Inhibition of small G proteins of the Rho family by statins or Clostridium difficile toxin B enhances cytokine-mediated induction of NO synthase II

British Journal of Pharmacology

Volumn 131, Issue 3, 2000, Pages 553-561

  Hausding, Michael ^a   Witteck, Andrea ^a   Rodriguez Pascual, Fernando ^a   Von Eichel Streiber, Christian ^a   Förstermann, Ulrich ^a   Kleinert, Hartmut ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Clostridium difficile toxin B; HMG CoA inhibitors; Nitric oxide synthase II; Post transcriptional regulation; Promoter activity; Rho family; RNA stability; Small G proteins; Statins

Indexed keywords

ATORVASTATIN; CLOSTRIDIUM DIFFICILE TOXIN B; CYTOKINE; FARNESYL DIPHOSPHATE; GLUCOSYLTRANSFERASE; GUANINE NUCLEOTIDE BINDING PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MESSENGER RNA; MEVINOLIN; NITRIC OXIDE SYNTHASE; RAS PROTEIN; RHO FACTOR;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME STABILITY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY;

EID: 0033780872     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703607     Document Type: Article

References (32)

1. The small GTP-binding protein Rho potentiates AP-1 transcription in T cells
2. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
3. Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: Initial analysis of the human NOS2 promoter
4. Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: The potential for multiplex signalling
5. Molecular mechanisms of inducible nitric oxide synthase gene expression by IL-1β and cAMP in rat mesangial cells
6. Permanent cell line expressing human factor VIII-related antigen established by hybridization
7. Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1β in vascular smooth muscle cells
8. Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III)
9. Nitric oxide synthase: Expression and expressional control of the three isoforms
10. Molecular biology of nitric oxide synthases
11. The potential of farnesyltransferase inhibitors as cancer chemotherapeutics
12. 'Macrophage' nitric oxide synthase is a glucocorticoid-inhibitable primary response gene in 3T3 cells
13. Regulation of the expression of nitric oxide synthase isoforms
14. Involvement of protein kinases in the induction of NO synthase II in human DLD-1 cells
15. Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-kB
16. In murine 3T3 fibroblasts, different second messenger pathways resulting in the induction of NO synthase II (iNOS) converge in the activation of transcription factor NF-κB
17. Cytokine induction of NO Synthase II in human DLD-1 cells: Roles of the JAK-STAT AP-1 and NF-κB-signaling pathways
18. Inducible nitric oxide synthase in human diseases
19. Platelet-derived growth factor and fibroblast growth factor differentially regulate interleukin 1β- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells
20. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
21. Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras- related Rho subfamily and its role in phosphorylation signalling pathways
22. Transcriptional regulation of human inducible nitric oxide synthase gene in an intestinal epithelial cell line
23. Rho GTPases
24. Nitric oxide and macrophage function
25. Modulation of inducible nitric oxide synthase in Rinm5F Cells
26. Nitric oxide synthases: Roles, tolls, and controls
27. Coordinate activation of activator protein 1 and inflammatory cytokines in response to Neisseria gonorrhoeae epithelial cell contact involves stress response kinases
28. Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages
29. Complex contribution of the 3'-untranslated region to the expressional regulation of the human inducible nitric oxide synthase gene: Involvement of the RNA-binding protein HuR
30. Large clostridial cytotoxins - A family of glycosyltransferases modifying small GTP-binding proteins
31. Purification of two high molecular weight toxins of Clostridium difficile which are antigenically related
32. Closing in on the toxic domain through analysis of a variant Clostridium difficile cytotoxin B