Formation of nNOS/PSD-95 PDZ dimer requires a preformed β-finger structure from the nNOS PDZ domain

Journal of Molecular Biology

Volumn 303, Issue 3, 2000, Pages 359-370

  Tochio, Hidehito ^a   Mok, Yu Keung ^a   Zhang, Qiang ^a   Kan, Ho Man ^a   Bredt, David S ^b   Zhang, Mingjie ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Hetero dimer; Neuronal nitric oxide synthase; PDZ domain; PSD 95; Signal transduction

Indexed keywords

NITRIC OXIDE SYNTHASE; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; DIMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; X RAY CRYSTALLOGRAPHY;

EID: 0034721943     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4148     Document Type: Article

References (50)

1. Methodological advances in protein NMR
2. Nitric oxide signaling in the nervous system
3. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains
4. Comparison of the complete protein sets of worm and yeast: Orthology and divergence
5. PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain
6. Determining the structures of large proteins and protein complexes by NMR
7. PDZ proteins organize synaptic signaling pathways
8. PDZ motifs in PTP-BL and RIL bind to internal protein segments in the LIM domain protein RIL
9. Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition
10. NMRPipe: A multidi-mensional spectral processing system based on UNIX pipes
11. Crystal structures of a com-plexed and peptide-free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ
12. The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton
13. Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation
14. The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses
15. A common sense approach to peak picking in two, three and four-dimensional spectra using automatic computer analysis of contour diagrams
16. Cyclic peptides as non-carboxyl-terminal ligands of syntrophin PDZ domains
17. Subcellular localization and characterization of neuronal nitric oxide synthase
18. Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex
19. Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses
20. Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins
21. Solution NMR spectroscopy beyond 25 kDa
22. GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules
23. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95
24. Solution structure of the PDZ2 domain from human-phosphatase hPTP1E and its interactions with C-terminal peptides from the fas receptor
25. Model-free approach to the interpretation of nuclear magnetic resonance relaxation in macromolecules. 1. Theory and range of validity
26. Backbone dynamics of Escherichia coli ribonuclease HI: Correlations with structure and function in an active enzyme
27. Crystal structure of a PDZ domain
28. Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases
29. CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90
30. Molecular mechanisms of glutamate receptor clustering at excitatory synapses
31. Signaling through scaffold, anchoring, and adaptor proteins
32. Comparative genomics of the eukaryotes
33. Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein
34. Specific interactions between the syntrophin PDZ domain and voltage- gated sodium channels
35. Ion channel targeting in neurons
36. Regulation of the TRP Ca2+ channel by INAD in Drosophila photo-receptors
37. Recognition of unique carboxyl-terminal motifs by distinct PDZ domains
38. Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP
39. SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density
40. Solution structure of the extended neuronal nitric oxide synthase PDZ domain complexed with an associated peptide
41. Solution structure and backbone dynamics of the second PDZ domain of postsynaptic density-95
42. The organization of INAD-signaling complexes by a multivalent PDZ domain protein in Drosophila photoreceptor cells ensures sensitivity and speed of signaling
43. Two distantly positioned PDZ domains mediate multivalent INAD-phospholipase C interactions essential for G protein-coupled signaling
44. Formation of a native like β-hairpin finger structure of a peptide from the extended PDZ domain of neuronal nitric oxide synthase in aqueous solution
45. The chemical shift index: A fast and simple method for the assignment of protein secondary structure through NMR spectroscopy
46. GRASP-1: A neuronal RasGEF associated with the AMPA receptor/GRIP complex
47. Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1
48. Coordination of an array of signaling proteins through homo- and heteromeric interactions between PDZ domains and target proteins
49. GRASP-1: A neuronal RasGEF associated with the AMPA receptor/GRIP complex
50. Molecular mechanisms of calmodulin's functional versatility