Failed clearance of aneuploid embryonic neural progenitor cells leads to excess aneuploidy in the Atm-deficient but not the Trp53-deficient adult cerebral cortex

Journal of Neuroscience

Volumn 24, Issue 37, 2004, Pages 8090-8096

  McConnell, Michael J ^a,b,c,e   Kaushal, Dhruv ^b,c,d   Yang, Amy H ^b,c,e   Kingsbury, Marcy A ^c,e   Rehen, Stevens K ^c,e   Treuner, Kai ^a   Helton, Robert ^a   Annas, Emily G ^a   Chun, Jerold ^b,c,e   Barlow, Carrolee ^a,b  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Aneuploidy; Apoptosis; Ataxia telangiectasia; Development; DNA damage signaling; Neurodegeneration

Indexed keywords

ATM PROTEIN; PROTEIN; TRANSFORMATION RELATED PROTEIN 53; UNCLASSIFIED DRUG;

ANEUPLOIDY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATAXIA; BRAIN CORTEX; CENTRAL NERVOUS SYSTEM; CHROMOSOME ABERRATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DNA REPAIR; GENE MUTATION; MALE; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SEX CHROMOSOME; STEM CELL; TELANGIECTASIA;

ANEUPLOIDY; ANIMALS; ANTIGENS, NUCLEAR; APOPTOSIS; ATAXIA TELANGIECTASIA; CELL CYCLE PROTEINS; CELL SURVIVAL; CEREBRAL CORTEX; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; GENES, P53; KARYOTYPING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; PROTEIN-SERINE-THREONINE KINASES; SEX CHROMOSOME ABERRATIONS; STEM CELLS; TRANSLOCATION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 4644245822     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2263-04.2004     Document Type: Article

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