Sensitivity analysis of intracellular signaling pathway kinetics predicts targets for stem cell fate control

PLoS Computational Biology

Volumn 3, Issue 7, 2007, Pages 1257-1267

  Mahdavi, Alborz ^a,b   Davey, Ryan E ^b   Bhola, Patrick ^b   Yin, Ting ^a   Zandstra, Peter W ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CELL SIGNALING; LIGANDS; SENSITIVITY ANALYSIS; SIGNALING; STEM CELLS;

CELL-FATE; COMPUTATIONAL MODELLING; EMBRYONIC STEM CELLS; INTRACELLULAR SIGNALING PATHWAYS; KINETIC (A); OVEREXPRESSIONS; SELF RENEWAL; SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTIONS; SIGNALING NETWORKS; STEM-CELL;

CHEMICAL ACTIVATION;

STAT3 PROTEIN; CYTOKINE; GLYCOPROTEIN GP 130; LIGAND;

ARTICLE; CELL DIFFERENTIATION; CELL FATE; CELL FUNCTION; CELL STIMULATION; COMPUTER MODEL; GENE OVEREXPRESSION; INTRACELLULAR TRANSPORT; LIGAND BINDING; MOLECULAR MODEL; PREDICTION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS REGULATION; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; STEM CELL; TARGET CELL; TRANSCRIPTION INITIATION; ACTIVE TRANSPORT; ANIMAL; BIOLOGICAL MODEL; COMPUTER SIMULATION; ENZYME ACTIVATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; KINETICS; METABOLISM; MOUSE; PHYSIOLOGY; SENSITIVITY AND SPECIFICITY; TIME;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL DIFFERENTIATION; COMPUTER SIMULATION; CYTOKINE RECEPTOR GP130; CYTOKINES; ENZYME ACTIVATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; KINETICS; LIGANDS; MICE; MODELS, BIOLOGICAL; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STEM CELLS; TIME FACTORS;

EID: 34547570814     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.0030130     Document Type: Article

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