Helm J.R., Bissada N., Cruz-Aguado R., Davidson T.L., et al. Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities. Proc Natl Acad Sci U S A 103 (2006) 9595-9600
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Devon, R.S.1
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Cao, L.P.6
Helm, J.R.7
Bissada, N.8
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Davidson, T.L.10
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23
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31144448704
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Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking
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Hadano S., Benn S.C., Kakuta S., Otomo A., Sudo K., Kunita R., Suzuki-Utsunomiya K., Mizumura H., Shefner J.M., Cox G.A., et al. Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking. Hum Mol Genet 15 (2006) 233-250
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Hadano, S.1
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Kunita, R.6
Suzuki-Utsunomiya, K.7
Mizumura, H.8
Shefner, J.M.9
Cox, G.A.10
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24
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32644434386
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Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease
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Pal A., Severin F., Lommer B., Shevchenko A., and Zerial M. Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease. J Cell Biol 172 (2006) 605-618
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J Cell Biol
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Pal, A.1
Severin, F.2
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Shevchenko, A.4
Zerial, M.5
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25
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3142636768
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Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules
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This study provided molecular insights into the mechanism of neurodegeneration occurring in HD. Htt was shown to increase BDNF trafficking, while the polyQ form of Htt could not. The deficiency in BDNF transport in cells derived from a mouse line overexpressing mutant Htt was rescued by wild-type Htt. The effect of Htt on transport was mediated by HAP1, which acts as an adaptor for the dynein/dynactin motor complex. This property was not shared by the pathological version of Htt.
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Gauthier L.R., Charrin B.C., Borrell-Pages M., Dompierre J.P., Rangone H., Cordelieres F.P., De Mey J., MacDonald M.E., Lessmann V., Humbert S., et al. Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 118 (2004) 127-138. This study provided molecular insights into the mechanism of neurodegeneration occurring in HD. Htt was shown to increase BDNF trafficking, while the polyQ form of Htt could not. The deficiency in BDNF transport in cells derived from a mouse line overexpressing mutant Htt was rescued by wild-type Htt. The effect of Htt on transport was mediated by HAP1, which acts as an adaptor for the dynein/dynactin motor complex. This property was not shared by the pathological version of Htt.
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Cell
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Gauthier, L.R.1
Charrin, B.C.2
Borrell-Pages, M.3
Dompierre, J.P.4
Rangone, H.5
Cordelieres, F.P.6
De Mey, J.7
MacDonald, M.E.8
Lessmann, V.9
Humbert, S.10
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26
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33745233087
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Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth
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Rong J., McGuire J.R., Fang Z.H., Sheng G., Shin J.Y., Li S.H., and Li X.J. Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth. J Neurosci 26 (2006) 6019-6030
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J Neurosci
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Rong, J.1
McGuire, J.R.2
Fang, Z.H.3
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Li, S.H.6
Li, X.J.7
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27
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Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons
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McGuire J.R., Rong J., Li S.H., and Li X.J. Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons. J Biol Chem 281 (2006) 3552-3559
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McGuire, J.R.1
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Li, S.H.3
Li, X.J.4
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28
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33745512851
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Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration
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Two mouse strains segmentally trisomic for Chr16 have been used to study the molecular basis of DS: Ts65Dn where an extra copy of the app gene is present together with 140 additional genes; and Ts1Cje that has only 2 copies of app but still bears 100 of the genes present in Ts65Dn. NGF transport was tested by injecting radiolabeled NGF into the hippocampus of control versus diseased mice. Greater impairment of NGF transport was detected in Ts65Dn than in Ts1Cje mice. This was attributed to APP overexpression, since deletion of the extra copy of app in Ts65Dn partially restored transport. This inhibition of NGF transport was observed in mice expressing human APP or mutations in PS1, an APP partner mutated in a familial form of Alzheimer disease (AD). This study provides insights into the AD-like symptoms caused by cholinergic neurodegeneration occurring in elderly DS patients.
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Salehi A., Delcroix J.D., Belichenko P.V., Zhan K., Wu C., Valletta J.S., Takimoto-Kimura R., Kleschevnikov A.M., Sambamurti K., Chung P.P., et al. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron 51 (2006) 29-42. Two mouse strains segmentally trisomic for Chr16 have been used to study the molecular basis of DS: Ts65Dn where an extra copy of the app gene is present together with 140 additional genes; and Ts1Cje that has only 2 copies of app but still bears 100 of the genes present in Ts65Dn. NGF transport was tested by injecting radiolabeled NGF into the hippocampus of control versus diseased mice. Greater impairment of NGF transport was detected in Ts65Dn than in Ts1Cje mice. This was attributed to APP overexpression, since deletion of the extra copy of app in Ts65Dn partially restored transport. This inhibition of NGF transport was observed in mice expressing human APP or mutations in PS1, an APP partner mutated in a familial form of Alzheimer disease (AD). This study provides insights into the AD-like symptoms caused by cholinergic neurodegeneration occurring in elderly DS patients.
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(2006)
Neuron
, vol.51
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Salehi, A.1
Delcroix, J.D.2
Belichenko, P.V.3
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Wu, C.5
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Takimoto-Kimura, R.7
Kleschevnikov, A.M.8
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Chung, P.P.10
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Gunawardena S., and Goldstein L.S. Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila. Neuron 32 (2001) 389-401
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Stokin G.B., Lillo C., Falzone T.L., Brusch R.G., Rockenstein E., Mount S.L., Raman R., Davies P., Masliah E., Williams D.S., et al. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science 307 (2005) 1282-1288
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Stokin, G.B.1
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31
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Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1
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Lazarov O., Morfini G.A., Pigino G., Gadadhar A., Chen X., Robinson J., Ho H., Brady S.T., and Sisodia S.S. Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1. J Neurosci 27 (2007) 7011-7020
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Lazarov, O.1
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32
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Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited
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Lazarov O., Morfini G.A., Lee E.B., Farah M.H., Szodorai A., DeBoer S.R., Koliatsos V.E., Kins S., Lee V.M., Wong P.C., et al. Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. J Neurosci 25 (2005) 2386-2395
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Lazarov, O.1
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Muresan Z., and Muresan V. Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. J Cell Biol 171 (2005) 615-625
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The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport
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Araki Y., Kawano T., Taru H., Saito Y., Wada S., Miyamoto K., Kobayashi H., Ishikawa H.O., Ohsugi Y., Yamamoto T., et al. The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. EMBO J 26 (2007) 1475-1486
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