Therapeutic use of PDZ protein-protein interaction antagonism

Drug News and Perspectives

Volumn 21, Issue 3, 2008, Pages 137-141

  Wang, Nick X ^a   Lee, Ho Jin ^a   Zheng, Jie J ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BAICALIN; DISHEVELLED PROTEIN; FJ 9; FLAVONOID; G PROTEIN COUPLED RECEPTOR; GLUTAMIC ACID; GLYCYLSERYLLYSYLTHREONYLLEUCYLGLUTAMINYLSERYLTRYPTOPHYLARGINYLARGINYLTYROSYLHISTIDINE; GUANYLATE KINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NA 1; NITRIC OXIDE; NORWOGONOSIDE; NSC 668036; OROXYLIN A GLUCURONIDE; PDZ PROTEIN; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN INHIBITOR; PROTEIN SH3; SERYLGLYCYLSERYLLEUCYLLYSYLLEUCYLMETHIONYLTHREONYLTHREONYLVALINE; TRANSACTIVATOR PROTEIN; WOGONOSIDE;

BINDING SITE; BRAIN ISCHEMIA; CLINICAL TRIAL; ENZYME LINKED IMMUNOSORBENT ASSAY; EPILEPSY; EXCITOTOXICITY; HUMAN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; STROKE; TRAUMATIC BRAIN INJURY;

ANIMALS; ANTINEOPLASTIC AGENTS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; NEOPLASMS; NITRIC OXIDE SYNTHASE TYPE I; PDZ DOMAINS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 44949212919     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2008.21.3.1203409     Document Type: Review

References (52)

1. Schultz, J., Milpetz, F., Bork, P. and Ponting, C.P. SMART, a simple modular architecture research tool: identification of signaling domains. Proc Natl Acad Sci U S A 1998, 95(11): 5857-64.
2. Fan, J.S. and Zhang, M. Signaling complex organization by PDZ domain proteins. Neurosignals 2002, 11(6): 315-21.
3. Zhang, M. and Wang, W. Organization of signaling complexes by PDZ-domain scaffold proteins. Acc Chem Res 2003, 36(7): 530-38.
4. Morais Cabral, J.H., Petosa, C., Sutcliffe, M.J. et al Crystal structure of a PDZ domain. Nature 1996, 382(6592): 649-52.
5. Bockaert, J., Fagni, L., Dumuis, A. and Marin, P. GPCR interacting proteins (GIP). Pharmacol Ther 2004, 103(3): 203-21.
6. Songyang, Z., Fanning, A.S., Fu, C. et al Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science 1997, 275(5296): 73-7.
7. Fanning, A.S. and Anderson, J.M. Protein-protein interactions: PDZ domain networks. Curr Biol 1996, 6(11): 1385-88.
8. Kurakin, A., Swistowski, A., Wu, S.C. and Bredesen, D.E. The PDZ domain as a complex adaptive system. PLoS ONE 2007, 2(9): e953.
9. Wen, W., Wang, W. and Zhang, M. Targeting PDZ domain proteins for treating NMDA receptor-mediated excitotoxicity. Curr Top Med Chem 2006, 6(7): 711-21.
10. Dev, K.K. PDZ domain protein-protein interactions: A case study with PICK1. Curr Top Med Chem 2007, 7(1): 3-20.
11. Dev, K.K. Making protein interactions druggable: Targeting PDZ domains. Nat Rev Drug Discov 2004, 3(12): 1047-56.
12. Day, P. and Kobilka, B. PDZ-domain arrays for identifying components of GPCR signaling complexes. Trends Pharmacol Sci 2006, 27(10): 509-11.
13. Schulte, G. and Bryja, V. The Frizzled family of unconventional G-protein-coupled receptors. Trends Pharmacol Sci 2007, 28(10): 518-25.
14. Hopkins, A.L. and Groom, C.R. The druggable genome. Nat Rev Drug Discov 2002, 1(9): 727-30.
15. McKinsey, T.A. and Kass, D.A. Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface. Nat Rev Drug Discov 2007, 6(8): 617-35.
16. Fujii, N., You, L., Xu, Z. et al An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth. Cancer Res 2007, 67(2): 573-9.
17. Fujii, N., Shelat, A., Hall, R.A., Guy, R.K. Design of a selective chemical probe for class I PDZ domains. Bioorg Med Chem Lett 2007, 17(2): 546-8.
18. Fujii, N., Haresco, J.J., Novak, K.A. et al. Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions. Bioorg Med Chem Lett 2007, 17(2): 549-52.
19. Fujii, N., Haresco, J.J., Novak, K.A., Stokoe, D., Kuntz, I.D. and Guy, R.K. A selective irreversible inhibitor targeting a PDZ protein interaction domain. J Am Chem Soc 2003, 125(40): 12074-5.
20. Klosi, E., Saro, D. and Spaller, M.R. Bivalent peptides as PDZ domain ligands. Bioorg Med Chem Lett 2007, 17(22): 6147-50.
21. Li, T., Saro, D. and Spalier, M.R. Thermodynamic profiling of conformationally constrained cyclic ligands for the PDZ domain. Bioorg Med Chem Lett 2004, 14(6): 1385-8.
22. Piserchio, A., Salinas, G.D., Li, T., Marshall, J., Spaller, M.R. and Mierke, D.F. Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem Biol 2004, 11(4): 469-73.
23. Saro, D., Li, T., Rupasinghe, C., Paredes, A., Caspers, N. and Spalier, M.R. A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95. Biochemistry 2007, 46(21): 6340-52.
24. Saro, D., Klosi, E., Paredes, A. and Spaller, M.R. Thermodynamic analysis of a hydrophobic binding site: Probing the PDZ domain with nonproteinogenic peptide ligands. Org Lett 2004, 6(20): 3429-32.
25. Sharma, S.C., Rupasinghe, C.N., Parisien, R.B. and Spalier, M.R. Design, Synthesis, and Evaluation of Linear and Cyclic Peptide Ligands for PDZ10 of the Multi-PDZ Domain Protein MUPP1. Biochemistry 2007, 46(44): 12709-20.
26. Udugamasooriya, G., Saro, D. and Spaller, M.R. Bridged peptide macrocycles as ligands for PDZ domain proteins. Org Lett 2005, 7(7): 1203-6.
27. Joshi, M., Vargas, C., Boisguerin, P. et al. Discovery of low-molecular-weight ligands for the AF6 PDZ domain. Angew Chem Int Ed Engl 2006, 45(23): 3790-5.
28. Malbon, C.C. and Wang, H.Y. Dishevelled: A mobile scaffold catalyzing development. Curr Top Dev Biol 2006, 72: 153-66.
29. Wallingford, J.B. and Habas, R. The developmental biology of Dishevelled: An enigmatic protein governing cell fate and cell polarity. Development 2005, 132(20): 4421-36.
30. Sattler, R., Xiong, Z., Lu, W.Y., Hafner, M., MacDonald, J.F. and Tymianski, M. Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science 1999, 284(5421): 1845-8.
31. Kemp, J.A. and McKernan, R.M. NMDA receptor pathways as drug targets. Nat Neurosci 2002, 5(Suppl.): 1039-42.
32. Aarts, M.M. and Tymianski, M. Molecular mechanisms underlying specificity of excitotoxic signaling in neurons. Curr Mol Med 2004, 4(2): 137-47.
33. Ikonomidou, C. and Turski, L. Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury? Lancet Neurol 2002, 1(6): 383-6.
34. Cui, H., Hayashi, A., Sun, H.S. et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci 2007, 27(37): 9901-15.
35. Aarts, M., Liu, Y., Liu, L. et al. Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions. Science 2002, 298(5594): 846-50.
36. Tang, W., Sun, X., Fang, J.S., Zhang, M. and Sucher, N.J. Flavonoids from Radix Scutellariae as potential stroke therapeutic agents by targeting the second postsynaptic density 95 (PSD-95)/disc large/zonula occludens-1 (PDZ) domain of PSD-95. Phytomedicine 2004, 11(4): 277-84.
37. Long, J.F., Tochio, H., Wang, P. et al. Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95. J Mol Biol 2003, 327(1): 203-14.
38. Tochio, H., Mok, Y.K., Zhang, Q., Kan, H.M., Bredt, D.S. and Zhang, M. Formation of nNOS/PSD-95 PDZ dimer requires a preformed beta-finger structure from the nNOS PDZ domain. J Mol Biol 2000, 303(3): 359-70.
39. Zhang, W., Vazquez, L., Apperson, M. and Kennedy, M.B. Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus. J Neurosci 1999, 19(1): 96-108.
40. Dawson, V.L., Dawson, T.M., London, E.D., Bredt, D.S. and Snyder, S.H. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci U S A 1991, 88(14): 6368-71.
41. Passafaro, M., Sala, C., Niethammer, M. and Sheng, M. Microtubule binding by CRlPT and its potential role in the synaptic clustering of PSD-95. Nat Neurosci 1999, 2(12): 1063-9.
42. Niethammer, M., Valtschanoff, J.G., Kapoor, T.M. et al. CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90. Neuron 1998, 20(4): 693-707.
43. Wharton, K.A. Jr. Runnin' with the Dvl: Proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. Dev Biol 2003, 253: 1-17.
44. Wong, H.C., Bourdelas, A., Krauss, A. et al. Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell 2003, 12(5): 1251-60.
45. Schwarz-Romond, T., Fiedler, M., Shibata, N. et al. The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization. Nat Struct Mol Biol 2007, 14(6): 484-92.
46. Wong, H.C., Mao, J., Nguyen, J.T. et al. Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway. Nat Struct Biol 2000, 7(12): 1178-84.
47. Umbhauer, M., Djiane, A., Goisset, C., Penzo-Mendez, A., Riou, J.F., Boucaut, J.C. and Shi, D.L. The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling. EMBO J 2000, 19(18): 4944-54.
48. Uematsu, K., Kanazawa, S., You, L. et al. Wnt pathway activation in mesothelioma: Evidence of Dishevelled overexpression and transcriptional activity of beta-catenin. Cancer Res 2003, 63(15): 4547-51.
49. Uematsu, K., He, B., You, L., Xu, Z., McCormick, F. and Jablons, D.M. Activation of the Wnt pathway in non small cell lung cancer: Evidence of dishevelled overexpression. Oncogene 2003, 22(46): 7218-21.
50. Mizutani, K., Miyamoto, S., Nagahata, T., Konishi, N., Emi, M. and Onda, M. Upregulation and overexpression of DVL1, the human counterpart of the Drosophila dishevelled gene, in prostate cancer. Tumori 2005, 91(6): 546-51.
51. Shan, J., Shi, D.L., Wang, J. and Zheng, J. Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry 2005,44(47): 15495-503.
52. Hammond, M.C., Harris, B.Z., Lim, W.A. and Bartlett, P.A. Beta strand peptidomimetics as potent PDZ domain ligands. Chem Biol 2006, 13(12): 1247-51.