Inhibitor binding alters the directions of domain motions in HIV-1 reverse transcriptase

Proteins: Structure, Function and Genetics

Volumn 49, Issue 1, 2002, Pages 61-70

  Temiz, N Alpay ^a   Bahar, Ivet ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Collective dynamics; Domain motions; Hinge bending; HIV 1 reverse transcriptase; Ligand binding; Molecular mechanisms

Indexed keywords

EFAVIRENZ; NEVIRAPINE; PROTEIN P66; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ARTICLE; BINDING SITE; DRUG BINDING; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME MECHANISM; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; BINDING SITES; DRUG DELIVERY SYSTEMS; HIV-1 REVERSE TRANSCRIPTASE; LIGANDS; MODELS, MOLECULAR; MOTION; NEVIRAPINE; OXAZINES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; REVERSE TRANSCRIPTASE INHIBITORS; RIBONUCLEASE H, CALF THYMUS; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0036782103     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.10183     Document Type: Article

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