An ESI-MS/MS method for screening of small-molecule mixtures against glycogen synthase kinase-3β (GSK-3β)

ChemBioChem

Volumn 9, Issue 7, 2008, Pages 1065-1073

  Partserniak, Ivan ^a   Werstuck, Geoff ^a   Capretta, Alfredo ^b   Brennan, John D ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Enzymes; Glycogen synthase kinases; Inhibition; Mass spectrometry; Screening

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; MAGNESIUM ION; BUFFER; GLYCOGEN SYNTHASE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; SERINE;

ARTICLE; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SUBSTRATE; HIGH THROUGHPUT SCREENING; IC 50; IONIC STRENGTH; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REACTION TIME; CHEMISTRY; DRUG ANTAGONISM; DRUG SCREENING; ENZYME SPECIFICITY; KINETICS; METABOLISM; METHODOLOGY; MOLECULAR LIBRARY; PHOSPHORYLATION; TANDEM MASS SPECTROMETRY; TIME;

BUFFERS; DRUG EVALUATION, PRECLINICAL; GLYCOGEN SYNTHASE; GLYCOGEN SYNTHASE KINASE 3; INHIBITORY CONCENTRATION 50; KINETICS; PHOSPHORYLATION; SERINE; SMALL MOLECULE LIBRARIES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTRATE SPECIFICITY; TANDEM MASS SPECTROMETRY; TIME FACTORS;

EID: 46649101371     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200700674     Document Type: Article

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