메뉴 건너뛰기




Volumn 9, Issue 3, 1998, Pages 229-238

Dominant-negative interference of the transforming growth factor β type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA2;

EID: 0031927686     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (112)

References (60)
  • 1
    • 0029131839 scopus 로고
    • Analysis of homozygous TGFβ1 null mouse embryos demonstrates defects in yolk sac vasculogenesis and hematopoiesis
    • Martin, J. S., Dickson, M. C., Cousins, F. M., Kulkarni, A. B., Karlsson, S., and Akhurst, R. J. Analysis of homozygous TGFβ1 null mouse embryos demonstrates defects in yolk sac vasculogenesis and hematopoiesis. Ann. N. Y. Acad. Sci., 752: 300-308, 1995.
    • (1995) Ann. N. Y. Acad. Sci. , vol.752 , pp. 300-308
    • Martin, J.S.1    Dickson, M.C.2    Cousins, F.M.3    Kulkarni, A.B.4    Karlsson, S.5    Akhurst, R.J.6
  • 2
    • 0025984020 scopus 로고
    • Stromal-epithelial interactions in normal and neoplastic mammary gland
    • Haslam, S. Z. Stromal-epithelial interactions in normal and neoplastic mammary gland. Cancer Treat. Res., 53: 401-420, 1991.
    • (1991) Cancer Treat. Res. , vol.53 , pp. 401-420
    • Haslam, S.Z.1
  • 3
    • 0025122809 scopus 로고
    • TGF-β receptors and TGF-β binding proteoglycans: Recent progress in identifying their functional properties
    • Massague, J., Cheifetz, S., Boyd, F. T., and Andres, J. L. TGF-β receptors and TGF-β binding proteoglycans: recent progress in identifying their functional properties. Ann. N. Y. Acad. Sci., 593: 59-72, 1990.
    • (1990) Ann. N. Y. Acad. Sci. , vol.593 , pp. 59-72
    • Massague, J.1    Cheifetz, S.2    Boyd, F.T.3    Andres, J.L.4
  • 4
    • 0003048826 scopus 로고
    • The biological actions of transforming growth factor β
    • V. Sara, K. Hall, and H. Low. (eds.). New York: Raven Press
    • Moses, H. L. The biological actions of transforming growth factor β. In: V. Sara, K. Hall, and H. Low. (eds.), Growth Factors From Genes to Clinical Application, pp. 141-155. New York: Raven Press, 1990.
    • (1990) Growth Factors from Genes to Clinical Application , pp. 141-155
    • Moses, H.L.1
  • 5
    • 0025104027 scopus 로고
    • TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights
    • Moses, H, L., Yang, E. Y., and Pietenpol, J. A. TGF-β stimulation and inhibition of cell proliferation: new mechanistic insights. Cell, 63: 245-247, 1990.
    • (1990) Cell , vol.63 , pp. 245-247
    • Moses, H.L.1    Yang, E.Y.2    Pietenpol, J.A.3
  • 6
    • 0025944885 scopus 로고
    • Regulated expression and growth inhibitory effects of transforming growth factor-β isoforms in mouse mammary gland development
    • Robinson, S. D., Silberstein, G. B., Roberts, A. B., Flanders, K. C., and Daniel, C. W. Regulated expression and growth inhibitory effects of transforming growth factor-β isoforms in mouse mammary gland development. Development (Camb.), 113: 867-878, 1991.
    • (1991) Development (Camb.) , vol.113 , pp. 867-878
    • Robinson, S.D.1    Silberstein, G.B.2    Roberts, A.B.3    Flanders, K.C.4    Daniel, C.W.5
  • 7
    • 0025696919 scopus 로고
    • Transforming growth factor-β inhibits lactogenic hormone induction of β-casein expression in HC11 mouse mammary epithelial cells
    • Mieth, M., Boehmer, F. D., Ball, R., Groner, B., and Grosse, R. Transforming growth factor-β inhibits lactogenic hormone induction of β-casein expression in HC11 mouse mammary epithelial cells. Growth Factors, 4: 9-15, 1990.
    • (1990) Growth Factors , vol.4 , pp. 9-15
    • Mieth, M.1    Boehmer, F.D.2    Ball, R.3    Groner, B.4    Grosse, R.5
  • 8
    • 0027498034 scopus 로고
    • TGFβ suppresses casein synthesis in mouse mammary expiants and may play a role in controlling milk levels during pregnancy
    • Robinson, S. D., Roberts, A. B., and Daniel, C. W. TGFβ suppresses casein synthesis in mouse mammary expiants and may play a role in controlling milk levels during pregnancy. J. Cell Biol., 120: 245-251, 1993.
    • (1993) J. Cell Biol. , vol.120 , pp. 245-251
    • Robinson, S.D.1    Roberts, A.B.2    Daniel, C.W.3
  • 9
    • 0023251107 scopus 로고
    • Reversible inhibition of mammary gland growth by transforming growth factor-β
    • Silberstein, G. B and Daniel, C. W. Reversible inhibition of mammary gland growth by transforming growth factor-β. Science (Washington DC), 237: 291-293, 1987.
    • (1987) Science (Washington DC) , vol.237 , pp. 291-293
    • Silberstein, G.B.1    Daniel, C.W.2
  • 10
    • 0027286692 scopus 로고
    • Targeting expression of a transforming growth factor β1 transgene to the pregnant mammary gland inhibits alveolar development and lactation
    • Jhappan, C., Geiser, A. G., Kordon, E. C., Bagheri, D., Hennighausen, L, Roberts, A. B., Smith, G. H., and Merlino, G. Targeting expression of a transforming growth factor β1 transgene to the pregnant mammary gland inhibits alveolar development and lactation. EMBO J., 12: 1835-1845, 1993.
    • (1993) EMBO J. , vol.12 , pp. 1835-1845
    • Jhappan, C.1    Geiser, A.G.2    Kordon, E.C.3    Bagheri, D.4    Hennighausen, L.5    Roberts, A.B.6    Smith, G.H.7    Merlino, G.8
  • 12
    • 0028173316 scopus 로고
    • TGF-β-receptor-mediated signaling
    • Derynck, R. TGF-β-receptor-mediated signaling. Trends Biochem. Sci., 19: 548-553, 1994.
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 548-553
    • Derynck, R.1
  • 13
    • 0028179120 scopus 로고
    • The TGF-β family and its composite receptors
    • Massague, J., Attisano, L., and Wrana, J. L. The TGF-β family and its composite receptors. Trends Cell Biol., 4: 172-178, 1994.
    • (1994) Trends Cell Biol. , vol.4 , pp. 172-178
    • Massague, J.1    Attisano, L.2    Wrana, J.L.3
  • 14
    • 0029944441 scopus 로고    scopus 로고
    • Signaling via heterooligomeric complexes of type I and type II serine threonine kinase receptors
    • Ten Dijke, P., Miyazono, K., and Heldin, C-H. Signaling via heterooligomeric complexes of type I and type II serine threonine kinase receptors. Curr. Opin. Cell Biol., 8: 139-145, 1996.
    • (1996) Curr. Opin. Cell Biol. , vol.8 , pp. 139-145
    • Ten Dijke, P.1    Miyazono, K.2    Heldin, C.-H.3
  • 15
    • 0025714554 scopus 로고
    • Distinct transforming growth factor-β receptor subsets as determinants of cellular responsiveness to three TGF-β isoforms
    • Cheifetz, S., Hernandez, H., Laiho, M., tenDijke, P., Iwata, K. K., and Massague, J. Distinct transforming growth factor-β receptor subsets as determinants of cellular responsiveness to three TGF-β isoforms. J. Biol. Chem., 265: 20533-20538, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 20533-20538
    • Cheifetz, S.1    Hernandez, H.2    Laiho, M.3    TenDijke, P.4    Iwata, K.K.5    Massague, J.6
  • 16
    • 0025773387 scopus 로고
    • Responsiveness to transforming growth factor-β (TGF-β) restored by genetic complementation between cells defective in TGF-β receptors I and M
    • Laiho, M., Weis, F. M. B., Boyd, F. T., Ignotz, R. A., and Massague, J. Responsiveness to transforming growth factor-β (TGF-β) restored by genetic complementation between cells defective in TGF-β receptors I and M. J. Biol. Chem., 266: 9108-9112, 1991.
    • (1991) J. Biol. Chem. , vol.266 , pp. 9108-9112
    • Laiho, M.1    Weis, F.M.B.2    Boyd, F.T.3    Ignotz, R.A.4    Massague, J.5
  • 17
    • 0027250810 scopus 로고
    • Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-β activities
    • Chen, R-H., Ebner, R., and Derynck, R. Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-β activities. Science (Washington DC), 260: 1335-1338, 1993.
    • (1993) Science (Washington DC) , vol.260 , pp. 1335-1338
    • Chen, R.-H.1    Ebner, R.2    Derynck, R.3
  • 18
    • 0028910192 scopus 로고
    • Inactive type II and type I receptors for TGFβ are dominant inhibitors of TGFβ-dependent transcription
    • Brand, T., and Schneider, M. D. Inactive type II and type I receptors for TGFβ are dominant inhibitors of TGFβ-dependent transcription. J. Biol. Chem., 270: 8274-8284, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 8274-8284
    • Brand, T.1    Schneider, M.D.2
  • 19
    • 0027300034 scopus 로고
    • A dominant-negative receptor for type β transforming growth factors created by deletion of the kinase domain
    • Brand, T., MacLellan, W. R., and Schneider, M. D. A dominant-negative receptor for type β transforming growth factors created by deletion of the kinase domain. J. Biol. Chem., 260: 11500-11503, 1993.
    • (1993) J. Biol. Chem. , vol.260 , pp. 11500-11503
    • Brand, T.1    MacLellan, W.R.2    Schneider, M.D.3
  • 20
    • 0029098259 scopus 로고
    • Inhibition of capillary morphogenesis and associated apoptosis by dominant negative mutant transforming growth factor-β receptors
    • Choi, M. E., and Ballermann, B. J. Inhibition of capillary morphogenesis and associated apoptosis by dominant negative mutant transforming growth factor-β receptors. J. Biol. Chem., 270: 21144-21150, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 21144-21150
    • Choi, M.E.1    Ballermann, B.J.2
  • 21
    • 0029980518 scopus 로고    scopus 로고
    • Modulation of transforming growth factor β receptor levels on microvascular endothelial cells during in vitro angiogenesis
    • Sankar, S., Mahooti-Brooks, N., Bensen, L., McCarthy, T. L., Centrella, M., and Madri, J. A. Modulation of transforming growth factor β receptor levels on microvascular endothelial cells during in vitro angiogenesis. J. Clin. Invest., 97: 1436-1446, 1996.
    • (1996) J. Clin. Invest. , vol.97 , pp. 1436-1446
    • Sankar, S.1    Mahooti-Brooks, N.2    Bensen, L.3    McCarthy, T.L.4    Centrella, M.5    Madri, J.A.6
  • 22
    • 0030953639 scopus 로고    scopus 로고
    • Expression of a dominant-negative type II transforming growth factor β(TGF-β) receptor in the epidermis of transgenic mice blocks TGF-β-mediated growth inhibition
    • Wang, X-J., Greenhalgh, D. A., Bickenbach, J. R., Jiang, A., Bundman, D. S., Krieg, T., Derynck, R., and Roop, D. R. Expression of a dominant-negative type II transforming growth factor β(TGF-β) receptor in the epidermis of transgenic mice blocks TGF-β-mediated growth inhibition. Proc. Natl. Acad. Sci. USA, 94: 2386-2391, 1997.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2386-2391
    • Wang, X.-J.1    Greenhalgh, D.A.2    Bickenbach, J.R.3    Jiang, A.4    Bundman, D.S.5    Krieg, T.6    Derynck, R.7    Roop, D.R.8
  • 23
    • 0342460497 scopus 로고    scopus 로고
    • Expression of a dominant-negative mutant TGF-β type II receptor in transgenic mice reveals essential roles for TGF-β in regulation of growth and differentiation in the exocrine pancreas
    • Bottinger, E. P., Jakubczak, J. L., Roberts, I. S. D., Mumy, M., Hemmati, P., Bagnall, K., Merlino, G., and Wakefield, L. M. Expression of a dominant-negative mutant TGF-β type II receptor in transgenic mice reveals essential roles for TGF-β in regulation of growth and differentiation in the exocrine pancreas. EMBO J., 16: 2621-2633, 1997.
    • (1997) EMBO J. , vol.16 , pp. 2621-2633
    • Bottinger, E.P.1    Jakubczak, J.L.2    Roberts, I.S.D.3    Mumy, M.4    Hemmati, P.5    Bagnall, K.6    Merlino, G.7    Wakefield, L.M.8
  • 24
    • 0030727351 scopus 로고    scopus 로고
    • Expression of a truncated, kinase-defective TGF-β type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis
    • Serra, R., Johnson, M., Filvaroff, E. H., LaBorde, J., Sheehan, D. M., Derynck, R., and Moses, H. L. Expression of a truncated, kinase-defective TGF-β type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J. Cell Biol., 139: 541-552, 1997.
    • (1997) J. Cell Biol. , vol.139 , pp. 541-552
    • Serra, R.1    Johnson, M.2    Filvaroff, E.H.3    LaBorde, J.4    Sheehan, D.M.5    Derynck, R.6    Moses, H.L.7
  • 25
    • 0021720781 scopus 로고
    • Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes
    • Stewart, T. A., Pattengale, P. K., and Leder, P. Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes. Cell, 38: 627-637, 1984.
    • (1984) Cell , vol.38 , pp. 627-637
    • Stewart, T.A.1    Pattengale, P.K.2    Leder, P.3
  • 26
  • 27
    • 0025175707 scopus 로고
    • Negative regulation in correct tissue-specific expression of mouse mammary tumor virus in transgenic mice
    • Ross, S. R., Hsu, C-L. L., Choi, Y., Mok, E., and Dudley, J. P. Negative regulation in correct tissue-specific expression of mouse mammary tumor virus in transgenic mice. Mol. Cell. Biol., 10: 5822-5829, 1990.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 5822-5829
    • Ross, S.R.1    Hsu, C.-L.L.2    Choi, Y.3    Mok, E.4    Dudley, J.P.5
  • 28
    • 0025372023 scopus 로고
    • Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice
    • Matsui, Y., Halter, S. A., Holt, J. T., Hogan, B. L. M., and Coffey, R. J., Jr. Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice. Cell, 61: 1147-1156, 1990.
    • (1990) Cell , vol.61 , pp. 1147-1156
    • Matsui, Y.1    Halter, S.A.2    Holt, J.T.3    Hogan, B.L.M.4    Coffey Jr., R.J.5
  • 29
    • 0029006446 scopus 로고
    • Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation
    • Robinson, G. W., McKnight, R. A., Smith, G. H., and Hennighausen, L. Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation. Development (Camb.), 121: 2079-2090, 1995.
    • (1995) Development (Camb.) , vol.121 , pp. 2079-2090
    • Robinson, G.W.1    McKnight, R.A.2    Smith, G.H.3    Hennighausen, L.4
  • 30
    • 0028302990 scopus 로고
    • Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression
    • Sympson, C. J., Talhouk, R. S., Alexander, C. M., Chin, J. R., Clift, S. M., Bissell, M. J., and Werb, Z. Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression. J. Cell Biol., 125: 681-692, 1994.
    • (1994) J. Cell Biol. , vol.125 , pp. 681-692
    • Sympson, C.J.1    Talhouk, R.S.2    Alexander, C.M.3    Chin, J.R.4    Clift, S.M.5    Bissell, M.J.6    Werb, Z.7
  • 31
    • 0028877124 scopus 로고
    • Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development
    • Witty, J. P., Wright, J. H., and Matrisian, L. M. Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development. Mol. Biol. Cell, 6: 1287-1303, 1995.
    • (1995) Mol. Biol. Cell , vol.6 , pp. 1287-1303
    • Witty, J.P.1    Wright, J.H.2    Matrisian, L.M.3
  • 32
    • 0022982416 scopus 로고
    • Isolation of the oncogene and epidermal growth factor-induced transin gene: Complex control in rat fibroblasts
    • Matrisian, L. M., Leroy, P., Ruhlmann, C., Gesnel, M-C., and Breathnach, R. Isolation of the oncogene and epidermal growth factor-induced transin gene: complex control in rat fibroblasts. Mol. Cell. Biol., 6: 1679-1686, 1986.
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 1679-1686
    • Matrisian, L.M.1    Leroy, P.2    Ruhlmann, C.3    Gesnel, M.-C.4    Breathnach, R.5
  • 33
    • 0025344028 scopus 로고
    • TGF-β1 inhibition of transin-stromelysin gene expression is mediated through a fos binding sequence
    • Kerr, L. D., Miller, D. B., and Matrisian, L. M. TGF-β1 inhibition of transin-stromelysin gene expression is mediated through a fos binding sequence. Cell, 61: 267-278, 1990.
    • (1990) Cell , vol.61 , pp. 267-278
    • Kerr, L.D.1    Miller, D.B.2    Matrisian, L.M.3
  • 34
    • 0028229714 scopus 로고
    • Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung
    • Peters, K., Werner, S., Liao, X., Wert, S., Whitsett, J., and Williams, L. Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung. EMBO J., 13: 3296-3301, 1994.
    • (1994) EMBO J. , vol.13 , pp. 3296-3301
    • Peters, K.1    Werner, S.2    Liao, X.3    Wert, S.4    Whitsett, J.5    Williams, L.6
  • 35
    • 0029098931 scopus 로고
    • Molecular analysis of TGFβ signal transduction: Dominant-inhibitory mutations of the type II and type I TGFβ receptor
    • Schneider, M. D., and Brand, T. Molecular analysis of TGFβ signal transduction: dominant-inhibitory mutations of the type II and type I TGFβ receptor. Ann. N. Y. Acad. Sci., 752: 309-316, 1995.
    • (1995) Ann. N. Y. Acad. Sci. , vol.752 , pp. 309-316
    • Schneider, M.D.1    Brand, T.2
  • 36
    • 0028303030 scopus 로고
    • Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-β receptor
    • Filvaroff, E. H., Ebner, R., and Derynck, R. Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-β receptor. Development (Camb.), 120: 1085-1095, 1994.
    • (1994) Development (Camb.) , vol.120 , pp. 1085-1095
    • Filvaroff, E.H.1    Ebner, R.2    Derynck, R.3
  • 39
    • 0027935432 scopus 로고
    • Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg1 and activin: Does activin play a role in mesoderm induction
    • Schulte-Merker, S., Smith, J. C., and Dale, L. Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg1 and activin: does activin play a role in mesoderm induction. EMBO J., 13: 3533-3541, 1994.
    • (1994) EMBO J. , vol.13 , pp. 3533-3541
    • Schulte-Merker, S.1    Smith, J.C.2    Dale, L.3
  • 40
    • 0028176755 scopus 로고
    • Activin/inhibin βB subunit gene disruption leads to defects in eyelid development and female reproduction
    • Vassalli, A., Matzuk, M. M., Gardner, H. A., Lee, K-F., and Jaenisch, R. Activin/inhibin βB subunit gene disruption leads to defects in eyelid development and female reproduction. Genes Dev., 8: 414-427, 1994.
    • (1994) Genes Dev. , vol.8 , pp. 414-427
    • Vassalli, A.1    Matzuk, M.M.2    Gardner, H.A.3    Lee, K.-F.4    Jaenisch, R.5
  • 41
    • 0024366047 scopus 로고
    • TGF-β1 -induced inhibition of mouse mammary ductal growth: Developmental specificity and characterization
    • Daniel, C. W., Silberstein, G. B., Van Horn, K., Strickland, P., and Robinson, S. TGF-β1 -induced inhibition of mouse mammary ductal growth: developmental specificity and characterization. Dev. Biol., 135: 20-30, 1989.
    • (1989) Dev. Biol. , vol.135 , pp. 20-30
    • Daniel, C.W.1    Silberstein, G.B.2    Van Horn, K.3    Strickland, P.4    Robinson, S.5
  • 42
    • 0028300009 scopus 로고
    • Involvement of autocrine mechanism of transforming growth factor-β in the functional differentiation of pregnant mouse mammary gland
    • Yamamoto, T., Komura, H., Morishige, K., Tadokoro, C., Sakata, M., Kurachi, H., and Miyake, A. Involvement of autocrine mechanism of transforming growth factor-β in the functional differentiation of pregnant mouse mammary gland. Acta Endocrinol., 130: 302-307, 1994.
    • (1994) Acta Endocrinol. , vol.130 , pp. 302-307
    • Yamamoto, T.1    Komura, H.2    Morishige, K.3    Tadokoro, C.4    Sakata, M.5    Kurachi, H.6    Miyake, A.7
  • 43
    • 0028172760 scopus 로고
    • Transforming growth factor-β1 inhibits casein secretion from differentiating mammary-gland expiants but not from lactating mammary cells
    • Sudlow, A. W., Wilde, C. J., and Burgoyne, R. D. Transforming growth factor-β1 inhibits casein secretion from differentiating mammary-gland expiants but not from lactating mammary cells. Biochem. J., 304: 333-336, 1994.
    • (1994) Biochem. J. , vol.304 , pp. 333-336
    • Sudlow, A.W.1    Wilde, C.J.2    Burgoyne, R.D.3
  • 44
    • 0025302390 scopus 로고
    • Epithelium-dependent extracellular matrix synthesis in transforming growth factor-β1-growth-inhibited mouse mammary gland
    • Silberstein, G. B., Strickland, P., Coleman, S., and Daniel, C. W. Epithelium-dependent extracellular matrix synthesis in transforming growth factor-β1-growth-inhibited mouse mammary gland. J. Cell Biol., 110: 2209-2219, 1990.
    • (1990) J. Cell Biol. , vol.110 , pp. 2209-2219
    • Silberstein, G.B.1    Strickland, P.2    Coleman, S.3    Daniel, C.W.4
  • 45
    • 0026661308 scopus 로고
    • Regulation of mammary morphogenesis: Evidence for extracellular matrix-mediated inhibition of ductal budding by transforming growth factor-β1
    • Silberstein, G. B., Flanders, K. C., Roberts, A. B., and Daniel, C. W. Regulation of mammary morphogenesis: evidence for extracellular matrix-mediated inhibition of ductal budding by transforming growth factor-β1. Dev. Biol., 152: 354-362, 1992.
    • (1992) Dev. Biol. , vol.152 , pp. 354-362
    • Silberstein, G.B.1    Flanders, K.C.2    Roberts, A.B.3    Daniel, C.W.4
  • 46
    • 0028787260 scopus 로고
    • Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation
    • Jones, C. M., Kuehn, M. R., Hogan, B. L. M., Smith, J. C., and Wright, C. V. E. Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. Development (Camb.), 121: 3651-3662, 1995.
    • (1995) Development (Camb.) , vol.121 , pp. 3651-3662
    • Jones, C.M.1    Kuehn, M.R.2    Hogan, B.L.M.3    Smith, J.C.4    Wright, C.V.E.5
  • 47
    • 0029056909 scopus 로고
    • Extracellular matrix regulates whey acidic protein gene expression by suppression of TGF-a in mouse mammary epithelial cells: Studies in culture and in transgenic mice
    • Lin, C. Q., Dempsey, P. J., Coffey, R. J., and Bissell, M. J. Extracellular matrix regulates whey acidic protein gene expression by suppression of TGF-a in mouse mammary epithelial cells: studies in culture and in transgenic mice. J. Cell Biol., 129: 1115-1126, 1995.
    • (1995) J. Cell Biol. , vol.129 , pp. 1115-1126
    • Lin, C.Q.1    Dempsey, P.J.2    Coffey, R.J.3    Bissell, M.J.4
  • 48
    • 0028986768 scopus 로고
    • Ectopic TGFβ1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population
    • Kordon, E. C., McKnight, R. A., Jhappan, C., Hennighausen, L., Merlino, G., and Smith, G. H. Ectopic TGFβ1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population. Dev. Biol., 168: 47-61, 1995.
    • (1995) Dev. Biol. , vol.168 , pp. 47-61
    • Kordon, E.C.1    McKnight, R.A.2    Jhappan, C.3    Hennighausen, L.4    Merlino, G.5    Smith, G.H.6
  • 49
    • 0028826282 scopus 로고
    • Cloning and sequencing of the murine farnesyltransferase a-encoding cDNA from a cell line which expresses the human papilloma-virus type-16 E6 gene
    • Shirasawa, H., Kinoshita, T., Shino, Y., Mori, K., Shimizu, K., and Simizu, B. Cloning and sequencing of the murine farnesyltransferase a-encoding cDNA from a cell line which expresses the human papilloma-virus type-16 E6 gene. Gene, 164: 373-374, 1995.
    • (1995) Gene , vol.164 , pp. 373-374
    • Shirasawa, H.1    Kinoshita, T.2    Shino, Y.3    Mori, K.4    Shimizu, K.5    Simizu, B.6
  • 51
    • 84916265276 scopus 로고
    • Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal
    • Cohen, S. Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. J. Biol. Chem., 237: 1555-1562, 1962.
    • (1962) J. Biol. Chem. , vol.237 , pp. 1555-1562
    • Cohen, S.1
  • 52
    • 0025297086 scopus 로고
    • Overexpression of TGF-a in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast
    • Sandgren, E. P., Luetteke, N. C., Palmiter, R. D., Brinster, R. L., and Lee, D. C. Overexpression of TGF-a in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell, 61: 1121-1136, 1990.
    • (1990) Cell , vol.61 , pp. 1121-1136
    • Sandgren, E.P.1    Luetteke, N.C.2    Palmiter, R.D.3    Brinster, R.L.4    Lee, D.C.5
  • 53
    • 0025341727 scopus 로고
    • TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas
    • Jhappan, C., Stahle, C., Harkins, R. N., Fausto, N., Smith, G. M., and Merlino, G. T. TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell, 61: 1137-1146, 1990.
    • (1990) Cell , vol.61 , pp. 1137-1146
    • Jhappan, C.1    Stahle, C.2    Harkins, R.N.3    Fausto, N.4    Smith, G.M.5    Merlino, G.T.6
  • 57
    • 0016700864 scopus 로고
    • Detection of specific sequences among DNA fragments separated by gel electrophoresis
    • Southern, E. M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol., 98: 503-517, 1975.
    • (1975) J. Mol. Biol. , vol.98 , pp. 503-517
    • Southern, E.M.1
  • 58
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction
    • Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 59
    • 0019876486 scopus 로고
    • Construction and preliminary characterization of the rat casein and a-lactalbumin cDNA clones
    • Richards, D. A., Rodgers, J. R., Supowit, S. C., and Rosen, J. M. Construction and preliminary characterization of the rat casein and a-lactalbumin cDNA clones. J. Biol. Chem., 256: 526-532, 1981.
    • (1981) J. Biol. Chem. , vol.256 , pp. 526-532
    • Richards, D.A.1    Rodgers, J.R.2    Supowit, S.C.3    Rosen, J.M.4
  • 60
    • 0025132988 scopus 로고
    • In situ hybridization analysis of TGF-β3 RNA expression during mouse development: Comparative studies with TGF-β1 and -β2
    • Pelton, R. W., Dickinson, M. E., Moses, H. L., and Hogan, B. L. M. In situ hybridization analysis of TGF-β3 RNA expression during mouse development: comparative studies with TGF-β1 and -β2. Development (Camb.), 110: 600-620, 1990.
    • (1990) Development (Camb.) , vol.110 , pp. 600-620
    • Pelton, R.W.1    Dickinson, M.E.2    Moses, H.L.3    Hogan, B.L.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.