CDK9 (PITALRE): A multifunctional cdc2-related kinase

Journal of Cellular Physiology

Volumn 177, Issue 4, 1998, Pages 501-506

  De Falco, Giulia ^a   Giordano, Antonio ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; APOPTOSIS; CELL CYCLE; CELL CYCLE G1 PHASE; CELL DIVISION; CELL GROWTH; CELL PROLIFERATION; COMPLEX FORMATION; GENE DISRUPTION; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; CELL CYCLE; CHROMOSOMES, HUMAN, PAIR 9; CYCLIN-DEPENDENT KINASE 9; CYCLIN-DEPENDENT KINASES; CYCLINS; HUMANS; MICE; MODELS, BIOLOGICAL; TRANSCRIPTION, GENETIC;

EID: 0031792768     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199812)177:4<501::AID-JCP1>3.0.CO;2-4     Document Type: Review

References (59)

1. Bagella, L., MacLachlan, T.K., Buono, R.J., Pisano, M.M., Giordano, A., and De Luca, A. (in press) Cloning of murine CDK9/PITALRE and tissue-specific expression in development. J. Cell. Physiol.
2. Bai, C., Richman, R., and Elledge, S.J. (1994) Human cyclin F. EMBO J., 13:6087-6098.
3. Baldin, V., Lukas, J., Marcote, M.J., Pagano, M., and Draetta, G. (1993) Cyclin D1 is a nuclear protein required for the cell progression in G1. Genes Dev., 7:812-821.
4. Brambilla, R., and Draetta, G. (1994) Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases. Oncogene, 9:3037-3041.
5. Bullrich, F., MacLachlan, T., Sang, N., Druck, T., Veronese, M.L., Allen, S., Chiorazzi, N., Koff, A., Heubner, K., Croce, C.M., and Giordano, A. (1995) Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE and PITALRE and a cdk inhibitor, p27Kipl, to region involved in human cancer. Cancer Res., 55:1199-1205.
6. Bunnell, B.A., Heath, L.S., Adams, D.E., Lahti, J.M., and Kidd, V.J. (1990) Increased expression of a 58-kDa protein kinase leads to change in the CHO cell cycle. Proc. Natl. Acad. Sci. U. S. A., 87:7467-7471.
7. Chun, R.F., and Jeang, K.T. (1996) Requirements for RNA polymerase II carboxyl-terminal domain for transcription of human retro-viruses, human T-cell lymphotropic virus, and HIV-1. J. Biol. Chem., 271:27888-27894.
8. Dahmus, M.E. (1996) Reversible phosphorylation of the C-terminal domain of RNA polymerase II. J. Biol. Chem., 217:19009-19012.
9. De Luca, A., Esposito, V., Baldi, A., Claudio, P.P., Fu, Y., Caputi, M., Pisano, M.M., Baldi, F., and Giordano, A. (1997) Cdc2-related kinase PITALRE phosphorylates pRb exclusively on serine and is widely expressed in human tissues. J. Cell. Physiol., 172:265-273.
10. Draetta, G. (1990) Cell cycle control in eucaryotes: Molecular mechanism of cdc2 activation. Trends Biochem. Sci., 15:378-383.
11. Dynlacht, B.D. (1997) Regulation of transcription by proteins that control the cell cycle. Nature, 389:149-152.
12. Feinberg, M.B., Baltimore, D., and Frankel, A.D. (1991) The role of Tat in the human immunodeficiency virus life cycle indicates a primary effect on transcriptional elongation. Proc. Natl. Acad. Sci. U. S. A., 88:4045-4049.
13. Forsburg, S.L., and Nurse, P. (1991) Cell cycle regulation in the yeast Saccaromyces cerevisiae and Saccaromyces pombe. Annu. Rev. Cell Biol., 7:227-256.
14. Garcia-Bustos, J., Heitman, J., and Hall, M.N. (1991) Nuclear protein localization. Biochim. Biophys. Acta, 1071:83-101.
15. Giordano, A. Human cyclin-dependent kinase-like proteins and methods of using the same; U.S. Serial Number 5,674,748, issued October 7, 1997.
16. Gold, M.O., Yang, X., Hermann, C.H., and Rice, A.P. (1998) PITALRE, the catalytic subunit of TAK, is required for human immunodeficiency virus Tat transactivation in vivo. J. Virol., 72:4448-4453.
17. Graña, X., Claudio, P.P., De Luca, A., Sang, A., and Giordano, A. (1994a) PISSLRE, a human novel cdc2-related protein kinase. Oncogene, 9:2097-2103.
18. Graña, X., De Luca, A., Sang, N., Fu, Y., Claudio, P.P., Rosenblatt, J., Morgan, D.O., and Giordano, A. (1994b) PITALRE, a nuclear cdc2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. Proc. Natl. Acad. Sci. U. S. A., 91:3834-3838.
19. Hanks, S.K., Quinn, A.M., and Hunter, T. (1988) The protein kinase family: Conserved features and deduced phylogeny of the catalytic domain. Science, 241:42-52.
20. Hartwell, L.H., and Kastan, M.B. (1994) Cell cycle control and cancer. Science, 266:1821-1828.
21. Hermann, C.H., and Rice., A.P. (1993) Specific interaction of the human immunodeficiency virus Tat proteins with a cellular protein kinase. Virology, 197:601-608.
22. Hermann, C.H., and Rice., A.P. (1995) Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit RNA polymerase II, candidate for a Tat cofactor. J. Virol., 69:1612-1620.
23. Hunter, T., and Pines, J. (1994) Cyclins and cancer. II. Cyclin D and CDK inhibitors come of age. Cell, 79:573-582.
24. Jones, K.A. (1997) Taking a new TAK on Tat transactivation. Genes Dev., 11:2593-2599.
25. Jones, K.A., and Peterlin, B.M. (1994) Control of RNA initiation and elongation of the HTV-1 promoter. Annu. Rev. Biochem., 63:717-743.
26. Kao, S.Y., Calman, A.F., Luciw, P.A., and Peterlin, E.M. (1987) Anti-termination of transcription within the long terminal repeat of HIV by the Tat gene product. Nature, 330:489-493.
27. Kasten, M.M., and Giordano, A. (1998) pRb and the Cdks in apoptosis and cell cycle. Cell Death Differ., 5:132-140.
28. Keen, N.J., Gait, M.J., and Karn, J. (1996) Human immunodeficiency virus type 1 Tat is an integral component of the activated transcription-elongation complex. Proc. Natl. Acad. Sci. U. S. A., 93:2505-2510.
29. King, R.W., Jackson, P.K., and Kirschner, M.W. (1994) Mitosis in transition. Cell, 79:563-571.
30. King, R.W., Deshaies, R.J., Peters, J.M., and Kirschner, M.W. (1996) How proteolisis drives the cell cycle. Science, 274:1652-1658.
31. Lapidot-Lipson, Y., Patinkin, D., Prody, C.A., Dhrlich, G., Seidman, S., Ben, A.R., Bensele F., Eckstein, F., Zakut, H., and Soreq, H. (1992) Cloning and antisense oligodeoxynucleotides inhibition of a human homolog of cdc2 required in hematopoiesis. Proc. Natl. Acad. Sci. U. S. A., 89:579-583.
32. Lapsia, M.F., Rice, A.P., and Mathews, M.B. (1989) HIV-1 Tat protein increases transcriptional elongation on and stabilizes elongation. Cell, 59:283-292.
33. Lazzaro, M.A., Albert, P.R., and Julien, J.P. (1997) A novel cdc2-related protein kinase expressed in the nervous system. J. Neurochem., 69:348-364.
34. Lew, J., Huang, Q.Q., Qi, Z., Winfkein, R.J., Aebersold, R., Hunt, T., and Wang, J.H. (1994) A brain-specific activator of cyclin-dependent kinase and CDKs inhibitors: Implication in cell cycle control and cancer. Nature, 371:423-426.
35. MacLachlan, T.K., Sang, N., and Giordano, A. (1995) Cyclins, cyclin-dependent kinases and Cdk inhibitors: Implication in cell cycle control and cancer. Critical Reviews in Eucaryotic Gene Expression, 5:127-156.
36. MacLachlan, T.K., and Giordano, A. (1998) TRAF2 expression in differentiated muscle, J. Cell. Biochem., (in press).
37. MacLachlan, T.K., Sang, N., Puri, P.L., De Luca, A., Levrero, M., and Giordano, A. (1998) PITALRE/CDK9 interacts with TRAF2. J. Cell. Biochem., (in press).
38. Matsuhime, H., Quelle, D.E., Shurtleff, S.A., Shibuya, M., Sherr, C.J., and Kato, J.Y. (1994) D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol., 14:2066-2076.
39. Meyerson, M., and Harlow, E. (1994) Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol. Cell. Biol., 14:2077-2086.
40. Meyerson, M., Enders, G.H., Wu, C.L., Su, L.K., Gorka, C., Nelson, C., Harlow, E., and Tsai, L.H. (1992) A family of human cde2-related protein kinases. EMBO J., 11:2909-2917.
41. Morgan, D.O. (1995) Principles of CDK regulation. Nature, 374:131-134.
42. Nurse, P., and Bisset, Y. (1991) Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast. Nature, 292:558-560.
43. Offit, K., Parza, N.Z., Jhanwar, S.C., Filippa, D., Wachtel, M., and Chagenti, R.S. (1993) Clusters of chromosome 9 aberration are associated with clinico-pathologic subsets of non-Hodgkins lymphoma. Genes Chromosom. Cancer, 7:1-7.
44. Ohtsubo, M., Theodoras, A.M., Achumacher, J., Roberts, J.M., and Pagano, M. (1995) Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol. Cell. Biol., 15:2612-2624.
45. Okamoto, K., and Beach, D. (1994) Cyclin G is a transcriptional target of a p53 tumor suppressor protein. EMBO J., 13:4816-4822.
46. Orlow, I., Lianes, P., Lacombe, L., Dalbagni, G., Reuter, V.E., and Cordon-Cardo, C. (1994) Chromosome 9 allelic losses and microsatellite alterations in human bladder tumors. Cancer Res., 54:2848-2851.
47. Pagano, M., Pepperkok, R, Lukas, J., Baldin, V., Ansorge, W., Bartek, J., and Draetta, G. (1993) Regulation of the cell cycle by the cdc2 protein kinase in human cultured fibroblasts. J. Cell Biol., 121:101-111.
48. Paggi, M.G., Baldi, A., Bonetto, A., and Giordano, A. (1996) Retinoblastoma protein family in cell cycle and cancer: A review. J. Cell. Biochem., 62:418-430.
49. Parada, C.A., and Roeder, R.G. (1996) Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain. Nature, 384:375-378.
50. Peng, J., Zhu, Y., Milton, J.T., and Price, D.H. (1998) Identification of multiple cyclin subunits of human P-TEFb. Genes Dev., 12:755-762.
51. Quelle, D.E., Ashmun, R.A., Shurtleff, S.A., Kato, J.Y., Bar, S.D., Roussel, M.F., and Sherr, C.J. (1993) Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes Dev., 7:1559-1571.
52. Reed, S.I., and Wittenberg, C. (1990) Mitotic role for the Cdc28 protein kinase of Saccaromyces cerevisiae. Proc. Natl. Acad. Sci. U. S. A., 87:5697-5701.
53. Tamura, K., Kanaoka, Y., Jinno, S., Nagata, A., Ogiso, Y., Shimizu, K., Hayakawa, T., Nojima, H., and Okayama, H. (1993) Cyclin G: A new mammalian cyclin with homology to fission yeast Cig1. Oncogene, 8:2113-2118.
54. Tsai, L.H., Takahashi, T., Caviness, V.S., and Harlow, E. (1993) Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development, 119:1029-1040.
55. Tsai, L.H., Delalle, I., Caviness, V.J., Chae, T., and Harlow, E. (1994) p35 is a neural- specific regulatory subunit of cyclin-dependent kinase 5. Nature, 371:419-423.
56. Wei, P., Garber, M.E., Fang, S.M., Fischer, W.H., and Jones, K. (1998) A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high affinity, loop specific binding to TAR RNA. Cell, 92:451-462.
57. Yang X., Hermann C.H., and Rice A.P. (1996) The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function. J. Virology, 70(7): 4576-4584.
58. Yang, X., Gold, M.O., Tang, D.N., Lewis, D.E., Aguilar-Cordova, E., Rice, A.P., and Herrmann, C. (1997) TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines. Proc. Natl. Acad. Sci. U. S. A., 94:12331-12336.
59. Zhu, Y., Pe'ery, T., Ramanathan, J., Marshall, N., Marshall, T., Amendt, B., Mathews, M.B., and Price, D.H. (1997) Transcription elongation factor p-TEFb is required for HIV-1 Tat transactivation in vitro. Genes Dev., 11:2622-2632.