The Aspergillus nidulans npkA gene encodes a Cdc2-related kinase that genetically interacts with the UvsBATR kinase

Genetics

Volumn 167, Issue 4, 2004, Pages 1629-1641

  Kress Fagundes, Marcia R V Z ^a   Fernandes Lima, Joel ^a   Savoldi, Marcela ^a   Malavazi, Iran ^a   Larson, Roy E ^a   Goldman, Maria H S ^a   Goldman, Gustavo H ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; CDC2 RELATED KINASE; DNA TOPOISOMERASE; PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS NIDULANS; CELL CYCLE S PHASE; DNA DAMAGE; DNA PROTEIN COMPLEX; DNA REPLICATION; FUNGAL GENE; GENE DELETION; GENE INDUCTION; GENETIC ANALYSIS; GENETIC CODE; NONHUMAN; NPKA GENE; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; UVSB ATR GENE;

AMINO ACID SEQUENCE; ASPERGILLUS NIDULANS; BASE SEQUENCE; CDC2 PROTEIN KINASE; CLONING, MOLECULAR; DNA DAMAGE; DNA PRIMERS; DNA TOPOISOMERASES, TYPE I; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

ASPERGILLUS; EMERICELLA NIDULANS;

EID: 4644335877     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: 10.1534/genetics.103.024166     Document Type: Article

References (65)

1. ABRAHAM, R. T., 2001 Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15: 2177-2196.
2. AIST, J. R., and N. R. MORRIS, 1999 Mitosis in filamentous fungi: how we got where we are. Fungal Genet. Biol. 27: 1-25.
3. ALLEN, J. B., Z. ZHOU, W. SIEDE, E. C. FRIEBERG and S. J. ELLEDGE, 1994 The Sad1/Rad53 protein kinase controls multiple check-points and DNA damage-induced transcription in yeast. Genes Dev. 8: 2401-2415.
4. BERGEN, L. G., and N. R. MORRIS, 1983 Kinetics of the nuclear division cycle of Aspergillus nidulans. J. Bacteriol. 156: 155-160.
5. BRAMBILLA, R., and G. DRAETTA, 1994 Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases. Oncogene 9: 3037-3041.
6. BROWN, E. J., and D. BALTIMORE, 2003 Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev. 17: 615-628.
7. BRUSCHI, G. C. M., C. C. DE SOUZA, M. R. Z. K. FAGUNDES, M. A. C. DANI, M. H. S. GOLDMAN et al., 2001 Sensitivity to camptothecin in Aspergillus nidulans identifies a novel gene, scaA, related to the cellular DNA damage response. Mol. Genet. Genomics 265: 264-275.
8. BUSSINK, H. J., and S. A. OSMANI, 1998 A cyclin-dependent kinase family member (PHOA) is required to link developmental fate to environmental conditions in Aspergillus nidulans. EMBO J. 17: 3990-4003.
9. CASPARI, T., and A. M. CARR, 1999 DNA structure checkpoint pathways in Schizosaccharomyces pombe. Biochimie 81: 173-181.
10. CHAVEROCHE, M.-K., J.-M. GHIGO and C. D'ENFERT, 2000 A rapid method for efficient gene replacement in the filamentous fungus Aspergillus nidulans. Nucleic Acids Res. 28: e97.
11. CLIBY, W. A., C. J. ROBERTS, K. A. CIMPRICH, C. M. STRINGER, J. R. LAMB et al., 1998 Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J. 17: 159-169.
12. 2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function. J. Biol. Chem. 277:1599-1606.
13. CORTEZ, D., S. GUNTUKU, J. QIN and S. J. ELLEDGE, 2001 ATR and ATRIP: partners in checkpoint signalling. Science 294: 1713-1716.
14. DE FALCO, G., and A. GIORDANO, 1998 CDK9 (PITALRE): a multifunctional cdc-2 related kinase. J. Cell. Physiol. 177: 501-506.
15. DESANY, B. A., A. A. ALCASABAS, J. B. BACHANT and S.J. ELLEDGE, 1998 Recovery from DNA replicational stress is the essential function of the S phase checkpoint pathway. Genes Dev. 12: 2956-2970.
16. DE SOUZA, C. P. C., X. S. YE and S. A. OSMANI, 1999 Checkpoint defects leading to premature mitosis also cause endoreplication of DNA in Aspergillus nidulans. Mol. Biol. Cell 10: 3661-3674.
17. DOU, X., D. Wu, W. AN, J. DAVIES, S. B. HASHIMI et al., 2003 The PHOA and PHOB cyclin-dependent kinases perform an essential function in Aspergillus nidulans. Genetics 165: 1105-1115.
18. FROELICH-AMMON, S. J., and N. OSHEROFF, 1995 Topoisomerase poisons: harnessing the dark side of enzyme mechanism. J. Biol. Chem. 270: 21429-21432.
19. GOLDMAN, G. H., and E. KAFER, 2004 Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotes. Fungal Genet. Biol. 41: 428-442.
20. GOLDMAN, G. H., S. L. MCGUIRE and S. D. HARRIS, 2002 The DNA damage response in filamentous fungi. Fungal Genet. Biol. 35: 183-195.
21. GRANA, X., P. P. CLAUDIO, A. DE LUCA, A. SANG and A. GIORDANO, 1994 PISSLRE, a human novel Cdc2-related protein kinase. Oncogene 9: 2097-2103.
22. GUPTA, M., A. FUJIMORI and Y. POMMIER, 1995 Eukaryotic DNA topoisomerases I. Biochim. Biophys. Acta 1262: 1-14.
23. GUZMAN, L. M., D. BELIN, M. J. CARSON and J. BECKWITH, 1995 Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. J. Bacteriol. 177: 4121-4130.
24. HARRIS, S. D., and P. R. KRAUS, 1998 Regulation of septum formation in Aspergillus nidulans by a DNA damage checkpoint pathway. Genetics 148: 1055-1067.
25. HOFMANN, A. F., and S. D. HARRIS, 2000 The Aspergillus nidulans uvsB gene encodes an ATM-related kinase required for multiple facets of the DNA damage response. Genetics 154: 1577-1586.
26. HOPP, T. P., K. S. PRICKETT, V. L. PRICE, R. T. LIBBY, C. J. MARCH et al., 1988 A short polypeptide marker sequence useful for recombinant protein identification and purification. Biotechnology 6: 1204-1210.
27. HSIANG, Y.-H., R. HERTZBERG, S. HECHT and L. F. LIU, 1985 Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J. Biol. Chem. 260: 14873-14878.
28. KAFER, E., 1977 Meiotic and mitotic recombination in Aspergillus and its chromosomal aberrations. Adv. Genet. 19: 33-131.
29. Ko, T. K., E. KELLY and J. PINES, 2001 CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles. J. Cell Sci. 114: 2591-2603.
30. KRAUS, P. R., and S. D. HARRIS, 2001 The Aspergillus nidulans snt genes are required for the regulation of septum formation and cell cycle checkpoints. Genetics 159: 557-569.
31. NBS1, the apparent homolog of human nibrin in Aspergillus nidulans. Genetics 164: 935-945.
32. LAHTI, J. M., J. XIANG and V. J. KIDD, 1995 The P1TSLRE protein kinase family. Prog. Cell Cycle Res. 1: 329-338.
33. LAPIDOT-LIPSON, Y., D. PATINKIN, C. A. PRODY, G. DHRLICH, S. SEIDMAN et al., 1992 Cloning and antisense oligodeoxynucleotides inhibition of a human homolog of Cdc2 required in hematopoiesis. Proc. Natl. Acad. Sci. USA 89: 579-583.
34. LEVITT, N. C., and I. D. HICKSON, 2002 Caretaker tumour suppressor genes that defend genome integrity. Trends Mol. Med. 8: 179-186.
35. LIANG, P., and A. B. PARDEE, 1992 Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 257: 967-971.
36. LIU, L. F., 1989 DNA topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem. 58: 351-375.
37. LIU, L. F., 1994 DNA Topoisomerases: Topoisomemse-Targeting Drugs (Advances in Pharmacology, Vol. 29B). Academic Press, San Diego.
38. LIU, C., J. J. POULIOT and H. A. NASH, 2002 Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1. Proc. Natl. Acad. Sci. USA 99: 14970-14975.
39. MERRILL, B. J., and C. HOLM, 1999 A requirement for recombinational repair in Saccharomyces cerevisiae is caused by DNA replication defects of mec1 mutants. Genetics 153: 595-605.
40. MEYERSON, M., G. H. ENDERS, C. L. Wu, L. K. SU, C. GORKA et al., 1992 A family of human Cdc2-related kinase protein kinases. EMBO J. 11: 2909-2917.
41. NYBERG, K. A., R. J. MICHELSON, C. W. PUTNAM and T. A. WEINERT, 2002 Toward maintaining the genome: DNA damage and replication checkpoints. Annu. Rev. Genet. 36: 617-656.
42. OSBORN, A. J., S. J. ELLEDGE and L. ZOU, 2002 Checking on the fork: the DNA-replication stress-response pathway. Trends Cell Biol. 12: 509-516.
43. Cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in Aspergillus nidulans. Cell 67: 283-291.
44. 2 in Aspergillus nidulans. J. Cell Sci. 107: 1519-1528.
45. OSMANI, S. A., and P. MIRABITO, 2004 The early impact of genetics on our understanding of cell cycle regulation in Aspergillus nidulans. Fungal Genet. Biol. 41: 401-410.
46. OSMANI, S. A., and X. S. YE, 1996 Cell cycle regulation in Aspergillus nidulans by two protein kinases. Biochem. J. 317: 633-641.
47. OSMANI, S. A., and X. S. YE, 1997 Targets of checkpoints controlling mitosis: lessons from lower eukaryotes. Trends Cell Biol. 7: 283-288.
48. OSMANI, S. A., G. S. MAY and N. R. MORRIS, 1987 Regulation of the mRNA levels of nimA, a gene required for the G2-M transition in Aspergillus nidulans. J. Cell Biol. 104: 1495-1504.
49. PACIOTTI, V., M. CLERICI, G. LUCCHINI and M. P. LONGHESE, 2000 The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast. Genes Dev. 14: 2046-2059.
50. PRELICH, G, 1999 Suppression mechanisms: themes from variations. Trends Genet. 15: 261-266.
51. ROTMAN, G., and Y. SHILOH, 1998 ATM: from gene to function. Hum. Mol. Genet. 7: 1555-1563.
52. SAMBROOK, J., E. F. FRITSCH and T. MANIATIS, 1989 Molecular Cloning: A Laboratory Manual, Ed. 2. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
53. Cdc2. FEBS Lett. 523: 143-146.
54. SCHIER, N., R. LIESE and R. FISCHER, 2001 A Pcl-like cyclin of Aspergillus nidulans is transcriptionally activated by developmental regulators and is involved in sporulation. Mol. Cell. Biol. 21:4075-4088.
55. SEMIGHINI, C. P., M. MARINS, M. H. S. GOLDMAN and G. H. GOLDMAN, 2002 Quantitative analysis of the relative transcript levels of ABC transporter Air genes in Aspergillus nidulans by real-time reverse transcription-PCR assay. Appl. Environ. Microbiol. 68: 1351-1357.
56. SEMIGHINI, C. P., M. R. VON ZESKA KRESS FAGUNDES, J. C. FERREIRA, R. C. PASCON, M. H. S. GOLDMAN et al., 2003 Different roles of the Mre11 complex in the DNA damage response in Aspergillus nidulans. Mol. Microbiol. 48: 1693-1709.
57. SHILOH, Y., 2001 ATM and ATR: networking cellular responses to DNA damage. Curr. Opin. Genet. Dev. 11: 71-77.
58. VANCE, J. R., and T. E. WILSON, 2002 Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Topi replicative damage. Proc. Natl. Acad. Sci. USA 99: 13669-13674.
59. WANG, J. C., 2002 Cellular roles of DNA topoisomerases: a molecular perspective. Nature 3: 430-441.
60. WARING, R. B., G. S. MAY and N. R. MORRIS, 1989 Characterization of an inducible expression system in Aspergillus nidulans using alcA and tubulin-coding genes. Gene 79: 119-130.
61. WOLKOW, T. D., and T. ENOCH, 2002 Fission yeast Rad26 is a regulatory subunit of the Rad3 checkpoint kinase. Mol. Biol. Cell 13: 480-492.
62. YANG, J., Y. Yu, H. E. HAMRICK and P. J. DUERKSEN-HUGUES, 2003 ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses. Carcinogenesis 24: 1571-1580.
63. Cdc2, inhibit NIMA and prevent premature mitosis. EMBO J. 15: 3599-3610.
64. Cdc2 in Aspergillus nidulans. EMBO J. 16: 182-192.
65. ZHOU, B. B., and S. J. ELLEDGE, 2000 The DNA damage response: putting checkpoints in perspective. Nature 408: 433-439.