메뉴 건너뛰기




Volumn 105, Issue 19, 2008, Pages 7016-7021

Identification of innate immunity genes and pathways using a comparative genomics approach

Author keywords

Caenorhabditis elegans; Macrophage

Indexed keywords

ACY1 GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CAENORHABDITIS ELEGANS; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; GENE; HOST RESISTANCE; IMMUNOREGULATION; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; TBC1 GENE; TUB2 GENE; ANIMAL; CHROMOSOME; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENETICS; GENOMICS; METABOLISM; METHODOLOGY; MUTATION; PROTEIN ANALYSIS; RNA INTERFERENCE; SEQUENCE HOMOLOGY;

EID: 44349138378     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0802405105     Document Type: Article
Times cited : (69)

References (62)
  • 3
    • 5444254408 scopus 로고    scopus 로고
    • Toll-like receptors in the pathogenesis of human disease
    • Cook DN, Pisetsky DS, Schwartz DA (2004) Toll-like receptors in the pathogenesis of human disease. Nat Immunol 5:975-979.
    • (2004) Nat Immunol , vol.5 , pp. 975-979
    • Cook, D.N.1    Pisetsky, D.S.2    Schwartz, D.A.3
  • 4
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • Takeda K, Akira S (2005) Toll-like receptors in innate immunity. Int Immunol 17:1-14.
    • (2005) Int Immunol , vol.17 , pp. 1-14
    • Takeda, K.1    Akira, S.2
  • 5
    • 33750574752 scopus 로고    scopus 로고
    • TLR signaling pathways: Opportunities for activation and blockade in pursuit of therapy
    • Hoebe K, et al. (2006) TLR signaling pathways: Opportunities for activation and blockade in pursuit of therapy. Curr Pharm Des 12:4123-4134.
    • (2006) Curr Pharm Des , vol.12 , pp. 4123-4134
    • Hoebe, K.1
  • 7
    • 33750542135 scopus 로고    scopus 로고
    • Toll gates for future immunotherapy
    • Ishii KJ, Uematsu S, Akira S (2006) "Toll" gates for future immunotherapy. Curr Pharm Des 12:4135-4142.
    • (2006) Curr Pharm Des , vol.12 , pp. 4135-4142
    • Ishii, K.J.1    Uematsu, S.2    Akira, S.3
  • 8
    • 0042493163 scopus 로고    scopus 로고
    • Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases
    • O'Neill LA (2003) Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases. Curr Opin Pharmacol 3:396-403.
    • (2003) Curr Opin Pharmacol , vol.3 , pp. 396-403
    • O'Neill, L.A.1
  • 9
    • 0042303835 scopus 로고    scopus 로고
    • Spotlight on new anti-inflammatory drug targets in the immune system
    • Ward SG, O'Neill LA (2003) Spotlight on new anti-inflammatory drug targets in the immune system. Curr Opin Pharmacol 3:391-395.
    • (2003) Curr Opin Pharmacol , vol.3 , pp. 391-395
    • Ward, S.G.1    O'Neill, L.A.2
  • 10
    • 33749366706 scopus 로고    scopus 로고
    • Transcriptional response to endotoxin reveals role for interferon γ in lung neutrophil recruitment
    • Burch LH, et al. (2006) Transcriptional response to endotoxin reveals role for interferon γ in lung neutrophil recruitment. Am J Physiol Lung Cell Mol Physiol 291:L677-L682.
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.291
    • Burch, L.H.1
  • 11
    • 27144509163 scopus 로고    scopus 로고
    • A network-based analysis of systemic inflammation in humans
    • Calvano SE, et al. (2005) A network-based analysis of systemic inflammation in humans. Nature 437:1032-1037.
    • (2005) Nature , vol.437 , pp. 1032-1037
    • Calvano, S.E.1
  • 12
    • 2642568384 scopus 로고    scopus 로고
    • Genetic regulation of endotoxin-induced airway disease
    • Cook DN, et al. (2004) Genetic regulation of endotoxin-induced airway disease. Genomics 83:961-969.
    • (2004) Genomics , vol.83 , pp. 961-969
    • Cook, D.N.1
  • 13
    • 33749152085 scopus 로고    scopus 로고
    • Toll-like receptors: From the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity
    • Doyle SL, O'Neill LA (2006) Toll-like receptors: From the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity. Biochem Pharmacol 72:1102-1113.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1102-1113
    • Doyle, S.L.1    O'Neill, L.A.2
  • 14
    • 19344370696 scopus 로고    scopus 로고
    • Functional dissection of an innate immune response by a genome-wide RNAi screen
    • Foley E, O'Farrell PH (2004) Functional dissection of an innate immune response by a genome-wide RNAi screen. PLoS Biol 2:E203.
    • (2004) PLoS Biol , vol.2
    • Foley, E.1    O'Farrell, P.H.2
  • 15
    • 33748136556 scopus 로고    scopus 로고
    • Genetic analysis of innate immunity
    • Hoebe K, et al. (2006) Genetic analysis of innate immunity. Adv Immunol 91:175-227.
    • (2006) Adv Immunol , vol.91 , pp. 175-227
    • Hoebe, K.1
  • 16
    • 9244230604 scopus 로고    scopus 로고
    • Transcriptional profiling of lipopolysaccharide-induced acute lung injury
    • Jeyaseelan S, Chu HW, Young SK, Worthen GS (2004) Transcriptional profiling of lipopolysaccharide-induced acute lung injury. Infect Immun 72:7247-7256.
    • (2004) Infect Immun , vol.72 , pp. 7247-7256
    • Jeyaseelan, S.1    Chu, H.W.2    Young, S.K.3    Worthen, G.S.4
  • 17
    • 3142691844 scopus 로고    scopus 로고
    • The road to Toll
    • Lemaitre B (2004) The road to Toll. Nat Rev Immunol 4:521-527.
    • (2004) Nat Rev Immunol , vol.4 , pp. 521-527
    • Lemaitre, B.1
  • 18
    • 7644240681 scopus 로고    scopus 로고
    • TLRs: Professor Mechnikov, sit on your hat
    • O'Neill LA (2004) TLRs: Professor Mechnikov, sit on your hat. Trends Immunol 25:687-693.
    • (2004) Trends Immunol , vol.25 , pp. 687-693
    • O'Neill, L.A.1
  • 19
    • 2442587841 scopus 로고    scopus 로고
    • Differential gene expression in gram-negative and gram-positive sepsis
    • Yu SL, et al. (2004) Differential gene expression in gram-negative and gram-positive sepsis. Am J Respir Crit Care Med 169:1135-1143.
    • (2004) Am J Respir Crit Care Med , vol.169 , pp. 1135-1143
    • Yu, S.L.1
  • 21
    • 0037162295 scopus 로고    scopus 로고
    • Inducible antibacterial defense system in C. elegans
    • Mallo GV, et al. (2002) Inducible antibacterial defense system in C. elegans. Curr Biol 12:1209-1214.
    • (2002) Curr Biol , vol.12 , pp. 1209-1214
    • Mallo, G.V.1
  • 22
    • 0037448540 scopus 로고    scopus 로고
    • Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
    • Kamath RS, et al. (2003) Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421:231-237.
    • (2003) Nature , vol.421 , pp. 231-237
    • Kamath, R.S.1
  • 23
    • 2442664007 scopus 로고    scopus 로고
    • TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM
    • Couillault C, et al. (2004) TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM. Nat Immunol 5:488-494.
    • (2004) Nat Immunol , vol.5 , pp. 488-494
    • Couillault, C.1
  • 24
    • 44449150730 scopus 로고    scopus 로고
    • Ewbank JJ (2006) Signaling in the immune response. WormBook, ed The C. elegans Research Community. Available at www.wormbook.org.
    • Ewbank JJ (2006) Signaling in the immune response. WormBook, ed The C. elegans Research Community. Available at www.wormbook.org.
  • 25
    • 0037178731 scopus 로고    scopus 로고
    • A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity
    • Kim DH, et al. (2002) A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science 297:623-626.
    • (2002) Science , vol.297 , pp. 623-626
    • Kim, D.H.1
  • 26
    • 2342475724 scopus 로고    scopus 로고
    • Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response
    • Liberati NT, et al. (2004) Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. Proc Natl Acad Sci USA 101:6593-6598.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6593-6598
    • Liberati, N.T.1
  • 27
    • 0035811018 scopus 로고    scopus 로고
    • A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans
    • Pujol N, et al. (2001) A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans. Curr Biol 11:809-821.
    • (2001) Curr Biol , vol.11 , pp. 809-821
    • Pujol, N.1
  • 28
    • 9144264169 scopus 로고    scopus 로고
    • A map of the interactome network of the metazoan C elegans
    • Li S, et al. (2004) A map of the interactome network of the metazoan C elegans. Science 303:540-543.
    • (2004) Science , vol.303 , pp. 540-543
    • Li, S.1
  • 29
    • 0345600247 scopus 로고    scopus 로고
    • A protein interaction map of Drosophila melanogaster
    • Giot L, et al. (2003) A protein interaction map of Drosophila melanogaster. Science 302:1727-1736.
    • (2003) Science , vol.302 , pp. 1727-1736
    • Giot, L.1
  • 30
    • 3242685944 scopus 로고    scopus 로고
    • Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositolanchored protein from the Golgi to the cell periphery
    • Kakinuma T, Ichikawa H, Tsukada Y, Nakamura T, Toh BH (2004) Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositolanchored protein from the Golgi to the cell periphery. Exp Cell Res 298:388-398.
    • (2004) Exp Cell Res , vol.298 , pp. 388-398
    • Kakinuma, T.1    Ichikawa, H.2    Tsukada, Y.3    Nakamura, T.4    Toh, B.H.5
  • 31
    • 0031882496 scopus 로고    scopus 로고
    • A genetic screen to identify components of the sina signaling pathway in Drosophila eye development
    • Neufeld TP, Tang AH, Rubin GM (1998) A genetic screen to identify components of the sina signaling pathway in Drosophila eye development. Genetics 148:277-286.
    • (1998) Genetics , vol.148 , pp. 277-286
    • Neufeld, T.P.1    Tang, A.H.2    Rubin, G.M.3
  • 32
    • 0030849728 scopus 로고    scopus 로고
    • PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism
    • Tang AH, Neufeld TP, Kwan E, Rubin GM (1997) PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism. Cell 90:459-467.
    • (1997) Cell , vol.90 , pp. 459-467
    • Tang, A.H.1    Neufeld, T.P.2    Kwan, E.3    Rubin, G.M.4
  • 33
    • 0036143826 scopus 로고    scopus 로고
    • Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling
    • Polekhina G, et al. (2002) Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling. Nat Struct Biol 9:68-75.
    • (2002) Nat Struct Biol , vol.9 , pp. 68-75
    • Polekhina, G.1
  • 34
    • 33748871187 scopus 로고    scopus 로고
    • The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
    • Carty M, et al. (2006) The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nat Immunol 7:1074-1081.
    • (2006) Nat Immunol , vol.7 , pp. 1074-1081
    • Carty, M.1
  • 35
    • 2442650484 scopus 로고    scopus 로고
    • cC1q-R (calreticulin) and gC1q-R/p33: Ubiquitously expressed multi-ligand binding cellular proteins involved in inflammation and infection
    • Ghebrehiwet B, Peerschke EI (2004) cC1q-R (calreticulin) and gC1q-R/p33: Ubiquitously expressed multi-ligand binding cellular proteins involved in inflammation and infection. Mol Immunol 41:173-183.
    • (2004) Mol Immunol , vol.41 , pp. 173-183
    • Ghebrehiwet, B.1    Peerschke, E.I.2
  • 36
    • 0037290876 scopus 로고    scopus 로고
    • Mammalian Toll-like receptors
    • Akira S (2003) Mammalian Toll-like receptors. Curr Opin Immunol 15:5-11.
    • (2003) Curr Opin Immunol , vol.15 , pp. 5-11
    • Akira, S.1
  • 37
    • 0742324860 scopus 로고    scopus 로고
    • TLR signaling pathways
    • Takeda K, Akira S (2004) TLR signaling pathways. Semin Immunol 16:3-9.
    • (2004) Semin Immunol , vol.16 , pp. 3-9
    • Takeda, K.1    Akira, S.2
  • 38
    • 34748826813 scopus 로고    scopus 로고
    • Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade
    • Kurz CL, Shapira M, Chen K, Baillie DL, Tan MW (2007) Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade. Biochem Biophys Res Comm 363:438-443.
    • (2007) Biochem Biophys Res Comm , vol.363 , pp. 438-443
    • Kurz, C.L.1    Shapira, M.2    Chen, K.3    Baillie, D.L.4    Tan, M.W.5
  • 39
    • 33751118764 scopus 로고    scopus 로고
    • Short communication: Differences between macrophages and dendritic cells in the cyclic AMP-dependent regulation of lipopolysaccharide-induced cytokine and chemokine synthesis
    • Aronoff DM, Carstens JK, Chen GH, Toews GB, Peters-Golden M (2006) Short communication: Differences between macrophages and dendritic cells in the cyclic AMP-dependent regulation of lipopolysaccharide-induced cytokine and chemokine synthesis. J Interferon Cytokine Res 26:827-833.
    • (2006) J Interferon Cytokine Res , vol.26 , pp. 827-833
    • Aronoff, D.M.1    Carstens, J.K.2    Chen, G.H.3    Toews, G.B.4    Peters-Golden, M.5
  • 40
    • 0025431173 scopus 로고
    • Differential regulation of IL 6, IL 1 A, IL 1 beta and TNF alpha production in LPS-stimulated human monocytes: Role of cyclic AMP
    • Bailly S, Ferrua B, Fay M, Gougerot-Pocidalo MA (1990) Differential regulation of IL 6, IL 1 A, IL 1 beta and TNF alpha production in LPS-stimulated human monocytes: Role of cyclic AMP. Cytokine 2:205-210.
    • (1990) Cytokine , vol.2 , pp. 205-210
    • Bailly, S.1    Ferrua, B.2    Fay, M.3    Gougerot-Pocidalo, M.A.4
  • 41
    • 27744450703 scopus 로고    scopus 로고
    • Effects of forskolin on Kupffer cell production of interleukin-10 and tumor necrosis factor alpha differ from those of endogenous adenylyl cyclase activators: Possible role for adenylyl cyclase 9
    • Dahle MK, Myhre AE, Aasen AO, Wang JE (2005) Effects of forskolin on Kupffer cell production of interleukin-10 and tumor necrosis factor alpha differ from those of endogenous adenylyl cyclase activators: Possible role for adenylyl cyclase 9. Infect Immun 73:7290-7296.
    • (2005) Infect Immun , vol.73 , pp. 7290-7296
    • Dahle, M.K.1    Myhre, A.E.2    Aasen, A.O.3    Wang, J.E.4
  • 42
    • 0025905301 scopus 로고
    • Differential regulation of Interleukin-6, macrophage inflammatory protein-1, and JE/MCP-1 cytokine expression in macrophage cell lines
    • Martin CA, Dorf MA (1991) Differential regulation of Interleukin-6, macrophage inflammatory protein-1, and JE/MCP-1 cytokine expression in macrophage cell lines. Cell Immunol 135:245-258.
    • (1991) Cell Immunol , vol.135 , pp. 245-258
    • Martin, C.A.1    Dorf, M.A.2
  • 43
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124:783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 44
    • 0036144763 scopus 로고    scopus 로고
    • Regulatory functions of ubiquitination in the immune system
    • Ben-Neriah Y (2002) Regulatory functions of ubiquitination in the immune system. Nat Immunol 3:20-26.
    • (2002) Nat Immunol , vol.3 , pp. 20-26
    • Ben-Neriah, Y.1
  • 45
    • 33750443289 scopus 로고    scopus 로고
    • IkappaB kinase complexes: Gateways to NF-kappaB activation and transcription
    • Scheidereit C (2006) IkappaB kinase complexes: Gateways to NF-kappaB activation and transcription. Oncogene 25:6685-6705.
    • (2006) Oncogene , vol.25 , pp. 6685-6705
    • Scheidereit, C.1
  • 46
    • 0034984663 scopus 로고    scopus 로고
    • Mif1: A missing link between the unfolded protein response pathway and ER-associated protein degradation?
    • van Laar T, van der Eb AJ, Terleth C (2001) Mif1: A missing link between the unfolded protein response pathway and ER-associated protein degradation? Curr Protein Pept Sci 2:169-190.
    • (2001) Curr Protein Pept Sci , vol.2 , pp. 169-190
    • van Laar, T.1    van der Eb, A.J.2    Terleth, C.3
  • 47
    • 0030016595 scopus 로고    scopus 로고
    • Structure and functions of the 20S and 26S proteasomes
    • Coux O, Tanaka K, Goldberg AL (1996) Structure and functions of the 20S and 26S proteasomes. Annu Rev Biochem 65:801-847.
    • (1996) Annu Rev Biochem , vol.65 , pp. 801-847
    • Coux, O.1    Tanaka, K.2    Goldberg, A.L.3
  • 48
    • 33847188791 scopus 로고    scopus 로고
    • NF-kappaB inhibitors for the treatment of inflammatory diseases and cancer
    • Calzado MA, Bacher S, Schmitz ML (2007) NF-kappaB inhibitors for the treatment of inflammatory diseases and cancer. Curr Med Chem 14:367-376.
    • (2007) Curr Med Chem , vol.14 , pp. 367-376
    • Calzado, M.A.1    Bacher, S.2    Schmitz, M.L.3
  • 49
    • 0037569481 scopus 로고    scopus 로고
    • Proteasome inhibition: A new antiinflammatory strategy
    • Elliott PJ, Zollner TM, Boehncke WH (2003) Proteasome inhibition: A new antiinflammatory strategy. J Mol Med 81:235-245.
    • (2003) J Mol Med , vol.81 , pp. 235-245
    • Elliott, P.J.1    Zollner, T.M.2    Boehncke, W.H.3
  • 50
    • 34250011799 scopus 로고    scopus 로고
    • The ubiquitin-proteasome system and its role in inflammatory and autoimmune diseases
    • Wang J, Maldonado MA (2006) The ubiquitin-proteasome system and its role in inflammatory and autoimmune diseases. Cell Mol Immunol 3:255-261.
    • (2006) Cell Mol Immunol , vol.3 , pp. 255-261
    • Wang, J.1    Maldonado, M.A.2
  • 51
    • 0016685474 scopus 로고
    • Phagocytosis and cytolysis by a macrophage tumour and its cloned cell line
    • Ralph P, Nakoinz I (1975) Phagocytosis and cytolysis by a macrophage tumour and its cloned cell line. Nature 257:393-394.
    • (1975) Nature , vol.257 , pp. 393-394
    • Ralph, P.1    Nakoinz, I.2
  • 53
    • 0141552295 scopus 로고    scopus 로고
    • Gene silencing by systemic delivery of synthetic siRNAs in adult mice
    • Sorensen DR, Leirdal M, Sioud M (2003) Gene silencing by systemic delivery of synthetic siRNAs in adult mice. J Mol Biol 327:761-766.
    • (2003) J Mol Biol , vol.327 , pp. 761-766
    • Sorensen, D.R.1    Leirdal, M.2    Sioud, M.3
  • 54
    • 0029035765 scopus 로고
    • Common virulence factors for bacterial pathogenicity in plants and animals
    • Rahme LG, et al. (1995) Common virulence factors for bacterial pathogenicity in plants and animals. Science 268:1899-1902.
    • (1995) Science , vol.268 , pp. 1899-1902
    • Rahme, L.G.1
  • 55
    • 0018346542 scopus 로고
    • Synchronous growth and aging of Caenorhabditis elegans in the presence of fluorodeoxyuridine
    • Mitchell DH, Stiles JW, Santelli J, Sanadi DR (1979) Synchronous growth and aging of Caenorhabditis elegans in the presence of fluorodeoxyuridine. J Gerontol 34:28-36.
    • (1979) J Gerontol , vol.34 , pp. 28-36
    • Mitchell, D.H.1    Stiles, J.W.2    Santelli, J.3    Sanadi, D.R.4
  • 56
    • 33749014641 scopus 로고    scopus 로고
    • A conserved role for a GATA transcription factor in regulating epithelial innate immune responses
    • Shapira M, et al. (2006) A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Proc Natl Acad Sci USA 103:14086-14091.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 14086-14091
    • Shapira, M.1
  • 57
    • 33746617003 scopus 로고    scopus 로고
    • Extracting gene networks for low-dose radiation using graph theoretical algorithms
    • Voy BH, et al. (2006) Extracting gene networks for low-dose radiation using graph theoretical algorithms. PLoS Comput Biol 2:e89.
    • (2006) PLoS Comput Biol , vol.2
    • Voy, B.H.1
  • 58
    • 22244458539 scopus 로고    scopus 로고
    • Single-nucleotide polymorphisms associated with symptomatic infection and differential human gene expression in healthy seropositive persons each implicate the cytoskeleton, integrin signaling, and oncosuppression in the pathogenesis of human parvovirus B19 infection
    • Kerr JR, et al. (2005) Single-nucleotide polymorphisms associated with symptomatic infection and differential human gene expression in healthy seropositive persons each implicate the cytoskeleton, integrin signaling, and oncosuppression in the pathogenesis of human parvovirus B19 infection. J Infect Dis 192:276-286.
    • (2005) J Infect Dis , vol.192 , pp. 276-286
    • Kerr, J.R.1
  • 59
    • 12144289400 scopus 로고    scopus 로고
    • A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
    • Bouwmeester T, et al. (2004) A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol 6:97-105.
    • (2004) Nat Cell Biol , vol.6 , pp. 97-105
    • Bouwmeester, T.1
  • 60
    • 4444229437 scopus 로고    scopus 로고
    • -/- mice leads to chronic hepatic inflammation and failure of liver regeneration
    • -/- mice leads to chronic hepatic inflammation and failure of liver regeneration. Nat Genet 36:969-977.
    • (2004) Nat Genet , vol.36 , pp. 969-977
    • Mohammed, F.F.1
  • 61
    • 30744471132 scopus 로고    scopus 로고
    • Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation
    • Smookler DS, et al. (2006) Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation. J Immunol 176:721-725.
    • (2006) J Immunol , vol.176 , pp. 721-725
    • Smookler, D.S.1
  • 62
    • 21144460742 scopus 로고    scopus 로고
    • Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression
    • Halaschek-Wiener J, et al. (2005) Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression. Genome Res 15:603-615.
    • (2005) Genome Res , vol.15 , pp. 603-615
    • Halaschek-Wiener, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.