Retinoic acid inhibits nitric oxide synthase-2 expression through the retinoic acid receptor-α

Biochemical and Biophysical Research Communications

Volumn 270, Issue 3, 2000, Pages 846-851

  Sirsjö, Allan ^a   Gidlöf, Andreas C ^a   Olsson, Anneli ^a   Törmä, Hans ^b   Ares, Mikko ^a   Kleinert, Hartmut ^c   Förstermann, Ulrich ^c   Hansson, Göran K ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Cytokine; Interleukin 1 ; Nitric oxide; NO synthase (EC 1.14.13.39); Retinoic acid; Retinoic acid receptor; Vascular smooth muscle cells

Indexed keywords

4 (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 2 ANTHRYL)BENZOIC ACID; CD 3106; CD 336; INTERLEUKIN 1BETA; LUCIFERASE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RECEPTOR BLOCKING AGENT; RETINOIC ACID; RETINOIC ACID RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; AORTA; ARTICLE; CONTROLLED STUDY; GENETIC TRANSFECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; REPORTER GENE; TRANSCRIPTION REGULATION; VASCULAR SMOOTH MUSCLE;

ANIMALIA;

EID: 0034696849     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.2535     Document Type: Article

References (39)

1. Knowles R. G., Moncada S. Nitric oxide as a signal in blood vessels. TIBS, 1992;399-402.
2. Bredt D. S., Snyder S. H. Nitric oxide: A physiologic messenger molecule. Annu. Rev. Biochem. 63:1994;175-195.
3. Nussler A. K., Billiar T. R. Inflammation, immunoregulation, and inducible nitric oxide synthase. J. Leukocyte Biol. 54:1993;171-178.
4. Wei X.-q., Charles I. G., Smith A., Ure J., Feng G.-j., Huang F.-p., Xu D., Muller W., Moncada S., Liew F. Y. Altered immune responses in mice lacking inducible nitric oxide synthase. Nature. 375:1995;408-411.
5. Hansson G. K., Geng Y. J., Holm J., Hårdhammar P., Wennmalm Å, ;. and Jennische. Arterial smooth muscle cells express nitric oxide synthase in response to endothelial injury. J. Exp. Med. 180:1994;733-738.
6. Yan Z.-q., Yokota T., Hansson G. K. Expression of inducible nitric oxide synthase inhibits platelet adhesion to the injured artery. Circ. Res. 79:1996;38-44.
7. Geng Y.-J., Hellstrand K., Wennmalm Å, ;. and Hansson. Apoptotic death of human leukemic cells induced by vascular cells expressing nitric oxide synthase in response to γ-interferon and tumor necrosis factor-α Cancer Res. 56:1996;866-874.
8. Hock C. E., Yin K., Yue G., Wong P. Y. Effects of inhibition of nitric oxide synthase by aminoguanidine in acute endotoxemia. Am. J. Phys. 272:1997;H843-H850.
9. Liniyonu A. A., Coston A. F., Klabunde R. E. Endotoxin-induced microvascular leakage is prevented by a PAF antagonist and NO synthase inhibitor. Shock. 7:1997;49-54.
10. Geng Y. J., Wu Q., Muszynski M., Hansson G. K., Libby P. Apoptosis of vascular smooth muscle cells induced by in vitro stimulation with interferon-gamma, tumor necrosis factor-alpha, and interleukin-1 beta. Arterioscler. Thromb. Vasc. Biol. 16:1996;19-27.
11. Iwashina M., Shichiri M., Marumo F., Hirata Y. Transfection of inducible nitric oxide synthase gene causes apoptosis in vascular smooth muscle cells. Circulation. 98:1998;1212-1218.
12. Eberhardt W., Kuntz D., Hummel R., Pfeilschifter J. Molecular cloning of the rat inducible nitric oxide synthase gene promoter. Biochem. Biophys. Res. Commun. 223:1996;752-756.
13. Spitsin S. V., Farber J. L., Bertovich M., Moehren G., Koprowski H., Michaels F. H. Human- and mouse-inducible nitric oxide synthase promotors require activation of phosphatidylcholine-specific phospholipase C and NF-κB. Mol. Med. 3:1997;315-326.
14. Spink J., Cohen J., Evens T. J. The cytokine responsive vascular smooth muscle cell enhancer of inducible nitric oxide synthase. J. Biol. Chem. 270:1995;29541-29547.
15. Sirsjö A., Söderkvist P., Sundqvist T., Carlsson M., Öst M., Gidlöf A. Different induction mechanism of mRNA for inducible nitric oxide synthase in rat smooth muscle cells in culture and in aortic strips. FEBS Lett. 338:1994;191-196.
16. Giguere V. Retinoic acid receptors and cellular retinoid binding proteins: Complex interplay in retinoid signaling. Endocrinol. Rev. 15:1994;61-79.
17. Mendelsohn C., Lohnes D., Decimo D., Lufkin T., LeMeur M., Chambon P., Mark M. Function of the retinoic acid receptors (RARs) during development. Development. 120:1994;2749-2771.
18. Becherel P. A., Mossalayi M. D., Le Goff L., Frances C., Chosidow O., Debre P., Arock M. Mechanism of anti-inflammatory actions of retinoids on keratinocytes. Lancet. 344:1994;1570-1571.
19. Minucci, S., and Ozato, K. Retinoid receptors in transcriptional regulation. Curr. Opin. Genet. Dev.6, 567-574.
20. Becherel P. A., Le Goff L., Ktorza S., Chosidow O., Frances C., Issaly F., Mencia-Huerta J. M., Debre P., Djavad P., Mossalayi M. D., Arock M. CD23-mediated nitric oxide synthase pathway induction in human keratinocytes is inhibited by retinoic acid derivates. J. Invest. Dermatol. 106:1996;1182-1186.
21. Mehta K., McQueen T., Tucker S., Pandita R., Aggarwal B. B. Inhibition by all-trans-retinoic acid of tumor necrosis factor and nitric oxide production by peritoneal macrophages. J. Leukocyte Biol. 55:1994;336-342.
22. Hirokawa K., Oshaughnessy K. M., Ramrakha P., Wilkins M. R. Inhibition of nitric oxide synthesis in vascular smooth muscle by retinoids. Br. J. Pharmacol. 113:1994;1448-1454.
23. Delescluse C., Cavey M. T, Martin B., Bernard B. A., Reichert U., Maignan J., Darmon M., Shroot B. Selective high affinity retinoic acid receptor α or β-γ ligands. Mol. Pharm. 40:1991;556-562.
24. Martin B., Bernardon J. M., Cavey M. T., Bernard B., Carlavan I., Charpentier B., Pilgrim W. R., Shroot B., Reichert U. Selective synthetic ligands for human nuclear retinoic acid receptors. Skin Pharm. 5:1992;57-65.
25. 15N)nitrate in biological fluids. Anal. Biochem. 126:1982;131-138.
26. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
27. Geng Y.-J., Almqvist M., Hansson G. K. cDNA cloning and expression of inducible nitric oxide synthase from rat vascular smooth muscle cells. Biochim. Biophys. Acta. 1994;421-424.
28. Kleinert H., Euchenhofer C., Ihrig-Biedert I., Förstermann U. Glucocorticoids inhibit the induction of nitric oxide synthase II by downregulating cytokine-induced activity of transcription factor NF-κB. Mol. Pharmacol. 49:1996;15-21.
29. Wigler M., Silverstein S., Lee L. S., Pellicer A., Cheng Y. C., Axel R. Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell. 11:1977;223-232.
30. Miano J. M., Stavros T., Mark W., Majevski M., Olson E. N. Retinoid receptor expression and all-trans retinoic acid-mediated growth inhibition in vascular smooth muscle cells. Circulation. 93:1996;1886-1895.
31. Neuville P., Yan Z.-Q., Gidlöf A. C., Pepper M. S., Hansson G. K., Gabbiani G., Sirsjö A. Retinoic acid regulates arterial smooth muscle cell proliferation and phenotypic features in vivo and in vitro through a RARa-dependent-signaling pathway. Arterioscler. Thromb. Vasc. Biol. 19:1999;1430-1436.
32. Schroen D. J., Brinckerhoff C. E. Inhibition of rabbit collagenase (matrix metalloproteinase-1; MMP-1) transcription by retinoid receptors: Evidence for binding of RARs/RXRs to -77 AP-1 site through interaction with c-Jun. J. Cell. Phys. 169:1996;320-332.
33. Salbert G., Fanjul A., Piedrafita J., Lu X. P., Kim S. J., Tran R., Pfahl M. Retinoic acid receptors and retinoid X receptor-a down-regulate the transforming growth factor-β1 promotor by antagonizing AP-1 activity. Mol. Endocrinol. 7:1993;1347-1356.
34. Gille J., Paxton L., Lawley T. J., Wright F., Caughman S., Swerlic R. A. Retinoic acid inhibits the regulated expression of vascular adhesion molecule-1 by cultured dermal microvascular endothelial cells. J. Clin. Invest. 99:1997;492-500.
35. Xie Q.-W., Whisnant R., Nathan C. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide. J. Exp. Med. 177:1993;1779-1784.
36. Ricote M., Li A. C., Willson T. M., Kelly C. J., Glass C. K. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature. 391:1998;79-82.
37. Massacesi L., Castigli E., Vergelli M., Olivotto J., Abbamondi A. L., Sarlo F., Amaducci L. Immunosuppressive activity of 13-cis-retinoic acid and prevention of experimental autoimmune encephalomyelitis in rats. J. Clin. Invest. 88:1991;1331-1337.
38. Norris D. A., Osborn R., Robinson W., Tonnesen M. G. Isotretinoin produces significant inhibition of monocyte and neutrophil chemotaxis in vivo in patients with cystic acne. J. Invest. Dermatol. 89:1987;38-43.
39. Wiedermann U., Chen X. J., Enerback L., Hanson L. A., Kahu H., Dahlgren U. I. Vitamin A deficiency increases inflammatory responses. Scand. J. Immunol. 44:1996;578-584.