Acoustically active lipospheres containing paclitaxel: A new therapeutic ultrasound contrast agent

Investigative Radiology

Volumn 33, Issue 12, 1998, Pages 886-892

  Unger, Evan C ^a   McCreery, Thomas P ^a   Sweitzer, Robert H ^a   Caldwell, Veronica E ^a   Wu, Yunqiu ^a  

^a ImaRx Therapeutics Inc   (United States)

Author keywords

Contrast agent; Drug delivery; Paclitaxel; Ultrasound

Indexed keywords

MICROSPHERE; MRX 552; PACLITAXEL; PHOSPHOLIPID; SOYBEAN OIL; UNCLASSIFIED DRUG;

ACOUSTICS; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; TOXICITY TESTING; ULTRASOUND;

EID: 0032470386     PISSN: 00209996     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004424-199812000-00007     Document Type: Article

References (10)

1. Skyba DM, Camarano G, Goodman NC, Price RH, Skalak TC, Kaul S. Hemodynamic characteristics, myocardial kinetics, and microvascular rheology of FS-069, a second-generation echocardiographic contrast agent capable of producing myocardial opacification from a venous injection. J Am Coll Cardiol 1996;28:1292-1300.
2. Metzger-Rose C, Krupinski EA, Wright WH, Baker MR, McCreery TP, Barrette TR, Unger EC. Ultrasonographic detection of testicular ischemia in a canine model using phospholipid-coated microbubbles (MRX-115). J Ultrasound Med 1997;16:317-324.
3. Fritz TA, Unger EC, Sutherland G, Sahn DJ. Phase I clinical trials of MRX-115, a new ultrasound contrast agent. Invest Radiol 1997;32: 735-740.
4. Walker KW, Pantely GA, Sahn DJ. Ultrasound-mediated destruction of contrast agents, effect of ultrasound intensity, exposure, and frequency. Invest Radiol 1997;32:728-734.
5. Unger EC, McCreery TP, Sweitzer RH, et al. MRX-501: A novel ultrasound contrast agent with therapeutic properties. Acad Radiol 1998;5(suppl 1):S247-S249.
6. Miller MW, Miller DL, Brayman AA. A review of in vitro bioeffects of inertial ultrasonic cavitation from a mechanistic perspective. Ultrasound Med Biol 1996;22:1131-1154.
7. Dalecki D, Raeman CH, Child SZ, Cox C, Meltzer RS, Carstensen EL. Hemolysis in vivo from exposure to pulsed ultrasound. Ultrasound Med Biol 1997;23:307-313.
8. Taxol. In: Physicians' Desk Reference. 49th ed. Montvale, NJ: Medical Economics Data Production Company, 1995:682-685.
9. Skyba DM, Price RJ, Linka AZ, Skalak TC, Kaul S. Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue. Circulation 1998;98:290-293.
10. Netti PA, Baxter LT, Boucher Y, Skalak R, Jain RK. Time-dependent behavior of interstitial fluid pressure in solid tumors: Implications for drug delivery. Cancer Research 1995;55:5451-5458.