메뉴 건너뛰기




Volumn 32, Issue 5, 1999, Pages 321-335

The kinetic origins of the restriction point in the mammalian cell cycle

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN E; MITOGENIC AGENT; PROTEIN P27; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

EID: 0033453231     PISSN: 09607722     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2184.1999.3250321.x     Document Type: Article
Times cited : (88)

References (46)
  • 1
    • 0033529124 scopus 로고    scopus 로고
    • Instabilities in phosphorylation-dephosphorylation cascades and cell cycle checkpoints
    • AGUDA BD. (1999) Instabilities in phosphorylation-dephosphorylation cascades and cell cycle checkpoints. Oncogene 18, 2846.
    • (1999) Oncogene , vol.18 , pp. 2846
    • Aguda, B.D.1
  • 3
    • 0029050533 scopus 로고
    • Deficiency of pRb leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis
    • ALMASAN A, YIN Y, KELLY RE et al. (1995) Deficiency of pRb leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc. Natl. Acad. Sci. USA 92, 5436.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5436
    • Almasan, A.1    Yin, Y.2    Kelly, R.E.3
  • 4
    • 0030561571 scopus 로고    scopus 로고
    • The retinoblastoma protein pathway and the restriction point
    • BARTER J, BARTKOVA J, LUKAS J. (1996) The retinoblastoma protein pathway and the restriction point. Curr. Opin. Cell Biol. 8, 805.
    • (1996) Curr. Opin. Cell Biol. , vol.8 , pp. 805
    • Barter, J.1    Bartkova, J.2    Lukas, J.3
  • 5
    • 0031586604 scopus 로고    scopus 로고
    • The retinoblastoma protein pathway in cell cycle control and cancer
    • BARTER J, BARTKOVA J, LUKAS J. (1997) The retinoblastoma protein pathway in cell cycle control and cancer. Exptl. Cell Res. 237, 1.
    • (1997) Exptl. Cell Res. , vol.237 , pp. 1
    • Barter, J.1    Bartkova, J.2    Lukas, J.3
  • 6
    • 0031561477 scopus 로고    scopus 로고
    • E2F: A nodal point in cell cycle regulation
    • BERNARDS R. (1997) E2F: a nodal point in cell cycle regulation. Biochim. Biophys. Acta 1333, M33.
    • (1997) Biochim. Biophys. Acta , vol.1333
    • Bernards, R.1
  • 7
    • 0030903750 scopus 로고    scopus 로고
    • Regulation of E2F through ubiquitin-proteosome-dependent degradation: Stabilization by the pRB tumor suppressor protein
    • CAMPANERO MR, FLEMINGTON EK. (1997) Regulation of E2F through ubiquitin-proteosome-dependent degradation: stabilization by the pRB tumor suppressor protein. Proc. Natl. Acad. Sci. USA 94, 2221.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2221
    • Campanero, M.R.1    Flemington, E.K.2
  • 8
    • 0029664461 scopus 로고    scopus 로고
    • Requirement of p27Kip1 for R point control of the fibroblast cell cycle
    • COATS S, FLANAGAN WM, NOURSE J, ROBERTS JM. (1996) Requirement of p27Kip1 for R point control of the fibroblast cell cycle. Science 272, 877.
    • (1996) Science , vol.272 , pp. 877
    • Coats, S.1    Flanagan, W.M.2    Nourse, J.3    Roberts, J.M.4
  • 9
    • 15144341364 scopus 로고    scopus 로고
    • Expression of p16 induces transcriptional downregulation of the RB gene
    • FANG X, JIN X, XU H-J et al. (1998) Expression of p16 induces transcriptional downregulation of the RB gene. Oncogene 16, 1.
    • (1998) Oncogene , vol.16 , pp. 1
    • Fang, X.1    Jin, X.2    Xu, H.-J.3
  • 10
    • 0016038059 scopus 로고
    • Dynamics of open chemical systems and the algebraic structure of the underlying reaction network
    • FEINBERG M, HORN FJM. (1974) Dynamics of open chemical systems and the algebraic structure of the underlying reaction network. Chem. Eng. Sci. 29, 775.
    • (1974) Chem. Eng. Sci. , vol.29 , pp. 775
    • Feinberg, M.1    Horn, F.J.M.2
  • 11
    • 0029779280 scopus 로고    scopus 로고
    • Cdc25 cell-cycle phosphatase as a target of c-myc
    • GALAKTIONOV K, CHEN X, BEACH D. (1996) Cdc25 cell-cycle phosphatase as a target of c-myc. Nature 382, 511.
    • (1996) Nature , vol.382 , pp. 511
    • Galaktionov, K.1    Chen, X.2    Beach, D.3
  • 12
    • 0029986337 scopus 로고    scopus 로고
    • Regulation of cyclin E transcription by E2Fs and retinoblastoma protein
    • GENG Y, Ng EATON E, PICON M et al. (1996) Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. Oncogene 12, 1173.
    • (1996) Oncogene , vol.12 , pp. 1173
    • Geng, Y.1    Ng Eaton, E.2    Picon, M.3
  • 13
    • 0029670477 scopus 로고    scopus 로고
    • Translational control of p27Kip1 accumulation during the cell cycle
    • HENGST L, REED SI. (1996) Translational control of p27Kip1 accumulation during the cell cycle. Science 271, 1861.
    • (1996) Science , vol.271 , pp. 1861
    • Hengst, L.1    Reed, S.I.2
  • 14
    • 0029863840 scopus 로고    scopus 로고
    • Altered cell cycle kinetics. gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts
    • HERRERA RE, SAH VP, WILLIAMS BO, MAKELA TP, WEINBERG RA, JACKS T. (1996) Altered cell cycle kinetics. gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts. Mol. Cell. Biol. 16, 2402.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2402
    • Herrera, R.E.1    Sah, V.P.2    Williams, B.O.3    Makela, T.P.4    Weinberg, R.A.5    Jacks, T.6
  • 15
    • 0024670325 scopus 로고
    • E1A-dependent transctivation of the human MYC promoter is mediated by the E2F factor
    • HIEBERT SW, LIPP M, NEVINS JR. (1989) E1A-dependent transctivation of the human MYC promoter is mediated by the E2F factor. Proc. Natl. Acad. Sci. USA 86, 3594.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 3594
    • Hiebert, S.W.1    Lipp, M.2    Nevins, J.R.3
  • 16
    • 0028022034 scopus 로고
    • Activation of the phosphatase activity of human cdc25a by a cdk2-cyclin E dependent phosphorylation at the G1/S transition
    • HOFFMANN I, DRAETTA G, KARSENTI E. (1994) Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition. EMBO J. 13, 4302.
    • (1994) EMBO J. , vol.13 , pp. 4302
    • Hoffmann, I.1    Draetta, G.2    Karsenti, E.3
  • 17
    • 0029868367 scopus 로고    scopus 로고
    • A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation
    • IKEDA M, JAKOI L, NEVINS JR. (1996) A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. Proc. Natl. Acad. Sci. USA 93, 3215.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3215
    • Ikeda, M.1    Jakoi, L.2    Nevins, J.R.3
  • 18
    • 0026649165 scopus 로고
    • Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle
    • KOFF A, GIORDANO A, DESAI D et al. (1992) Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science 257, 1689.
    • (1992) Science , vol.257 , pp. 1689
    • Koff, A.1    Giordano, A.2    Desai, D.3
  • 19
    • 0032568043 scopus 로고    scopus 로고
    • Functional capabilities of molecular network components controlling the mammalian G1/S cell cycle phase transition
    • KOHN KW. (1998) Functional capabilities of molecular network components controlling the mammalian G1/S cell cycle phase transition. Oncogene 16, 1065.
    • (1998) Oncogene , vol.16 , pp. 1065
    • Kohn, K.W.1
  • 20
    • 0028362359 scopus 로고
    • Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase
    • KREK W, EWEN ME, SHIRODKAR S, ARANY Z, KAELIN WG, LIVINGSTON DM. (1994) Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell 78, 161.
    • (1994) Cell , vol.78 , pp. 161
    • Krek, W.1    Ewen, M.E.2    Shirodkar, S.3    Arany, Z.4    Kaelin, W.G.5    Livingston, D.M.6
  • 21
    • 0030995824 scopus 로고    scopus 로고
    • Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F
    • LEONE G, DEGREGORI J, SEARS R, JAKOI L, NEVINS JR. (1997) Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature 387, 422.
    • (1997) Nature , vol.387 , pp. 422
    • Leone, G.1    Degregori, J.2    Sears, R.3    Jakoi, L.4    Nevins, J.R.5
  • 22
    • 0033536059 scopus 로고    scopus 로고
    • Collaborative role of E2F transcriptional activity and G1 cyclin-dependent kinase activity in the induction of S phase
    • LEONE G, DEGREGORI J, JAKOI L, COOK JG, NEVINS JR. (1999) Collaborative role of E2F transcriptional activity and G1 cyclin-dependent kinase activity in the induction of S phase. Proc. Natl. Acad. Sci. USA 96, 6626.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 6626
    • Leone, G.1    Degregori, J.2    Jakoi, L.3    Cook, J.G.4    Nevins, J.R.5
  • 23
    • 0028034775 scopus 로고
    • Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb
    • LI Y, NICHOLS MA, SHAY JW, XIONG Y. (1994) Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb. Cancer Res. 54, 6078.
    • (1994) Cancer Res. , vol.54 , pp. 6078
    • Li, Y.1    Nichols, M.A.2    Shay, J.W.3    Xiong, Y.4
  • 24
    • 0031008465 scopus 로고    scopus 로고
    • Cyclin E-induced S phase without activation of the pRb/E2F pathway
    • LUKAS J, HERZINGER T, HANSEN K et al. (1997) Cyclin E-induced S phase without activation of the pRb/E2F pathway. Genes Dev. 11, 1479.
    • (1997) Genes Dev. , vol.11 , pp. 1479
    • Lukas, J.1    Herzinger, T.2    Hansen, K.3
  • 25
    • 0031951182 scopus 로고    scopus 로고
    • Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
    • LUNDBERG AS, WEINBERG RA. (1998) Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Molec. Cell. Biol. 18, 753.
    • (1998) Molec. Cell. Biol. , vol.18 , pp. 753
    • Lundberg, A.S.1    Weinberg, R.A.2
  • 26
    • 0031935648 scopus 로고    scopus 로고
    • Control of pRB phosphorylation
    • MITTNACHT S. (1998) Control of pRB phosphorylation. Curr. Opin. Gen. Dev. 8, 21.
    • (1998) Curr. Opin. Gen. Dev. , vol.8 , pp. 21
    • Mittnacht, S.1
  • 27
    • 0031758421 scopus 로고    scopus 로고
    • Restriction point control in human cancer
    • MOROY T. (1998) Restriction point control in human cancer. Tumordiagn. U. Ther. 19, 93.
    • (1998) Tumordiagn. U. Ther. , vol.19 , pp. 93
    • Moroy, T.1
  • 28
    • 0028136903 scopus 로고
    • Transcription of the E2F1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter
    • NEUMAN E, FLEMINGTON EK, SELLERS WR, KAELIN WG JR. (1994) Transcription of the E2F1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter. Mol. Cell. Biol. 14, 6607.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6607
    • Neuman, E.1    Flemington, E.K.2    Sellers, W.R.3    Kaelin Jr., W.G.4
  • 29
    • 0030731071 scopus 로고    scopus 로고
    • A mathematical model of the regulation of the G1 phase of Rb+/+ and Rb-/- mouse embryonic fibroblasts and an osteosarcoma cell line
    • OBEYESEKERE MN, KNUDSEN ES, WANG JYJ, ZIMMERMAN SO. (1997) A mathematical model of the regulation of the G1 phase of Rb+/+ and Rb-/- mouse embryonic fibroblasts and an osteosarcoma cell line. Cell Prolif. 30, 171.
    • (1997) Cell Prolif. , vol.30 , pp. 171
    • Obeyesekere, M.N.1    Knudsen, E.S.2    Wang, J.Y.J.3    Zimmerman, S.O.4
  • 31
    • 0003418645 scopus 로고
    • A restriction point for control of normal animal cell proliferation
    • PARDEE AB. (1974) A restriction point for control of normal animal cell proliferation. Proc. Natl. Acad. Sci. USA 71, 1286.
    • (1974) Proc. Natl. Acad. Sci. USA , vol.71 , pp. 1286
    • Pardee, A.B.1
  • 32
    • 0024473604 scopus 로고
    • G1 events and regulation of cell proliferation
    • PARDEE AB (1989). G1 events and regulation of cell proliferation. Science 246, 603.
    • (1989) Science , vol.246 , pp. 603
    • Pardee, A.B.1
  • 33
    • 0030665150 scopus 로고    scopus 로고
    • The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells
    • POON RYC, CHAU MS, YAMASHITA K, HUNTER T. (1997) The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells. Cancer Res. 57, 5168.
    • (1997) Cancer Res. , vol.57 , pp. 5168
    • Poon, R.Y.C.1    Chau, M.S.2    Yamashita, K.3    Hunter, T.4
  • 34
    • 0030573463 scopus 로고    scopus 로고
    • Cyclin E: In mid-cycle
    • REED SI. (1996) Cyclin E: in mid-cycle. Biochim. Biophys. Acta 1287, 151.
    • (1996) Biochim. Biophys. Acta , vol.1287 , pp. 151
    • Reed, S.I.1
  • 35
    • 0031948741 scopus 로고    scopus 로고
    • Key effectors of signal transduction and G1 progression
    • ROUSSEL MF. (1998) Key effectors of signal transduction and G1 progression. Adv. Cancer Res. 74, 1.
    • (1998) Adv. Cancer Res. , vol.74 , pp. 1
    • Roussel, M.F.1
  • 37
    • 0033590632 scopus 로고    scopus 로고
    • A rate limiting function of Cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2
    • SEXL V, DIEHL JA, SHERR CJ, ASHMUN R, BEACH D, ROUSSEL MF. (1999) A rate limiting function of Cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2. Oncogene 18, 573.
    • (1999) Oncogene , vol.18 , pp. 573
    • Sexl, V.1    Diehl, J.A.2    Sherr, C.J.3    Ashmun, R.4    Beach, D.5    Roussel, M.F.6
  • 38
    • 0030855138 scopus 로고    scopus 로고
    • Regulation of mammalian cyclin-dependent kinase 2
    • Dunphy WG, ed. New York: Academic Press
    • SHEAFF RJ. (1997) Regulation of mammalian cyclin-dependent kinase 2. In: Dunphy WG, ed. Cell Cycle Control (Methods in Enzymology, Vol 283). New York: Academic Press, 173.
    • (1997) Cell Cycle Control Methods in Enzymology , vol.283 , pp. 173
    • Sheaff, R.J.1
  • 40
    • 0030434467 scopus 로고    scopus 로고
    • Signal transduction of cell-cycle regulation: Its temporospacial architecture
    • TAKUWA N, TAKUWA Y. (1996) Signal transduction of cell-cycle regulation: its temporospacial architecture. Jap. J. Physiol. 46, 431.
    • (1996) Jap. J. Physiol. , vol.46 , pp. 431
    • Takuwa, N.1    Takuwa, Y.2
  • 41
    • 0030740210 scopus 로고    scopus 로고
    • Ras activity late in G1 phase required for p27Kip1 downregulation, passage through the Restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts
    • TAKUWA N, TAKUWA Y. (1997) Ras activity late in G1 phase required for p27Kip1 downregulation, passage through the Restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts. Mol. Cell. Biol. 17, 5348.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5348
    • Takuwa, N.1    Takuwa, Y.2
  • 42
    • 0024651359 scopus 로고
    • Nuclear factor E2F mediates basic transcription and transactivation by E1A of the human MYC promoter
    • THALMEIER K, SYNOVZIK H, MERTZ R, WINNACKER EL, LIPP M. (1989) Nuclear factor E2F mediates basic transcription and transactivation by E1A of the human MYC promoter. Genes Dev. 3, 527.
    • (1989) Genes Dev. , vol.3 , pp. 527
    • Thalmeier, K.1    Synovzik, H.2    Mertz, R.3    Winnacker, E.L.4    Lipp, M.5
  • 43
    • 0032980308 scopus 로고    scopus 로고
    • The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer
    • TSIHLIAS J, KAPUSTA L, SLINGERLAND J. (1999) The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer. Annu. Rev. Med. 50, 401.
    • (1999) Annu. Rev. Med. , vol.50 , pp. 401
    • Tsihlias, J.1    Kapusta, L.2    Slingerland, J.3
  • 45
    • 0021855166 scopus 로고
    • Kinetic analysis of regulatory events in G1 leading to proliferation or quiescence of Swiss 3T3 cells
    • ZETTERBERO A, LARSSON O. (1985) Kinetic analysis of regulatory events in G1 leading to proliferation or quiescence of Swiss 3T3 cells. Proc. Natl. Acad. Sci. USA 82, 5365.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 5365
    • Zetterbero, A.1    Larsson, O.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.