Active c-jun N-terminal kinase induces caspase cleavage of tau and additional phosphorylation by GSK-3β is required for tau aggregation

European Journal of Neuroscience

Volumn 27, Issue 11, 2008, Pages 2897-2906

  Sahara, Naruhiko ^a   Murayama, Miyuki ^a   Lee, Boyoung ^a   Park, Jung Mi ^a   Lagalwar, Sarita ^b   Binder, Lester I ^b   Takashima, Akihiko ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

C jun N terminal kinase; Caspase cleavage; Caspase 3 activity; Human tau; Tau phosphorylation

Indexed keywords

CASPASE 3; DODECYL SULFATE SODIUM; GLYCOGEN SYNTHASE KINASE 3BETA; STRESS ACTIVATED PROTEIN KINASE; TAU PROTEIN;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CELL STRAIN COS7; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; ENZYME ACTIVATION; ENZYME INDUCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NEUROFIBRILLARY TANGLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; TAUOPATHY; VIRUS INFECTION;

ALZHEIMER DISEASE; ANIMALS; BRAIN; CASPASE 3; CASPASES; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; ENZYME ACTIVATION; GENETIC VECTORS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; NEUROFIBRILLARY TANGLES; NEURONS; PHOSPHORYLATION; SODIUM DODECYL SULFATE; SURFACE-ACTIVE AGENTS; TAU PROTEINS; TRANSFECTION;

EID: 45149095739     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2008.06258.x     Document Type: Article

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