Cytokine-induced nitric oxide synthase gene transcription is blocked by the heat shock response in human liver cells

Surgery

Volumn 120, Issue 2, 1996, Pages 144-149

  De Vera, M E ^a   Wong, J M ^a   Zhou, J Y ^a   Tzeng, E ^a   Wong, H R ^a   Billiar, T R ^a   Geller, D A ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; HEAT SHOCK PROTEIN; NITRIC OXIDE SYNTHASE;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HEAT SHOCK; HUMAN; HUMAN CELL; LIVER CELL; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION;

EID: 0029819656     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-6060(96)80281-9     Document Type: Article

References (23)

1. de Vera ME Geller DA Billiar TR Hepatic inducible nitric oxide synthase: regulation and function Biochem Soc Trans 23 1995 1008 1013
2. G-methyl- l .-arginine, an inhibitor of nitric oxide synthesis Biochem Biophys Res Commun 172 1990 1132 1138
3. Szabo C Southan GJ Thiemermann C Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea, a potent and selective inhibitor of inducible nitric oxide synthase Proc Natl Acad Sci USA 91 1994 12472 12476
4. Geller DA Freeswick PD Nguyen D Differential induction of nitric oxide synthase in hepatocytes during endotoxemia and the acute phase response Arch Surg 129 1994 165 171
5. Kelly E, Shah NS, Morgan NN, Watkins SC, Peitzman AB, Billiar TR. Physiologic and molecular characterization of the role of nitric oxide in hemorrhagic shock: evidence that type II nitric oxide synthase does not regulate vascular decompensation. Shock in press.
6. Geller DA de Vera ME Russell DA A central role for IL-1β in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase J Immunol 155 1995 4890 4898
7. Geller DA Nussler AK Di Silvio M Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes Proc Natl Acad Sci USA 90 1993 522 526
8. Nussler AK Di Silvio M Billiar TR Stimulation of the nitric oxide pathway in human hepatocytes by cytokines and endotoxin J Exp Med 176 1992 261 264
9. de Vera ME Shapiro RA Nussler AK Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter Proc Natl Acad Sci USA 93 1996 1054 1059
10. Minowada G Welch WJ Clinical implications of the stress response J Clin Invest 95 1995 3 12
11. 4B promotes assembly of enzyme subunits into an active dimer Proc Natl Acad Sci USA 92 1995 11771 17775
12. Geller DA Lowenstein CJ Shapiro RA Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes Proc Natl Acad Sci USA 90 1993 3491 3495
13. Wong HR Finder JD Pitt BR Expression of inducible nitric oxide synthase gene in cultured rat pulmonary artery smooth muscle cells is inhibited by the heat shock response Am J Physiol 269 1995 L843 L848
14. Snyder YM Guthrie L Evans GF Zuckerman SH Transcriptional inhibition of endotoxin-induced monokine synthesis following heat shock in murine peritioneal macrophages J Leukoc Biol 51 1992 181 187
15. Schoeniger LO Reilly PM Bulkley GB Buchman TG Heat-shock gene expression excludes hepatic acute-phase gene expression after resuscitation from hemorrhagic shock Surgery 112 1992 355 363
16. Salzman J Bowman PD Independent regulation of prostaglandin production and the stress response in human fibroblasts J Cell Physiol 152 1992 626 631
17. Xie QW Kashiwabara Y Nathan C Role of transcription factor NF-κB/Rel in the induction of nitric oxide synthase J Biol Chem 269 1993 4705 4708
18. Geller DA Freeswick PD Luss H Nussler AK Billiar TR Cytokine-induced nitric oxide synthesis in hepatocytes involves the transcription factor NF-κB Surg Forum 45 1994 117 119
19. Simon MM Reikerstorfer A Schwarz A Heat shock protein 70 overexpression affects the response to ultraviolet light in murine fibroblasts J Clin Invest 95 1995 926 933
20. Ma T Ischiropoulos H Brass CA Endotoxin-stimulated nitric oxide production increases injury and reduces rat liver chemiluminescence during reperfusion Gastroenterology 108 1995 463 469
21. Villar J Ribeiro SP Mullen BM Kuliszewski M Post M Slutsky AS Induction of the heat shock response reduces mortality rate and organ damage in a sepsis-induced acute lung injury model Crit Care Med 22 1994 914 921
22. Bellman K Wenz A Radons J Burkart V Kleeman R Kolb H Heat shock induces resistance in rat pancreatic islet cells against nitric oxide, oxygen radicals, and streptozotocin toxicity in vitro J Clin Invest 92 1995 503 508
23. Buchman TG Abello PA Smith EH Bulkley GB Induction of heat shock response leads to apoptosis in endothelial cells previously exposed to endotoxin Am J Physiol 265 1993 H165 H170