A requirement for recombinational repair in Saccharomyces cerevisiae is caused by DNA replication defects of mec1 mutants

Genetics

Volumn 153, Issue 2, 1999, Pages 595-605

  Merrill, Bradley J ^a   Holm, Connie ^a  

^a San Diego   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL MUTANT; CELL VIABILITY; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; DNA SYNTHESIS INHIBITION; GENE ISOLATION; GENETIC RECOMBINATION; LETHAL MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

DNA REPAIR; DNA REPLICATION; DNA, FUNGAL; DNA, SINGLE-STRANDED; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENOTYPE; HYDROXYUREA; MUTAGENESIS; RAD52 DNA REPAIR AND RECOMBINATION PROTEIN; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 0032870740     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. ALLEN, J. B., Z. ZHOU, W. SIEDE, E. C. FRIEDBERG and S. J. ELLEDGE, 1994 The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev. 8: 2401-2415.
2. AUSUBEL, F. M., R. BRENT, R. E. KINGSTON, D. D. MOORE, J. G. SEIDMAN et al. (Editors), 1988 Current Protocols in Molecular Biology. Greene Publishing Associates and Wiley Interscience, New York.
3. BERGER, C. A., and H. J. EDENBERG, 1986 Pyrimidine dimers block simian virus 40 replication forks. Mol. Cell. Biol. 6: 3443-3450.
4. BOSCO, G., and J. E. HABER, 1998 Chromosome break-induced DNA replication leads to nonreciprocal translocations and telomere capture. Genetics 150: 1037-1047.
5. CARNEY, J. P., R. S. MASER, H. OLIVARES, E. M. DAVIS, M. LE BEAU et al., 1998 The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 93: 477-486.
6. CHEN, C., K. UMEZU and R. D. KOLODNER, 1998 Chromosomal rearrangements occur in S. cerevisiae rfa1 mutator mutants due to mutagenic lesions processed by double-strand-break repair. Mol. Cell 2: 9-22.
7. GAME, J. C., and R. K. MORTIMER, 1974 A genetic study of X-ray sensitive mutants in yeast. Mutat. Res. 24: 281-292.
8. GIOT, L., R. CHANET, M. SIMON, C. FACCA and G. FAYE, 1997 Involvement of the yeast DNA polymerase delta in DNA repair in vivo. Genetics 146: 1239-1251.
9. HARTWELL, L. H., and D. SMITH, 1985 Altered fidelity of mitotic chromosome transmission in cell cycle mutants of S. cerevisiae. Genetics 110: 381-395.
10. ISHIMI, Y., A. CLAUDE, P. BULLOCK and J. HURWITZ, 1988 Complete enzymatic synthesis of DNA containing the SV40 origin of replication. J. Biol. Chem. 263: 19723-19733.
11. JOHNSTON, L. H., 1983 The cdc9ligase joins completed replicons in baker's yeast. Mol. Gen. Genet. 190: 315-317.
12. JOHNSTON, L. H., and K. A. NASMYTH, 1978 Saccharomyces cerevisiae cell cycle mutant cdc9 is defective in DNA ligase. Nature 274: 891-893.
13. JOHNSTON, L. H., and D. H. WILLIAMSON, 1978 An alkaline sucrose gradient analysis of the mechanism of nuclear DNA synthesis in the yeast Saccharomyces cerevisiae. Mol. Gen. Genet. 164: 217-225.
14. KADYK, L. C., and L. H. HARTWELL, 1993 Replication-dependent sister chromatid recombination in rad1 mutants of Saccharomyces cerevisiae. Genetics 133: 469-487.
15. KRANZ, J. E., and C. HOLM, 1990 Cloning by function: an alternative approach for identifying yeast homologs of genes from other organisms. Proc. Natl. Acad. Sci. USA 87: 6629-6633.
16. MALKOVA, A., E. L. IVANOV and J. E. HABER, 1996 Double-strand break repair in the absence of RAD51 in yeast: a possible role for break-induced DNA replication. Proc. Natl. Acad. Sci. USA 93: 7131-7136.
17. MALONE, R. E., and M. F. HOEKSTRA, 1984 Relationships between a hyper-rec mutation (REM1) and other recombination and repair genes in yeast. Genetics 107: 33-48.
18. MCALEAR, M. A., K. M. TUFFO and C. HOLM, 1996 The large subunit of replication factor C (Rfc1p/Cdc44p) is required for DNA replication and DNA repair in Saccharomyces cerevisiae. Genetics 142: 65-78.
19. MERRILL, B. J., and C. HOLM, 1998 The RAD52 recombinational repair pathway is essential in pol30 (PCNA) mutants that accumulate small single-stranded DNA fragments during DNA synthesis. Genetics 148: 611-624.
20. MICHEL, B., S. D. EHRLICH and M. UZEST, 1997 DNA double-strand breaks caused by replication arrest. EMBO J. 16: 430-438.
21. MONTELONE, B. A., S. PRAKASH and L. PRAKASH, 1981 Spontaneous mitotic recombination in mms8-1, an allele of the CDC9 gene of Saccharomyces cerevisiae. J. Bacteriol. 147: 517-525.
22. MORROW, D. M., C. CONNELLY and P. HIETER, 1997 "Break copy" duplication: a model for chromosome fragment formation in Saccharomyces cerevisiae. Genetics 147: 371-382.
23. MOSIG, G., N. COLOWICK, M. E. GRUIDL, A. CHANG and A. J. HARVEY, 1995 Multiple initiation mechanisms adapt phage T4 DNA replication to physiological changes during T4's development. FEMS Microbiol. Rev. 17: 83-98.
24. NAGASAWA, H., S. A. LATT, M. E. LALANDE and J. B. LITTLE, 1985 Effects of X-irradiation on cell-cycle progression, induction of chromosomal aberrations and cell killing in ataxia telangiectasia. Mutat. Res. 148: 71-82.
25. NOSKOV, V. N., H. ARAKI and A. SUGINO, 1998 The RFC2 gene, encoding the third-largest subunit of the replication factor C complex, is required for an S-phase checkpoint in Saccharomyces cerevisiae. Mol. Cell. Biol. 18: 4914-4923.
26. PAULOVICH, A. G., and L. H. HARTWELL, 1995 A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage. Cell 82: 841-847.
27. PAULOVICH, A. G., D. P. TOCZYSKI and L. H. HARTWELL, 1997 When checkpoints fail. Cell 88: 315-321.
28. PAULOVICH, A. G., C. D. ARMOUR and L. H. HARTWELL, 1998 The Saccharomyces cerevisiae RAD9, RAD17, RAD24 and MEC3 genes are required for tolerating irreparable, ultraviolet-induced DNA damage. Genetics 150: 75-93.
29. RESNICK, M. A., and P. MARTIN, 1976 The repair of double-strand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic control. Mol. Gen. Genet. 143: 119-129.
30. ROBZYK, K., and Y. KASSIR, 1992 A simple and highly efficient procedure for rescuing autonomous plasmids from yeast. Nucleic Acids Res. 20: 3790.
31. SANTOCANALE, C., and J. F. DIFFLEY, 1998 A Mec1-and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature 395: 615-618.
32. SAVITSKY, K., A. BAR-SHIRA, S. GILAD, G. ROTMAN, Y. ZIV et al., 1995 A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268: 1749-1753.
33. SEIGNEUR, M., V. BIEDENKO, S. D. EHRLICH and B. MICHEL, 1998 RuvAB acts at arrested replication forks. Cell 95: 419-430.
34. SHERMAN, F., G. R. FINK and J. B. HICKS, 1986 Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
35. SHIRAHIGE, K., Y. HORI, K. SHIRAISHI, M. YAMASHITA, K. TAKAHASHI et al., 1998 Regulation of DNA-replication origins during cell-cycle progression. Nature 395: 618-621.
36. SIEDE, W., A. S. FRIEDBERG, and E. C. FRIEDBERG, 1993 RAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 90: 7985-7989.
37. STRAUSS, B. S., 1985 Translesion DNA synthesis: polymerase response to altered nucleotides. Cancer Surv. 4: 493-516.
38. SUGIMOTO, K., T. SHIMOMURA, K. HASHIMOTO, H. ARAKI, A. SUGINO et al., 1996 Rfc5, a small subunit of replication factor C complex, couples DNA replication and mitosis in budding yeast. Proc. Natl. Acad. Sci. USA 93: 7048-7052.
39. SUGIMOTO, K., S. ANDO, T. SHIMOMURA and K. MATSUMOTO, 1997 Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway. Mol. Cell. Biol. 17: 5905-5914.
40. TAALMAN, R. D., T. W. HUSTINX, C. M. WEEMAES, E. SEEMANOV, A. A. SCHMIDT et al., 1989 Further delineation of the Nijmegen breakage syndrome. Am. J. Med. Genet. 32: 425-431.
41. TISHKOFF, D. X., N. FILOSI, G. M. GAIDA and R. D. KOLODNER, 1997 A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair. Cell 88: 253-263.
42. TSURIMOTO, T., and B. STILLMAN, 1991 Replication factors required for SV40 DNA replication in vitro: II. Switching of DNA polymerase a and 8 during initiation of leading and lagging strand synthesis. J. Biol. Chem. 266: 1961-1968.
43. TURCHI, J. J., L. HUANG, R. S. MURANTE, Y. KIM and R. A. BAMBARA, 1994 Enzymatic completion of mammalian lagging-strand DNA replication. Proc. Natl. Acad. Sci. USA 91: 9803-9807.
44. VALLEN, E. A., and F. R. CROSS, 1995 Mutations in RAD27 define a potential link between G1 cyclins and DNA replication. Mol. Cell. Biol. 15: 4291-4303.
45. VARON, R., C. VISSINGA, M. PLATZER, K. M. CEROSALETTI, K. H. CHRZANOWSKA et al., 1998 Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell 93: 467-476.
46. WACH, A., A. BRACHAT, R. PEOHLMANN and P. PHILIPPSEN, 1994 New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10: 1793-1808.
47. WAGA, S., and B. STILLMAN, 1994 Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro. Nature 369: 207-212.
48. WALMSLEY, R. M., L. H. JOHNSTON, D. H. WILLIAMSON and S. G. OLIVER, 1984 Replicon size of yeast ribosomal DNA. Mol. Gen. Genet. 195: 260-266.
49. WEINERT, T., 1998 DNAdamage and checkpoint pathways: molecular anatomy and interactions with repair. Cell 94: 555-558.
50. WEINERT, T. A., and L. H. HARTWELL, 1988 The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science 241: 317-322.
51. WEINERT, T. A., G. L. KISER and L. H. HARTWELL, 1994 Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev. 8: 652-665.
52. ZHAO, X., E. G. MULLER and R. ROTHSTEIN, 1998 A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol. Cell 2: 329-340.
53. ZHOU, Z., and S. J. ELLEDGE, 1993 DUN1 encodes a protein kinase that controls the DNA damage response in yeast. Cell 75: 1119-1127.