Mental development in polysomy X Klinefelter syndrome (47,XXY; 48,XXXY): Effects of incomplete X inactivation

Seminars in Reproductive Medicine

Volumn 19, Issue 2, 2001, Pages 193-202

  Samango Sprouse, C ^a  

^a Neurodevelopmental Diagnostic Center   (United States)

Author keywords

Cognition; Klinefelter syndrome; Neurodevelopment; XXY

Indexed keywords

CLINICAL FEATURE; COGNITION; HUMAN; KARYOTYPE 47,XXY; KLINEFELTER SYNDROME; LEARNING DISORDER; MENTAL DEVELOPMENT; MOTOR DEVELOPMENT; NEUROBIOLOGY; PHENOTYPE; PRENATAL DIAGNOSIS; REVIEW; X CHROMOSOME INACTIVATION;

ANEUPLOIDY; CHILD; DOSAGE COMPENSATION, GENETIC; HUMANS; KLINEFELTER SYNDROME; LEARNING DISORDERS; MALE; MOSAICISM; MOTOR SKILLS DISORDERS; X CHROMOSOME;

EID: 0034843903     PISSN: 15268004     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2001-15400     Document Type: Review

References (57)

1. Syndrome characterized by gynecomastia aspermatogenesis without aleydigism and increased excretion of follicle stimulating hormone
2. Intrauterine diagnosis of sex chromosome aneuploidy
3. Sex chromosome abnormalities found among 34,910 newborn children: Results from a 13-year study in Arhus, Denmark
4. Sex chromosome aneuploidy, prospective and longitudinal studies
5. Sex chromosome aneuploidy: The Denver Prospective Study
6. Genetics: An overview
7. Aggressive behavior, mental subnormality and the XXY male
8. Behavior disorders and pattern of crime among XXY males identified at a maximum security hospital
9. Chromosomal abnormalities in the New Haven Newborn Study: A prospective study of development of children with sex chromosome anomalies
10. Edinburgh study of growth and development of children with sex chromosome abnormalities
11. Cognitive and behavioral factors in the learning disabilities of 47,XXY and 47,XYY boys
12. Intelligence and achievement in children with extra X aneuploidy: A longitudinal perspective
13. The neurocognitive profile of boys with XXY diagnosed through prenatal diagnosis
14. The contribution of neuroimaging: Fragile X syndrome, Turner syndrome and neurofibromatosis-1
15. Evidence from Turner syndrome of an imprinted X-linked locus affecting cognitive function
16. Uniparental and functional X disomy in Turner syndrome patients with unexplained mental retardation and X derived marker chromosomes
17. Neurobehavioral phenotype of Klinefelter syndrome
18. Dyslexia in 47,XXY boys identified at birth
19. The psychoeducational profile of boys with Klinefelter syndrome
20. Summary overview of behavioral development in individuals with neonatally identified X and Y aneuploidy
21. Growth and development from early to midadolescence of children with X and Y chromosomal aneuploidy: The Toronto Study
22. Abnormalities of the sex chromosomes: A prospective study on randomly identified newborns
23. The sex chromosomes and X chromosome inactivation
24. Klinefelter syndrome: An analysis of the origin of the additional sex chromosome using molecular probes
25. Reduced recombination and paternal age effect in Klinefelter syndrome
26. Evidence of skewed X-chromosome inactivation in 47,XXY Klinefelter patients
27. Cerebral lateralization: Biological mechanisms associations and pathology
28. Relations between dermatoglyphs measure of hemispheric specialization and intellectual abilities in 47,XXY males
29. Neuropsychological profiles of adults with Klinefelter syndrome
30. Sex chromosome aneuploidy: The Denver Prospective Study
31. Verbal deficits in Klinefelter (XXY) adults living in the community
32. Prognosis of prenatally diagnosed children with sex chromosome aneuploidy
33. Frontal lobe development in childhood
34. Early development of children with sex chromosome aberrations
35. Oral and written language abilities of XXY boys: Implications for anticipatory guidance
36. Summary of clinical findings: Profiles of children with 47,XXY, 47,XXX and 47,XYY karyotypes
37. The neurocognitive profile of children with sex chromosome anomalies
38. Specific neurocognitional impairment associated with Turner (45,XXX) and Klinefelter (47,XXY) syndrome: A review
39. Physical and mental development of adolescent males in the Klinefelter syndrome
40. Early development of children with abnormalities of the X chromosome: A prospective study
41. The personality and psycho-sexual development of boys with 47,XXY chromosome constitution
42. A psychological study of the personalities of XYY and XXY men
43. Preliminary observations on language and learning in XXY boys
44. Follow-up until age four to eight of 25 unselected children with sex chromosome abnormalities, compared with sibling and controls
45. New angles on motor and sensory coordination in learning disabilities: A report on the 1988 LDA medical symposium
46. A review of Klinefelter's syndrome in children and adolescents
47. Brain morpohology in Klinefelter syndrome: Extra X chromosome and testosterone supplementation
48. Klinefelter's syndrome: A genetic model for learning disabilities in the verbal and frontal-attentional domains
49. Children with language disorders: Natural history and academic success
50. Follow-up until age: Age seven to eleven of 25 unselected children with sex chromosome abnormalities, compared with sibling and controls
51. Angelman syndrome and Prader-Willi syndrome
52. Sex chromosome tetrasomy and pentasomy
53. The hidden disability: Sex chromosome variations (SCV)