Targeting TrkB neurotrophin receptor to treat depression

Expert Opinion on Therapeutic Targets

Volumn 12, Issue 6, 2008, Pages 705-715

  Rantamäki, Tomi ^a   Castrén, Eero ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

BDNF cleavage; Chromatin remodeling; P75NTR receptor; Pro BDNF; Transactivation; TrkB agonist; Truncated TrkB receptor

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; G PROTEIN COUPLED RECEPTOR; HISTONE DEACETYLASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHIN 3; NEUROTROPHIN 4; NEUROTROPHIN RECEPTOR; NEUROTROPHIN RECEPTOR P75; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C GAMMA1; PROTEIN KINASE B; PROTEIN SHC; PROTEIN TYROSINE PHOSPHATASE SHP 2;

CELL SURVIVAL; DEPRESSION; DIMERIZATION; DRUG TARGETING; ELECTROCONVULSIVE THERAPY; HUMAN; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NONHUMAN; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN SYNTHESIS; PSYCHOTHERAPY; RECEPTOR BINDING; RECEPTOR UPREGULATION; REVIEW; SIGNAL TRANSDUCTION; TRANSACTIVATION;

ANIMALS; ANTIDEPRESSIVE AGENTS; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEPRESSION; HUMANS; RECEPTOR, TRKB;

EID: 45849115466     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.12.6.705     Document Type: Review

References (110)

1. Slattery DA, Hudson AL, Nutt DJ. Invited review: the evolution of antidepressant mechanisms. Fundam Clin Pharmacol 2004;18(1):1-21
2. Berton O, Nestler EJ. New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci 2006;7(2):137-51
3. Castrén E. Is mood chemistry? Nat Rev Neurosci 2005;6(3):241-6
4. Pederson KJ, Roerig JL, Mitchell JE. Towards the pharmacotherapy of eating disorders. Expert Opin Pharmacother 2003;4(10):1659-78
5. Kumar A, Balan S. Fluoxetine for persistent developmental stuttering. Clin Neuropharmacol 2007;30(1):58-9
6. Doris A, Ebmeier K, Shajahan P. Depressive illness. Lancet 1999;354(9187):1369-75
7. Posternak MA, Zimmerman M. Is there a delay in the antidepressant effect? A meta-analysis. J Clin Psychiatry 2005;66(2):148-58
8. Manji HK, Drevets WC, Chamey DS. The cellular neurobiology of depression. Nat Med 2001;7(5):541-7
9. Nestler EJ, Barrot M, Dileone RJ, et al. Neurobiology of depression. Neuron 2002;34(1):13-25
10. Schechter LE, Ring RH, Beyer CE, et al. Innovative approaches for the development of antidepressant drugs: current and future strategies. NeuroRx 2005;2(4):590-611
11. Drevets WC. Neuroimaging studies of mood disorders. Biol Psychiatry 2000;48(8):813-29
12. Drevets WC. Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression. Prog Brain Res 2000;126:413-31
13. Castrén E. Neurotrophic effects of antidepressant drugs. Curr Opin Pharmacol 2004;4(1):58-64
14. Ebmeier KP, Donaghey C, Steele JD. Recent developments and current controversies in depression. Lancet 2006;367(9505):153-67
15. Czeh B, Michaelis T, Watanabe T, et al. Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc Natl Acad Sci USA 2001;98(22):12796-801
16. McEwen BS. Stress and hippocampal plasticity. Ann Rev Neurosci 1999;22:105-22
17. Duman RS, Heninger GR, Nestler EJ. A molecular and cellular theory of depression. Arch Gen Psychiatry 1997;54(7):597-606
18. Lewin GR, Barde YA. Physiology of the neurotrophins. Ann Rev Neurosci 1996,19:289-317
19. Huang EJ, Reichardt LF. Neurotrophins: roles in neuronal development and function. Ann Rev Neurosci 2001;24:677-736
20. Thoenen H. Nearotrophins and neuronal plasticity. Science 1995;270(5236):593-8
21. Altar CA. Neurotrophins and depression. Trends Phannacol Sci 1999;20(2):59-61
22. McAllister AK, Katz LC, Lo DC. Neurotrophins and synaptic plasticity. Ann Rev Neurosci 1999;22:295-318
23. Poo MM. Neuratrophins as synaptic modulators. Nat Rev Neurosci 2001;2(1):24-32
24. Seidah NG, Benjannet S, Pareek S, et al. Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases. Biochem J 1996;314(Pt 3):951-60
25. Seidah NG, Benjannet S, Pareek S, et al. Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases FEBS Lett 1996;379(3):247-50
26. Lee R, Kermani P, Teng KK, Hempstead BL. Regulation of cell survival by secreted proneurotrophins. Science 2001;294(5548):1945-8
27. Beck KD, Lamballe F, Klein R. et al. Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus. J Neurosci 1993;13(9):4001-14
28. Biffo S, Offenhauser N, Carter BD, Barde YA. Selective binding and internalisation by truncated receptors restrict the availability of BDNF during development. Development 1995;121(8):2461-70
29. Rubio N. Mouse astrocytes store and deliver brain-derived neurotrophic factor using the non-catalytic gp95trkB receptor. Eur J Neurosci 1997;9(9):1847-53
30. Eide FF, Vining ER, Eide BL, et al. Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling. J Neurosci 1996;16(10):3123-9
31. Knusel B, Rabin SJ, Hefti F, Kaplan DR. Regulated neurotrophin receptor responsiveness during neuronal migrationand early differentiation. J Neurosci 1994;14(3 Pt 2):1542-54
32. Haapasalo A, Koponen E, Hoppe E, et al. Truncated trkB.T1 is dominant negative inhibitor of trkB.TK+-mediated cell survival. Biochem Biophys Res Commun 2001;280(5):1352-8
33. Teng HK, Teng KK, Lee R, et al. ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci 2005;25(22):5455-63
34. Pang PT, Teng HK, Zaitsev E, et al. Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science 2004;306(5695):487-91
35. Woo NH, Teng HK, Siao CJ, et al. Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nat Neurosci 2005;8(8):1069-77
36. Lu B, Pang PT Woo NH. The yin and yang of neurotrophin action. Nat Rev Neurosci 2005;6(8):603-14
37. Martinowich K, Manji H, Lu B. New insights into BDNF function in depression and anxiety. Nat Neurosci 2007;10(9):1089-93
38. Matsumoto T, Rauskolb S, Polack M, et al. Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF. Nat Neurosci 2008;11(2):131-3
39. Duman RS, Monteggia LM. A neurotrophic model for stress-related mood disorders. Biol Psychiatry 2006;59(12):1116-27
40. Nibuya M, Morinobu S, Duman RS. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 1995;15(11):7539-47
41. Chen B, Dowlatshahi D, MacQueen GM, et al. Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol Psychiatry 2001;50(4):260-5
42. Russo-Neustadt A, Ha T, Ramirez R, Kesslak JP, Physical activity-antidepressant treatment combination: impact on brain-derived neurotrophic factor and behavior in an animal model. Behav Brain Res 2001;120(1):87-95
43. Alfonso J, Frick LR, Silberman DM, et al. Regulation of hippocampal gene expression is conserved in two species subjected to different stressors and antidepressant treatments. Biol Psychiatry 2006;59(3):244-51
44. Xu H, Luo C, Richardson JS, Li XM. Recovery of hippocampal cell proliferation and BDNF levels, both of which are reduced by repeated restraint stress, is accelerated by chronic venlafaxine. Pharmacogenomics J 2004;4(5):322-31
45. Tsankova NM, Berton O, Renthal W, et al. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci 2006;9(4):519-25
46. Shimizu E, Hashimoto K, Okamura N, et al. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 2003;54(1):70-5
47. Gonul AS, Akdeniz F. Taneli F, et al. Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients. Eur Arch Psychiatry Clin Neurosci 2005;255(6):381-6
48. Gervasoni N, Aubry JM, Bondolfi G, et al. Partial normalization of serum brain-derived neurotrophic factor in remitted patients after a major depressive episode. Neuropsychobiology 2005;51(4):234-8
49. Saarelainen T, Hendolin P, Lucas G, et al. Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-incluced behavioral effects. J Neurosci 2003;23(1):349-57
50. Monteggia LM, Barrot M, Powell CM, et al. Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci USA 2004;101(29):10827-32
51. Siuciak JA, Lewis DR, Wiegand SJ, Lindsay RM. Antidepressant-like effect of brain-derived neurotmphic factor (BDNF). Pharmacol Biochem Behav 1997;56(1):131-7
52. Shirayama Y, Chen AC, Nakagawa S, et al. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci 2002;22(8):3251-61
53. Timmusk T, Palm K, Metsis M, et al. Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron 1993;10(3):475-89
54. Aid T, Kazantseva A, Piirsoo M, et al. Mouse and rat BDNF gene structure and expression revisited. J Neurosci Res 2007;85(3):525-35
55. Pruunsild P, Kazantseva A, Aid T, et al. Dissecting the human BDNF locus: bidirectional transcription, Complex splicing, and multiple promoters. Genomics 2007;90(3):397-406
56. Blendy JA. The role of CREB in depression and antidepressant treatment. Biol Psychiatry 2006;59(12):1144-50
57. Finkbeiner S, Tavazoie SF, Maloratsky A, et al. CREB: a major mediator of neuronal neurotrophin responses. Neuron 1997;19(5):1031-47
58. Dias BG, Banerjee SB, Duman RS, Vaidya VA. Differential regulation of brain derived neurotrophic factor transcripts by antidepressant treatments in the adult rat brain. Neuropharmacology 2003;45(4):553-63
59. Conti AC, Cryan JF, Dalvi A, et al. cAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioral or endocrine responses to antidepressant drugs. J Neurosci 2002;22(8):3262-8
60. Fujimaki K, Morinobu S, Duman RS. Administration of a cAMP phosphodiesterase 4 inhibitor enhances antidepressant-induction of BDNF mRNA in rat hippocampus. Neuropsychopharmacology 2000;22(1):42-51
61. Itoh T, Tokumura M, Abe K. Effects of rolipram, a phosphodiesterase 4 inhibitor, in combination with imipramine on depressive behavior, CRE-binding activity and BDNF level in learned helplessness rats. Eur J Pharmacol 2004;498(1-3):13542
62. Tsankova N, Renthal W, Kumar A, Nestler EJ. Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci 2007;8(5):355-67
63. Schroeder FA, Lin CL, Crusio WE, Akbarian S. Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. Biol Psychiatry 2007;62(1):55-64
64. Zetterström TS, Pei Q, Madhav TR, et al. Manipulations of brain 5-HT levels affect gene expression for BDNF in rat brain. Neuropharmacology 1999;38(7):1063-73
65. Miro X, Perez-Torres S, Artigas F, et al. Regulation of cAMP phosphodiesterase mRNAs expression in rat brain by acute and chronic fluoxetine treatment. An in situ hybridization study. Neuropharmacology 2002;43(7):1148-57
66. Coppell AL, Pei Q, Zetterström TS. Bi-phasic change in BDNF gene expression following antidepressant drug treatment. Neuropharmacology 2003;44(7):903-10
67. Torregrossa MM, Isgor C, Folk JE, et al. The δ-opioid receptor agonist (+) BW373U86 regulates BDNF mRNA expression in rats. Neuropsychopharmacology 2004;29(4):649-59
68. Rantamäki T, Knuuttila JE, Hokkanen ME, Castrin E. The effects of acute and long-term lithium treatments on trkB neurotrophin receptor activation in the mouse hippocampus and anterior cingulate cortex. Neuropharmacology 2006;50(4):421-7
69. Rantamäki T, Hendolin P Kankaanpää A, et al. Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cγ1 signaling pathways in mouse brain. Neuropsychopharmacology 2007; 32(10):2152-62
70. Aloyz R, Fawcett JP, Kaplan DR, et al. Activity-dependent activation of TrkB neurotrophin receptors in the adult CNS. Learn Mem 1999;6(3):216-31
71. Wyneken U, Sandoval M, Sandoval S, et al. clinically relevant doses of fluoxetine and reboxetine induce changes in the Trkb content of central excitatory synapses. Neuropsychopharmacology 2006;31(11):2415-23
72. Haapasalo A, Sipola I, Larsson K, et al. Regulation of TRKB surface expression by brain-derived neurotrophic factor and truncated TRKB isoforms. J Biol Chem 2002;277(45):43160-7
73. Lessmann V, Gottmann K, Malcangio M. Neurotrophin secretion: current facts and future prospects. Prog Neurobiol 2003;69(5):341-74
74. Balkowiec A, Katz DM. Cellular mechanisms regulating activity-dependent release of native brain-derived neurotrophic factor from hippocampal neurons. J Neurosci 2002;22(23):10399-407
75. Hwang JJ, Park MH, Koh JY. Copper activates TrkB in cortical neurons in a metalloproteinase-dependent manner. J Neurosci Res 2007;85(10):2160-6
76. Hwang JJ, Park MH, Choi SY, Koh JY. Activation of the Trk signaling pathway by extracellular zinc. Role of metalloproteinases. J Biol Chem 2005;280(12):11995-2001
77. Huang YZ, Pan E, Xiong ZQ, McNamara JO. Zinc-mcdiated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse. Neuron 2008;57(4):546-58
78. Fujimura H, Altar CA, Chen R, et al. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemost 2002;87(4):728-34
79. Meyer-Franke A, Wilkinson CA, Kruttgen A, et al. Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons. Neuron 1998;21(4):681-93
80. Du J, Feng L, Zaitsev E. et al. Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx. J Cell Biol 2003;163(2):385-95
81. Ji Y, Pang PT, Feng L, Lu B. Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons. Nat Neurosci 2005;8(2):164-72
82. Takebayashi M, Hayashi T. Su TP. A perspective on the new mechanism of antidepressants: neuritogenesis through sigma-1 receptors. Pharmacopsychiatry 2004;37(Suppl 3):S208-13
83. Yagasaki Y, Numakawa T, Kumamaru E, et al. Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release. J Biol Chem 2006;281(18):12941-9
84. Koponen E, Võikar V, Riekki R, et al. Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCγ pathway, reduced anxiety, and facilitated learning. Mol Cell Neurosci 2004;26(1):166-81
85. Koponen E, Rantamäki T, Võikar V, et al. Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines. Cell Mol Neurobiol 2005;25(6):973-80
86. Nibuya M, Takahashi M, Russell DS, Duman RS. Repeated stress increases catalytic TrkB mRNA in rat hippocampus. Neurosci Lett 1999;267(2):81-4
87. Rajagopal R, Chao MV. A role for Fyn in Trk receptor transactivation by G-protein-coupled receptor signaling. Mol Cell Neurosci 2006;33(1):36-46
88. Araki T, Yamada M, Ohnishi H, et al. Shp-2 specifically regulates several tyrosine-phosphorylated proteins in brain-derived neurotrophic factor signaling in cultured cerebral cortical neurons. J Neurochem 2000;74(2):659-68
89. Yang T, Massa SM, Longo FM. LAR protein tyrosine phosphatase receptor associates with TrkB and modulates neurotrophic signaling pathways. J Neurobiol 2006;66(13):1420-36
90. O'Leary PD, Hughes RA. Design of potent peptide mimetics of brain-derived neurotrophic factor. J Biol Chem 2003;278(28):25738-44
91. Peleshok J, Saragovi HU. Functional mimetics of neurotrophins and their receptors. Biochem Soc Trans 2006;34(Pt 4):612-7
92. Qian MD, Zhang J, Tan XY, et al. Novel agonist monoclonal antibodies activate TrkB receptors and demonstrate potent neurotrophic activities. J Neurosci 2006;26(37):9394-403
93. Lee FS, Rajagopal R, Kim AH, et al. Activation of Trk neurotrophin receptor signaling by pituitary adenylate cyclase-activating polypeptides. J Biol Chem 2002;277(11):9096-102
94. Lee FS, Rajagopal R, Chao MV. Distinctive features of Trk neurotrophin receptor transactivation by G protein-coupled receptors. Cytokine Growth Factor Rev 2002;13(1):11-7
95. Lee FS, Chao MV. Activation of Trk neurotrophin receptors in the absence of neurotrophins. Proc Natl Acad Sci USA 2001;98(6):3555-60
96. Rajagopal R, Chen ZY, Lee FS, Chao MV. Transactivation of Trk neurotrophin receptors by G-protein-coupled receptor ligands occurs on intracellular membranes. J Neurosci 2004;24(30):6650-8
97. Berghuis P, Dobszay MB, Wang X, et al. Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. Proc Natl Acad Sci USA 2005;102(52):19115-20
98. Marvanova M, Lakso M, Pirhonen J, et al. The neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brain. Mol Cell Neurosci 2001;18(3):247-58
99. Garcia LS, Comim CM, Valvassori SS, et al. Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus. Prog Neuropsychopharmacol Biol Psychiatry 2008;32(1):140-4
100. Meisner F, Scheller C, Kneitz S, et al. Memantine upregulates BDNF and prevents dopamine deficits in SIV-infected macaques: a novel pharmacological action of memantine. Neuropsychopharmacology 2007; published online 31 October 2007, doi:10.1038/sj.npp.1301615
101. Lauterborn JC, Lynch G, Vanderklish P, et al. Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons. J Neurosci 2000;20(1):8-21
102. Arai AC, Kessler M. Pharmacology of ampakine modulators: from AMPA receptors to synapses and behavior. Curr Drug Targets 2007;8(5):583-602
103. Paul IA, Skolnick P. Glutamate and depression: clinical and prectinical studies. Ann NY Acad Sci 2003:1003:250-72
104. Zarate CA Jr, Singh JB, Quiroz JA, et al. A double-blind, placebo-controlled study of memantine in the treatment of major depression. Am J Psychiatry 2006;163(1):153-5
105. Eisch AJ, Bolanos CA, De Wit J, et al. Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression. Biol Psychiatry 2003;54(10):994-1005
106. Berton O, McClung CA, Dileone RJ, et al. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 2006;311(5762):864-8
107. Groves JO. Is it time to reassess the BDNF hypothesis of depression? Mol Psychiatry 2007;12(12):1079-88
108. Binder DK, Croll SD, Gall CM, Scharfman HE. BDNF and epilepsy: too much of a good thing? Trends Neurosci 2001;24(1):47-53
109. McNamara JO, Huang YZ, Leonard AS. Molecular signaling mechanisms underlying epileptogenesis. Sci STKE 2006;2006(356):re12
110. Govindarajan A, Rao BS, Nair D, et al. Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effects. Proc Natl Acad Sci USA 2006;103(35):13208-13