The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport

EMBO Journal

Volumn 26, Issue 6, 2007, Pages 1475-1486

  Araki, Yoichi ^a   Kawano, Takanori ^a   Taru, Hidenori ^a   Saito, Yuhki ^a   Wada, Sachiyo ^a   Miyamoto, Kanako ^b   Kobayashi, Hisako ^b   Ishikawa, Hiroyuki O ^b   Ohsugi, Yu ^a   Yamamoto, Tohru ^a   Matsuno, Kenji ^b   Kinjo, Masataka ^a   Suzuki, Toshiharu ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Alcadein; Alzheimer's disease; APP; Axonal transport; Kinesin

Indexed keywords

ADAPTOR PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC ACID; KINESIN; STRESS ACTIVATED PROTEIN KINASE; TRYPTOPHAN;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; MOUSE; NERVE FIBER; NERVE FIBER TRANSPORT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN METABOLISM; VELOCITY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; AXONAL TRANSPORT; BLOTTING, WESTERN; CALCIUM-BINDING PROTEINS; DROSOPHILA; IMMUNOPRECIPITATION; KINESIN; MEMBRANE PROTEINS; MICE; MICROSCOPY, FLUORESCENCE; MOLECULAR MOTOR PROTEINS; RNA, SMALL INTERFERING; TRANSPORT VESICLES;

EID: 33947607769     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601609     Document Type: Article

References (32)

1. Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T (2004) Coordinated metabolism of Alcadein and amyloid b-protein precursor regulates FE65-dependent gene transactivation. J Biol Chem 279: 24343-24354
2. Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T (2003) Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid β-protein precursor metabolism. J Biol Chem 278: 49448-49458
3. Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415
4. Chalvet F, Samson M-L (2002) Characterization of fly strains permitting GAL4-directed expression of found in neuron. Genesis 34: 71-73
5. Citron M, Oltesdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ (1992) Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases b-protein production. Nature 360: 672-674
6. Cras P, Kawai M, Lowery D, Gonzalez-DeWhitt P, Greenberg B, Perry G (1991) Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein. Proc Natl Acad Sci USA 88: 7552-7556
7. Gandy S (2005) The role of cerebral amyloid β accumulation in common forms of Alzheimer disease. J Clin Invest 115: 1121-1129
8. Gauger AK, Goldstein LSB (1993) The Drosophila kinesin light chain. Primary structure and interaction with kinesin heavy chain. J Biol Chem 268: 13657-13666
9. Gindhart JG, Goldstein LSB (1996) Tetratrico peptide repeats are present in the kinesin light chain. Trends Biochem Sci 21: 52-53
10. Gunawardena S, Goldstein LSB (2001) Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila. Neuron 32: 389-401
11. Guzik BW, Goldstein LSB (2004) Microtubule-dependent transport in neurons: steps towards an understanding of regulation, function and dysfunction. Cur Opin Cell Biol 16: 443-450
12. Hirokawa N (1998) Kinesin and dynein superfamily proteins and the mechanism of organelle transport. Science 279: 519-526
13. Horiuchi D, Barkus RV, Pilling AD, Gassman A, Saxton WM (2005) APLIP1, a kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport of both vesicles and mitochondria in Drosophila. Curr Biol 15: 2137-2141
14. Inomata H, Nakamura Y, Hayakawa A, Tanaka H, Suzuki T, Miyazawa K, Kitamura N (2003) A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1. J Biol Chem 278: 22946-22955
15. Kaether C, Skehel P, Dotti CG (2000) Axonal membrane proteins are transported in distinct carriers: a two-color video microscopy study in cultured hippocampal neurons. Mol Biol Cell 11: 1213-1224
16. Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LSB (2001) Kinesin-mediated axonal transport containing β-secretase and presenilin-1 requires APP. Nature 414: 643-648
17. Kamal A, Stokin GB, Yang Z, Xia C-H, Goldstein LB (2000) Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Neuron 28: 449-459
18. Konecna A, Frischknecht R, Kinter J, Ludwig A, Steuble M, Meskenaite V, Indermuhle M, Engel M, Cen C, Mateos JM, Streit P, Sonderegger P (2006) Calsyntenin-1 docks vesicular cargo to kinesin-1. Mol Biol Cell 17: 3651-3663
19. Lazarov O, Morfini GA, Lee EB, Farah MH, Szodorai A, DeBoer SR, Koliatsos VE, Kins S, Lee VM-Y, Wong PC, Price DL, Brady ST, Sisodia SS (2005) Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. J Neurosci 25: 2386-2395
20. Matsuda S, Matsuda Y, D'Adamio L (2003) Amyloid b protein precursor (AβPP), but not AβPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1. J Biol Chem 278: 38601-38606
21. Qi Y, Wang JT, McMillian M, Chikaraishi DM (1997) Characterization of a CNS cell line, CAD, in which morphological differentiation is initiated by serum deprivation. J Neurosci 17: 1217-1225
22. Robertson HM, Preston CR, Phillis RW, Johnson-Schlitz DM, Benz WK, Engels WR (1988) A stable genomic source of P element transposase in Drosophila melanogaster. Genetics 118: 461-470
23. Shoji M, Hirai S, Yamaguchi H, Harigaya Y, Kawarabayashi T (1990) Amyloid β-protein precursor accumulates in dystrophic neuritis of senile plaques in Alzheimer-type dementia. Brain Res 512: 164-168
24. Stokin GB, Lillo C, Falzone TL, Brusch RG, Rockenstein E, Mount SL, Raman R, Davies P, Masliah E, Williams DS, Goldstein LSB (2005) Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science 307: 1282-1288
25. Taru H, Iijima K, Hase M, Kirino Y, Yagi Y, Suzuki T (2002b) Interaction of Alzheimer's β-amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade. J Biol Chem 277: 20070-20078
26. Taru H, Kirino Y, Suzuki T (2002a) Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism. J Biol Chem 277: 27567-27574
27. Tomita S, Ozaki T, Taru H, Oguchi S, Takeda S, Yagi Y, Sakiyama S, Kirino Y, Suzuki T (1999) Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein. J Biol Chem 274: 2243-2254
28. Torroja L, Chu H, Kotovsky I, White K (1999) Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport. Current Biol 9: 489-492
29. Verhey KJ, Lizotte DL, Abramson T, Barenboim L, Schnapp BL, Rapoport TA (1998) Light chain-dependent regulation of kinesin's interaction with microtubules. J Cell Biol 143: 1053-1066
30. Verhey KJ, Meyer D, Deehan R, Blenis J, Schnapp B, Rapoprt T, Margolis B (2001) Cargo of kinesin identified as JIP scaffolding protein and associated signaling molecules. J Cell Biol 152: 959-970
31. Vogt L, Schrimpf SP, Meskenaite V, Frischknecht R, Kinter J, Leone DP, Ziegler U, Sonderegger P (2001) Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain. Mol Cell Neurosci 17: 151-166
32. Yagishita S (1978) Morphological investigations on axonal swellings and spheroids in various human disease. Virchows Arch A Pathol Anat Histol 378: 181-197