Rac1 changes the substrate specificity of γ-secretase between amyloid precursor protein and Notch1

Biochemical and Biophysical Research Communications

Volumn 372, Issue 4, 2008, Pages 913-917

  Boo, Jung Hyun ^a   Sohn, Ji Hoon ^a   Kim, Ji Eun ^a   Song, Hyundong ^a   Mook Jung, Inhee ^a  

^a Seoul National University College of Medicine   (South Korea)

Author keywords

secretase; Alzheimer's disease; Amyloid precursor protein; Intermembranous cleavage; Notch1; Presenilin 1; Rac1; Small G protein

Indexed keywords

AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; NOTCH1 RECEPTOR; NSC 23766; PRESENILIN 1; PROTEIN INHIBITOR; RAC1 PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

ALZHEIMER DISEASE; AMINOQUINOLINES; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; DRUG DESIGN; ENZYME ACTIVATION; HUMANS; PRESENILIN-1; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; RAC1 GTP-BINDING PROTEIN; RECEPTOR, NOTCH1; SEQUENCE DELETION; SUBSTRATE SPECIFICITY;

EID: 45449087037     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.05.153     Document Type: Article

References (32)

1. De Strooper B. Aph-1, Pen-2, and Nicastrin with Presenilin generate an active γ-secretase complex. Neuron 38 (2003) 9-12
2. Naruse S., Thinakaran G., Luo J.J., Kusiak J.W., Tomita T., Iwatsubo T., Qian X., Ginty D.D., Price D.L., Borchelt D.R., Wong P.C., and Sisodia S.S. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron 21 (1998) 1213-1221
3. Ye Y., Lukinova N., and Fortini M.E. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants. Nature 398 (1999) 525-529
4. Ikeuchi T., and Sisodia S.S. The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "γ-secretase" cleavage. J. Biol. Chem. 278 (2003) 7751-7754
5. Ni C.Y., Murphy M.P., Golde T.E., and Carpenter G. γ-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 294 (2001) 2179-2181
6. Lammich S., Okochi M., Takeda M., Kaether C., Capell A., Zimmer A.K., Edbauer D., Walter J., Steiner H., and Haass C. Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide. J. Biol. Chem. 277 (2002) 44754-44759
7. Murakami D., Okamoto I., Nagano O., Kawano Y., Tomita T., Iwatsubo T., De Strooper B., Yumoto E., and Saya H. Presenilin-dependent γ-secretase activity mediates the intramembranous cleavage of CD44. Oncogene 22 (2003) 1511-1516
8. Marambaud P., Shioi J., Serban G., Georgakopoulos A., Sarner S., Nagy V., Baki L., Wen P., Efthimiopoulos S., Shao Z., Wisniewski T., and Robakis N.K. A presenilin-1/γ-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J. 21 (2002)
9. Zhang Z., Nadeau P., Song W., Donovie D., Yuan M., Bernstein A., and Yankner B.A. Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1. Nat. Cell Biol. 2 (2000) 463-465
10. De Strooper B., Annaert W., Cupers P., Saftig P., Craessaerts K., Mumm J.S., Schroeter E.H., Schrijvers V., Wolfe M.S., Ray W.J., Goate A., and Kopan R. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain. Nature 398 (1999) 518-522
11. Luo W.J., Wang H., Li H., Kim B.S., Shah S., Lee H.J., Thinakaran G., Kim T.W., Yu G., and Xu H. PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin. J. Biol. Chem. 278 (2003) 7850-7854
12. Shiraishi H., Sai X., Wang H.Q., Maeda Y., Kurono Y., Nishimura M., and Yanagisawa K. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation. J. Neurochem. 90 (2004) 1402-1413
13. Dumanchin C., Czech C., Campion D., Cuif M.H., Poyot T., Martin C., Charbonnier F., Goud B., Pradier L., and Frebourg T. Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport. Hum. Mol. Genet. 8 (1999) 1263-1269
14. Buxbaum J.D., Choi E., Luo Y., Lilliehook C., Crowley A.C., Merriam D.E., and Wasco W. Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nat. Med. 4 (1998) 1177-1181
15. Georgakopoulos A., Marambaud P., Efthimiopoulos S., Shioi J., Cui W., Li H.C., Schutte M., Gordon R., Holstein G.R., Martinelli G., Mehta P., Friedrich Jr. V.L., and Robakis N.K. Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. Mol. Cell 4 (1999) 893-902
16. Lai E.C. Notch signaling: control of cell communication and cell fate. Development 131 (2004) 965-973
17. Pack-Chung E., Meyers M.B., Pettingell W.P., Moir R.D., Brownawell A.M., Cheng I., Tanzi R.E., and Kim T.W. Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor. J. Biol. Chem. 275 (2000) 14440-14445
18. Hadland B.K., Manley N.R., Longmore G.D., Moore C.L., Wolfe M.S., Schroeter E.H., and Kopan R. γ-Secretase inhibitors repress thymocyte development. Proc. Natl. Acad. Sci. USA 98 (2001) 7487-7491
19. Wong G.T., Manfra D., Poulet F.M., Zhang Q., Josien H., Bara T., Engstrom L., Pinzon-Ortiz M., Fine J.S., Lee H.J., Zhang L., Higgins G.A., and Parker E.M. Chronic treatment with the γ-secretase inhibitor LY-411,575 inhibits β-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J. Biol. Chem. 279 (2004) 12876-12882
20. Netzer W.J., Dou F., Cai D., Veach D., Jean S., Li Y., Bornmann W.G., Clarkson B., Xu H., and Greengard P. Gleevec inhibits β-amyloid production but not Notch cleavage. Proc. Natl. Acad. Sci. USA 100 (2003) 12444-12449
21. Desire L., Bourdin J., Loiseau N., Peillon H., Picard V., De Oliveira C., Bachelot F., Leblond B., Taverne T., Beausoleil E., Lacombe S., Drouin D., and Schweighoffer F. RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo. J. Biol. Chem. 280 (2005) 37516-37525
22. Jaffe A.B., and Hall A. Rho GTPases: biochemistry and biology. Annu. Rev. Cell Dev. Biol. 21 (2005) 247-269
23. Gianni D., Zambrano N., Bimonte M., Minopoli G., Mercken L., Talamo F., Scaloni A., and Russo T. Platelet-derived growth factor induces the β-γ-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway. J. Biol. Chem. 278 (2003) 9290-9297
24. Jefferies C.A., and O'Neill L.A. Rac1 regulates interleukin 1-induced nuclear factor κB activation in an inhibitory protein κBα-independent manner by enhancing the ability of the p65 subunit to transactivate gene expression. J. Biol. Chem. 275 (2000) 3114-3120
25. Deshpande S.S., Angkeow P., Huang J., Ozaki M., and Irani K. Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive oxygen species. FASEB J. 14 (2000) 1705-1714
26. Sastre M., Steiner H., Fuchs K., Capell A., Multhaup G., Condron M.M., Teplow D.B., and Haass C. Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep. 2 (2001) 835-841
27. Kim S., Park H., Hong H.S., Baik E.J., Jung M.W., and Mook-Jung I. ERK1/2 is an endogenous negative regulator of the γ-secretase activity. FASEB J. 20 (2006) 157-159
28. Kim S., Ikeuchi T., Yu C., and Sisodia S.S. Regulated hyperaccumulation of presenilin-1 and the "γ-secretase" complex. J. Biol. Chem. 278 (2003) 33992-34002
29. Yamasaki A., Eimer S., Okochi M., Smialowska A., Kaether C., Baumeister R., Haass C., and Steiner H. The GxGD motif of presenilin contributes to catalytic function and substrate identification of γ-secretase. J. Neurosci. 26 (2006) 3821-3828
30. Fraering P.C., Ye W., LaVoie M.J., Ostaszewski B.L., Selkoe D.J., and Wolfe M.S. γ-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site. J. Biol. Chem. 280 (2005) 41987-41996
31. Vetrivel K.S., Cheng H., Kim S., Chen Y., Barnes N.Y., Parent A.T., Sisodia S.S., and Thinakaran G. Spatial segregation of γ-secretase and substrates in distinct membrane domains. J. Biol. Chem. 280 (2005) 25892-25900
32. Ridley A.J., Paterson H.F., Johnston C.L., Diekmann D., and Hall A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70 (1992) 401-410