Possible involvement of Janus kinase Jak2 in interferon-γ induction of nitric oxide synthase in rat glial cells

European Journal of Pharmacology

Volumn 306, Issue 1-3, 1996, Pages 297-306

  Kitamura, Yoshihisa ^a   Takahashi, Hideaki ^a   Nomura, Yasuyuki ^b   Taniguchi, Takashi ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

herbimycin A; interferon ; Janus kinase; microglia; nitric oxide (NO) synthase, inducible; signal transducer and activator of transcription 1 (STAT1)

Indexed keywords

ENZYME ANTIBODY; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; HERBIMYCIN A; JANUS KINASE; NITRIC OXIDE SYNTHASE; NITRITE; PROTEIN TYROSINE KINASE INHIBITOR; RECOMBINANT GAMMA INTERFERON; STAT 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG INHIBITION; ENZYME INDUCTION; GLIA CELL; IMMUNOPRECIPITATION; MACROPHAGE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

EID: 0030582087     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00212-9     Document Type: Article

References (34)

1. Adachi, H., S. Iida, S. Oguchi, H. Ohshima, H. Suzuki, K. Nagasaki, H. Kawasaki, T. Sugimura and H. Esumi, 1993, Molecular cloning of a cDNA encoding an inducible calmodulin-dependent nitric-oxide synthase from rat liver and its expression in COS 1 cells, Eur. J. Biochem. 217, 37.
2. Banati, R.B., J. Gehrmann, P. Schubert and G.W. Kreutzberg, 1993, Cytotoxicity of microglia, Glia 7, 111.
3. Benveniste, E.N., 1993, Astrocyte-microglia interactions, in: Astrocytes: Pharmacology and Function, ed. S. Murphy (Academic Press. San Diego, CA) p. 355.
4. Boje, K.M. and P.K. Arora, 1992. Microglial-producted nitric oxide and reactive nitrogen oxides mediate neuronal cell death, Brain Res. 587, 250.
5. Bredt, D.S., C.E. Glatt, P.M. Hwang, M. Fotuhi, T.M. Dawson and S.H. Snyder, 1991, Nitric oxide synthase protein and mRNA are discretely localizated in neuronal populations of the mammalian CNS together with NADPH diaphorase, Neuron 7, 615.
6. Darnell, Jr., J.E., I.M. Kerr and G.R. Stark, 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signalling proteins, Science 264, 1415.
7. Dickson, D.W., S.C. Lee, L.A. Mattiace. S.C. Yen and C. Brosnan, 1993. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease, Glia 7, 75.
8. Feinstein, D.L., E. Galea, J. Cermak, P. Chugh, L. Lyandvert and D J. Reis, 1994, Nitric oxide synthase expression in glial cells: Suppression by tyrosine kinase inhibitors, J. Neurochem. 62, 811.
9. Galea, E., D.L. Feinstein and D.J. Reis, 1992, Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures, Proc. Natl. Acad. Sci. USA 89, 10945.
10. 15N]nitrate in biological fluids. Anal. Biochem. 126, 131.
11. Hokari, A., M. Zeniya and H. Esumi. 1994, Cloning and functional expression of human inducible nitric oxide synthase (NOS) cDNA from a glioblastoma cell line A-172. J. Biochem. 116, 575.
12. Igarashi, K., G.G. Garotta, L. Ozmen, A. Ziemiecki, A.F. Wilks, A.G. Harpur, A.C. Larner and D.S. Finbloom, 1994, Interferon-γ induces tyrosine phosphorylation of interferon-γ receptor and regulated association of protein tyrosine kinases. Jak1 and Jak2, with its receptor, J. Biol. Chem. 269, 14333.
13. 2+-insensitive but calmodulin-coupling nitric oxide synthase in rat glial cells. J. Neurosci. Res. 43, 235.
14. Knowles, R.G. and S. Moncada, 1994. Nitric oxide synthases in mammals, Biochem. J. 298, 249.
15. Laemmli, U.K., 1970, Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature 227, 680.
16. Lowenstein, C.J. and S.H. Snyder. 1992, Nitric oxide, a novel biologic messenger. Cell 70, 705.
17. Lowenstein, C.J., E.W. Alley, P. Raval, A.M. Snowman, S.H. Snyder, S.W. Russell and W.J. Murphy, 1993, Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon γ and lipopolysaccharide. Proc. Natl. Acad. Sci. USA 90, 9730.
18. McGeer, P.L., T. Kawamata, D.G. Walker, H. Akiyama, I. Tooyama and E.G. McGeer, 1993, Microglia in degenerative neurological disease, Glia 7, 84.
19. Müller, M., J. Briscoe, C. Laxton, D. Guschin, A. Ziemiecki, O. Silvennoinen, A.G. Harpur, G. Barbieri. B.A. Witthuhn, C. Schindler, S. Pellegrini, A.F. Wilks, J.N. Ihle, G.R. Stark and I.M. Kerr, 1993, The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction, Nature 366, 129.
20. Nathan C, 1992, Nitric oxide as a secretory product of mammalian cells, FASEB J. 6, 3051.
21. Nishida, E. and Y. Gotoh, 1993, The MAP kinase cascade is essential for diverse signal transduction pathways, Trends Biochem. Sci. 18, 128.
22. Nishiya, T., T. Uehara and Y. Nomura, 1995, Herbimycin A suppresses NF-κB activation and tyrosine phosphorylation of JAK2 and the subsequent induction of nitric oxide synthase in C6 glioma cells, FEBS Lett. 371, 333.
23. Nomura, Y. and Y. Kitamura, 1993. Inducible nitric oxide synthase in glial cells, Neurosci. Res. 18, 103.
24. Novogrodsky, A., A. Vanichkin, M. Patya, A. Gazit, N. Osherov and A. Levitzki. 1994, Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors, Science 264, 1319.
25. 2+/calmodulin-dependent NO synthase in various organs of rats by Propionibacterium acnes and lipopolysaccharide treatment, FEBS Lett. 308, 22.
26. Raschke, W.C., S. Baird, P. Palph and I. Nakoinz, 1978, Functional macrophage cell lines transformed by Abelson leukemia virus, Cell 15, 261.
27. 2+-independent nitric oxide synthases, FEBS Lett. 291, 145.
28. Schmidt, H.H.H.W., 1992, NO., CO and .OH endogenous soluble guanylyl cyclase-activating factors, FEBS Lett. 307, 102.
29. lyn, J. Biol. Chem. 268, 20725.
30. Simmons, M.L. and S. Murphy, 1992, Induction of nitric oxide synthase in glial cells, J. Neurochem. 59, 897.
31. Weinstein. S.L., J.S. Sanghera, K. Lemke, A.L. DeFranco and S.L. Pelech, 1992, Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages. J. Biol. Chem. 267, 14955.
32. Wood, E.R., H. Berger, Jr., P.A. Scherman and E.G. Lapetina, 1993, Hepatocytes and macrophages express an identical cytokine inducible nitric oxide synthase gene, Biochem. Biophys. Res. Commun. 191, 767.
33. Xie, Q., R. Whisnant and C. Nathan, 1993, Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide, J. Exp. Med. 177, 1779.
34. Xie, Q., Y. Kashiwabara and C. Nathan, 1994, Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase, J. Biol. Chem. 269, 4705.