Conformational flexibility of the C terminus with implications for substrate binding and catalysis revealed in a new crystal form of deacetoxycephalosporin C synthase

Journal of Molecular Biology

Volumn 343, Issue 1, 2004, Pages 157-171

  Öster, Linda M ^a   Van Scheltinga, Anke C Terwisscha ^a   Valegård, Karin ^b   Hose, Alasdair MacKenzie ^a   Dubus, Alain ^c   Hajdu, Janos ^b   Andersson, Inger ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

2 oxoglutarate dependent oxygenases; cephalosporin; mononuclear ferrous enzymes; penicillin; peptide binding

Indexed keywords

2 OXOGLUTARIC ACID; DEACETOXYCEPHALOSPORIN C SYNTHASE; OXYGEN; PENICILLIN G; SYNTHETASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME CONFORMATION; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ANALYSIS;

STREPTOMYCES; STREPTOMYCES CLAVULIGERUS;

EID: 4644366115     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.07.049     Document Type: Article

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