Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formation

Biochemistry

Volumn 45, Issue 3, 2006, Pages 852-860

  Maiti, Pranab ^a   Kong, Jian ^b   Kim, So Ra ^b   Sparrow, Janet R ^b,c   Allikmets, Rando ^b,c   Rando, Robert R ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c NewYork Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BYPRODUCTS; CHROMOPHORES; DISEASE CONTROL; MATHEMATICAL MODELS; MOLECULES; RISK ASSESSMENT;

MACULAR DEGENERATION; RATE-LIMITING STEPS; RETINAL PIGMENT EPITHELIAL (RPE) CELLS; VISUAL CYCLE;

PIGMENTS;

11 CIS RETINAL; 13,17,21 TRIMETHYLDOCOSA 12,16,20 TRIEN 11 ONE; 3,7,11 TRIMETHYLDODECA 2,6,10 TRIENOIC ACID HEXADECYLAMIDE; ISOPRENOID; ISOTRETINOIN; LIPOFUSCIN; PROTEIN; PROTEIN RPE65; RHODOPSIN; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RETINA MACULA DEGENERATION; STARGARDT DISEASE; STRUCTURE ACTIVITY RELATION; VISION;

AMIDES; ANIMALS; CARRIER PROTEINS; CATTLE; EYE PROTEINS; GENE EXPRESSION REGULATION; ISOTRETINOIN; KETONES; LIPOFUSCIN; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; VISION;

ANIMALIA;

EID: 31044444376     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0518545     Document Type: Article

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