Making protein interactions druggable: Targeting PDZ domains

Nature Reviews Drug Discovery

Volumn 3, Issue 12, 2004, Pages 1047-1056

  Dev, Kumlesh K ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPHETAMINE; ANTISENSE OLIGONUCLEOTIDE; COCAINE; DOPAMINE TRANSPORTER; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GLUTAMATE RECEPTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PDZ PROTEIN; POSTSYNAPTIC DENSITY PROTEIN 95; PROLACTIN RELEASING FACTOR; PROTEIN INTERACTING WITH PROTEIN KINASE C; PROTEIN KINASE B; PROTEIN KINASE C ALPHA; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SODIUM CHANNEL; SODIUM ION; TYROSINE KINASE RECEPTOR;

BINDING SITE; DRUG EFFICACY; DRUG SELECTIVITY; DRUG TARGETING; GENE EXPRESSION REGULATION; HIGH THROUGHPUT SCREENING; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; REVIEW; RNA INTERFERENCE; SCHIZOPHRENIA; SIGNAL TRANSDUCTION;

ANIMALS; CARRIER PROTEINS; DRUG DELIVERY SYSTEMS; HUMANS; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEINS;

EID: 10444276589     PISSN: 14741776     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrd1578     Document Type: Review

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