Novel agonist monoclonal antibodies activate TrkB receptors and demonstrate potent neurotrophic activities

Journal of Neuroscience

Volumn 26, Issue 37, 2006, Pages 9394-9403

  Qian, Ming D ^a   Zhang, Jie ^a   Tan, Xiang Yang ^a   Wood, Andrew ^a   Gill, Davinder ^a   Cho, Seongeun ^a  

^a PFIZER INC   (United States)

Author keywords

Agonists; Binding; Monoclonal antibodies; Neurite outgrowth; Neuroprotection; Phosphorylation

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; MONOCLONAL ANTIBODY; TYROSINE KINASE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN DISEASE; EPITOPE MAPPING; HYBRIDOMA; MALE; MOUSE; NERVE CELL; NERVE FIBER GROWTH; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VALIDATION PROCESS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BINDING SITES, ANTIBODY; BRAIN DISEASES; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; CROSS REACTIONS; FEMALE; HUMANS; HYBRIDOMAS; MICE; MICE, INBRED BALB C; NEURITES; RATS; RECEPTOR, TRKB; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION;

EID: 33748691607     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1118-06.2006     Document Type: Article

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