Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina

Journal of Biological Chemistry

Volumn 283, Issue 15, 2008, Pages 9543-9554

  Golczak, Marcin ^a   Maeda, Akiko ^a   Bereta, Grzegorz ^a   Maeda, Tadao ^a   Kiser, Philip D ^a   Hunzelmann, Silke ^a,b   Von Lintig, Johannes ^b   Blaner, William S ^c   Palczewski, Krzysztof ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF FREIBURG   (Germany)

^c Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION; AMINES; BIOCHEMISTRY; LIGHT; PHOSPHOLIPIDS; PHOTOISOMERIZATION; PLANTS (BOTANY);

BINDING PROTEINS; CELLULAR TOXICITIES; GENE PRODUCTS; GENES ENCODING; IN-VIVO; ISOMERASE; LECITHIN:RETINOL ACYLTRANSFERASE; LONG LASTINGS; METABOLIC SYSTEMS; PRIMARY AMINES; REACTIVE NUCLEOPHILES; RETINAL PHOTORECEPTORS; RETINOIC ACIDS; RETINOID; SHORT DURATIONS; SPECIFIC ABSORPTIONS; SPECIFIC INHIBITORS; THERAPEUTIC EFFECTS; TRANS ISOMERS; VERTEBRATE RETINAS; VISUAL CYCLES; WIDE SPECTRUMS;

ALDEHYDES;

13,17,21 TRIMETHYLDOCOSA 12,16,20 TRIEN 11 ONE; FARNESYLAMINE; FENRETINIDE; ISOMERASE; ISOPRENOID; ISOTRETINOIN; N HEXADECYL 3,7,11 TRIMETHYLDODECA 2,6,10 TRIENAMINE; PHOSPHATIDYLCHOLINE; RETINOIC ACID; RETINOID; RETINOID DERIVATIVE; RETINOL ACYLTRANSFERASE; RETINOL BINDING PROTEIN; RETINYLAMINE; UNCLASSIFIED DRUG; CARRIER PROTEIN; CIS TRANS ISOMERASE; DITERPENE; DRUG DERIVATIVE; ENZYME INHIBITOR; EYE PROTEIN; FARNESOL; RETINAL; RETINOL ISOMERASE; RHODOPSIN; RPE65 PROTEIN, MOUSE;

AMINE TRANSPORT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; VISION; ABSORPTION; ANIMAL; ANTIBODY SPECIFICITY; CELL STRAIN 3T3; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM; MOUSE; MOUSE MUTANT; PHOTORECEPTOR; TRANSPORT AT THE CELLULAR LEVEL; VISUAL DISORDER;

VERTEBRATA;

ABSORPTION; ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CIS-TRANS-ISOMERASES; DITERPENES; ENZYME INHIBITORS; EYE PROTEINS; FARNESOL; MICE; MICE, KNOCKOUT; NIH 3T3 CELLS; ORGAN SPECIFICITY; PHOTORECEPTORS, VERTEBRATE; RETINALDEHYDE; RHODOPSIN; VISION; VISION DISORDERS;

EID: 44349161777     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708982200     Document Type: Article

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