-
1
-
-
0344622606
-
The serial cultivation of human diploid cell strains
-
L. Hayflick P. S. Moorhead 1961 The serial cultivation of human diploid cell strains Experimental Cell Research 25 585 621
-
(1961)
Experimental Cell Research
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
2
-
-
50549218525
-
The limited in vitro lifetime of human diploid cell strains
-
L. Hayflick 1965 The limited in vitro lifetime of human diploid cell strains Experimental Cell Research 37 614 636
-
(1965)
Experimental Cell Research
, vol.37
, pp. 614-636
-
-
Hayflick, L.1
-
3
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
G. P. Dimri X. Lee G. Basile M. Acosta G. Scott C. Roskelley E. E. Medrano M. Linskens I. Rubelj O. Pereira-Smith 1995 A biomarker that identifies senescent human cells in culture and in aging skin in vivo Proceedings of the National Academy of Sciences of the United States of America 92 9363 9367
-
(1995)
Proceedings of the National Academy of Sciences of the United States of America
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
Roskelley, C.6
Medrano, E.E.7
Linskens, M.8
Rubelj, I.9
Pereira-Smith, O.10
-
5
-
-
0035500487
-
Cellular senescence as a tumor-suppressor mechanism
-
J. Campisi 2001 Cellular senescence as a tumor-suppressor mechanism Trends in Cell Biology 11 S27 S31
-
(2001)
Trends in Cell Biology
, vol.11
-
-
Campisi, J.1
-
6
-
-
0037667702
-
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
-
M. Narita S. Nunez E. Heard A. W. Lin S. A. Hearn D. L. Spector G. J. Hannon S. W. Lowe 2003 Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence Cell 113 703 716
-
(2003)
Cell
, vol.113
, pp. 703-716
-
-
Narita, M.1
Nunez, S.2
Heard, E.3
Lin, A.W.4
Hearn, S.A.5
Spector, D.L.6
Hannon, G.J.7
Lowe, S.W.8
-
7
-
-
23244447893
-
Tumour biology: Senescence in premalignant tumours
-
M. Collado J. Gil A. Efeyan C. Guerra A. J. Schuhmacher M. Barradas A. Benguria A. Zaballos J. M. Flores M. Barbacid D. Beach M. Serrano 2005 Tumour biology: Senescence in premalignant tumours Nature 436 642
-
(2005)
Nature
, vol.436
, pp. 642
-
-
Collado, M.1
Gil, J.2
Efeyan, A.3
Guerra, C.4
Schuhmacher, A.J.5
Barradas, M.6
Benguria, A.7
Zaballos, A.8
Flores, J.M.9
Barbacid, M.10
Beach, D.11
Serrano, M.12
-
9
-
-
0029778901
-
Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent
-
V. V. Ogryzko T. H. Hirai V. R. Russanova D. A. Barbie B. H. Howard 1996 Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent Molecular and Cellular Biology 16 5210 5218
-
(1996)
Molecular and Cellular Biology
, vol.16
, pp. 5210-5218
-
-
Ogryzko, V.V.1
Hirai, T.H.2
Russanova, V.R.3
Barbie, D.A.4
Howard, B.H.5
-
14
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
A. G. Bodnar M. Ouellette M. Frolkis S. E. Holt C. P. Chiu G. B. Morin C. B. Harley J. W. Shay S. Lichtsteiner W. E. Wright 1998 Extension of life-span by introduction of telomerase into normal human cells Science 279 349 352
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
Holt, S.E.4
Chiu, C.P.5
Morin, G.B.6
Harley, C.B.7
Shay, J.W.8
Lichtsteiner, S.9
Wright, W.E.10
-
15
-
-
0032489012
-
TRF2 protects human telomeres from end-to-end fusions
-
B. van Steensel A. Smogorzewska T. de Lange 1998 TRF2 protects human telomeres from end-to-end fusions Cell 92 401 413
-
(1998)
Cell
, vol.92
, pp. 401-413
-
-
Van Steensel, B.1
Smogorzewska, A.2
De Lange, T.3
-
17
-
-
0030761351
-
ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
-
H. Vaziri M. D. West R. C. Allsopp T. S. Davison Y. S. Wu C. H. Arrowsmith G. G. Poirier S. Benchimol 1997 ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase EMBO Journal 16 6018 6033
-
(1997)
EMBO Journal
, vol.16
, pp. 6018-6033
-
-
Vaziri, H.1
West, M.D.2
Allsopp, R.C.3
Davison, T.S.4
Wu, Y.S.5
Arrowsmith, C.H.6
Poirier, G.G.7
Benchimol, S.8
-
18
-
-
11144268164
-
Significant role for p16INK4a in p53-independent telomere-directed senescence
-
J. J. Jacobs T. de Lange 2004 Significant role for p16INK4a in p53-independent telomere-directed senescence Current Biology 14 2302 2308
-
(2004)
Current Biology
, vol.14
, pp. 2302-2308
-
-
Jacobs, J.J.1
De Lange, T.2
-
19
-
-
0037383795
-
Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms
-
T. Davis S. K. Singhrao F. S. Wyllie M. F. Haughton P. J. Smith M. Wiltshire D. Wynford-Thomas C. J. Jones R. G. Faragher D. Kipling 2003 Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms Journal of Cell Science 116 1349 1357
-
(2003)
Journal of Cell Science
, vol.116
, pp. 1349-1357
-
-
Davis, T.1
Singhrao, S.K.2
Wyllie, F.S.3
Haughton, M.F.4
Smith, P.J.5
Wiltshire, M.6
Wynford-Thomas, D.7
Jones, C.J.8
Faragher, R.G.9
Kipling, D.10
-
20
-
-
0033979731
-
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics
-
M. A. Dickson W. C. Hahn Y. Ino V. Ronfard J. Y. Wu R. A. Weinberg D. N. Louis F. P. Li J. G. Rheinwald 2000 Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics Molecular and Cellular Biology 20 1436 1447
-
(2000)
Molecular and Cellular Biology
, vol.20
, pp. 1436-1447
-
-
Dickson, M.A.1
Hahn, W.C.2
Ino, Y.3
Ronfard, V.4
Wu, J.Y.5
Weinberg, R.A.6
Louis, D.N.7
Li, F.P.8
Rheinwald, J.G.9
-
21
-
-
0033525558
-
Longevity, stress response, and cancer in aging telomerase-deficient mice
-
K. L. Rudolph S. Chang H. W. Lee M. Blasco G. J. Gottlieb C. Greider R. A. DePinho 1999 Longevity, stress response, and cancer in aging telomerase-deficient mice Cell 96 701 712
-
(1999)
Cell
, vol.96
, pp. 701-712
-
-
Rudolph, K.L.1
Chang, S.2
Lee, H.W.3
Blasco, M.4
Gottlieb, G.J.5
Greider, C.6
Depinho, R.A.7
-
23
-
-
0020610446
-
Evidence for the recessive nature of cellular immortality
-
O. M. Pereira-Smith J. R. Smith 1983 Evidence for the recessive nature of cellular immortality Science 221 964 966
-
(1983)
Science
, vol.221
, pp. 964-966
-
-
Pereira-Smith, O.M.1
Smith, J.R.2
-
25
-
-
33846128155
-
The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
-
F. A. Mallette M. F. Gaumont-Leclerc G. Ferbeyre 2007 The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence Genes and Development 21 43 48
-
(2007)
Genes and Development
, vol.21
, pp. 43-48
-
-
Mallette, F.A.1
Gaumont-Leclerc, M.F.2
Ferbeyre, G.3
-
27
-
-
0345654336
-
Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes
-
M. J. Bertram N. G. Berube X. Hang-Swanson Q. Ran J. K. Leung S. Bryce K. Spurgers R. J. Bick A. Baldini Y. Ning L. J. Clark E. K. Parkinson J. C. Barrett J. R. Smith O. M. Pereira-Smith 1999 Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes Molecular and Cellular Biology 19 1479 1485
-
(1999)
Molecular and Cellular Biology
, vol.19
, pp. 1479-1485
-
-
Bertram, M.J.1
Berube, N.G.2
Hang-Swanson, X.3
Ran, Q.4
Leung, J.K.5
Bryce, S.6
Spurgers, K.7
Bick, R.J.8
Baldini, A.9
Ning, Y.10
Clark, L.J.11
Parkinson, E.K.12
Barrett, J.C.13
Smith, J.R.14
Pereira-Smith, O.M.15
-
28
-
-
0035925659
-
Conservation of the MORF4 related gene family: Identification of a new chromo domain subfamily and novel protein motif
-
M. J. Bertram O. M. Pereira-Smith 2001 Conservation of the MORF4 related gene family: Identification of a new chromo domain subfamily and novel protein motif Gene 266 111 121
-
(2001)
Gene
, vol.266
, pp. 111-121
-
-
Bertram, M.J.1
Pereira-Smith, O.M.2
-
29
-
-
0842324785
-
The nucleosome: From genomic organization to genomic regulation
-
S. Khorasanizadeh 2004 The nucleosome: From genomic organization to genomic regulation Cell 116 259 272
-
(2004)
Cell
, vol.116
, pp. 259-272
-
-
Khorasanizadeh, S.1
-
30
-
-
0034610814
-
The language of covalent histone modifications
-
B. D. Strahl C. D. Allis 2000 The language of covalent histone modifications Nature 403 41 45
-
(2000)
Nature
, vol.403
, pp. 41-45
-
-
Strahl, B.D.1
Allis, C.D.2
-
32
-
-
0033529565
-
Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome
-
R. D. Kornberg Y. Lorch 1999 Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome Cell 98 285 294
-
(1999)
Cell
, vol.98
, pp. 285-294
-
-
Kornberg, R.D.1
Lorch, Y.2
-
33
-
-
2942726546
-
Structural and chemical basis of histone acetylation
-
discussion 98-101, 163-109
-
R. Marmorstein 2004 Structural and chemical basis of histone acetylation Novartis Foundation Symposium 259 78 98 discussion 98-101, 163-109
-
(2004)
Novartis Foundation Symposium
, vol.259
, pp. 78-98
-
-
Marmorstein, R.1
-
34
-
-
24144475284
-
Reversing histone methylation
-
A. J. Bannister T. Kouzarides 2005 Reversing histone methylation Nature 436 1103 1106
-
(2005)
Nature
, vol.436
, pp. 1103-1106
-
-
Bannister, A.J.1
Kouzarides, T.2
-
35
-
-
16844362441
-
Histone deacetylation in epigenetics: An attractive target for anticancer therapy
-
A. Mai S. Massa D. Rotili I. Cerbara S. Valente R. Pezzi S. Simeoni R. Ragno 2005 Histone deacetylation in epigenetics: An attractive target for anticancer therapy Medicinal Research Reviews 25 261 309
-
(2005)
Medicinal Research Reviews
, vol.25
, pp. 261-309
-
-
Mai, A.1
Massa, S.2
Rotili, D.3
Cerbara, I.4
Valente, S.5
Pezzi, R.6
Simeoni, S.7
Ragno, R.8
-
37
-
-
0032558998
-
Structure and function of the core histone N-termini: More than meets the eye
-
J. C. Hansen C. Tse A. P. Wolffe 1998 Structure and function of the core histone N-termini: More than meets the eye Biochemistry 37 17637 17641
-
(1998)
Biochemistry
, vol.37
, pp. 17637-17641
-
-
Hansen, J.C.1
Tse, C.2
Wolffe, A.P.3
-
39
-
-
0032514742
-
Enhanced transcription factor access to arrays of histone H3/H4 tetramer DNA complexes in vitro: Implications for replication and transcription
-
C. Tse T. M. Fletcher J. C. Hansen 1998 Enhanced transcription factor access to arrays of histone H3/H4 tetramer DNA complexes in vitro: Implications for replication and transcription Proceedings of the National Academy of Sciences of the United States of America 95 12169 12173
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, pp. 12169-12173
-
-
Tse, C.1
Fletcher, T.M.2
Hansen, J.C.3
-
40
-
-
0030798245
-
Histone acetylation in chromatin structure and transcription
-
M. Grunstein 1997 Histone acetylation in chromatin structure and transcription Nature 389 349 352
-
(1997)
Nature
, vol.389
, pp. 349-352
-
-
Grunstein, M.1
-
41
-
-
33745425100
-
Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing
-
A. S. Clarke E. Samal L. Pillus 2006 Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing Molecular Biology of the Cell 17 1744 1757
-
(2006)
Molecular Biology of the Cell
, vol.17
, pp. 1744-1757
-
-
Clarke, A.S.1
Samal, E.2
Pillus, L.3
-
42
-
-
2942729993
-
Beyond the double helix: Writing and reading the histone code
-
discussion 17-21, 163-169
-
Y. Wang W. Fischle W. Cheung S. Jacobs S. Khorasanizadeh C. D. Allis 2004 Beyond the double helix: Writing and reading the histone code Novartis Foundation Symposium 259 3 17 discussion 17-21, 163-169
-
(2004)
Novartis Foundation Symposium
, vol.259
, pp. 3-17
-
-
Wang, Y.1
Fischle, W.2
Cheung, W.3
Jacobs, S.4
Khorasanizadeh, S.5
Allis, C.D.6
-
43
-
-
0037197806
-
The MYST domain acetyltransferase Chameau functions in epigenetic mechanisms of transcriptional repression
-
A. Grienenberger B. Miotto T. Sagnier G. Cavalli V. Schramke V. Geli M. C. Mariol H. Berenger Y. Graba J. Pradel 2002 The MYST domain acetyltransferase Chameau functions in epigenetic mechanisms of transcriptional repression Current Biology 12 762 766
-
(2002)
Current Biology
, vol.12
, pp. 762-766
-
-
Grienenberger, A.1
Miotto, B.2
Sagnier, T.3
Cavalli, G.4
Schramke, V.5
Geli, V.6
Mariol, M.C.7
Berenger, H.8
Graba, Y.9
Pradel, J.10
-
44
-
-
0035076210
-
Histone acetylation at promoters is differentially affected by specific activators and repressors
-
J. Deckert K. Struhl 2001 Histone acetylation at promoters is differentially affected by specific activators and repressors Molecular and Cellular Biology 21 2726 2735
-
(2001)
Molecular and Cellular Biology
, vol.21
, pp. 2726-2735
-
-
Deckert, J.1
Struhl, K.2
-
46
-
-
0036830642
-
Role of histone H3 lysine 27 methylation in Polycomb-group silencing
-
R. Cao L. Wang H. Wang L. Xia H. Erdjument-Bromage P. Tempst R. S. Jones Y. Zhang 2002 Role of histone H3 lysine 27 methylation in Polycomb-group silencing Science 298 1039 1043
-
(2002)
Science
, vol.298
, pp. 1039-1043
-
-
Cao, R.1
Wang, L.2
Wang, H.3
Xia, L.4
Erdjument-Bromage, H.5
Tempst, P.6
Jones, R.S.7
Zhang, Y.8
-
48
-
-
23844526831
-
K4, K9 and K18 in human histone H3 are targets for biotinylation by biotinidase
-
K. Kobza G. Camporeale B. Rueckert A. Kueh J. B. Griffin G. Sarath J. Zempleni 2005 K4, K9 and K18 in human histone H3 are targets for biotinylation by biotinidase FEBS Journal 272 4249 4259
-
(2005)
FEBS Journal
, vol.272
, pp. 4249-4259
-
-
Kobza, K.1
Camporeale, G.2
Rueckert, B.3
Kueh, A.4
Griffin, J.B.5
Sarath, G.6
Zempleni, J.7
-
50
-
-
0036337759
-
Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes
-
B. A. Boggs P. Cheung E. Heard D. L. Spector A. C. Chinault C. D. Allis 2002 Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes Nature Genetics 30 73 76
-
(2002)
Nature Genetics
, vol.30
, pp. 73-76
-
-
Boggs, B.A.1
Cheung, P.2
Heard, E.3
Spector, D.L.4
Chinault, A.C.5
Allis, C.D.6
-
52
-
-
0035282573
-
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
-
M. Lachner D. O'Carroll S. Rea K. Mechtler T. Jenuwein 2001 Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins Nature 410 116 120
-
(2001)
Nature
, vol.410
, pp. 116-120
-
-
Lachner, M.1
O'Carroll, D.2
Rea, S.3
Mechtler, K.4
Jenuwein, T.5
-
53
-
-
0033603396
-
Regulation of transcription by a protein methyltransferase
-
D. Chen H. Ma H. Hong S. S. Koh S. M. Huang B. T. Schurter D. W. Aswad M. R. Stallcup 1999 Regulation of transcription by a protein methyltransferase Science 284 2174 2177
-
(1999)
Science
, vol.284
, pp. 2174-2177
-
-
Chen, D.1
Ma, H.2
Hong, H.3
Koh, S.S.4
Huang, S.M.5
Schurter, B.T.6
Aswad, D.W.7
Stallcup, M.R.8
-
54
-
-
33845194691
-
RAS unplugged: Negative feedback and oncogene-induced senescence
-
N. Bardeesy N. E. Sharpless 2006 RAS unplugged: Negative feedback and oncogene-induced senescence Cancer Cell 10 451 453
-
(2006)
Cancer Cell
, vol.10
, pp. 451-453
-
-
Bardeesy, N.1
Sharpless, N.E.2
-
55
-
-
35648954068
-
From old organisms to new molecules: Integrative biology and therapeutic targets in accelerated human ageing
-
L. S. Cox R. G. Faragher 2007 From old organisms to new molecules: Integrative biology and therapeutic targets in accelerated human ageing Cellular and Molecular Life Sciences 64 2620 2641
-
(2007)
Cellular and Molecular Life Sciences
, vol.64
, pp. 2620-2641
-
-
Cox, L.S.1
Faragher, R.G.2
-
57
-
-
23244461708
-
Oncogene-induced senescence as an initial barrier in lymphoma development
-
M. Braig S. Lee C. Loddenkemper C. Rudolph A. H. Peters B. Schlegelberger H. Stein B. Dorken T. Jenuwein C. A. Schmitt 2005 Oncogene-induced senescence as an initial barrier in lymphoma development Nature 436 660 665
-
(2005)
Nature
, vol.436
, pp. 660-665
-
-
Braig, M.1
Lee, S.2
Loddenkemper, C.3
Rudolph, C.4
Peters, A.H.5
Schlegelberger, B.6
Stein, H.7
Dorken, B.8
Jenuwein, T.9
Schmitt, C.A.10
-
58
-
-
20244376464
-
Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin
-
S. Gonzalo M. Garcia-Cao M. F. Fraga G. Schotta A. H. Peters S. E. Cotter R. Eguia D. C. Dean M. Esteller T. Jenuwein M. A. Blasco 2005 Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin Nature Cell Biology 7 420 428
-
(2005)
Nature Cell Biology
, vol.7
, pp. 420-428
-
-
Gonzalo, S.1
Garcia-Cao, M.2
Fraga, M.F.3
Schotta, G.4
Peters, A.H.5
Cotter, S.E.6
Eguia, R.7
Dean, D.C.8
Esteller, M.9
Jenuwein, T.10
Blasco, M.A.11
-
59
-
-
19944427674
-
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA
-
R. Zhang M. V. Poustovoitov X. Ye H. A. Santos W. Chen S. M. Daganzo J. P. Erzberger I. G. Serebriiskii A. A. Canutescu R. L. Dunbrack J. R. Pehrson J. M. Berger P. D. Kaufman P. D. Adams 2005 Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA Developmental Cell 8 19 30
-
(2005)
Developmental Cell
, vol.8
, pp. 19-30
-
-
Zhang, R.1
Poustovoitov, M.V.2
Ye, X.3
Santos, H.A.4
Chen, W.5
Daganzo, S.M.6
Erzberger, J.P.7
Serebriiskii, I.G.8
Canutescu, A.A.9
Dunbrack, R.L.10
Pehrson, J.R.11
Berger, J.M.12
Kaufman, P.D.13
Adams, P.D.14
-
60
-
-
33746752125
-
A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation
-
M. Narita V. Krizhanovsky S. Nunez A. Chicas S. A. Hearn M. P. Myers S. W. Lowe 2006 A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation Cell 126 503 514
-
(2006)
Cell
, vol.126
, pp. 503-514
-
-
Narita, M.1
Krizhanovsky, V.2
Nunez, S.3
Chicas, A.4
Hearn, S.A.5
Myers, M.P.6
Lowe, S.W.7
-
61
-
-
0032846669
-
Histone variants of H2A and H3 families are regulated during in vitro aging in the same manner as during differentiation
-
E. P. Rogakou K. E. Sekeri-Pataryas 1999 Histone variants of H2A and H3 families are regulated during in vitro aging in the same manner as during differentiation Experimental Gerontology 34 741 754
-
(1999)
Experimental Gerontology
, vol.34
, pp. 741-754
-
-
Rogakou, E.P.1
Sekeri-Pataryas, K.E.2
-
62
-
-
33847703331
-
Cellular senescence and chromatin organisation
-
M. Narita 2007 Cellular senescence and chromatin organisation British Journal of Cancer 96 686 691
-
(2007)
British Journal of Cancer
, vol.96
, pp. 686-691
-
-
Narita, M.1
-
63
-
-
34648816970
-
Cellular senescence and chromatin structure
-
R. Funayama F. Ishikawa 2007 Cellular senescence and chromatin structure Chromosoma 116 431 440
-
(2007)
Chromosoma
, vol.116
, pp. 431-440
-
-
Funayama, R.1
Ishikawa, F.2
-
64
-
-
36049028058
-
New nomenclature for chromatin-modifying enzymes
-
C. D. Allis S. L. Berger J. Cote S. Dent T. Jenuwien T. Kouzarides L. Pillus D. Reinberg Y. Shi R. Shiekhattar A. Shilatifard J. Workman Y. Zhang 2007 New nomenclature for chromatin-modifying enzymes Cell 131 633 636
-
(2007)
Cell
, vol.131
, pp. 633-636
-
-
Allis, C.D.1
Berger, S.L.2
Cote, J.3
Dent, S.4
Jenuwien, T.5
Kouzarides, T.6
Pillus, L.7
Reinberg, D.8
Shi, Y.9
Shiekhattar, R.10
Shilatifard, A.11
Workman, J.12
Zhang, Y.13
-
65
-
-
0346873027
-
Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts
-
W. Wei U. Herbig S. Wei A. Dutriaux J. M. Sedivy 2003 Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts EMBO Reports 4 1061 1066
-
(2003)
EMBO Reports
, vol.4
, pp. 1061-1066
-
-
Wei, W.1
Herbig, U.2
Wei, S.3
Dutriaux, A.4
Sedivy, J.M.5
-
66
-
-
33947236204
-
Molecular dissection of formation of senescence-associated heterochromatin foci
-
R. Zhang W. Chen P. D. Adams 2007 Molecular dissection of formation of senescence-associated heterochromatin foci Molecular and Cellular Biology 27 2343 2358
-
(2007)
Molecular and Cellular Biology
, vol.27
, pp. 2343-2358
-
-
Zhang, R.1
Chen, W.2
Adams, P.D.3
-
67
-
-
34447635892
-
Dynamic assembly of chromatin complexes during cellular senescence: Implications for the growth arrest of human melanocytic nevi
-
D. Bandyopadhyay J. L. Curry Q. Lin H. W. Richards D. Chen P. J. Hornsby N. A. Timchenko E. E. Medrano 2007 Dynamic assembly of chromatin complexes during cellular senescence: Implications for the growth arrest of human melanocytic nevi Aging Cell 6 577 591
-
(2007)
Aging Cell
, vol.6
, pp. 577-591
-
-
Bandyopadhyay, D.1
Curry, J.L.2
Lin, Q.3
Richards, H.W.4
Chen, D.5
Hornsby, P.J.6
Timchenko, N.A.7
Medrano, E.E.8
-
68
-
-
0033637086
-
Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization
-
J. Sage G. J. Mulligan L. D. Attardi A. Miller S. Chen B. Williams E. Theodorou T. Jacks 2000 Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization Genes and Development 14 3037 3050
-
(2000)
Genes and Development
, vol.14
, pp. 3037-3050
-
-
Sage, J.1
Mulligan, G.J.2
Attardi, L.D.3
Miller, A.4
Chen, S.5
Williams, B.6
Theodorou, E.7
Jacks, T.8
-
69
-
-
33645219500
-
Primary and compensatory roles for RB family members at cell cycle gene promoters that are deacetylated and downregulated in doxorubicin-induced senescence of breast cancer cells
-
J. G. Jackson O. M. Pereira-Smith 2006 Primary and compensatory roles for RB family members at cell cycle gene promoters that are deacetylated and downregulated in doxorubicin-induced senescence of breast cancer cells Molecular and Cellular Biology 26 2501 2510
-
(2006)
Molecular and Cellular Biology
, vol.26
, pp. 2501-2510
-
-
Jackson, J.G.1
Pereira-Smith, O.M.2
-
70
-
-
33749363609
-
The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14
-
P. Zhang J. Zhao B. Wang J. Du Y. Lu J. Chen J. Ding 2006 The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14 Protein Science 15 2423 2434
-
(2006)
Protein Science
, vol.15
, pp. 2423-2434
-
-
Zhang, P.1
Zhao, J.2
Wang, B.3
Du, J.4
Lu, Y.5
Chen, J.6
Ding, J.7
-
72
-
-
0037184965
-
MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation
-
P. S. Pardo J. K. Leung J. C. Lucchesi O. M. Pereira-Smith 2002 MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation Journal of Biological Chemistry 277 50860 50866
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 50860-50866
-
-
Pardo, P.S.1
Leung, J.K.2
Lucchesi, J.C.3
Pereira-Smith, O.M.4
-
73
-
-
1542782281
-
MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner
-
K. Tominaga J. K. Leung P. Rookard J. Echigo J. R. Smith O. M. Pereira-Smith 2003 MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner Journal of Biological Chemistry 278 49618 49624
-
(2003)
Journal of Biological Chemistry
, vol.278
, pp. 49618-49624
-
-
Tominaga, K.1
Leung, J.K.2
Rookard, P.3
Echigo, J.4
Smith, J.R.5
Pereira-Smith, O.M.6
-
74
-
-
84860105218
-
MRG15 regulates embryonic development and cell proliferation
-
K. Tominaga B. Kirtane J. G. Jackson Y. Ikeno T. Ikeda C. Hawks J. R. Smith M. M. Matzuk O. M. Pereira-Smith 2005 MRG15 regulates embryonic development and cell proliferation Molecular and Cellular Biology 25 2924 2937
-
(2005)
Molecular and Cellular Biology
, vol.25
, pp. 2924-2937
-
-
Tominaga, K.1
Kirtane, B.2
Jackson, J.G.3
Ikeno, Y.4
Ikeda, T.5
Hawks, C.6
Smith, J.R.7
Matzuk, M.M.8
Pereira-Smith, O.M.9
-
75
-
-
0033868471
-
Origin and evolution of the regulatory gene male-specific lethal-3
-
I. Marin B. S. Baker 2000 Origin and evolution of the regulatory gene male-specific lethal-3 Molecular Biology and Evolution 17 1240 1250
-
(2000)
Molecular Biology and Evolution
, vol.17
, pp. 1240-1250
-
-
Marin, I.1
Baker, B.S.2
-
76
-
-
10844233155
-
Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions
-
T. Kusch L. Florens W. H. Macdonald S. K. Swanson R. L. Glaser J. R. Yates III S. M. Abmayr M. P. Washburn J. L. Workman 2004 Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions Science 306 2084 2087
-
(2004)
Science
, vol.306
, pp. 2084-2087
-
-
Kusch, T.1
Florens, L.2
MacDonald, W.H.3
Swanson, S.K.4
Glaser, R.L.5
Yates III, J.R.6
Abmayr, S.M.7
Washburn, M.P.8
Workman, J.L.9
-
77
-
-
0035793642
-
The yeast NuA4 and Drosophila MSL complexes contain homologous subunits important for transcription regulation
-
A. Eisen R. T. Utley A. Nourani S. Allard P. Schmidt W. S. Lane J. C. Lucchesi J. Cote 2001 The yeast NuA4 and Drosophila MSL complexes contain homologous subunits important for transcription regulation Journal of Biological Chemistry 276 3484 3491
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 3484-3491
-
-
Eisen, A.1
Utley, R.T.2
Nourani, A.3
Allard, S.4
Schmidt, P.5
Lane, W.S.6
Lucchesi, J.C.7
Cote, J.8
-
78
-
-
0028802784
-
The chromo superfamily: New members, duplication of the chromo domain and possible role in delivering transcription regulators to chromatin
-
E. V. Koonin S. Zhou J. C. Lucchesi 1995 The chromo superfamily: New members, duplication of the chromo domain and possible role in delivering transcription regulators to chromatin Nucleic Acids Research 23 4229 4233
-
(1995)
Nucleic Acids Research
, vol.23
, pp. 4229-4233
-
-
Koonin, E.V.1
Zhou, S.2
Lucchesi, J.C.3
-
80
-
-
0036841723
-
Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and transducin-like enhancer of split
-
G. S. Yochum D. E. Ayer 2002 Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and transducin-like enhancer of split Molecular and Cellular Biology 22 7868 7876
-
(2002)
Molecular and Cellular Biology
, vol.22
, pp. 7868-7876
-
-
Yochum, G.S.1
Ayer, D.E.2
-
81
-
-
0035914347
-
MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14
-
J. K. Leung N. Berube S. Venable S. Ahmed N. Timchenko O. M. Pereira-Smith 2001 MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14 Journal of Biological Chemistry 276 39171 39178
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 39171-39178
-
-
Leung, J.K.1
Berube, N.2
Venable, S.3
Ahmed, S.4
Timchenko, N.5
Pereira-Smith, O.M.6
-
84
-
-
33947319151
-
MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegans
-
T. Takasaki Z. Liu Y. Habara K. Nishiwaki J. Nakayama K. Inoue H. Sakamoto S. Strome 2007 MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegans Development 134 757 767
-
(2007)
Development
, vol.134
, pp. 757-767
-
-
Takasaki, T.1
Liu, Z.2
Habara, Y.3
Nishiwaki, K.4
Nakayama, J.5
Inoue, K.6
Sakamoto, H.7
Strome, S.8
-
85
-
-
0347986672
-
Eaf3 regulates the global pattern of histone acetylation in Saccharomyces cerevisiae
-
J. L. Reid Z. Moqtaderi K. Struhl 2004 Eaf3 regulates the global pattern of histone acetylation in Saccharomyces cerevisiae Molecular and Cellular Biology 24 757 764
-
(2004)
Molecular and Cellular Biology
, vol.24
, pp. 757-764
-
-
Reid, J.L.1
Moqtaderi, Z.2
Struhl, K.3
-
86
-
-
27744577727
-
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription
-
M. J. Carrozza B. Li L. Florens T. Suganuma S. K. Swanson K. K. Lee W. J. Shia S. Anderson J. Yates M. P. Washburn J. L. Workman 2005 Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription Cell 123 581 592
-
(2005)
Cell
, vol.123
, pp. 581-592
-
-
Carrozza, M.J.1
Li, B.2
Florens, L.3
Suganuma, T.4
Swanson, S.K.5
Lee, K.K.6
Shia, W.J.7
Anderson, S.8
Yates, J.9
Washburn, M.P.10
Workman, J.L.11
-
87
-
-
29144468972
-
Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation
-
A. A. Joshi K. Struhl 2005 Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation Molecular Cell 20 971 978
-
(2005)
Molecular Cell
, vol.20
, pp. 971-978
-
-
Joshi, A.A.1
Struhl, K.2
-
88
-
-
34249099730
-
Combined action of PHD and chromo domains directs the Rpd3S HDAC to transcribed chromatin
-
B. Li M. Gogol M. Carey D. Lee C. Seidel J. L. Workman 2007 Combined action of PHD and chromo domains directs the Rpd3S HDAC to transcribed chromatin Science 316 1050 1054
-
(2007)
Science
, vol.316
, pp. 1050-1054
-
-
Li, B.1
Gogol, M.2
Carey, M.3
Lee, D.4
Seidel, C.5
Workman, J.L.6
-
89
-
-
27744587302
-
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex
-
M. C. Keogh S. K. Kurdistani S. A. Morris S. H. Ahn V. Podolny S. R. Collins M. Schuldiner K. Chin T. Punna N. J. Thompson C. Boone A. Emili J. S. Weissman T. R. Hughes B. D. Strahl M. Grunstein J. F. Greenblatt S. Buratowski N. J. Krogan 2005 Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex Cell 123 593 605
-
(2005)
Cell
, vol.123
, pp. 593-605
-
-
Keogh, M.C.1
Kurdistani, S.K.2
Morris, S.A.3
Ahn, S.H.4
Podolny, V.5
Collins, S.R.6
Schuldiner, M.7
Chin, K.8
Punna, T.9
Thompson, N.J.10
Boone, C.11
Emili, A.12
Weissman, J.S.13
Hughes, T.R.14
Strahl, B.D.15
Grunstein, M.16
Greenblatt, J.F.17
Buratowski, S.18
Krogan, N.J.19
-
90
-
-
33845910902
-
Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3
-
P. Zhang J. Du B. Sun X. Dong G. Xu J. Zhou Q. Huang Q. Liu Q. Hao J. Ding 2006 Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3 Nucleic Acids Research 34 6621 6628
-
(2006)
Nucleic Acids Research
, vol.34
, pp. 6621-6628
-
-
Zhang, P.1
Du, J.2
Sun, B.3
Dong, X.4
Xu, G.5
Zhou, J.6
Huang, Q.7
Liu, Q.8
Hao, Q.9
Ding, J.10
-
91
-
-
33646027860
-
Chromatin modification and senescence: Linkage by tumor suppressors?
-
X. Han P. Berardi K. Riabowol 2006 Chromatin modification and senescence: Linkage by tumor suppressors? Rejuvenation Research 9 69 76
-
(2006)
Rejuvenation Research
, vol.9
, pp. 69-76
-
-
Han, X.1
Berardi, P.2
Riabowol, K.3
-
92
-
-
1342346531
-
Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans
-
Y. Doyon W. Selleck W. S. Lane S. Tan J. Cote 2004 Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans Molecular and Cellular Biology 24 1884 1896
-
(2004)
Molecular and Cellular Biology
, vol.24
, pp. 1884-1896
-
-
Doyon, Y.1
Selleck, W.2
Lane, W.S.3
Tan, S.4
Cote, J.5
-
93
-
-
0242322038
-
Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex
-
Y. Cai J. Jin C. Tomomori-Sato S. Sato I. Sorokina T. J. Parmely R. C. Conaway J. W. Conaway 2003 Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex Journal of Biological Chemistry 278 42733 42736
-
(2003)
Journal of Biological Chemistry
, vol.278
, pp. 42733-42736
-
-
Cai, Y.1
Jin, J.2
Tomomori-Sato, C.3
Sato, S.4
Sorokina, I.5
Parmely, T.J.6
Conaway, R.C.7
Conaway, J.W.8
-
95
-
-
0038064220
-
Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest
-
P. Iakova S. S. Awad N. A. Timchenko 2003 Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest Cell 113 495 506
-
(2003)
Cell
, vol.113
, pp. 495-506
-
-
Iakova, P.1
Awad, S.S.2
Timchenko, N.A.3
-
96
-
-
0028060515
-
The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest
-
J. L. Dunaief B. E. Strober S. Guha P. A. Khavari K. Alin J. Luban M. Begemann G. R. Crabtree S. P. Goff 1994 The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest Cell 79 119 130
-
(1994)
Cell
, vol.79
, pp. 119-130
-
-
Dunaief, J.L.1
Strober, B.E.2
Guha, S.3
Khavari, P.A.4
Alin, K.5
Luban, J.6
Begemann, M.7
Crabtree, G.R.8
Goff, S.P.9
-
97
-
-
0032929628
-
Cyclin e associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest
-
F. Shanahan W. Seghezzi D. Parry D. Mahony E. Lees 1999 Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest Molecular and Cellular Biology 19 1460 1469
-
(1999)
Molecular and Cellular Biology
, vol.19
, pp. 1460-1469
-
-
Shanahan, F.1
Seghezzi, W.2
Parry, D.3
Mahony, D.4
Lees, E.5
-
98
-
-
33845269825
-
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
-
R. Di Micco M. Fumagalli A. Cicalese S. Piccinin P. Gasparini C. Luise C. Schurra M. Garre P. G. Nuciforo A. Bensimon R. Maestro P. G. Pelicci F. d'Adda di Fagagna 2006 Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication Nature 444 638 642
-
(2006)
Nature
, vol.444
, pp. 638-642
-
-
Di Micco, R.1
Fumagalli, M.2
Cicalese, A.3
Piccinin, S.4
Gasparini, P.5
Luise, C.6
Schurra, C.7
Garre, M.8
Nuciforo, P.G.9
Bensimon, A.10
Maestro, R.11
Pelicci, P.G.12
D'Adda Di Fagagna, F.13
-
99
-
-
33845235459
-
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
-
J. Bartkova N. Rezaei M. Liontos P. Karakaidos D. Kletsas N. Issaeva L. V. Vassiliou E. Kolettas K. Niforou V. C. Zoumpourlis M. Takaoka H. Nakagawa F. Tort K. Fugger F. Johansson M. Sehested C. L. Andersen L. Dyrskjot T. Orntoft J. Lukas C. Kittas T. Helleday T. D. Halazonetis J. Bartek V. G. Gorgoulis 2006 Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints Nature 444 633 637
-
(2006)
Nature
, vol.444
, pp. 633-637
-
-
Bartkova, J.1
Rezaei, N.2
Liontos, M.3
Karakaidos, P.4
Kletsas, D.5
Issaeva, N.6
Vassiliou, L.V.7
Kolettas, E.8
Niforou, K.9
Zoumpourlis, V.C.10
Takaoka, M.11
Nakagawa, H.12
Tort, F.13
Fugger, K.14
Johansson, F.15
Sehested, M.16
Andersen, C.L.17
Dyrskjot, L.18
Orntoft, T.19
Lukas, J.20
Kittas, C.21
Helleday, T.22
Halazonetis, T.D.23
Bartek, J.24
Gorgoulis, V.G.25
more..
-
100
-
-
0027970713
-
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
-
A. Di Leonardo S. P. Linke K. Clarkin G. M. Wahl 1994 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts Genes and Development 8 2540 2551
-
(1994)
Genes and Development
, vol.8
, pp. 2540-2551
-
-
Di Leonardo, A.1
Linke, S.P.2
Clarkin, K.3
Wahl, G.M.4
-
101
-
-
35548941765
-
Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation
-
S. N. Garcia B. M. Kirtane A. J. Podlutsky O. M. Pereira-Smith K. Tominaga 2007 Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation FEBS Letters 581 5275 5281
-
(2007)
FEBS Letters
, vol.581
, pp. 5275-5281
-
-
Garcia, S.N.1
Kirtane, B.M.2
Podlutsky, A.J.3
Pereira-Smith, O.M.4
Tominaga, K.5
-
102
-
-
26444525344
-
Dynamics of chromatin during the repair of DNA double-strand breaks
-
J. A. Downs J. Cote 2005 Dynamics of chromatin during the repair of DNA double-strand breaks Cell Cycle 4 1373 1376
-
(2005)
Cell Cycle
, vol.4
, pp. 1373-1376
-
-
Downs, J.A.1
Cote, J.2
-
103
-
-
35848949304
-
DNA damage response as an anti-cancer barrier: Damage threshold and the concept of 'conditional haploinsufficiency'
-
J. Bartek J. Lukas J. Bartkova 2007 DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency' Cell Cycle 6 2344 2347
-
(2007)
Cell Cycle
, vol.6
, pp. 2344-2347
-
-
Bartek, J.1
Lukas, J.2
Bartkova, J.3
|