-
1
-
-
0034820022
-
1 phase: A promising target for the development of new chemotherapeutic anticancer agents
-
1 phase: A promising target for the development of new chemotherapeutic anticancer agents. Curr Med Chem 2001; 8: 1487-503.
-
(2001)
Curr Med Chem
, vol.8
, pp. 1487-1503
-
-
Owa, T.1
Yoshino, H.2
Yoshimatsu, K.3
Nagasu, T.4
-
2
-
-
0029849620
-
Cancer cell cycles
-
Sherr JC. Cancer cell cycles. Science 1993; 274: 1672-7.
-
(1993)
Science
, vol.274
, pp. 1672-1677
-
-
Sherr, J.C.1
-
3
-
-
0033377979
-
Control of the cell cycle and apoptosis
-
Lundberg AS, Weinberg RA. Control of the cell cycle and apoptosis. Eur J Cancer 1999; 35: 1886-94.
-
(1999)
Eur J Cancer
, vol.35
, pp. 1886-1894
-
-
Lundberg, A.S.1
Weinberg, R.A.2
-
4
-
-
0029417832
-
The role of cyclin E in the regulation of entry into the S phase
-
Sauer K, Lehner CF. The role of cyclin E in the regulation of entry into the S phase. Prog Cell Cycle Res 1995; 1: 125-39.
-
(1995)
Prog Cell Cycle Res
, vol.1
, pp. 125-139
-
-
Sauer, K.1
Lehner, C.F.2
-
5
-
-
0026719782
-
Novel sulfonamides as potential, systemically active antitumor agents
-
Yoshino H, Ueda N, Niijma J, et al. Novel sulfonamides as potential, systemically active antitumor agents. J Med Chem 1992; 35: 2496-7.
-
(1992)
J Med Chem
, vol.35
, pp. 2496-2497
-
-
Yoshino, H.1
Ueda, N.2
Niijma, J.3
-
6
-
-
0016912115
-
Relations between structure and biological activity of sulfonamides
-
Maren TH. Relations between structure and biological activity of sulfonamides. Annu Rev Pharmacol 1976; 16: 309-27.
-
(1976)
Annu Rev Pharmacol
, vol.16
, pp. 309-327
-
-
Maren, T.H.1
-
7
-
-
0030756156
-
Mechanism of action of E7010, an orally active sulfonamide antitumor agent: Inhibition of mitosis by binding to the colchicine site of tubulin
-
Yoshimatsu K, Yamaguchi A, Yoshino N, Kitoh K. Mechanism of action of E7010, an orally active sulfonamide antitumor agent: Inhibition of mitosis by binding to the colchicine site of tubulin. Cancer Res 1997; 57: 3208-13.
-
(1997)
Cancer Res
, vol.57
, pp. 3208-3213
-
-
Yoshimatsu, K.1
Yamaguchi, A.2
Yoshino, N.3
Kitoh, K.4
-
8
-
-
0033395393
-
Evaluation of antivascular and antimitotic effects of tubulin binding agents in solid tumor therapy
-
Nihei Y, Suzuki M, Okano A, et al. Evaluation of antivascular and antimitotic effects of tubulin binding agents in solid tumor therapy. Jpn J Cancer Res 1999; 90: 1387-95.
-
(1999)
Jpn J Cancer Res
, vol.90
, pp. 1387-1395
-
-
Nihei, Y.1
Suzuki, M.2
Okano, A.3
-
9
-
-
0031793404
-
Preferential binding of E7010 to murine beta 3-tubulin and decreased beta 3-tubulin in E7010-resistant cells
-
Iwamoto Y, Nishio K, Fukumoto H, Yoshimatsu K, Yamakido M, Saijio N. Preferential binding of E7010 to murine beta 3-tubulin and decreased beta 3-tubulin in E7010-resistant cells. Jpn J Cancer Res 1998; 89: 954-62.
-
(1998)
Jpn J Cancer Res
, vol.89
, pp. 954-962
-
-
Iwamoto, Y.1
Nishio, K.2
Fukumoto, H.3
Yoshimatsu, K.4
Yamakido, M.5
Saijio, N.6
-
10
-
-
0028351192
-
In vivo tumor growth inhibition produced by a novel sulfonamide, E7010, against rodent and human tumors
-
Koyanagi N, Nagasu T, Fujita F, et al. In vivo tumor growth inhibition produced by a novel sulfonamide, E7010, against rodent and human tumors. Cancer Res 1994; 54: 1702-6.
-
(1994)
Cancer Res
, vol.54
, pp. 1702-1706
-
-
Koyanagi, N.1
Nagasu, T.2
Fujita, F.3
-
12
-
-
0034916962
-
Effect of E7010 in liver metastasis and life span of syngeneic C57BL/6 mice bearing orthotopically transplanted murine Colon 38 tumor
-
Funahashi Y, Koyanagi N, Kitoh K. Effect of E7010 in liver metastasis and life span of syngeneic C57BL/6 mice bearing orthotopically transplanted murine Colon 38 tumor. Cancer Chemother Pharmacol 2001; 47: 179-84.
-
(2001)
Cancer Chemother Pharmacol
, vol.47
, pp. 179-184
-
-
Funahashi, Y.1
Koyanagi, N.2
Kitoh, K.3
-
13
-
-
0034608622
-
A focused compound library of novel N-(7-indolyl)-benzene-sulfonamides for the discovery of potent cell cycle inhibitors
-
Owa T, Okauchi T, Yoshimatsu K, et al. A focused compound library of novel N-(7-indolyl)-benzene-sulfonamides for the discovery of potent cell cycle inhibitors. Bioorg Med Chem Lett 2000; 10: 1223-6.
-
(2000)
Bioorg Med Chem Lett
, vol.10
, pp. 1223-1226
-
-
Owa, T.1
Okauchi, T.2
Yoshimatsu, K.3
-
16
-
-
0002660758
-
Mechanism of action of a novel sulfonamide antitumor agent, E7070
-
Fukuoka K, Usuda J, Fukumoto H, et al. Mechanism of action of a novel sulfonamide antitumor agent, E7070. Proc Am Ass Cancer Res 2000; 41: 59.
-
(2000)
Proc Am Ass Cancer Res
, vol.41
, pp. 59
-
-
Fukuoka, K.1
Usuda, J.2
Fukumoto, H.3
-
17
-
-
0034773165
-
E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo
-
Ozawa Y, Sugi NH, Nagasu T, et al. E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo. Eur J Cancer 2001; 37: 2275-82.
-
(2001)
Eur J Cancer
, vol.37
, pp. 2275-2282
-
-
Ozawa, Y.1
Sugi, N.H.2
Nagasu, T.3
-
18
-
-
0036202672
-
Corrigendum to 'E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo'
-
Ozawa Y, Sugi NH, Nagasu T, et al. Corrigendum to 'E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo'. Eur J Cancer 2002; 38: 736.
-
(2002)
Eur J Cancer
, vol.38
, pp. 736
-
-
Ozawa, Y.1
Sugi, N.H.2
Nagasu, T.3
-
19
-
-
0035209725
-
Anticancer agent E7070 inhibits amino acid and uracil transport in fission yeast
-
Tsukahara K, Watanabe T, Hata-Sugi N, Yoshimatsu K, Okayama H, Ngasu T. Anticancer agent E7070 inhibits amino acid and uracil transport in fission yeast. Mol Pharmacol 2001; 60: 1254-9.
-
(2001)
Mol Pharmacol
, vol.60
, pp. 1254-1259
-
-
Tsukahara, K.1
Watanabe, T.2
Hata-Sugi, N.3
Yoshimatsu, K.4
Okayama, H.5
Ngasu, T.6
-
20
-
-
12244302270
-
Synergistic effect of E7070 combined with CPT-11 in human tumor xenograft models
-
Ozawa Y, Kai J, Kusano K, Asada M, Yoshimatsu K. Synergistic effect of E7070 combined with CPT-11 in human tumor xenograft models. Proc NCI-EORTC-AACR 2000; 11: 144.
-
(2000)
Proc NCI-EORTC-AACR
, vol.11
, pp. 144
-
-
Ozawa, Y.1
Kai, J.2
Kusano, K.3
Asada, M.4
Yoshimatsu, K.5
-
21
-
-
0037102283
-
Phase I and pharmacokinetic study of E7070, a novel chloro-indolysulfonamide cell cycle inhibitor, administered as a one-hour infusion every three weeks in patients with advanced cancer
-
in press
-
Raymond E, ten Bokkel Huinink WW, Taïeb J, et al. Phase I and pharmacokinetic study of E7070, a novel chloro-indolysulfonamide cell cycle inhibitor, administered as a one-hour infusion every three weeks in patients with advanced cancer. J Clin Oncol 2002; in press.
-
(2002)
J Clin Oncol
-
-
Raymond, E.1
Ten Bokkel Huinink, W.W.2
Taïeb, J.3
-
22
-
-
0034772246
-
Phase I and pharmacokinetic study of E7070, a novel sulfonamide, given at a daily × 5 schedule in patients with solid tumors. A study by the EORTC-Early Clinical Studies Group (ECSG)
-
Punt CJA, Fumoleau P, van de Walle B, et al. Phase I and pharmacokinetic study of E7070, a novel sulfonamide, given at a daily × 5 schedule in patients with solid tumors. A study by the EORTC-Early Clinical Studies Group (ECSG). Ann Oncol 2001; 12: 1289-93.
-
(2001)
Ann Oncol
, vol.12
, pp. 1289-1293
-
-
Punt, C.J.A.1
Fumoleau, P.2
Van de Walle, B.3
-
23
-
-
0000287733
-
Phase I trial of five-days continuous infusion E7070. [N(3-chloro-7-indoly)-1,4-bezene-disulfonamide] in patients with solid tumors
-
Droz JP, Roch H, Zanetta S, et al. Phase I trial of five-days continuous infusion E7070. [N(3-chloro-7-indoly)-1,4-bezene-disulfonamide] in patients with solid tumors. Proc Am Ass Cancer Res 2000; 41: 609.
-
(2000)
Proc Am Ass Cancer Res
, vol.41
, pp. 609
-
-
Droz, J.P.1
Roch, H.2
Zanetta, S.3
-
24
-
-
0000287735
-
Phase I and pharmacokinetic study of E7070 in patients with solid tumors as single IV infusion, weekly × 4, q 6 weeks
-
Dittrich C, Dumez H, Calvert H, et al. Phase I and pharmacokinetic study of E7070 in patients with solid tumors as single IV infusion, weekly × 4, q 6 weeks. Proc Am Ass Cancer Res 2000; 41: 609.
-
(2000)
Proc Am Ass Cancer Res
, vol.41
, pp. 609
-
-
Dittrich, C.1
Dumez, H.2
Calvert, H.3
-
25
-
-
4243296525
-
Combined results of 4 phase I and pharmacokinetic studies of E7070, a novel chloroindoly-sulphonamide inhibiting the activation of cdk2 and cyclin E
-
Raymond E, Fumoleau P, Roché H, et al. Combined results of 4 phase I and pharmacokinetic studies of E7070, a novel chloroindoly-sulphonamide inhibiting the activation of cdk2 and cyclin E. Clin Cancer Res 2000; 6: 4529s.
-
(2000)
Clin Cancer Res
, vol.6
-
-
Raymond, E.1
Fumoleau, P.2
Roché, H.3
-
26
-
-
0036789730
-
Population pharmacokinetics of the novel anti-cancer agent E7070 during four phase I studies: Model building and validation
-
in press
-
Van Kesteren Ch, Mathôt RAA, Raymond E, et al. Population pharmacokinetics of the novel anti-cancer agent E7070 during four phase I studies: Model building and validation. J Clin Oncol 2002; in press.
-
(2002)
J Clin Oncol
-
-
Van Kesteren, Ch.1
Mathôt, R.A.A.2
Raymond, E.3
-
27
-
-
0000660979
-
Population pharmacokinetics and pharmacokinetic - Pharmacodynamic relationships of the novel anticancer agent E7070 in four phase I studies
-
van Kesteren Ch, Mathôt RAA, Raymond E, et al. Population pharmacokinetics and pharmacokinetic - Pharmacodynamic relationships of the novel anticancer agent E7070 in four phase I studies. Br J Clin Pharmacol 2002; 53: 553P.
-
(2002)
Br J Clin Pharmacol
, vol.53
-
-
Van Kesteren, Ch.1
Mathôt, R.A.A.2
Raymond, E.3
-
28
-
-
0036746940
-
An excretion balance and pharmacokinetic study of the anticancer agent E7070 in cancer patients
-
Van den Bongard HJGD, Pluim D, Rosing H, et al. An excretion balance and pharmacokinetic study of the anticancer agent E7070 in cancer patients. Anti-Cancer Drugs 2002; 13: 807-14.
-
(2002)
Anti-Cancer Drugs
, vol.13
, pp. 807-814
-
-
Van den Bongard, H.J.G.D.1
Pluim, D.2
Rosing, H.3
-
29
-
-
0000902909
-
A multicentre randomised phase II study of E7070 in patients with colorectal cancer who have failed 5-fluorouracil-based chemotherapy
-
Mainwaring PN, van Cutsem E, van Laethem JL, et al. A multicentre randomised phase II study of E7070 in patients with colorectal cancer who have failed 5-fluorouracil-based chemotherapy. Proc Am Ass Cancer Res 2002; 21: 153a.
-
(2002)
Proc Am Ass Cancer Res
, vol.21
-
-
Mainwaring, P.N.1
Van Cutsem, E.2
Van Laethem, J.L.3
-
30
-
-
0242421438
-
A phase II and pharmacodynamic study of E7070 in patients with non-small cell lung cancer (NSCLC) who have failed platinum-based chemotherapy
-
Talbot D, Norbury C, Slade M, et al. A phase II and pharmacodynamic study of E7070 in patients with non-small cell lung cancer (NSCLC) who have failed platinum-based chemotherapy. Proc Am Ass Cancer Res 2002; 21: 327a.
-
(2002)
Proc Am Ass Cancer Res
, vol.21
-
-
Talbot, D.1
Norbury, C.2
Slade, M.3
-
31
-
-
0000741071
-
Microarray-based expression profiling of sulfonamide antitumor agents
-
Owa T, Yokoi A, Kuromitsu J, et al. Microarray-based expression profiling of sulfonamide antitumor agents. Proc Am Ass Cancer Res 2001; 42: 371.
-
(2001)
Proc Am Ass Cancer Res
, vol.42
, pp. 371
-
-
Owa, T.1
Yokoi, A.2
Kuromitsu, J.3
-
32
-
-
0035154256
-
Clinical trial designs for cytostatic agents: Are new approaches needed?
-
Korn EL, Arbuck SG, Pluda JM, Simon R, Kaplan RS, Christian MC. Clinical trial designs for cytostatic agents: Are new approaches needed? J Clin Oncol 2001; 19: 265-72.
-
(2001)
J Clin Oncol
, vol.19
, pp. 265-272
-
-
Korn, E.L.1
Arbuck, S.G.2
Pluda, J.M.3
Simon, R.4
Kaplan, R.S.5
Christian, M.C.6
-
33
-
-
0031797332
-
Phase I and II trials of novel anticancer agents: Endpoints, efficacy and existentialism
-
Eisenhauer EA. Phase I and II trials of novel anticancer agents: Endpoints, efficacy and existentialism. Ann Oncol 1998; 9: 1047-52.
-
(1998)
Ann Oncol
, vol.9
, pp. 1047-1052
-
-
Eisenhauer, E.A.1
|