Role of endogenous somatostatin in regulating GH output under basal conditions and in response to metabolic extremes

Molecular and Cellular Endocrinology

Volumn 286, Issue 1-2, 2008, Pages 155-168

  Luque, Raul M ^a,b   Park, Seungjoon ^c   Kineman, Rhonda D ^a,d  

^a Section of Endocrinology Diabetes and Metabolism   (United States)

^b UNIVERSITY OF CÓRDOBA   (Spain)

^c Kyung Hee University Hospital   (South Korea)

^d JESSE BROWN VA MEDICAL CENTER   (United States)

Author keywords

Fasting; Ghrelin; GHRH; Growth hormone; Hypothalamus; Obesity; Pituitary; Somatostatin; Somatostatin receptors; Somatotrope

Indexed keywords

GHRELIN; SOMATOMEDIN C; SOMATOSTATIN;

AGING; DEVELOPMENTAL STAGE; GENE EXPRESSION; GROWTH HORMONE RELEASE; GROWTH HORMONE SECRETING CELL; HORMONE SYNTHESIS; HUMAN; HYPOTHALAMUS; METABOLISM; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVIEW;

EID: 43549123303     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2007.12.005     Document Type: Review

References (180)

1. H. Abe Y. Kato Y. Iwasaki K. Chihara H. Imura Central effect of somatostatin on the secretion of growth hormone in the anesthesized rat Proc. Soc. Exp. Biol. Med. 159 1978 346 349
2. A. Baragli H. Alturaihi H.L. Watt A. Abdallah U. Kumar Heterooligomerization of human dopamine receptor 2 and somatostatin receptor 2: co-immunoprecipitation and fluorescence resonance energy transfer analysis Cell. Signal. 19 2007 2304 2316
3. A. Beaudet D. Greenspun J. Raelson G.S. Tannenbaum Patterns of expression of SSTR1 and SSTR2 somatostatin receptor subtypes in the hypothalamus of the adult rat: relationship to neuroendocrine function Neuroscience 65 1995 551 561
4. A. Ben-Shlomo S. Melmed Somatostatin agonists for treatment of acromegaly Mol. Cell. Endocrinol. 286 2008 192 198
5. M. Berelowitz Y. Xu J. Song J.F. Bruno Regulation of somatostatin receptor mRNA expression Ciba Found. Symp. 190 1995 111 126
6. J. Bertherat P. Dournaud A. Berod E. Normand B. Bloch W. Rostene C. Kordon J. Epelbaum Growth hormone-releasing hormone-synthesizing neurons are a subpopulation of somatostatin receptor-labelled cells in the rat arcuate nucleus: a combined in situ hybridization and receptor light-microscopic radioautographic study Neuroendocrinology 56 1992 25 31
7. I. Bossis T.E. Porter Identification of the somatostatin receptor subtypes involved in regulation of growth hormone secretion in chickens Mol. Cell. Endocrinol. 182 2001 203 213
8. K. Bouyer C. Loudes I.C.A.F. Robinson J. Epelbaum A. Faivre-Bauman Sexually dimorphic distribution of sst2A somatostatin receptors on growth hormone-releasing hormone neurons in mice Endocrinology 147 2006 2670 2674
9. P. Brazeau W. Vale R. Burgus N. Ling M. Butcher J. Rivier R. Guillemin Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone Science 179 1973 77 79
10. R.S. Brogan S.K. Fife L.K. Conley A. Giustina W.B. Wehrenberg Effects of food deprivation on the GH axis: immunocytochemical and molecular analysis Neuroendocrinology 65 1997 129 135
11. F. Broglio S. Grottoli E. Arvat E. Ghigo Endocrine actions of cortistatin: In vivo studies Mol. Cell. Endocrinol. 286 2008 123 127
12. J.F. Bruno D. Olchovsky J.D. White J.W. Leidy J. Song M. Berelowitz Influence of food deprivation in the rat on hypothalamic expression of growth hormone-releasing factor and somatostatin Endocrinology 127 1990 2111 2116
13. J.F. Bruno Y. Xu J. Song M. Berelowitz Pituitary and hypothalamic somatostatin receptor subtype messenger ribonucleic acid expression in the food-deprived and diabetic rat Endocrinology 135 1994 1787 1792
14. B. Burguera D.H. Frank R. DiMarchi S. Long J.F. Caro The interaction of proinsulin with the insulin-like growth factor-I receptor in human liver, muscle, and adipose tissue J. Clin. Endocrinol. Metab. 72 1991 1238 1241
15. K.A. Burton E.B. Kabigting D.K. Clifton R.A. Steiner Growth hormone receptor messenger ribonucleic acid distribution in the adult male rat brain and its colocalization in hypothalamic somatostatin neurons Endocrinology 131 1993 958 963
16. M. Cammalleri D. Cervia M.D. Monte D. Martini D. Langenegger D. Fehlmann D. Feuerbach B. Pavan D. Hoyer P. Bagnoli Compensatory changes in the hippocampus of somatostatin knockout mice: upregulation of somatostatin receptor 2 and its function in the control of bursting activity and synaptic transmission Eur. J. Neurosci. 23 2006 2404 2422
17. L.F. Canosa J.P. Chang R.E. Peter Neuroendocrine control of growth hormone in fish Gen. Comp. Endocrinol. 151 2007 1 26
18. E. Carro R.M. Senaris L.M. Seoane L.A. Frohman A. Arimura F.F. Casaneuva C. Dieguez Role of GHRH and somatostatin on leptin-induced GH secretion Neuroendocrinology 69 1999 3 10
19. L. Cattaneo V. De Gennaro-Colonna M. Zoli E. Muller D. Cocchi Characterization of the hypothalamo-pituitary-IGF-I axis in rats made obese by overfeeding J. Endocrinol. 148 1996 347 353
20. D. Cervia C. Petrucci M.T. Bluet-Pajot J. Epelbaum P. Bagnoli Inhibitory control of growth hormone secretion by somatostatin in rat pituitary GC cells: sst2 not sst1 receptors are coupled to inhibition of single-cell intracellular free calcium concentrations Neuroendocrinology 76 2002 99 110
21. Y.Y. Chan R.A. Steiner D.K. Clifton Regulation of hypothalamic neuropeptide-Y neurons by growth hormone in the rat Endocrinology 137 1996 1319 1325
22. K. Chihara N. Minamitani H. Kaji A. Arimura T. Fujita Intraventricularly injected growth hormone stimulates somatostatin release into rat hypophyseal portal blood Endocrinology 109 1981 2279 2281
23. J.A. Chowen L.M. Frago J. Argente The regulation of GH secretion by sex steroids Eur. J. Endocrinol. 151 2004 U95 U100
24. L. Cuttler J.B. Welsh M. Szabo The effect of age on somatostatin suppression of basal, growth hormone (GH)-releasing factor-stimulated, and dibutyryl adenosine 3′,5′-monophospate-stimulated GH release from rat pituitary cells in monolayer culture Endocrinology 119 1986 152 158
25. V.A.S.H. Dalm L.J. Hofland S.W.J. Lamberts Future clinical prospects in somatostatin/cortistatin/somatostatin receptor field Mol. Cell. Endocrinol. 286 2008 262 277
26. Y. Date N. Murakami M. Kojima T. Kuroiwa S. Matsukura K. Kangawa M. Nakazato Central effects of a novel acylated peptide, ghrelin on growth release in rats Biochem. Biophys. Res. Commun. 275 2000 480
27. E.C. degli Uberti M.R. Ambrosio S.G. Cella A.R. Margutti G. Trasforini A.E. Rigamonti E. Petrone E.E. Muller Defective hypothalamic growth hormone (GH)-releasing hormone activity may contribute to declining GH secretion with age in man J. Clin. Endocrinol. Metab. 82 1997 2885 2888
28. R. Deghenghi M. Papotti E. Ghigo G. Muccioli Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland J. Endocrinol. Invest. 24 2001 RC1 RC3
29. J.A. De Schepper J.P. Smitz X.L. Zhou O. Louis B.E. Velkeniers L. Vanhaelst Cafeteria diet-induced obesity is associated with a low spontaneous growth hormone secretion and normal plasma insulin-like growth factor-I concentrations Growth Horm. IGF Res. 8 1998 397 401
30. E.V. Dimaraki C.A. Jaffe Role of endogenous ghrelin in growth hormone secretion, appetite regulation and metabolism Rev. Endocr. Metab. Disord. 7 2006 237 249
31. J.E. Drisko T.D. Faidley D. Zhang T.J. McDonald S. Nicolich D.F. Hora P. Cunningham C. Li E. Rickes L. McNamara C. Chang R.G. Smith G.J. Hickey Administration of a nonpeptidyl growth hormone secretagogue, L-163,255, changes somatostatin pattern, but has no effect on patterns of growth hormone-releasing factor in the hypophyseal-portal circulation of the conscious pig Proc. Soc. Exp. Biol. Med. 222 1999 70 77
32. M. Duran-Prado C. Bucharles B.J. Gonzalez R. Vazquez-Martinez A.J. Martinez-Fuentes S. Garcia-Navarro S.J. Rhodes H. Vaudry M.M. Malagon J.P. Castano Porcine somatostatin receptor 2 displays typical pharmacological sst2 features but unique dynamics of homodimerization and internalization Endocrinology 148 2007 411 421
33. K.M. Fairhall B.G. Gabrielsson I.C.A.F. Robinson Effect of food withdrawal and insulin on growth hormone secretion in the guinea pig Endocrinology 127 1990 716 723
34. S.O. Fetissov L.C. Byrne H. Hassani P. Ernfors T. Hokfelt Characterization of neuropeptide Y Y2 and Y5 receptor expression in the mouse hypothalamus J. Comp. Neurol. 470 2004 256 265
35. T.P. Fletcher G.B. Thomas I.J. Clarke Growth hormone-releasing hormone and somatostatin concentrations in the hypophysial portal blood of conscious sheep during infusion of growth hormone-releasing peptide-6 Domest. Anim. Endocrinol. 13 1996 251 258
36. T. Florio S. Thellung A. Corsaro L. Bocca S. Arena A. Pattarozzi V. Villa A. Massa F. Diana D. Schettini F. Barbieri J.L. Ravetti R. Spaziante M. Giusti G. Schettini Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro Clin. Endocrinol. (Oxf) 59 2003 115 128
37. A. Flyvbjerg W.F. Bennett R. Rasch J.J. Kopchick J.A. Scarlett Inhibitory effect of a growth hormone receptor antagonist (G120K-PEG) on renal enlargement, glomerular hypertrophy, and urinary albumin excretion in experimental diabetes in mice Diabetes 48 1999 377 382
38. M. Fodor C. Kordon J. Epelbaum Anatomy of the hypophysiotropic somatostatinergic and growth hormone-releasing hormone system Minireview Neurochem. Res. 31 2006 137 143
39. L.A. Frohman R.D. Kineman Growth hormone-releasing hormone: discovery, regulation, and actions J. Kostyo Handbook of Physiology: Hormonal Control of Growth 1999 Oxford University Press New York 189 221
40. M.G.S. Frutos L. Cacicedo C.F. Mendez D. Vicent M. Gonzalez F. Sanchez-Franco Pituitary alterations involved in the decline of growth hormone gene expression in the pituitary of aging rats J. Gerontol. Ser. A: Biol. Sci. Med. Sci. 62 2007 585 597
41. M.D. Gahete M. Duran-Prado R.M. Luque A.J. Martinex-Fuentes R. Vazquez-Martinez M.M. Malagon J.P. Castano Are somatostatin and cortistatin two siblings in regulating endocrine secretions? In vitro work ahead Mol. Cell. Endocrinol. 286 2008 128 134
42. L.M. Garcia-Segura J.R. Rodriguez I. Torres-Aleman Localization of the insulin-like growth factor I receptor in the cerebellum and hypothlamus of adult rats: an electron microscopic study J. Neurocytol. 26 1997 479 490
43. K.L. Geris B. de Groef S.P. Rohrer S. Geelissen E.R. Kuhn V.M. Darras Identification of somatostatin receptors controlling growth hormone and thyrotropin secretion in the chicken using receptor subtype-specific agonists J. Endocrinol. 177 2003 279 286
44. M.C. Ghigo A. Torsello R. Grilli M. Luoni V. Locatelli E.E. Muller Effects of GH and IGF-I administration on GHRH and somatostatin mRNA levels. I. A study on ad libitum fed and starved adult male rats J. Endocrinol. Invest. 20 1997 144 150
45. C.G. Goodyer S.I. Grigorakis Y.C. Patel U. Kumar Developmental changes in the expression of somatostatin receptors (1–5) in the brain, hypothalamus, pituitary and spinal cord of the human fetus Neuroscience 125 2004 441 448
46. M. Grant B. Collier U. Kumar Agonist-dependent dissociation of human somatostatin receptor 2 dimers: a role in receptor trafficking J. Biol. Chem. 279 2004 36179 36183
47. M. Grant R.C. Patel U. Kumar The role of subtype-specific ligand binding and the C-tail domain in dimer formation of human somatostatin receptors J. Biol. Chem. 279 2004 38636 38643
48. Y. Greenman S. Melmed Expression of three somatostatin receptor subtypes in pituitary adenomas: evidence for preferential SSTR5 expression in the mammosomatotroph lineage J. Clin. Endocrinol. Metab. 79 1994 724 729
49. Y. Greenman S. Melmed Heterogeneous expression of two somatostatin receptor subtypes in pituitary tumors J. Clin. Endocrinol. Metab. 78 1994 398 403
50. M.L. Hartman J.D. Veldhuis M.L. Johnson M.M. Lee K.G.M.M. Alberti E. Samojlik M.O. Thorner Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal man J. Clin. Endocrinol. Metab. 74 1992 757 765
51. M.L. Hartman J.D. Veldhuis M.O. Thorner Normal control of growth hormone secretion Horm. Res. 40 1993 37 47
52. O. Hasegawa H. Sugihara S. Minami I. Wakabayashi Masculinization of growth hormone (GH) secretory pattern by dihydrotestosterone is associated with augmentation of hypothalamic somatostatin and GH-releasing hormone mRNA levels in ovariectomized adult rats Peptides 13 1992 475 481
53. T. Hashizume N. Horiuchi N. Tate S. Nonaka M. Kojima H. Hosoda K. Kangawa Effects of ghrelin on growth hormone secretion from cultured adenohypophysial cells in cattle Endocr. J. 50 2003 289 295
54. T. Hashizume N. Horiuchi N. Tate S. Nonaka U. Mikami M. Kojima Effects of ghrelin on growth hormone secretion from cultured adenohypophysial cells in pigs Domest. Anim. Endocrinol. 24 2003 209 218
55. C. Heinrichs M. Colli J.A. Yanovski L. Laue A.A. Gerstl A.D. Kramer J.A. Uyeda J. Baron Effects of fasting on the growth plate: systemic and local mechanisms Endocrinology 138 1997 5359 5365
56. D.M. Henricks T.C. Jenkins J.R. Ward C.S. Krishnan L. Grimes Endocrine responses and body composition changes during feed restriction and realimentation in young bulls J. Anim. Sci. 72 1994 2289 2297
57. B.A. Henry A. Rao A.J. Tilbrook I.J. Clarke Chronic food-restriction alters the expression of somatostatin and growth hormone-releasing hormone in the ovariectomized ewe J. Endocrinol. 170 2001 R1 R5
58. S. Hisano Y. Tsuruo Y. Kagotani S. Daikoku K. Chihara Immunohistochemical evidence for synaptic connections between neuropeptide Y-containing axons and periventricular somatostatin neurons in the anterior hypothalamus in rats Brain Res. 520 1990 170 177
59. K.Y. Ho W.S. Evans R.M. Blizzard J.D. Veldhuis G.R. Merriam E. Samojlik R. Furlanetto A.D. Rogol D.L. Kaiser M.O. Thorner Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations J. Clin. Endocrinol. Metab. 64 1987 51 58
60. K.Y. Ho J.D. Veldhuis M.L. Johnson R. Furlanetto W.S. Evans K.G.M.M. Alberti M.O. Thorner Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man J. Clin. Invest. 81 1988 968 975
61. S. Horvath M. Palkovits T. Gorcs A. Arimura Electron microscopic immunocytochemical evidence for the existence of bidirectional synaptic connections between growth hormone-releasing hormone- and somatostatin-containing neurons in the hypothalamus of the rat Brain Res. 481 1989 8 15
62. M.A. Hynes J.J. Van Wyk P.J. Brooks A.J. D Ercole M. Jansen P.K. Lund Growth hormone dependence of somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II messenger ribonucleic acids Mol. Endocrinol. 1 1987 233 242
63. M. Ishikawa M. Mizobuchi H. Takahashi H. Bando S. Saito Somatostatin release as measured by in vivo microdialysis: circadian variation and effect of prolonged food deprivation Brain Res. 749 1997 226 231
64. M. Itoh Immunoreactive somatostatin in the hypothalamus and other regions of the rat brain: effects of insulin, glucose, alpha- or beta-blocker and L-dopa Endocrinol. Jpn. 26 1979 41 58
65. C.A. Jaffe B. Ocampo-Lim W. Guo K. Krueger I. Sugahara R. DeMott-Friberg M. Bermann A.L. Barkan Regulatory mechanisms of growth hormone secretion are sexually dimorphic J. Clin. Invest. 102 1998 153 164
66. B.A. Janowski N.C. Ling A. Giustina W.B. Wehrenberg Hypothalamic regulation of growth hormone secretion during food deprivation in the rat Life Sci. 52 1993 981 987
67. B.A. Janowski W.B. Wehrenberg Effects of passive immunization of growth hormone-releasing hormone and somatostatin on growth hormone secretion under conditions of high somatostatin tone Life Sci. 50 1992 951 958
68. J.-O. Jansson S. Eden O. Isaksson Sexual dimorphism in the control of growth hormone secretion Endocr. Rev. 6 1985 128 150
69. H. Jiang R.G. Smith Modification of ghrelin and somatostatin signaling by formation of GHS-R1a/SSTR5 heterodimers The Endocrine Society's 89th Annual Meeting Toronto, ON 2007
70. J. Kamegai S. Minami H. Sugihara O. Hasegawa H. Higuchi I. Wakabayashi Growth hormone receptor gene is expressed in neuropeptide Y neurons in hypothalamic arcuate nucleus of rats Endocrinology 137 1996 2109 2112
71. J. Kamegai S. Minami H. Sugihara H. Higuchi I. Wakabayashi Growth hormone induces expression of c- fos gene on hypothalamic neuropeptide-Y and somatostatin neurons in hypophysectomized rats Endocrinology 135 1994 2765 2771
72. J. Kamegai T.G. Unterman L.A. Frohman R.D. Kineman Hypothalamic/pituitary-axis of the spontaneous dwarf rat: autofeedback regulation of growth hormone (GH) includes suppression of GH releasing-hormone receptor messenger ribonucleic acid Endocrinology 139 1998 3554 3560
73. J.R. Kerrigan P.M. Martha R.J. Krieg A.D. Rogol W.S. Evans Somatostatin inhibition of growth hormone secretion by somatotropes from male, female, and androgen receptor-deficient rats: evidence for differing sensitivities Endocrinology 125 1989 3078 3083
74. O. Khorram L.R. DePalatis S.M. McCann Development of hypothalamic control of growth hormone secretion in the rat Endocrinology 113 1983 720 728
75. E. Kim S. Sohn M. Lee J. Jung R.D. Kineman S. Park Differential responses of the growth hormone axis in two rat models of streptozotocin-induced insulinopenic diabetes J. Endocrinol. 188 2006 263 270
76. 5 mRNA in rat pituitaries Endocrinology 139 1998 1573 1580
77. R.D. Kineman R.M. Luque Low doses of somatostatin signal through AC/cAMP to dramatically increase GH release in primary pituitary cell cultures from a non-human primate ( Papio anubis ) Proceedings of the 89th Annual Meeting of the Endocrine Society Toronto ON 2007 P2-391
78. R.D. Kineman R.M. Luque Evidence that ghrelin is as potent as growth hormone (GH)-releasing hormone (GHRH) in releasing GH from primary pituitary cell cultures of a nonhuman primate ( Papio anubis ), acting through intracellular signaling pathways distinct from GHRH Endocrinology 148 2007 4440 4449
79. S.E. Klein M.A. Sheridan Somatostatin signaling and the regulation of growth and metabolism in fish Mol. Cell. Endocrinol. 286 2008 148 154
80. M. Korbonits A.P. Goldstone M. Gueorguiev A.B. Grossman Ghrelin—a hormone with multiple functions Front. Neuroendocrinol. 25 2004 27 68
81. H.-J. Kreienkamp E. Akgün H. Baumeister W. Meyerhof D. Richter Somatostatin receptor subtype 1 modulates basal inhibition of growth hormone release in somatotrophs FEBS Lett. 462 1999 464 466
82. U. Kumar D. Laird C.B. Srikant E. Escher Y.C. Patel Expression of the five somatostatin receptor (SSTR1-5) subtypes in rat pituitary somatotropes: quantitative analysis by double-label immunoflourescence confocal microscopy Endocrinology 138 1997 4473 4476
83. D. Landau Y. Segev A. Flyvbjerg M. Phillip Changes in the growth hormone-IGF-I axis in non-obese diabetic mice Int. J. Exp. Diabetes Res. 1 2000 9 18
84. C. Lanneau M.T. Bluet-Pajot P. Zizzari Z. Csaba P. Dournaud L. Helboe D. Hoyer E. Pellegrini G.S. Tannenbaum J. Epelbaum R. Gardette Involvement of the Sst1 somatostatin receptor subtype in the intrahypothalamic neuronal network regulating growth hormone secretion: an in vitro and in vivo antisense study Endocrinology 141 2000 967 979
85. Z. Liposits I. Merchenthaler W.K. Paull B. Flerko Synaptic communication between somatostatinergic axons and growth hormone-releasing factor (GRF) synthesizing neurons in the arcuate nucleus of the rat Histochemistry 89 1988 247 252
86. M.J. Low V. Otero-Corchon A.F. Parlow J.L. Ramirez U. Kumar Y.C. Patel M. Rubinstein Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth J. Clin. Invest. 107 2001 1571 1580
87. M.D. Lumpkin A. Negro-Vilar S.M. McCann Paradoxical elevation of growth hormone by intraventricular somatostatin: possible ultrashort-loop feedback Science 211 1981 1072 1074
88. R.M. Luque M.D. Gahete U. Hochgeschwender R.D. Kineman Evidence that endogenous somatostatin (SST) inhibits adrenocorticotropin (ACTH) and ghrelin expression by independent pathways Am. J. Physiol. Endocrinol. Metab. 291 2006 E395 E403
89. R.M. Luque M.D. Gahete R.J. Valentine R.D. Kineman Examination of the direct effects of metabolic factors on somatotrope function in a non-human primate model, Papio anubis J. Mol. Endocrinol. 37 2006 25 38
90. R.M. Luque R.D. Kineman Somatostatin (SRIF) functions as a modulator of fasting-induced changes in neuropeptide Y (NPY) and growth hormone (GH)-releasing hormone (GHRH) expression Proceedings of the 85th Annual Meeting of the Endocrine Society 2004
91. R.M. Luque R.D. Kineman Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function Endocrinology 147 2006 2754 2763
92. R.M. Luque R.D. Kineman Gender-dependent role of endogenous somatostatin in regulating growth hormone (GH)-axis function in mice Endocrinology 148 2007 5998 6006
93. R.M. Luque S. Park R.D. Kineman Severity of the catabolic condition differentially modulates hypothalamic expression of growth hormone-releasing hormone (GHRH) in the fasted mouse; potential role of neuropeptide Y (NPY) and corticotropin-releasing hormone (CRH) Endocrinology 148 2007 300 309
94. R.M. Luque S. Park X.D. Peng E. Delgado F. Gracia-Navarro R.D. Kineman M.M. Malagon J.P. Castano Homologous and heterologous in vitro regulation of pig pituitary somatostatin receptor subtypes, sst1, sst2 and sst5 mRNA J. Mol. Endocrinol. 32 2004 437 448
95. R.M. Luque M. Duran-Prado S. Garcia-Navarro F. Gracia-Navarro R.D. Kineman M.M. Malagon J.P. Castano Identification of the somatostatin receptor subtypes (sst) mediating the divergent, stimulatory/inhibitory actions of somatostatin on growth hormone secretion Endocrinology 147 2006 2902 2908
96. M. Maccario M. Procopio S. Grottoli S.E. Oleandri P. Razzore F. Camanni E. Ghigo In obesity the somatotrope response to either growth hormone-releasing hormone or arginine is inhibited by somatostatin or pirenzepine but not by glucose J. Clin. Endocrinol. Metab. 80 1995 3774 3778
97. J.N. MacLeod N.A. Pampori B.H. Shapiro Sex differences in the ultradian pattern of plasma growth hormone concentrations in mice J. Endocrinol. 131 1991 395 399
98. K.E. Mayo T. Miller V. DeAlmeida P. Godfrey J. Zheng S.R. Cunha Regulation of the pituitary somatotroph cell by GHRH and its receptor Rec. Prog. Horm. Res. 55 2000 237 266
99. G.F. McCarthy A. Beaudet G.S. Tannenbaum Colocalization of somatostatin receptors and growth hormone-releasing factor immunoreactivity in neurons of the rat arcuate nucleus Neuroendocrinology 56 1992 18 24
100. R.H. McCusker P.J. Wangsness L.C. Griel J.F. Kavanaugh Effects of feeding, fasting and refeeding on growth hormone and insulin in obese pigs Physiol. Behav. 35 1985 383 388
101. M. Mercado G. Baumann Characteristics of the somatotropic axis in insulin dependent diabetes mellitus Arch. Med. Res. 26 1995 101 109
102. S. Minami J. Kamegai O. Hasegawa H. Sugihara K. Okada I. Wakabayashi Expression of growth hormone receptor gene in rat hypothalamus J. Neuroendocrinol. 5 1993 691 696
103. S. Minami J. Kamegai H. Sugihara O. Hasegawa I. Wakabayashi Systemic administration of recombinant human growth hormone induces expression of the c-fos gene in the hypothalamic arcuate and periventricular nuclei in hypophysectomized rats Endocrinology 131 1992 247 253
104. M.S. Mondal Y. Date H. Yamaguchi K. Toshinai T. Tsurata K. Kangawa M. Nakazato Indentification of ghrelin and its receptor in neurons of the rat arcuate nucleus Regul. Pept. 126 2005 55 59
105. Y. Murakami Y. Kato Y. Kabayama T. Inoue H. Koshiyama H. Imura Involvement of hypothalamic growth hormone (GH)-releasing factor in GH secretion induced by intracerebroventricular injection of somatostatin in rats Endocrinology 120 1987 311 316
106. L.J. Murphy G.I. Bell H.G. Friesen Tissue distribution of insulin-like growth factor I and II messenger ribonucleic acid in the adult rat Endocrinology 120 1987 1279 1282
107. H.E. Murray S.X. Simonian A.E. Herbison G.E. Gillies Correlation of hypothalamic somatostatin mRNA expression and peptide content with secretion:sexual dimorphism and differential regulation by gonadal factors J. Neuroendocrinol. 11 1999 27 33
108. H.E. Murray S.X. Simonian A.E. Herbison G.E. Gillies Ontogeny and sexual differentiation of somatostatin biosynthesis and secretion in the hypothalamic periventricular-median eminence pathway J. Neuroendocrinol. 11 1999 35 42
109. R.D. Murray K. Kim S.G. Ren I. Lewis G. Weckbecker C. Bruns S. Melmed The novel somatostatin ligand (SOM230) regulates human and rat anterior pituitary hormone secretion J. Clin. Endocrinol. Metab. 89 2004 3027 3032
110. M. Norman S. Moldovan V. Seghers X.-P. Wang J. DeMayo F.C. Brunicardi Sulfonylurea receptor knockout causes glucose intolerance in mice that is not alleviated by concomitant somatostatin subtype receptor 5 knockout Ann. Surg. 235 2002 767 774
111. Nurhidayat Y. Tsukamoto K. Sigit F. Sasaki Sex differentiation of growth hormone-releasing hormone and somatostatin neurons in the mouse hypothalamus: an immunohistochemical and morphological study Brain. Res. 821 1999 309 321
112. A.M. O’Carroll K. Krempels Widespread distribution of somatostatin receptor messenger ribonucleic acids in rat pituitary Endocrinology 136 1995 5224 5227
113. K. Okada H. Sugihara S. Minami I. Wakabayashi Effect of parenteral administration of selected nutrients and central injection of γ-globulin from antiserum to neuro peptide Y on growth hormone secretory pattern in food-deprived rats Neuroendocrinology 57 1993 678 686
114. R. Panetta Y.C. Patel Expression of mRNA for all five human somatostatin receptors (hSSTR1-5) in pituitary tumors Life Sci. 56 1995 333 342
115. S. Park J. Kamegai T.A. Johnson L.A. Frohman R.D. Kineman Modulation of pituitary somatostatin receptor subtype (sst1-5) messenger ribonucleic acid levels by changes in the growth hormone axis Endocrinology 141 2000 3556 3563
116. S. Park J. Kamegai R.D. Kineman Role of glucocorticoids in the regulation of pituitary somatostatin receptor subtype (sst1-sst5) mRNA levels: evidence for direct and somatostatin-mediated effects Neuroendocrinology 78 2003 163 175
117. −/−) mice Neuroendocrinology 81 2005 360 371
118. S. Park S. Sohn R.D. Kineman Fasting-induced changes in the hypothalamic-pituitary-GH axis in the absence of GH expression: lessons from the spontaneous dwarf rat J. Endocrinol. 180 2004 369 378
119. E. Pellegrini M.T. Bluet-Pajot F. Mounier P. Bennett C. Kordon J. Epelbaum Central administration of growth hormone (GH) reeptor mRNA antisense increases GH pulsatility and decreases hypothalamic somatostatin expression in rats J. Neurosci. 16 1996 8140 8148
120. X.-D. Peng S. Park M.R. Gadelha K.T. Coschigano J.J. Kopchick L.A. Frohman R.D. Kineman The growth hormone (GH)-axis of GH receptor/binding protein gene-disrupted and metallothionein-human GH-releasing hormone transgenic mice: hypothalamic neuropeptide and pituitary receptor expression in the absence and presence of GH feedback Endocrinology 142 2001 1117 1123
121. C. Petrucci D. Cervia M. Buzzi C. Biondi P. Bagnoli Somatostatin-induced control of cytosolic free calcium in pituitary tumour cells Br. J. Pharmacol. 129 2000 471 484
122. M. Pfeiffer T. Koch H. Schroder M. Klutzny S. Kirscht H.J. Kreienkamp V. Hollt S. Schulz Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst3 receptor function by heterocimerization with sst2A J. Biol. Chem. 276 2001 14027 14036
123. D.D. Pierroz C. Catzeflis A.C. Aebi J.E. Rivier M.L. Aubert Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in intact adult male rats Endocrinology 137 1996 3 12
124. P.M. Plotsky Hypothalamic secretion of somatostatin and growth hormone-releasing factor into the hypophysial-portal circulation is reduced in streptozotocin diabetic male rats Neuroendocrinology 53 1991 433 438
125. P.M. Plotsky W. Vale Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat Science 230 1985 461 463
126. J.M. Polak S.R. Bloom Somatostatin localization in tissues Scand. J. Gastroenterol. 119 1986 11 21
127. D.H. Presky A. Schonbrunn Somatostatin pretreatment increases the number of somatostatin receptors in GH4C1 pituitary cells and does not reduce cellular responsiveness to somatostatin J. Biol. Chem. 263 1988 714 721
128. J.L. Ramirez R. Mouchantaf U. Kumar V. Otero-Corchon M. Rubinstein M.J. Low Y.C. Patel Brain somatostatin receptors are up-regulated in somatostatin-deficient mice Mol. Endocrinol. 16 2002 1951 1963
129. D.K. Reed A.I. Korytko R.W. Hipkin W.B. Wehrenberg A. Schonbrunn L. Cuttler Pituitary somatostatin receptor (sst)1-5 expression during rat development: age-dependent expression of sst2 Endocrinology 140 1999 4739 4744
130. G. Renier P. Gaudreau H. Hajjad N. Deslauriers M. Houde-Nadeau P. Brazeau Decreased pituitary growth hormone response to growth hormone-releasing factor in cafeteria-fed rats: dietary and obesity effects Neuroendocrinology 52 1990 284 290
131. M. Riedel B. Hoeft W.F. Blum A. von zur Muhlen G. Brabant Pulsatile growth hormone secretion in normal-weight and obese men: differential metabolic regulation during energy restriction Metabolism 44 1995 605 610
132. A.E. Rigamonti N. Marazzi G. Cella L. Cattaneo E.E. Muller Growth hormone responses to growth hormone-releasing hormone and hexarelin in fed and fasted dogs: effect of somatostatin infusion or pretreatment with pirenzepine J. Endocrinol. 156 1998 341 348
133. I.C.A.F. Robinson P.C. Hindmarsh The growth hormone secretory pattern and statural growth A.I. Korytko H.M. Goodman Hormonal Control of Growth 1999 Oxford University Press New York 329 395
134. K.V. Rogers L. Vician R.A. Steiner D.K. Clifton The effects of hypophysectomy and growth hormone administration on pre-prosomatostatin messenger ribonucleic acid in the periventricular nucleus of the rat hypothalamus Endocrinology 122 1988 586 591
135. S.P. Rohrer E. Hayes S.C. Berk S.M. Hutchins D.-M. Shen Y. Xiong R. Parma P. Foor S.W. Mitra S.J. Degrado M. Shu J.M. Klopp S.J. Cai A. Blake W.W. Chan A. Pasternak L. Yang A. Patchett R.G. Smith K.T. Chapman J.M. Schaeffer Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry Science 282 1998 737 740
136. R.G. Rosenfeld G. Ceda D.M. Wilson L.A. Dollar A.R. Hoffman Characterization of high affinity receptors for insulin-like growth factors I and II on rat anterior pituitary cells Endocrinology 114 1984 1571 1575
137. P. Rotwein S.K. Burgess J.D. Milbrandt J.E. Krause Differential expression of insulin-like growth factor genes in rat central nervous system Proc. Natl. Acad. Sci. U.S.A. 85 1988 265 269
138. A. Sainsbury H. Herzog Inhibitory effects of central neuropeptide Y on the somatotropic and gonadotropic axes in male rats are independent of adrenal hormones Peptides 22 2001 467 471
139. M. San Frutos L.U.C.I. Caciedo C. Mendez D. Vicent B. Velasco H. Zapatero F. Sanchez-Franco Insights into a role of GH secretagogues in reversing the age-related decline in GH/IGF-I axis AJP Endocrinol. Metabol. 293 2007 E1140 E1152
140. M. Sato L.A. Frohman Differential effects of central and peripheral administration of growth hormone (GH) and insulin-like growth factor on hypothalamic GH-releasing hormone (GRH) and somatostatin gene expression in GH-deficient dwarf rats Endocrinology 133 1993 793 799
141. M. Scacchi A.I. Pincelli F. Cavagnini Growth hormone in obesity Int. J. Obes. Relat. Metab. Disord. 23 1999 260 271
142. C. Schulz I. Wieczorek K. Reschke H. Lehnert Effects of intracerebroventricularly and intraperitoneally administered growth hormone on body weight and food intake in fa/fa Zucker rats Neuropsychobiology 45 2002 36 40
143. L.M. Seoane M. López S. Tovar F.F. Casanueva R. Señarís C. Diéguez Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus Endocrinology 144 2003 544 551
144. B. Shapiro M. Berelowitz B.L. Pimstone S. Kronheim M. Sheppard Tissue and serum somatostatin-like immunoreactivity in fed, 15-h-fasted, and 72-h-fasted rats Diabetes 28 1979 182 184
145. A. Sherlock A.A. Toogood Aging and the growth hormone/insulin like growth factor-I axis Pituitary 10 2007 189 203
146. I. Shimon J.E. Taylor J.Z. Dong R.A. Bitonte S. Kim B. Margan D.H. Coy M.D. Culler S. Melmed Somatostatin receptor subtype specificity in human fetal pituitary cultures J. Clin. Invest. 99 1997 789 798
147. I. Shimon X. Yan J.E. Taylor M.H. Weiss M.D. Culler S. Melmed Somatostatin receptor (SSTR) subtype selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas: novel potential therapy for functioning pituitary tumors J. Clin. Invest. 100 1997 2386 2392
148. B.L. Silverman M. Bettendorf S.L. Kaplan M.M. Grumbach W.L. Miller Regulation of growth hormone (GH) secretion by GH-releasing factor, somatostatin, and insulin-like growth factor I in ovine fetal and neonatal pituitary cells in vitro Endocrinology 124 1989 84 89
149. W.E. Sonntag R.L. Boyd R.M. Booze Somatostatin gene expression in hypothalamus and cortex of aging male rats Neurobiol. Aging 11 1990 409 416
150. W.E. Sonntag L.J. Forman N. Miki R.W. Steger T. Ramos A. Arimura J. Meites Effects of CNS active drugs and somatostatin antiserum on growth hormone release in young and old male rats Neuroendocrinology 33 1981 73 78
151. W.E. Sonntag P.E. Gottschall J. Meites Increased secretion of somatostatin-28 from hypothalamic neurons of aged rats in vitro Brain Res. 380 1986 229 234
152. R.K. Stoving M. Andersen A. Flyvbjerg J. Frystyk J. Hangaard J. Vinten O.G. Koldkjaer C. Hagen Indirect evidence for decreased hypothalamic somatostatinergic tone in anorexia nervosa Clin. Endocrinol. 56 2002 391 396
153. R.K. Stoving J.D. Veldhuis A. Flyvbjerg J. Vinten J. Hangaard O.G. Koldkjaer J. Kristiansen C. Hagen Jointly amplified basal and pulsatile growth hormone (GH) secretion and increased process irregularity in women with anorexia nervosa: indirect evidence for disruption of feedback regulation within the GH-Insulin-like growth factor 1 axis J. Clin. Endocrinol. Metab. 84 1999 2056 2063
154. Strowski, M. Z., Blake, A.D. Function and expression of somatostatin receptors of the endocrine pancreas. Mol. Cell. Endocrinol., submitted for publication
155. H. Sugihara N. Emoto T. Shibasaki S. Minami I. Wakabayashi Increased pituitary growth hormone-releasing factor (GRF) receptor messenger ribonucleic acid expression in food-deprived rats Brain Res. 742 1996 355 358
156. N. Suzuki K. Okada S. Minami I. Wakabayashi Inhibitory effect of neuropeptide Y on growth hormone secretion in rats is mediated by both Y1- and Y2-receptor subtypes and abolished after anterolateral deafferentation of the medial basal hypothalamus Regul. Pept. 65 1996 145 151
157. G.S. Tannenbaum J. Epelbaum Somatostatin J.L. Kostyo The Endocrine System: Hormonal Control of Growth 1999 Oxford University Press New York 221 265
158. G.S. Tannenbaum J. Epelbaum C.Y. Bowers Interrelationship between the novel peptide ghrelin and somatostatin/growth hromone-releasing hormone in regulation of pulsatile growth hormone secretion Endocrinology 144 2003 967 974
159. G.S. Tannenbaum J. Epelbaum E. Colle P. Brazeau J.B. Martin Antiserum to somatostatin reverses starvation-induced inhibition of growth hormone but not insulin secretion Endocrinology 102 1978 1909 1914
160. G.S. Tannenbaum M. Lapointe A. Beaudet A.D. Howard Expression of growth hormone secretagogue-receptors by growth hormone-releasing hormone neurons in the mediobasal hypothalamus Endocrinology 139 1998 4420 4423
161. G.S. Tannenbaum J.C. Painson A.M.J. Lengyel P. Brazeau Paradoxical enhancement of pituitary growth hormone (GH) responsiveness to GH-releasing factor in the face of high somatostatin tone Endocrinology 124 1989 1380 1388
162. J.J. Tentler J.R. Hadcock A. Gutierrez-Hartmann Somatostatin acts by inhibiting the cyclic 3′,5′-adenosine monophosphate (cAMP)/protein kinase A pathway, cAMP response element-binding protein (CREB) phosphorylation, and CREB transcription potency Mol. Endocrinol. 11 1998 859 866
163. G.B. Thomas J.T. Cummins H. Francis A.W. Sudbury P.I. McCloud I.J. Clarke Effect of restricted feeding on the relationship between hypophysial portal concentrations of growth hormone(GH)-releasing factor and somatostatin, and jugular concentrations of GH in ovariectomized ewes Endocrinology 128 1991 1151 1158
164. G.B. Thomas J.E. Mercer T. Karalis A. Rao Effect of restricted feeding on the concentrations of growth hormone (GH), gonadotropins, and prolactin (PRL) in plasma, and on the amounts of messenger ribonucleic acid for GH, gonadotropin subunits, and PRL in the pituitary glands of adult ovariectomized ewes Endocrinology 126 1990 1361 1367
165. G. Tolis N.G. Angelopoulos E. Katounda G. Rombopoulos V. Kaltzidou D. Kaltsas A. Protonotariou A. Lytras Medical treatment of acromegaly: cormorbidities and their reversibility by somatostatin analogs Neuroendocrinology 83 2006 249 257
166. J. Unger T.H. McNeill R.T. Moxley III M. White A. Moss J.N. Livingston Distribution of insulin receptor-like immunoreactivity in the rat forebrain Neuroscience 31 1989 143 157
167. J.D. Veldhuis A. Iranmanesh K. Mielke J.M. Miles P.C. Carpenter C.Y. Bowers Ghrelin potentiates growth hormone secretion driven by putative somatostatin withdrawal and resists inhibition by human corticotropin-releasing hormone J. Clin. Endocrinol. Metab. 91 2006 2441 2446
168. C. Videau U. Hochgeschwender H.-J. Kreienkamp M.B. Brennan C. Viollet D. Richter J. Epelbaum Characterisation of [125I]-Tyr0DTrp8-somatostatin binding in sst1- to sst4- and SRIF-gene-invalidated mouse brain Naunyn. Schmiedebergs. Arch. Pharmacol. 367 2003 562 571
169. B.A.M. Vuagnat D.D. Pierroz M. Lalaoui P. Englaro F.P. Pralong W.F. Blum M.L. Aubert Evidence for a leptin-neuropeptide Y axis for the regulation of growth hormone secretion in the rat Neuroendocrinology 67 1998 291 300
170. M.G. Willesen P. Kirstensen J. Romer Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat Neuroendocrinology 70 1999 306 316
171. T.L. Wood M. Berelowitz M.C. Gelato C.T. Roberts Jr. D. LeRoith W.J. Millard J.F. McKelvy Hormonal regulation of rat hypothalamic neuropeptide mRNAs: effect of hypophysectomy and hormone replacement on growth-hormone-releasing factor, somatostatin and the insulin-like growth factors Neuroendocrinology 53 1991 298 305
172. M. Yan M.E.E. Jones M. Hernandez D. Liu E.R. Simpson C. Chen Oestrogen replacement in vivo rescues the dysfunction of pituitary somatotropes in ovariectomised aromatase knockout mice Neuroendocrinology 81 2005 158 166
173. M. Yan M.E.E. Jones M. Hernandez D. Liu E.R. Simpson C. Chen Functional modification of pituitary somatotropes in the aromatase knockout mouse and the effect of estrogen replacement Endocrinology 145 2004 604 612
174. S.K. Yang H.C. Parkington A.D. Blake D.J. Keating C. Chen Somatostatin increases voltage-gated K+ currents in GH3 cells through activation of multiple somatostatin receptors Endocrinology 146 2005 4975 4984
175. S.K. Yang H.C. Parkington J. Epelbaum D.J. Keating C. Chen Somatostatin decreases voltage-gated Ca2+ currents in GH3 cells through activation of somatostatin receptor 2 AJP Endocrinol. Metabol. 292 2007 E1863 E1870
176. T. Zeyda N. Diehl R. Paylor M.B. Brennan U. Hochgeschwender Impairment in motor learning of somatostatin null mutant mice Brain Res. 906 2001 107 117
177. W.-H. Zhang A. Beaudet G.S. Tannenbaum Sexually dimorphic expression of sst1 and sst2 somatostatin receptor subtypes in the arcuate nucleus and anterior pituitary of adult rats J. Neuroendocrinol. 11 1999 129 136
178. H. Zheng A. Bailey M.H. Jiang K. Honda H.Y. Chen M.E. Trumbauer H.T. Van Der Ploeg J.M. Schaeffer G. Leng R.G. Smith Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate nucleus Mol. Endocrinol. 11 1997 1709 1717
179. X. Zhou J. De Schepper D. De Craemer M. Delhase G. Gys J. Smitz E.L. Hooghe-Peters Pituitary growth hormone release and gene expression in cafeteria-diet-induced obese rats J. Endocrinol. 159 1 1998 Oct 165 172
180. X. Zhou J. De Schepper A. Vergeylen O. Luis M. Delhase E.L. Hooghe-Peters Cafeteria diet-induced obese rats have an increased somatostatin protein content and gene expression in the periventricular nucleus J. Endocrinol. Invest. 20 5 1997 264 269