G protein coupled receptors as drug targets: The role of β-arrestins

Endocrine, Metabolic and Immune Disorders - Drug Targets

Volumn 8, Issue 1, 2008, Pages 51-61

  Dromey, Jasmin R ^a   Pfleger, Kevin D G ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

arrestin; Endocytosis; G protein coupled receptor; GPCR; Internalisation

Indexed keywords

ADAPTOR PROTEIN; BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; RETINA S ANTIGEN; UBIQUINONE;

ARTICLE; COATED VESICLE; DRUG TARGETING; ENDOCRINE DISEASE; ENZYME PHOSPHORYLATION; HUMAN; IMMUNOPATHOLOGY; INTERNALIZATION; LIGAND BINDING; METABOLIC DISORDER; NONHUMAN; OLIGOMERIZATION; PROTEIN BINDING; SIGNAL TRANSDUCTION; UBIQUITINATION; ANIMAL; CLASSIFICATION; DRUG EFFECT; METABOLISM; PHYSIOLOGY; REVIEW;

ANIMALS; ARRESTINS; HUMANS; RECEPTORS, G-PROTEIN-COUPLED; UBIQUINONE;

EID: 45549093363     PISSN: 18715303     EISSN: None     Source Type: Journal    
DOI: 10.2174/187153008783928352     Document Type: Article

References (87)

1. Howard, A.D.; McAllister, G.; Feighner, S.D.; Liu, Q.; Nargund, R.P.; Van der Ploeg, L.H. and Patchett, A.A. (2001) Trends Pharmacol. Sci., 22(3), 132-140.
2. Takeda, S.; Kadowaki, S.; Haga, T.; Takaesu, H. and Mitaku, S. (2002) FEBS Lett., 520(1-3), 97-101.
3. Pfleger, K.D.; Dromey, J.R.; Dalrymple, M.B.; Lim, E.M.; Thomas, W.G. and Eidne, K.A. (2006) Cell Signal, 18(10), 1664-1670.
4. Heding, A.; Vrecl, M.; Hanyaloglu, A.C.; Sellar, R.; Taylor, P.L. and Eidne, K.A. (2000) Endocrinology, 141(1), 299-306.
5. van Koppen, C.J. and Jakobs, K.H. (2004) Mol. Pharmacol., 66(3), 365-367.
6. Vrecl, M.; Anderson, L.; Hanyaloglu, A.; McGregor, A.M.; Groarke, A.D.; Milligan, G., Taylor, P.L. and Eidne, K.A. (1998) Mol. Endocrinol., 12(12), 1818-1829.
7. Hislop, J.N.; Caunt, C.J.; Sedgley, K.R.; Kelly, E.; Mundell, S.; Green, L.D. and McArdle, C.A. (2005) J. Mol. Endocrinol., 35(1), 177-189.
8. Rasmussen, T.N.; Novak, I. and Nielsen, S.M. (2004) Eur. J. Biochem., 271(22), 4366-4374.
9. Violin, J.D. and Lefkowitz, R.J. (2007) Trends Pharmacol. Sci., 28(8), 416-422.
10. Reiter, E. and Lefkowitz, R.J. (2006) Trends Endocrinol. Metab., 17(4), 159-165.
11. Premont, R.T. and Gainetdinov, R.R. (2007) Annu. Rev. Physiol., 69, 511-534.
12. Oakley, R.H.; Laporte, S.A.; Holt, J.A.; Barak, L.S. and Caron, M.G. (2001) J. Biol. Chem., 276(22), 19452-19460.
13. Shiina, T.; Arai, K.; Tanabe, S.; Yoshida, N.; Haga, T.; Nagao, T. and Kurose, H. (2001) J. Biol. Chem., 276(35), 33019-33026.
14. Kim, J.; Ahn, S.; Ren, X.R.; Whalen, E.J.; Reiter, E.; Wei, H. and Lefkowitz, R.J. (2005) Proc. Natl. Acad Sci. USA, 102(5), 1442-1447.
15. Ren, X.R.; Reiter, E.; Ahn, S.; Kim, J.; Chen, W. and Lefkowitz, R.J. (2005) Proc. Natl. Acad Sci. USA, 102(5), 1448-1453.
16. Shenoy, S.K.; Drake, M.T.; Nelson, C.D.; Houtz, D.A.; Xiao, K.; Madabushi, S.; Reiter, E.; Premont, R.T.; Lichtarge, O. and Lefkowitz, R.J. (2006) J. Biol. Chem., 281(2), 1261-1273.
17. Benovic, J.L.; Kuhn, H.; Weyand, I.; Codina, J.; Caron, M.G. and Lefkowitz, R.J. (1987) Proc. Natl. Acad. Sci. USA, 84(24), 8879-8882.
18. Lohse, M.J.; Benovic, J.L.; Codina, J.; Caron, M.G. and Lefkowitz, R.J. (1990) Science, 248(4962), 1547-1550.
19. Attramadal, H.; Arriza, J.L.; Aoki, C.; Dawson, T.M.; Codina, J.; Kwatra, M.M.; Snyder, S.H.; Caron, M.G. and Lefkowitz, R.J. (1992) J. Biol. Chem., 267(25), 17882-17890.
20. Scott, M.G.; Pierotti, V.; Storez, H.; Lindberg, E.; Thuret, A.; Muntaner, O.; Labbe-Jullie, C.; Pitcher, J.A. and Marullo, S. (2006) Mol. Cell. Biol., 26(9), 3432-3445.
21. Granzin, J.; Wilden, U.; Choe, H.W.; Labahn, J.; Krafft, B. and Buldt, G. (1998) Nature, 391(6670), 918-921.
22. Han, M.; Gurevich, V.V.; Vishnivetskiy, S.A.; Sigler, P.B. and Schubert, C. (2001) Structure, 9(9), 869-880.
23. Hirsch, J.A.; Schubert, C.; Gurevich, V.V. and Sigler, P.B. (1999) Cell, 97(2), 257-269.
24. Dinh, D.T.; Qian, H.; Seeber, R.; Lim, E.; Pfleger, K.; Eidne, K.A. and Thomas, W.G. (2005) Mol. Pharmacol., 67(2), 375-382.
25. Milano, S.K.; Pace, H.C.; Kim, Y.M.; Brenner, C. and Benovic, J.L. (2002) Biochemistry, 41(10), 3321-3328.
26. Conner, D.A.; Mathier, M.A.; Mortensen, R.M.; Christe, M.; Vatner, S.F.; Seidman, C.E. and Seidman, J.G. (1997) Circ. Res., 81(6), 1021-1026.
27. Bohn, L.M.; Lefkowitz, R.J.; Gainetdinov, R.R.; Peppel, K.; Caron, M.G. and Lin, F.T. (1999) Science, 286(5449), 2495-2498.
28. Luttrell, L.M.; Roudabush, F.L.; Choy, E.W.; Miller, W.E.; Field, M.E.; Pierce, K.L. and Lefkowitz, R.J. (2001) Proc. Natl. Acad. Sci. USA, 98(5), 2449-2454.
29. Menard, L.; Ferguson, S.S.; Zhang, J.; Lin, F.T.; Lefkowitz, R.J.; Caron, M.G. and Barak, L.S. (1997) Mol. Pharmacol., 51(5), 800-808.
30. Ahn, S.; Wei, H.; Garrison, T.R. and Lefkowitz, R.J. (2004) J. Biol. Chem., 279(9), 7807-7811.
31. Macey, T.A.; Lowe, J.D. and Chavkin, C. (2006) J. Biol. Chem., 281(45), 34515-34524.
32. Oakley, R.H.; Laporte, S.A.; Holt, J.A.; Caron, M.G. and Barak, L.S. (2000) J. Biol. Chem., 275(22), 17201-17210.
33. Hanyaloglu, A.C.; Seeber, R.M.; Kohout, T.A.; Lefkowitz, R.J. and Eidne, K.A. (2002) J. Biol. Chem., 277(52), 50422-50430.
34. Celver, J.; Xu, M.; Jin, W.; Lowe, J. and Chavkin, C. (2004) Mol. Pharmacol., 65(3), 528-537.
35. Zhang, J.; Barak, L.S.; Anborgh, P.H.; Laporte, S.A.; Caron, M.G. and Ferguson, S.S. (1999) J. Biol. Chem., 274(16), 10999-11006.
36. Shenoy, S.K. and Lefkowitz, R.J. (2003) J. Biol. Chem., 278(16), 14498-14506.
37. Charest, P.G.; Terrillon, S. and Bouvier, M. (2005) EMBO Rep., 6(4), 334-340.
38. Simaan, M.; Bedard-Goulet, S.; Fessart, D.; Gratton, J.P. and Laporte, S.A. (2005) Cell Signal, 17(9), 1074-1083.
39. Tulipano, G.; Stumm, R.; Pfeiffer, M.; Kreienkamp, H.J.; Hollt, V. and Schulz, S. (2004) J. Biol. Chem., 279(20), 21374-21382.
40. Pfleger, K.D.G.; Dalrymple, M.B.; Schulz, S.; Lim, E.M.L.; Seeber, R.M. and Eidne, K.A. (2006) Frontiers in Neuroendocrinology, 27(1), 83.
41. Pfleger, K.D.; Dalrymple, M.B.; Dromey, J.R and Eidne, K.A. (2007) Biochem. Soc. Trans., 35(Pt 4), 764-766.
42. Hislop, J.N.; Everest, H.M.; Flynn, A.; Harding, T.; Uney, J.B.; Troskie, B.E.; Millar, R.P. and McArdle, C.A. (2001) J. Biol. Chem., 276(43), 39685-39694.
43. Caunt, C.J.; Finch, A.R.; Sedgley, K.R.; Oakley, L.; Luttrell, L.M. and McArdle, C.A. (2006) J. Biol. Chem., 281(5), 2701-2710.
44. Glickman, M.H. and Ciechanover, A. (2002) Physiol. Rev., 82(2), 373-428.
45. Perroy, J.; Pontier, S.; Charest, P.G.; Aubry, M. and Bouvier, M. (2004) Nat. Methods, 1(3), 203-208.
46. Shenoy, S.K.; McDonald, P.H.; Kohout, T.A. and Lefkowitz, R.J. (2001) Science, 294(5545), 1307-1313.
47. Schubert, C.; Hirsch, J.A.; Gurevich, V.V.; Engelman, D.M.; Sigler, P.B. and Fleming, K.G. (1999) J. Biol. Chem., 274(30), 21186-21190.
48. Milano, S.K.; Kim, Y.M.; Stefano, F.P.; Benovic, J.L. and Brenner, C. (2006) J. Biol. Chem., 281(14), 9812-9823.
49. Storez, H.; Scott, M.G.; Issafras, H.; Burtey, A.; Benmerah, A.; Muntaner, O.; Piolot, T.; Tramier, M.; Coppey-Moisan, M.; Bouvier, M.; Labbe-Jullie, C. and Marullo, S. (2005) J. Biol. Chem., 280(48), 40210-40215.
50. Pierce, K.L.; Luttrell, L.M. and Lefkowitz, R.J. (2001) Oncogene, 20(13), 1532-1539.
51. Goodman, O.B. Jr.; Krupnick, J.G.; Santini, F., Gurevich, V.V.; Penn, R.B.; Gagnon, A.W.; Keen, J.H. and Benovic, J.L. (1996) Nature, 383(6599), 447-450.
52. Krupnick, J.G.; Goodman, O.B. Jr.; Keen, J.H. and Benovic, J.L. (1997) J. Biol. Chem., 272(23), 15011-15016.
53. Claing, A.; Laporte, S.A.; Caron, M.G. and Lefkowitz, R.J. (2002) Prog. Neurobiol., 66(2), 61-79.
54. Laporte, S.A.; Oakley, R.H.; Zhang, J.; Holt, J.A.; Ferguson, S.S.; Caron, M.G. and Barak, L.S. (1999) Proc. Natl. Acad. Sci. USA, 96(7), 3712-3717.
55. Claing, A.; Chen, W.; Miller, W.E.; Vitale, N.; Moss, J.; Premont, R.T. and Lefkowitz, R.J. (2001) J. Biol. Chem., 276(45), 42509-42513.
56. Shenoy, S.K. and Lefkowitz, R.J. (2003) Biochem. J., 375(Pt 3), 503-515.
57. Luttrell, L.M.; Ferguson, S.S.; Daaka, Y.; Miller, W.E.; Maudsley, S.; Della Rocca, G.J.; Lin, F.; Kawakatsu, H.; Owada, K.; Luttrell, D.K.; Caron, M.G. and Lefkowitz, R.J. (1999) Science, 283(5402), 655-661.
58. Daaka, Y.; Luttrell, L.M.; Ahn, S.; Della Rocca, G.J.; Ferguson, S.S.; Caron, M.G. and Lefkowitz, R.J. (1998) J. Biol. Chem., 273(2), 685-688.
59. McDonald, P.H.; Chow, C.W.; Miller, W.E.; Laporte, S.A.; Field, M.E.; Lin, F.T.; Davis, R.J. and Lefkowitz, R.J. (2000) Science, 290(5496), 1574-1577.
60. Ahn, S.; Shenoy, S.K.; Wei, H. and Lefkowitz, R.J. (2004) J. Biol. Chem., 279(34), 35518-35525.
61. Wei, H.; Ahn, S.; Shenoy, S.K.; Karnik, S.S.; Hunyady, L.; Luttrell, L.M. and Lefkowitz, R.J. (2003) Proc. Natl. Acad. Sci. USA, 100(19), 10782-10787.
62. Kara, E.; Crepieux, P.; Gauthier, C.; Martinat, N.; Piketty, V.; Guillou, F. and Reiter, E. (2006) Mol. Endocrinol., 20(11), 3014-3026.
63. Roth, M.G. (2004) Physiol. Rev., 84(3), 699-730.
64. Beck, K.A. and Keen, J.H. (1991) J. Biol. Chem., 266(7), 4442-4447.
65. Gaidarov, I.; Krupnick, J.G.; Falck, J.R.; Benovic, J.L. and Keen, J.H. (1999) EMBO J., 18(4), 871-881.
66. Wang, Q.; Zhao, J.; Brady, A.E.; Feng, J.; Allen, P.B.; Lefkowitz, R.J.; Greengard, P. and Limbird, L.E. (2004). Science, 304(5679), 1940-1944.
67. Etienne-Manneville, S. and Hall, A. (2002) Nature, 420(6916), 629-635.
68. Seasholtz, T.M.; Majumdar, M. and Brown, J.H. (1999) Mol. Pharmacol., 55(6), 949-956.
69. Kjoller, L. and Hall, A. (1999) Exp. Cell Res., 253(1), 166-179.
70. Barnes, W.G.; Reiter, E.; Violin, J.D.; Ren, X.R.; Milligan, G. and Lefkowitz, R.J. (2005) J. Biol. Chem., 280(9), 8041-8050.
71. Bhattacharya, M.; Anborgh, P.H.; Babwah, A.V.; Dale, L.B.; Dobransky, T.; Benovic, J.L.; Feldman, R.D.; Verdi, J.M.; Rylett, R.J. and Ferguson, S.S. (2002) Nat. Cell. Biol., 4(8), 547-555.
72. Stossel, T.P.; Condeelis, J.; Cooley, L.; Hartwig, J.H.; Noegel, A.; Schleicher, M. and Shapiro, S.S. (2001) Nat. Rev. Mol. Cell Biol., 2(2), 138-145.
73. Lin, R.; Karpa, K.; Kabbani, N.; Goldman-Rakic, P. and Levenson, R. (2001) Proc. Natl. Acad. Sci. USA, 98(9), 5258-5263.
74. Hjalm, G.; MacLeod, R.J.; Kifor, O.; Chattopadhyay, N. and Brown, E.M. (2001) J. Biol. Chem., 276(37), 34880-34887.
75. Onoprishvili, I.; Andria, M.L.; Kramer, H.K.; Ancevska-Taneva, N.; Hiller, J.M. and Simon, E.J. (2003) Mol. Pharmacol., 64(5), 1092-1100.
76. Ohta, Y.; Suzuki, N.; Nakamura, S.; Hartwig, J.H. and Stossel, T.P. (1999) Proc. Natl. Acad Sci. USA, 96(5), 2122-2128.
77. Zhang, J.; Ferguson, S.S.; Barak, L.S.; Bodduluri, S.R.; Laporte, S.A.; Law, P.Y. and Caron, M.G. (1998) Proc. Natl. Acad. Sci. USA, 95(12), 7157-7162.
78. Bohn, L.M.; Dykstra, L.A.; Lefkowitz, R.J.; Caron, M.G. and Barak, L.S. (2004) Mol. Pharmacol., 66(1), 106-112.
79. Bohn, L.M.; Gainetdinov, R.R.; Lin, F.T.; Lefkowitz, R.J. and Caron, M.G. (2000) Nature, 408(6813), 720-723.
80. Bohn, L.M.; Lefkowitz, R.J. and Caron, M.G. (2002) J. Neurosci., 22(23), 10494-10500.
81. Beaulieu, J.M.; Sotnikova, T.D.; Marion, S.; Lefkowitz, R.J.; Gainetdinov, R.R. and Caron, M.G. (2005) Cell, 122(2), 261-273.
82. Kenakin, T. (2005) Nat. Rev. Drug. Discov., 4(11), 919-927.
83. Qian, H.; Pipolo, L. and Thomas, W.G. (2001) Mol. Endocrinol., 15(10), 1706-1719.
84. Holloway, A.C.; Qian, H.; Pipolo, L.; Ziogas, J.; Miura, S.; Karnik, S.; Southwell, B.R.; Lew, M.J. and Thomas, W.G. (2002) Mol. Pharmacol., 61(4), 768-777.
85. Pfleger, K.D. and Eidne, K.A. (2006) Nat. Methods, 3(3), 165-174.
86. Pfleger, K.D.; Seeber, R.M. and Eidne, K.A. (2006) Nat. Protoc., 1(1), 336-344.
87. Hamdan, F.F.; Audet, M.; Garneau, P.; Pelletier, J. and Bouvier, M. (2005) J. Biomol. Screen, 10(5), 463-475.