메뉴 건너뛰기




Volumn 18, Issue , 2003, Pages 61-73

TGF-β mammary gland development and breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; TUMOR SUPPRESSOR PROTEIN;

EID: 4444346007     PISSN: 08886008     EISSN: None     Source Type: Journal    
DOI: 10.3233/BD-2003-18107     Document Type: Review
Times cited : (33)

References (116)
  • 1
    • 0000116653 scopus 로고
    • The Transforming Growth Factor-bs
    • M.B. Sporn and A.B. Roberts, eds, Heidelberg: Springer-Verlag
    • A.B. Roberts and M.B. Sporn, The Transforming Growth Factor-bs, in: Peptide Growth Factors and their Receptors, M.B. Sporn and A.B. Roberts, eds, Heidelberg: Springer-Verlag, 1990, pp. 419-472.
    • (1990) Peptide Growth Factors and Their Receptors , pp. 419-472
    • Roberts, A.B.1    Sporn, M.B.2
  • 2
    • 0025105884 scopus 로고
    • Transforming growth factor-b: A family of growth regulatory peptides
    • D.A. Miller, R.W. Pelton, R. Derynck and H.L. Moses, Transforming growth factor-b: A family of growth regulatory peptides, Ann. N. Y. Acad. Sci. 593 (1990), 208-217.
    • (1990) Ann. N. Y. Acad. Sci. , vol.593 , pp. 208-217
    • Miller, D.A.1    Pelton, R.W.2    Derynck, R.3    Moses, H.L.4
  • 3
    • 0034644472 scopus 로고    scopus 로고
    • TGFbeta signaling in growth control, cancer, and heritable disorders
    • J. Massague, S.W. Blain and R.S. Lo, TGFbeta signaling in growth control, cancer, and heritable disorders, Cell 103 (2000), 295-309.
    • (2000) Cell , vol.103 , pp. 295-309
    • Massague, J.1    Blain, S.W.2    Lo, R.S.3
  • 4
    • 0019465899 scopus 로고
    • Transforming growth factor production by chemically transformed cells
    • H.L. Moses, E.B. Branum, J.A. Proper and R.A. Robinson, Transforming growth factor production by chemically transformed cells, Cancer Research 41 (1981), 2842-2848.
    • (1981) Cancer Research , vol.41 , pp. 2842-2848
    • Moses, H.L.1    Branum, E.B.2    Proper, J.A.3    Robinson, R.A.4
  • 5
    • 0346254671 scopus 로고
    • New class of transforming growth factors potentiated by epidermal growth factor: Isolation from non-neoplastic tissues
    • A.B. Roberts, M.A. Anzano, L.C. Lamb, J.M. Smith and M.B. Sporn, New class of transforming growth factors potentiated by epidermal growth factor: Isolation from non-neoplastic tissues, Proc. Natl. Acad. Sci. USA 78 (1981), 5339-5343.
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 5339-5343
    • Roberts, A.B.1    Anzano, M.A.2    Lamb, L.C.3    Smith, J.M.4    Sporn, M.B.5
  • 6
    • 0025104027 scopus 로고
    • TGF-b stimulation and inhibition of cell proliferation: New mechanistic insights
    • H.L. Moses, E.Y. Yang and J.A. Pietenpol, TGF-b stimulation and inhibition of cell proliferation: New mechanistic insights, Cell 63 (1990), 245-247.
    • (1990) Cell , vol.63 , pp. 245-247
    • Moses, H.L.1    Yang, E.Y.2    Pietenpol, J.A.3
  • 7
    • 0021720359 scopus 로고
    • Growth inhibitor from BSC-1 cells closely related to the platelet type beta transforming growth factor
    • R.F. Tucker, G.D. Shipley, H.L. Moses and R.W. Holley, Growth inhibitor from BSC-1 cells closely related to the platelet type beta transforming growth factor, Science 226 (1984), 705-707.
    • (1984) Science , vol.226 , pp. 705-707
    • Tucker, R.F.1    Shipley, G.D.2    Moses, H.L.3    Holley, R.W.4
  • 8
    • 0028180315 scopus 로고
    • The TGF-b superfamily: New members, new receptors, and new genetic tests of function in different organisms
    • D.M. Kingsley, The TGF-b superfamily: New members, new receptors, and new genetic tests of function in different organisms, Genes and Development 8 (1994), 133-146.
    • (1994) Genes and Development , vol.8 , pp. 133-146
    • Kingsley, D.M.1
  • 9
    • 0022477623 scopus 로고
    • Beta-transforming growth factor is stored in human blood platelets as a latent high molecular weight complex
    • R. Pircher, P. Jullien and D.A. Lawrence, Beta-transforming growth factor is stored in human blood platelets as a latent high molecular weight complex, Biochemical anal Biophysical Research Communications 136 (1986), 30-37.
    • (1986) Biochemical Anal Biophysical Research Communications , vol.136 , pp. 30-37
    • Pircher, R.1    Jullien, P.2    Lawrence, D.A.3
  • 10
    • 0024372267 scopus 로고
    • Recombinant TGF-beta 1 is synthesized as a two-component latent complex that shares some structural features with the native platelet latent TGF-beta 1 complex
    • L.M. Wakefield, D.M. Smith and S. Broz et al., Recombinant TGF-beta 1 is synthesized as a two-component latent complex that shares some structural features with the native platelet latent TGF-beta 1 complex, Growth Factors 1 (1989), 203-218.
    • (1989) Growth Factors , vol.1 , pp. 203-218
    • Wakefield, L.M.1    Smith, D.M.2    Broz, S.3
  • 11
  • 12
    • 0034109215 scopus 로고    scopus 로고
    • Activation of latent TGF-beta by thrombospondin-1: Mechanisms and physiology
    • J.E. Murphy-Ullrich and M. Poczatek, Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology, Cytokine Growth Factor Rev 11 (2000), 59-69.
    • (2000) Cytokine Growth Factor Rev. , vol.11 , pp. 59-69
    • Murphy-Ullrich, J.E.1    Poczatek, M.2
  • 14
    • 0024312217 scopus 로고
    • Site-directed mutagenesis of cysteine residues in the pro region of the transforming growth factor beta-1 precursor
    • A.M. Brunner, H. Marquardt, A.R. Malacko, M.N. Lioubin and A.F. Purchio, Site-directed mutagenesis of cysteine residues in the pro region of the transforming growth factor beta-1 precursor, J. Biol. Chem. 264 (1989), 13660-13664.
    • (1989) J. Biol. Chem. , vol.264 , pp. 13660-13664
    • Brunner, A.M.1    Marquardt, H.2    Malacko, A.R.3    Lioubin, M.N.4    Purchio, A.F.5
  • 15
    • 0034672359 scopus 로고    scopus 로고
    • The latent transforming growth factor beta binding protein (LTBP) family
    • R. Oklu and R. Hesketh, The latent transforming growth factor beta binding protein (LTBP) family, Biochem J 352(3) (2000), 601-610.
    • (2000) Biochem. J. , vol.352 , Issue.3 , pp. 601-610
    • Oklu, R.1    Hesketh, R.2
  • 16
    • 0028173316 scopus 로고
    • TGF-b-receptor-mediated signaling
    • R. Derynck, TGF-b-receptor-mediated signaling, Trends Biochem. Sci. 19 (1994), 548-553.
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 548-553
    • Derynck, R.1
  • 17
    • 0029944441 scopus 로고    scopus 로고
    • Signaling via hetero-oligomeric complexes of type I and type II serine treonine kinase receptors
    • P. Ten Dijke, K. Miyazono and C-H. Heldin, Signaling via hetero-oligomeric complexes of type I and type II serine treonine kinase receptors, Current Opinion in Cell Biology 8 (1996), 139-145.
    • (1996) Current Opinion in Cell Biology , vol.8 , pp. 139-145
    • Ten Dijke, P.1    Miyazono, K.2    Heldin, C.-H.3
  • 18
    • 0031685620 scopus 로고    scopus 로고
    • TGF-b signal transduction
    • J. Massague, TGF-b signal transduction, Annu. Rev. Biochem. 67 (1998), 753-791.
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 753-791
    • Massague, J.1
  • 20
    • 0030265714 scopus 로고    scopus 로고
    • Intracellular signaling: The MAD way to do it
    • R. Derynck and Y. Zhang, Intracellular signaling: The MAD way to do it, Current Biology 6 (1996), 1226-1229.
    • (1996) Current Biology , vol.6 , pp. 1226-1229
    • Derynck, R.1    Zhang, Y.2
  • 22
    • 0034678908 scopus 로고    scopus 로고
    • Transcriptional control by the TGF-beta/Smad signaling system
    • J. Massague and D. Wotton, Transcriptional control by the TGF-beta/Smad signaling system, Embo J 19 (2000), 1745-1754.
    • (2000) Embo. J. , vol.9 , pp. 1745-1754
    • Massague, J.1    Wotton, D.2
  • 24
    • 0028940853 scopus 로고
    • Genetic characterization and cloning of Mothers against DPP, a gene required for decapentaplegic function in drosophila melanogaster
    • J.J. Sekelsky, S.J. Newfeld, L.A. Raftery, E.H. Chartoff and W.M. Gelbart, Genetic characterization and cloning of Mothers against DPP, a gene required for decapentaplegic function in drosophila melanogaster, Genetics 139 (1995), 1347-1358.
    • (1995) Genetics , vol.139 , pp. 1347-1358
    • Sekelsky, J.J.1    Newfeld, S.J.2    Raftery, L.A.3    Chartoff, E.H.4    Gelbart, W.M.5
  • 25
    • 0030058914 scopus 로고    scopus 로고
    • Caenorhabditis elegans genes sma2, sma-3, and sma-4 define a conserved family of transforming growth factor b pathway components
    • C. Savage, P. Das and A.L. Finelli et al., Caenorhabditis elegans genes sma2, sma-3, and sma-4 define a conserved family of transforming growth factor b pathway components, Proc. Natl. Acad. Sci. USA 93 (1996), 790-794.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 790-794
    • Savage, C.1    Das, P.2    Finelli, A.L.3
  • 26
    • 0030593038 scopus 로고    scopus 로고
    • DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
    • S.A. Hahn, M. Schutte and A.T.M.S. Hoque et al., DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1, Science 271 (1996), 350-353.
    • (1996) Science , vol.271 , pp. 350-353
    • Hahn, S.A.1    Schutte, M.2    Hoque, A.T.M.S.3
  • 27
    • 16044369574 scopus 로고    scopus 로고
    • MADR2 maps to 18q21 and encodes a TGF-b regulated MAD-related protein that is functionally mutated in colorectal carcinoma
    • K. Eppert, S.W. Scherer and H. Ozcelik et al., MADR2 maps to 18q21 and encodes a TGF-b regulated MAD-related protein that is functionally mutated in colorectal carcinoma, Cell 86 (1996), 543-552.
    • (1996) Cell , vol.86 , pp. 543-552
    • Eppert, K.1    Scherer, S.W.2    Ozcelik, H.3
  • 28
    • 0033168915 scopus 로고    scopus 로고
    • Regulation of Smad signalling by protein associations and signalling crosstalk
    • Y. Zhang and R. Derynck, Regulation of Smad signalling by protein associations and signalling crosstalk, Trends Cell Biol 9 (1999), 274-279.
    • (1999) Trends Cell Biol. , vol.9 , pp. 274-279
    • Zhang, Y.1    Derynck, R.2
  • 29
    • 0034654497 scopus 로고    scopus 로고
    • Controlling TGF-beta signaling
    • J. Massague and Y.G. Chen, Controlling TGF-beta signaling, Genes Dev 14 (2000), 627-644.
    • (2000) Genes Dev. , vol.14 , pp. 627-644
    • Massague, J.1    Chen, Y.G.2
  • 30
    • 0034104591 scopus 로고    scopus 로고
    • Smads as transcriptional comodulators
    • L. Attisano and J.L. Wrana, Smads as transcriptional comodulators, Curr Opin Cell Biol 12 (2000), 235-243.
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 235-243
    • Attisano, L.1    Wrana, J.L.2
  • 31
    • 0031964859 scopus 로고    scopus 로고
    • Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
    • A. Hata, G. Lagna, J. Massague and A. Hemmati-Brivanlou, Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor, Genes Dev 12 (1998), 186-197.
    • (1998) Genes Dev. , vol.12 , pp. 186-197
    • Hata, A.1    Lagna, G.2    Massague, J.3    Hemmati-Brivanlou, A.4
  • 32
    • 0031587828 scopus 로고    scopus 로고
    • The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
    • H. Hayashi, S. Abdollah and Y. Qiu et al., The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling, Cell 89 (1997), 1165-1173.
    • (1997) Cell , vol.89 , pp. 1165-1173
    • Hayashi, H.1    Abdollah, S.2    Qiu, Y.3
  • 33
    • 0001078957 scopus 로고
    • Control of Mammary Gland Development
    • Second Edition, E. Knobil, and J.D. Neil, eds, New York: Raven Press, Ltd
    • W. Imagawa, J. Yang, R. Guzman and N. Satybrata, Control of Mammary Gland Development, in: The Physiology of Reproduction, Second Edition, E. Knobil, and J.D. Neil, eds, New York: Raven Press, Ltd. 1994, pp. 1033-1063.
    • (1994) The Physiology of Reproduction , pp. 1033-1063
    • Imagawa, W.1    Yang, J.2    Guzman, R.3    Satybrata, N.4
  • 34
    • 0035489712 scopus 로고    scopus 로고
    • Signaling pathways in mammary gland development
    • L. Hennighausen and G.W. Robinson, Signaling pathways in mammary gland development, Dev Cell 1 (2001), 467-475.
    • (2001) Dev. Cell , vol.1 , pp. 467-475
    • Hennighausen, L.1    Robinson, G.W.2
  • 35
    • 0035863007 scopus 로고    scopus 로고
    • Postnatal mammary gland morphogenesis
    • G.B. Silberstein, Postnatal mammary gland morphogenesis. Microsc Res Tech 52 (2001), 155-162.
    • (2001) Microsc. Res. Tech. , vol.52 , pp. 155-162
    • Silberstein, G.B.1
  • 36
    • 0035701794 scopus 로고    scopus 로고
    • The transforming growth factors beta in development and functional differentiation of the mouse mammary gland
    • C.W. Daniel, S. Robinson and G.B. Silberstein, The transforming growth factors beta in development and functional differentiation of the mouse mammary gland, Adv Exp Med Biol 501 (2001), 61-70.
    • (2001) Adv. Exp. Med. Biol. , vol.501 , pp. 61-70
    • Daniel, C.W.1    Robinson, S.2    Silberstein, G.B.3
  • 38
    • 0025944885 scopus 로고
    • Regulated expression and growth inhibitory effects of transforming growth factor-b isoforms in mouse mammary gland development
    • S.D. Robinson, G.B. Silberstein, A.B. Roberts, K.C. Flanders and C.W. Daniel, Regulated expression and growth inhibitory effects of transforming growth factor-b isoforms in mouse mammary gland development, Development 113 (1991), 867-878.
    • (1991) Development , vol.113 , pp. 867-878
    • Robinson, S.D.1    Silberstein, G.B.2    Roberts, A.B.3    Flanders, K.C.4    Daniel, C.W.5
  • 39
    • 0034091270 scopus 로고    scopus 로고
    • Differential expression of TGF-beta isoforms during postlactational mamary gland involution
    • E. Faure, N. Heisterkamp, J. Groffen and V. Kaartinen, Differential expression of TGF-beta isoforms during postlactational mamary gland involution, Cell Tissue Res 300 (2000), 89-95.
    • (2000) Cell Tissue Res. , vol.300 , pp. 89-95
    • Faure, E.1    Heisterkamp, N.2    Groffen, J.3    Kaartinen, V.4
  • 40
    • 0033858512 scopus 로고    scopus 로고
    • Transforming growth factor beta3 induces cell death during tbe first stage of mammary gland involution
    • A.V. Nguyen and J.W. Pollard, Transforming growth factor beta3 induces cell death during tbe first stage of mammary gland involution, Development 127 (2000), 3107-3118.
    • (2000) Development , vol.127 , pp. 3107-3118
    • Nguyen, A.V.1    Pollard, J.W.2
  • 41
    • 0026773069 scopus 로고
    • Apoptotic cell death and tissue remodelling during mouse mammary gland involution
    • R. Strange, F. Li, S. Saurer, A. Burkhardt and R.R. Friis, Apoptotic cell death and tissue remodelling during mouse mammary gland involution, Development 115 (1992), 49-58.
    • (1992) Development , vol.115 , pp. 49-58
    • Strange, R.1    Li, F.2    Saurer, S.3    Burkhardt, A.4    Friis, R.R.5
  • 42
    • 0026661308 scopus 로고
    • Regulation of mammary morphogenesis: Evidence for extracellular matrix-mediated inhibition of ductal budding by transforming growth factor-b1
    • G.B. Silberstein, K.C. Flanders, A.B. Roberts and C.W. Daniel, Regulation of mammary morphogenesis: Evidence for extracellular matrix-mediated inhibition of ductal budding by transforming growth factor-b1, Dev. Biol. 152 (1992), 354-362.
    • (1992) Dev. Biol. , vol.152 , pp. 354-362
    • Silberstein, G.B.1    Flanders, K.C.2    Roberts, A.B.3    Daniel, C.W.4
  • 44
    • 0036081239 scopus 로고    scopus 로고
    • Latent transforming growth factor-beta activation in mammary gland: Regulation by ovarian hormones affects ductal and alveolar proliferation
    • K.B. Ewan, G. Shyamala and S.A. Ravani et al., Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation, Am J Pathol 160 (2002), 2081-2093.
    • (2002) Am. J. Pathol. , vol.160 , pp. 2081-2093
    • Ewan, K.B.1    Shyamala, G.2    Ravani, S.A.3
  • 45
    • 0026567812 scopus 로고
    • Localization of transforming growth factor-b isotypes in lesions of the human breast
    • B.K. McCune, B.R. Mullin and K.C. Flanders et al., Localization of transforming growth factor-b isotypes in lesions of the human breast, Hum. Pathol. 23 (1992), 13-20.
    • (1992) Hum. Pathol. , vol.23 , pp. 13-20
    • McCune, B.K.1    Mullin, B.R.2    Flanders, K.C.3
  • 46
    • 0033572467 scopus 로고    scopus 로고
    • Transforming growth factor-beta and breast cancer risk in women with mammary epithelial hyperplasia
    • H. Gobbi, W.D. Dupont and J.F. Simpson et al., Transforming growth factor-beta and breast cancer risk in women with mammary epithelial hyperplasia, J Natl Cancer Inst 91 (1999), 2096-2101.
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 2096-2101
    • Gobbi, H.1    Dupont, W.D.2    Simpson, J.F.3
  • 47
    • 0032910954 scopus 로고    scopus 로고
    • Overexpression of a kinase-defiecient transforming growth factor-βtype II receptor In mouse mammary stroma results in increased epithelial branching
    • H. Joseph, A. Gorska, P. Sohn, H.L. Moses and R. Serra, Overexpression of a kinase-defiecient transforming growth factor-β type II receptor In mouse mammary stroma results in increased epithelial branching, Molecular Biology of the Cell 10 (1999), 1221-1234.
    • (1999) Molecular Biology of the Cell , vol.10 , pp. 1221-1234
    • Joseph, H.1    Gorska, A.2    Sohn, P.3    Moses, H.L.4    Serra, R.5
  • 48
    • 0036256156 scopus 로고    scopus 로고
    • Smad3 in the mammary epithelium has a nonredundant role in the induction of apoptosis, but not in the regulation of proliferation or differentiation by transforming growth factor-beta
    • Y.A. Yang, B. Tang and G. Robinson et al., Smad3 in the mammary epithelium has a nonredundant role in the induction of apoptosis, but not in the regulation of proliferation or differentiation by transforming growth factor-beta, Cell Growth Differ 13 (2002), 123-130.
    • (2002) Cell Growth Differ , vol.13 , pp. 123-130
    • Yang, Y.A.1    Tang, B.2    Robinson, G.3
  • 49
    • 0027531528 scopus 로고
    • Transforming growth factor b1 null mutation in mice causes excessive inflammatory response and early death
    • A.B. Kulkarni, C-G. Huh and D. Becker et al., Transforming growth factor b1 null mutation in mice causes excessive inflammatory response and early death, Proc. Natl. Acad. Sci. USA 90 (1993), 770-774.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 770-774
    • Kulkarni, A.B.1    Huh, C.-G.2    Becker, D.3
  • 50
    • 0030251480 scopus 로고    scopus 로고
    • TGF-beta and functional differentiation
    • G.H. Smith, TGF-beta and functional differentiation, J Mammary Gland Biol Neoplasia 1 (1996), 343-352.
    • (1996) J. Mammary Gland Biol. Neoplasia , vol.1 , pp. 343-352
    • Smith, G.H.1
  • 51
    • 0023251107 scopus 로고
    • Reversible inhibition of mammary gland growth by transforming growth factor-beta
    • G.B. Silberstein and C.W. Daniel, Reversible inhibition of mammary gland growth by transforming growth factor-beta, Science 237 (1987), 291-293.
    • (1987) Science , vol.237 , pp. 291-293
    • Silberstein, G.B.1    Daniel, C.W.2
  • 52
    • 0027136742 scopus 로고
    • Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-b1
    • D.F. Pierce, Jr., M.D. Johnson and Y. Matsui et al., Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-b1, Genes and Development 7 (1993), 2308-2317.
    • (1993) Genes and Development , vol.7 , pp. 2308-2317
    • Pierce Jr., D.F.1    Johnson, M.D.2    Matsui, Y.3
  • 53
    • 0028300009 scopus 로고
    • Involvement of autocrine mechanism of transforming growth factor-b in the functional differentiation of pregnant mouse mammary gland
    • T. Yamamoto, H. Komura and K. Morishige et al., Involvement of autocrine mechanism of transforming growth factor-b in the functional differentiation of pregnant mouse mammary gland, Acta Endocrinol. (Copenh.) 130 (1994), 302-307.
    • (1994) Acta Endocrinol. (Copenh.) , vol.130 , pp. 302-307
    • Yamamoto, T.1    Komura, H.2    Morishige, K.3
  • 54
    • 0027498034 scopus 로고
    • TGFb suppresses casein synthesis in mouse mammary explants and may play a role in controlling milk levels during pregnancy
    • S.D. Robinson, A.B. Roberts and C.W. Daniel, TGFb suppresses casein synthesis in mouse mammary explants and may play a role in controlling milk levels during pregnancy, Journal of Cell Biology 120 (1993), 245-251.
    • (1993) Journal of Cell Biology , vol.120 , pp. 245-251
    • Robinson, S.D.1    Roberts, A.B.2    Daniel, C.W.3
  • 55
    • 0028172760 scopus 로고
    • Transforming growth factor-b1 inhibits casein secretion from differentiating mammary-gland explants but not from lactating mammary cells
    • A.W. Sudlow, C.J. Wilde and R.D. Burgoyne, Transforming growth factor-b1 inhibits casein secretion from differentiating mammary-gland explants but not from lactating mammary cells, Biochem. J. 304 (1994), 333-336.
    • (1994) Biochem. J. , vol.304 , pp. 333-336
    • Sudlow, A.W.1    Wilde, C.J.2    Burgoyne, R.D.3
  • 56
    • 0024366047 scopus 로고
    • TGF-beta 1-induced inhibition of mouse mammary ductal growth: Developmental specificity and characterization
    • C.W. Daniel, G.B. Silberstein, K. Van Horn, P. Strickland and S. Robinson, TGF-beta 1-induced inhibition of mouse mammary ductal growth: developmental specificity and characterization, Dev. Biol. 135 (1989), 20-30.
    • (1989) Dev. Biol. , vol.135 , pp. 20-30
    • Daniel, C.W.1    Silberstein, G.B.2    Van Horn, K.3    Strickland, P.4    Robinson, S.5
  • 57
    • 0027286692 scopus 로고
    • Targeting expression of a transforming growth factor b1 transgene to the pregnant mammary gland inhibits alveolar development and lactation
    • C. Jhappan, A.G. Geiser and E.C. Kordon et al., Targeting expression of a transforming growth factor b1 transgene to the pregnant mammary gland inhibits alveolar development and lactation, EMBO J. 12 (1993), 1835-1845.
    • (1993) EMBO J. , vol.12 , pp. 1835-1845
    • Jhappan, C.1    Geiser, A.G.2    Kordon, E.C.3
  • 58
    • 0028986768 scopus 로고
    • Ectopic TGFb1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population
    • E.C. Kordon, R.A. McKnight and C. Jhappan et al., Ectopic TGFb1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population, Dev. Biol. 168 (1995), 47-61.
    • (1995) Dev. Biol. , vol.168 , pp. 47-61
    • Kordon, E.C.1    McKnight, R.A.2    Jhappan, C.3
  • 59
    • 0037816160 scopus 로고    scopus 로고
    • Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis
    • P.M. Siegel, W. Shu, R.D. Cardiff, W.J. Muller and J. Massague, Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis, Proc Natl Acad Sci USA (2003).
    • (2003) Proc. Natl. Acad. Sci. USA
    • Siegel, P.M.1    Shu, W.2    Cardiff, R.D.3    Muller, W.J.4    Massague, J.5
  • 60
    • 0031927686 scopus 로고    scopus 로고
    • Dominant-negative interference of the transforming growth factor beta type II receptor in mammary epithelium results in alveolar hyperplasia and differentiation in virgin mice
    • A.E. Gorska, H. Joseph, R. Derynck, H.L. Moses and R. Serra, Dominant-negative interference of the transforming growth factor beta type II receptor in mammary epithelium results in alveolar hyperplasia and differentiation in virgin mice, Cell Growth and Differentiation 9 (1998), 229-238.
    • (1998) Cell Growth and Differentiation , vol.9 , pp. 229-238
    • Gorska, A.E.1    Joseph, H.2    Derynck, R.3    Moses, H.L.4    Serra, R.5
  • 61
    • 0031441041 scopus 로고    scopus 로고
    • Transgenic mice overexpressing a dominant-negative mutant type II TGF-b receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz- [a]-anthracene
    • E.P. Bottinger, J.L. Jakubczak, D.C. Haines, K. Bagnall and L.M. Wakefield, Transgenic mice overexpressing a dominant-negative mutant type II TGF-b receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz- [a]-anthracene, Cancer Research 57 (1997), 5564-5570.
    • (1997) Cancer Research , vol.57 , pp. 5564-5570
    • Bottinger, E.P.1    Jakubczak, J.L.2    Haines, D.C.3    Bagnall, K.4    Wakefield, L.M.5
  • 62
    • 0035862998 scopus 로고    scopus 로고
    • Apoptosis in normal and neoplastic mammary gland development
    • R. Strange, T. Metcalfe, L. Thackray and M. Dang, Apoptosis in normal and neoplastic mammary gland development, Microsc Res Tech 52 (2001), 171-181.
    • (2001) Microsc. Res. Tech. , vol.52 , pp. 171-181
    • Strange, R.1    Metcalfe, T.2    Thackray, L.3    Dang, M.4
  • 63
    • 10744224096 scopus 로고    scopus 로고
    • Squamous cell carcinoma and mammary abscess formation through squamous metaplasia in Smad4/Dpc4 conditional knockout mice
    • W. Li, W. Qiao and L. Chen et al., Squamous cell carcinoma and mammary abscess formation through squamous metaplasia in Smad4/Dpc4 conditional knockout mice, Development 130 (2003), 6143-6153.
    • (2003) Development , vol.130 , pp. 6143-6153
    • Li, W.1    Qiao, W.2    Chen, L.3
  • 64
    • 0028953810 scopus 로고
    • Transforming growth factor b and cell cycle regulation
    • M.G. Alexandrow and H.L. Moses, Transforming growth factor b and cell cycle regulation, Cancer Research 55 (1995), 1452-1457.
    • (1995) Cancer Research , vol.55 , pp. 1452-1457
    • Alexandrow, M.G.1    Moses, H.L.2
  • 65
    • 0029066689 scopus 로고
    • Inactivation of the type II TGF-b receptor in colon cancer cells with microsatellite instability
    • S. Markowitz, J. Wang and L. Myeroff et al., Inactivation of the type II TGF-b receptor in colon cancer cells with microsatellite instability, Science 268 (1995), 1336-1338.
    • (1995) Science , vol.268 , pp. 1336-1338
    • Markowitz, S.1    Wang, J.2    Myeroff, L.3
  • 66
    • 0029944116 scopus 로고    scopus 로고
    • Tumor suppressor genes in the TGF-b signaling pathway?
    • R. Serra and H.L. Moses, Tumor suppressor genes in the TGF-b signaling pathway? Nature Medicine 2 (1996), 390-391.
    • (1996) Nature Medicine , vol.2 , pp. 390-391
    • Serra, R.1    Moses, H.L.2
  • 67
    • 0034785348 scopus 로고    scopus 로고
    • TGF-beta signaling in tumor suppression and cancer progression
    • R. Derynck, R.J. Akhurst and A. Balmain, TGF-beta signaling in tumor suppression and cancer progression, Nat Genet 29 (2001), 117-129.
    • (2001) Nat. Genet. , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 68
    • 2642614530 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency
    • B. Tang, E.P. Bottinger and S.B. Jakowlew et al., Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency, Nat Med 4 (1998), 802-807.
    • (1998) Nat. Med. , vol.4 , pp. 802-807
    • Tang, B.1    Bottinger, E.P.2    Jakowlew, S.B.3
  • 69
    • 0034004714 scopus 로고    scopus 로고
    • Loss of expression of transforming growth factor beta type II receptor correlates with high tumour grade in human breast in-situ and invasive carcinomas
    • (see comments)
    • H. Gobbi, C.L. Atteaga and R.A. Jensen et al., Loss of expression of transforming growth factor beta type II receptor correlates with high tumour grade in human breast in-situ and invasive carcinomas (see comments), Histopathology 36 (2000), 168-177.
    • (2000) Histopathology , vol.36 , pp. 168-177
    • Gobbi, H.1    Atteaga, C.L.2    Jensen, R.A.3
  • 70
    • 0025372023 scopus 로고
    • Development of mammary hyperplasia and neoplasia in MMTV- TGFalpha transgenic mice
    • Y. Matsui, S.A. Halter, J.T. Holt, B.L.M. Hogan and R.J. Coffey, Jr. Development of mammary hyperplasia and neoplasia in MMTV- TGFalpha transgenic mice, Cell 61 (1990), 1147-1156.
    • (1990) Cell , vol.61 , pp. 1147-1156
    • Matsui, Y.1    Halter, S.A.2    Holt, J.T.3    Hogan, B.L.M.4    Coffey Jr., R.J.5
  • 71
    • 0029010734 scopus 로고
    • Mammary tumor suppression by transforming growth factor b1 transgene expression
    • D.F. Pierce, Jr., A.E. Gorska and A. Chytil et al., Mammary tumor suppression by transforming growth factor b1 transgene expression, Proc. Natl. Acad. Sci. USA 92 (1995), 4254-4258.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4254-4258
    • Pierce Jr., D.F.1    Gorska, A.E.2    Chytil, A.3
  • 72
    • 0141537150 scopus 로고    scopus 로고
    • Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-beta receptor exhibit impaired mammary development and enhanced mammary tumor formation
    • A.E. Gorska, R.A. Jensen and Y. Shyr et al., Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-beta receptor exhibit impaired mammary development and enhanced mammary tumor formation, Am J Pathol 163 (2003), 1539-1549.
    • (2003) Am. J. Pathol. , vol.163 , pp. 1539-1549
    • Gorska, A.E.1    Jensen, R.A.2    Shyr, Y.3
  • 73
    • 0023713558 scopus 로고
    • Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c- neu oncogene
    • W.J. Muller, E. Sinn, P.K. Pattengale, R. Wallace and P. Leder, Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c- neu oncogene, Cell 54 (1988), 105-115.
    • (1988) Cell , vol.54 , pp. 105-115
    • Muller, W.J.1    Sinn, E.2    Pattengale, P.K.3    Wallace, R.4    Leder, P.5
  • 74
    • 0035953393 scopus 로고    scopus 로고
    • Reducing mammary cancer risk through premature stem cell senescence
    • C.A. Boulanger and G.H. Smith, Reducing mammary cancer risk through premature stem cell senescence, Oncogene 20 (2001), 2264-2272.
    • (2001) Oncogene , vol.20 , pp. 2264-2272
    • Boulanger, C.A.1    Smith, G.H.2
  • 75
    • 0035874055 scopus 로고    scopus 로고
    • Impairment of mammary lobular development induced by expression of TGFbeta1 under the control of WAP promoter does not suppress tumorigenesis in MMTV-infected transgenic mice
    • V. Buggiano, C. Schere-Levy and K. Abe et al., Impairment of mammary lobular development induced by expression of TGFbeta1 under the control of WAP promoter does not suppress tumorigenesis in MMTV-infected transgenic mice, Int J Cancer 92 (2001), 568-576.
    • (2001) Int. J. Cancer , vol.92 , pp. 568-576
    • Buggiano, V.1    Schere-Levy, C.2    Abe, K.3
  • 76
    • 0030598681 scopus 로고    scopus 로고
    • TGF-b1 inhibits the formation of benign skin tumors, but enhances the progression to invasive spindle carcinomas in transgenic mice
    • W. Cui, D.J. Fowlis and S. Bryson et al., TGF-b1 inhibits the formation of benign skin tumors, but enhances the progression to invasive spindle carcinomas in transgenic mice, Cell 86 (1996), 531-542.
    • (1996) Cell , vol.86 , pp. 531-542
    • Cui, W.1    Fowlis, D.J.2    Bryson, S.3
  • 77
    • 0027314411 scopus 로고
    • Microsatellite instability in cancer of the proximal colon
    • S.N. Thibodeau, G. Bren and D. Schaid, Microsatellite instability in cancer of the proximal colon, Science 260 (1993), 816-819.
    • (1993) Science , vol.260 , pp. 816-819
    • Thibodeau, S.N.1    Bren, G.2    Schaid, D.3
  • 78
    • 0032547895 scopus 로고    scopus 로고
    • TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis
    • M. Oft, K.H. Heider and H. Beug, TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis, Curr Biol 8 (1998), 1243-1252.
    • (1998) Curr. Biol. , vol.8 , pp. 1243-1252
    • Oft, M.1    Heider, K.H.2    Beug, H.3
  • 79
    • 0035689762 scopus 로고    scopus 로고
    • Malignant cells, directors of the malignant process: Role of transforming growth factor-beta
    • B.A. Teicher, Malignant cells, directors of the malignant process: role of transforming growth factor-beta, Cancer Metastasis Rev 20 (2001), 133-143.
    • (2001) Cancer Metastasis Rev. , vol.20 , pp. 133-143
    • Teicher, B.A.1
  • 80
    • 0034911060 scopus 로고    scopus 로고
    • Serum levels of transforming growth factor beta1 in patients with breast cancer
    • S.M. Sheen-Chen, H.S. Chen, C.W. Sheen, H.L. Eng and W.J. Chen, Serum levels of transforming growth factor beta1 in patients with breast cancer, Arch Surg 136 (2001), 937-940.
    • (2001) Arch. Surg. , vol.136 , pp. 937-940
    • Sheen-Chen, S.M.1    Chen, H.S.2    Sheen, C.W.3    Eng, H.L.4    Chen, W.J.5
  • 81
    • 0037363281 scopus 로고    scopus 로고
    • Elevated plasma levels of transforming growth factor-beta 1 (TGF-beta 1) in patients with advanced breast cancer: Association with disease progression
    • V. Ivanovic, N. Todorovic-Rakovic and M. Demajo et al., Elevated plasma levels of transforming growth factor-beta 1 (TGF-beta 1) in patients with advanced breast cancer: association with disease progression, Eur J Cancer 39 (2003), 454-461.
    • (2003) Eur. J. Cancer , vol.39 , pp. 454-461
    • Ivanovic, V.1    Todorovic-Rakovic, N.2    Demajo, M.3
  • 82
    • 0034468328 scopus 로고    scopus 로고
    • Transforming growth factor-beta and breast cancer: Lessons learned from genetically altered mouse models
    • L.M. Wakefield, Y.A. Yang and O. Dukhanina, Transforming growth factor-beta and breast cancer: Lessons learned from genetically altered mouse models, Breast Cancer Res 2 (2000), 100-106.
    • (2000) Breast Cancer Res. , vol.2 , pp. 100-106
    • Wakefield, L.M.1    Yang, Y.A.2    Dukhanina, O.3
  • 83
    • 0034468039 scopus 로고    scopus 로고
    • Transforming growth factor-beta and breast cancer: Tumor promoting effects of transforming growth factor-beta
    • N. Dumont and C.L. Arteaga, Transforming growth factor-beta and breast cancer: Tumor promoting effects of transforming growth factor-beta, Breast Cancer Res 2 (2000), 125-132.
    • (2000) Breast Cancer Res. , vol.2 , pp. 125-132
    • Dumont, N.1    Arteaga, C.L.2
  • 84
    • 11944255353 scopus 로고
    • Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential
    • D.R .Welch, A. Fabra and M. Nakajima, Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential, Proc Natl Acad Sci USA 87 (1990), 7678-7682.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 7678-7682
    • Welch, D.R.1    Fabra, A.2    Nakajima, M.3
  • 85
    • 0037049877 scopus 로고    scopus 로고
    • Enhancement of tumorigenic, metastatic and in vitro invasive capacity of rat mammary tumor cells by transforming growth factor-beta
    • D. Nakata, J. Hamada and Y. Ba et al., Enhancement of tumorigenic, metastatic and in vitro invasive capacity of rat mammary tumor cells by transforming growth factor-beta, Cancer Lett 175 (2002), 95-106.
    • (2002) Cancer Lett. , vol.175 , pp. 95-106
    • Nakata, D.1    Hamada, J.2    Ba, Y.3
  • 86
    • 0035199487 scopus 로고    scopus 로고
    • Invasion and metastasis of a mammary tumor involves TGF-beta signaling
    • J.A. McEarchern, J.J. Kobie and V. Mack et al., Invasion and metastasis of a mammary tumor involves TGF-beta signaling, Int J Cancer 91 (2001), 76-82.
    • (2001) Int. J. Cancer , vol.91 , pp. 76-82
    • McEarchern, J.A.1    Kobie, J.J.2    Mack, V.3
  • 87
    • 0029662049 scopus 로고    scopus 로고
    • TGF-beta1 and HaRas collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
    • M. Oft, J. Peli and C. Rudaz et al., TGF-beta1 and HaRas collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells, Genes Dev 10 (1996), 2462-2477.
    • (1996) Genes Dev. , vol.10 , pp. 2462-2477
    • Oft, M.1    Peli, J.2    Rudaz, C.3
  • 88
    • 0242552529 scopus 로고    scopus 로고
    • Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1
    • R.S. Muraoka, Y. Koh and L.R. Roebuck et al., Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1, Mol Cell Biol 23 (2003), 8691-8703.
    • (2003) Mol. Cell Biol. , vol.23 , pp. 8691-8703
    • Muraoka, R.S.1    Koh, Y.2    Roebuck, L.R.3
  • 89
    • 0037012009 scopus 로고    scopus 로고
    • Consequences of altered TGF-beta expression and responsiveness in breast cancer: Evidence for autocrine and paracrine effects
    • S.W. Tabin, K. Douville and U. Benbow et al., Consequences of altered TGF-beta expression and responsiveness in breast cancer: evidence for autocrine and paracrine effects, Oncogene 21 (2002), 108-118.
    • (2002) Oncogene , vol.21 , pp. 108-118
    • Tabin, S.W.1    Douville, K.2    Benbow, U.3
  • 90
    • 0037301981 scopus 로고    scopus 로고
    • Mechanisms of osteolytic bone metastases in breast carcinoma
    • S.M. Kakonen and G.R. Mundy, Mechanisms of osteolytic bone metastases in breast carcinoma, Cancer 97 (2003), 834-839.
    • (2003) Cancer , vol.97 , pp. 834-839
    • Kakonen, S.M.1    Mundy, G.R.2
  • 91
    • 0032918414 scopus 로고    scopus 로고
    • TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development
    • J.J. Yin, K. Selander and J.M. Chirgwin et al., TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development, J Clin Invest 103 (1999), 197-206.
    • (1999) J. Clin. Invest. , vol.103 , pp. 197-206
    • Yin, J.J.1    Selander, K.2    Chirgwin, J.M.3
  • 92
    • 4444362693 scopus 로고    scopus 로고
    • TGF-beta stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways
    • S.M. Kakonen, K.S. Selander and J.M. Chirgwin et al., TGF-beta stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways, J Biol Chem 8 (2002), 6.
    • (2002) J. Biol. Chem. , vol.8 , pp. 6
    • Kakonen, S.M.1    Selander, K.S.2    Chirgwin, J.M.3
  • 93
    • 0002415989 scopus 로고
    • Parathyroid hormone-related protein
    • J.P Bilezikian, M.A. Levine and R. Marcus, eds, New York: Raven Press, Ltd
    • A.E. Broadus and A.F. Stewart, Parathyroid hormone-related protein, in: The Parathyroids, J.P. Bilezikian, M.A. Levine and R. Marcus, eds, New York: Raven Press, Ltd, 1994, pp. 259-294.
    • (1994) The Parathyroids , pp. 259-294
    • Broadus, A.E.1    Stewart, A.F.2
  • 94
    • 0023228836 scopus 로고
    • A parathyroid hormone-related protein implicated in malignant hypercalcemia: Cloning and expression
    • L.J. Suva, G.A. Winslow and R.E.H. Wettenhall et al., A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression, Science 237 (1987), 893-896.
    • (1987) Science , vol.237 , pp. 893-896
    • Suva, L.J.1    Winslow, G.A.2    Wettenhall, R.E.H.3
  • 95
    • 0036084359 scopus 로고    scopus 로고
    • TGF-beta antagonists: Why suppress a tumor suppressor?
    • R.J. Akhurst, TGF-beta antagonists: why suppress a tumor suppressor? J Clin Invest 109 (2002), 1533-1536.
    • (2002) J. Clin. Invest. , vol.109 , pp. 1533-1536
    • Akhurst, R.J.1
  • 96
    • 0033215194 scopus 로고    scopus 로고
    • A soluble transforming growth factor beta type III receptor suppresses tumorigenicity and metastasis of human breast cancer MDA-MB-231 cells
    • A. Bandyopadhyay, Y. Zhu and M.L. Cibull et al., A soluble transforming growth factor beta type III receptor suppresses tumorigenicity and metastasis of human breast cancer MDA-MB-231 cells, Cancer Res 59 (1999), 5041-5046.
    • (1999) Cancer Res. , vol.59 , pp. 5041-5046
    • Bandyopadhyay, A.1    Zhu, Y.2    Cibull, M.L.3
  • 97
    • 0036086409 scopus 로고    scopus 로고
    • Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases
    • R.S. Muraoka, N. Dumont and C.A. Ritter et al., Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases, J Clin Invest 109 (2002), 1551-1559.
    • (2002) J. Clin. Invest. , vol.109 , pp. 1551-1559
    • Muraoka, R.S.1    Dumont, N.2    Ritter, C.A.3
  • 98
    • 0036087521 scopus 로고    scopus 로고
    • Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects
    • Y.A. Yang, O. Dukhanina and B. Tang et al., Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects, J Clin Invest 109 (2002), 1607-1615.
    • (2002) J. Clin. Invest. , vol.109 , pp. 1607-1615
    • Yang, Y.A.1    Dukhanina, O.2    Tang, B.3
  • 99
    • 0032034445 scopus 로고    scopus 로고
    • The role of stroma in breast carcinoma growth in vivo
    • A. Noel and J.M. Foidart, The role of stroma in breast carcinoma growth in vivo, J Mammary Gland Biol Neoplasia 3 (1998), 215-225.
    • (1998) J. Mammary Gland Biol. Neoplasia , vol.3 , pp. 215-225
    • Noel, A.1    Foidart, J.M.2
  • 100
    • 0037312899 scopus 로고    scopus 로고
    • The not-so innocent bystander: The microenvironment as a therapeutic target in cancer
    • A.C. Erickson and M.H. Barcellos-Hoff, The not-so innocent bystander: the microenvironment as a therapeutic target in cancer, Expert Opin Ther Targets 7 (2003), 71-88.
    • (2003) Expert Opin. Ther. Targets , vol.7 , pp. 71-88
    • Erickson, A.C.1    Barcellos-Hoff, M.H.2
  • 101
    • 0035170731 scopus 로고    scopus 로고
    • Reactive stroma in prostate cancer progression
    • J.A. Tuxhorn, G.E. Ayala and D.R. Rowley, Reactive stroma in prostate cancer progression, J Urol 166 (2001), 2472-2483.
    • (2001) J. Urol. , vol.166 , pp. 2472-2483
    • Tuxhorn, J.A.1    Ayala, G.E.2    Rowley, D.R.3
  • 102
    • 0035019915 scopus 로고    scopus 로고
    • Stromal cells can contribute oncogenic signals
    • T.D. Tlsty, Stromal cells can contribute oncogenic signals, Semin Cancer Biol 11 (2001), 97-104.
    • (2001) Semin. Cancer Biol. , vol.11 , pp. 97-104
    • Tlsty, T.D.1
  • 103
    • 0035253742 scopus 로고    scopus 로고
    • Know thy neighbor: S tromal cells can contribute oncogenic signals
    • T.D. Tlsty and P.W. Hein, Know thy neighbor: stromal cells can contribute oncogenic signals, Curr Opin Genet Dev 11 (2001), 54-59.
    • (2001) Curr. Opin. Genet. Dev. , vol.11 , pp. 54-59
    • Tlsty, T.D.1    Hein, P.W.2
  • 104
    • 0037052448 scopus 로고    scopus 로고
    • Stromal effects on mammary gland development and breast cancer
    • B.S. Wiseman and Z. Werb, Stromal effects on mammary gland development and breast cancer, Science 296 (2002), 1046-1049.
    • (2002) Science , vol.296 , pp. 1046-1049
    • Wiseman, B.S.1    Werb, Z.2
  • 105
    • 0032148387 scopus 로고    scopus 로고
    • Hypermethylation of the p16INK4a promoter in colectomy specimens of patients with long-standing and extensive ulcerative colitis
    • C.J. Hsieh, B. Klump and K. Holzmann et al., Hypermethylation of the p16INK4a promoter in colectomy specimens of patients with long-standing and extensive ulcerative colitis, Cancer Res 58 (1998), 3942-3945.
    • (1998) Cancer Res. , vol.58 , pp. 3942-3945
    • Hsieh, C.J.1    Klump, B.2    Holzmann, K.3
  • 106
    • 0033545334 scopus 로고    scopus 로고
    • Radial scars in benign breast-biopsy specimens and the risk of breast cancer
    • (see comments)
    • T.W. Jacobs, C. Byrne, G. Colditz, J.L. Connolly and S.J. Schnitt, Radial scars in benign breast-biopsy specimens and the risk of breast cancer (see comments), N Engl J Med 340 (1999), 430-436.
    • (1999) N. Engl. J. Med. , vol.340 , pp. 430-436
    • Jacobs, T.W.1    Byrne, C.2    Colditz, G.3    Connolly, J.L.4    Schnitt, S.J.5
  • 107
    • 0030987867 scopus 로고    scopus 로고
    • A juvenile polyposis tumor suppressor locus at 10q22 is deleted from nonepithelial cells in the lamina propria
    • R.F. Jacoby, S. Schlack and C.E. Cole et al., A juvenile polyposis tumor suppressor locus at 10q22 is deleted from nonepithelial cells in the lamina propria, Gastroenterology 112 (1997), 1398-1403.
    • (1997) Gastroenterology , vol.112 , pp. 1398-1403
    • Jacoby, R.F.1    Schlack, S.2    Cole, C.E.3
  • 108
    • 0032524069 scopus 로고    scopus 로고
    • Mutations in the SMAD4/DPC4 gene in juvenile polyposis
    • (see comments)
    • J.R. Howe, S. Roth and J.C. Ringold et al., Mutations in the SMAD4/DPC4 gene in juvenile polyposis (see comments), Science 280 (1998), 1086-1088.
    • (1998) Science , vol.280 , pp. 1086-1088
    • Howe, J.R.1    Roth, S.2    Ringold, J.C.3
  • 109
    • 0342264492 scopus 로고    scopus 로고
    • Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: Implications for tumorigenesis
    • F. Moinfar, Y.G. Man and L. Arnould et al., Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis, Cancer Res 60 (2000), 2562-2566.
    • (2000) Cancer Res. , vol.60 , pp. 2562-2566
    • Moinfar, F.1    Man, Y.G.2    Arnould, L.3
  • 110
    • 0034696350 scopus 로고    scopus 로고
    • The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter
    • M.D. Sternlicht, M.J. Bissell and Z. Werb, The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter, Oncogene 19 (2000), 1102-1113.
    • (2000) Oncogene , vol.19 , pp. 1102-1113
    • Sternlicht, M.D.1    Bissell, M.J.2    Werb, Z.3
  • 111
    • 0030051051 scopus 로고    scopus 로고
    • Cellular changes involved in conversion of normal to malignant breast: Importance of the stromal reaction
    • L. Ronnov-Jessen, O.W. Petersen and M.J. Bissell, Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction, Physiol Rev 76 (1996), 69-125.
    • (1996) Physiol. Rev. , vol.76 , pp. 69-125
    • Ronnov-Jessen, L.1    Petersen, O.W.2    Bissell, M.J.3
  • 112
    • 0026425678 scopus 로고
    • Mesenchyme-induced changes in the neoplastic characteristics of the Dunning prostatic adenocarcinoma
    • N. Hayashi and G.R. Cunha, Mesenchyme-induced changes in the neoplastic characteristics of the Dunning prostatic adenocarcinoma, Cancer Res 51 (1991), 4924-4930.
    • (1991) Cancer Res. , vol.51 , pp. 4924-4930
    • Hayashi, N.1    Cunha, G.R.2
  • 113
    • 0034161922 scopus 로고    scopus 로고
    • Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells
    • M.H. Barcellos-Hoff and S.A. Ravani, Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells, Cancer Res 60 (2000), 1254-1260.
    • (2000) Cancer Res. , vol.60 , pp. 1254-1260
    • Barcellos-Hoff, M.H.1    Ravani, S.A.2
  • 114
    • 0027293946 scopus 로고
    • Radiation-induced transforming growth factor b and subsequent extracellular matrix reorganization in murine mammary gland
    • M.H. Barcellos-Hoff, Radiation-induced transforming growth factor b and subsequent extracellular matrix reorganization in murine mammary gland, Cancer Research 53 (1993), 3880-3886.
    • (1993) Cancer Research , vol.53 , pp. 3880-3886
    • Barcellos-Hoff, M.H.1
  • 116
    • 0030770411 scopus 로고    scopus 로고
    • Latent transforming growth factor beta1 activation in situ: Quantitative and functional evidence after low-dose gamma-irradiation
    • E.J. Ehrhart, P. Segarini, M.L. Tsang, A.G. Caroll and M.H. Barcellos-Hoff, Latent transforming growth factor beta1 activation in situ: quantitative and functional evidence after low-dose gamma-irradiation, Faseb J 11 (1997), 991-1002.
    • (1997) Faseb J. , vol.11 , pp. 991-1002
    • Ehrhart, E.J.1    Segarini, P.2    Tsang, M.L.3    Caroll, A.G.4    Barcellos-Hoff, M.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.