Alzheimer's Aβ vaccination of rhesus monkeys (Macaca mulatta)

Mechanisms of Ageing and Development

Volumn 125, Issue 2, 2004, Pages 149-151

  Gandy, Sam ^a   DeMattos, Ron B ^b   Lemere, Cynthia A ^c   Heppner, Frank L ^d   Leverone, Jodi ^c   Aguzzi, Adriano ^d   Ershler, William B ^e   Dai, Jinlu ^f   Fraser, Paul ^g   St George Hyslop, Peter ^g   Holtzman, David M ^b   Walker, Lary C ^h   Keller, Evan T ^f  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e Inst for the Adv Studs in Aging   (United States)

^f UNIVERSITY OF MICHIGAN   (United States)

^g UNIVERSITY OF TORONTO   (Canada)

^h EMORY UNIVERSITY   (United States)

Author keywords

Alzheimer's vaccination; Alzheimers; Immunization; Rhesus monkey

Indexed keywords

ALZHEIMER DISEASE VACCINE; AMYLIN; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; PROTEIN ANTIBODY; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA-PROTEIN (1-42); ANTIBODY; PEPTIDE FRAGMENT; VACCINE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY TITER; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BLOOD LEVEL; IMMUNIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; RHESUS MONKEY; SPECIES; VACCINATION; AGING; ANIMAL; ARTICLE; BLOOD; FEMALE; IMMUNOLOGY; MACACA;

MACACA MULATTA; PRIMATES;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ANTIBODIES; FEMALE; MACACA MULATTA; PEPTIDE FRAGMENTS; VACCINES;

EID: 4644291447     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2003.12.002     Document Type: Conference Paper

References (4)

1. DeMattos R.B., Bales K.R., Cummins D.J., Dodart J.C., Paul S.M., Holtzman D.M. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 98(15):2001;8850-8855.
2. Hock, C., Konietzko, U., Streffer, J.R., Tracy, J., Signorelli, A., Muller-Tillmans, B., Lemke, U., Henke, K., Moritz, E., Garcia, E., Wollmer, M.A., Umbricht, D., de Quervain, D.J.F., Hofmann, M., Maddalena, A., Papassotiropoulos, Nitsch, R., 2003. Antibodies against β-amyloid slow cognitive decline in Alzheimer's disease. Neuron 38, 547-554.
3. Janus C., Pearson J., McLaurin J., Mathews P.M., Jiang Y., Schmidt S.D., Chishti M.A., Horne P., Heslin D., French J., Mount H.T., Nixon R.A., Mercken M., Bergeron C., Fraser P.E., St. George Hyslop P., Westaway D. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 8(6815):2000;979-9832.
4. Walker, L.C., Cork, L.C., 1999. The neurobiology of aging in nonhuman primates. In: Terry, R.D., et al. (Eds.), Alzheimer's Disease. Lippincott, Williams & Wilkins, Philadelphia PA, pp. 233-243.