Developmental changes in the expression of somatostatin receptors (1-5) in the brain, hypothalamus, pituitary and spinal cord of the human fetus

Neuroscience

Volumn 125, Issue 2, 2004, Pages 441-448

  Goodyer, C G ^a,b   Grigorakis, S I ^a,c   Patel, Y C ^a   Kumar, U ^a,d  

^a MCGILL UNIVERSITY   (Canada)

^b RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^c IASO GENERAL HOSPITAL   (Greece)

^d ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

Base pairs; bp; CNS; FA; Fetal; Fetal age; GH; GHRH; Growth hormone; Growth hormone releasing hormone; Hypothalamus; Pituitary; Reverse transcription polymerase chain reaction; RT PCR; Somatostatin; Somatostatin receptor; Spinal cord; SST; SSTR; SSTRs

Indexed keywords

MESSENGER RNA; PEPTIDE HORMONE; RECEPTOR SUBTYPE; SOMATOSTATIN; SOMATOSTATIN RECEPTOR 1; SOMATOSTATIN RECEPTOR 2; SOMATOSTATIN RECEPTOR 3; SOMATOSTATIN RECEPTOR 4; SOMATOSTATIN RECEPTOR 5;

ARTICLE; BRAIN; CONTROLLED STUDY; FETUS; HORMONE ACTION; HUMAN; HUMAN TISSUE; HYPOPHYSIS; HYPOTHALAMUS; NERVOUS SYSTEM DEVELOPMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RECEPTOR INTRINSIC ACTIVITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; SPINAL CORD; TISSUE DISTRIBUTION;

ABORTED FETUS; BLOTTING, SOUTHERN; CENTRAL NERVOUS SYSTEM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GESTATIONAL AGE; HUMANS; HYPOTHALAMUS; PITUITARY GLAND; RECEPTORS, SOMATOSTATIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPINAL CORD;

EID: 1842451731     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2004.02.001     Document Type: Article

References (89)

1. Ackland J., Ratter S., Bourne G.L., Rees L.H. Characterisation of immunoreactive somatostatin in human fetal hypothalamic tissue. Regul Pept. 5:1983;95-101.
2. Arvat E., di Vito L., Maccagno B., Broglio F., Boghen M.F., Deghenghi R., Camanni F., Ghigo E. Effects of GHRP-2 and hexarelin, two synthetic GH-releasing peptides, on GH, prolactin, ACTH and cortisol levels in man comparison with the effects of GHRH, TRH and hCRH. Peptides. 18:1997;885-891.
3. Asa S.L., Kovacs K., Horvath E., Losinski N.E., Laszlo F.A., Domokos I., Halliday W.C. Human fetal adenohypophysis electron microscopic and ultrastructural immunocytochemical analysis. Neuroendocrinology. 48:1988;423-431.
4. Aubert M.L., Grumbach M.M., Kaplan S.L. The ontogenesis of human fetal hormones IV. Somatostatin, luteinizing hormone releasing factor, and thyrotropin releasing factor in hypothalamus and cerebral cortex of human fetuses 10-22 weeks of age. J Clin Endocrinol Metab. 44:1977;1130-1141.
5. Barnett P. Somatostatin and somatostatin receptor physiology. Endocrine. 20:2003;255-264.
6. Benali N., Ferjoux G., Puente E., Buscail L., Susini C. Somatostatin receptors. Digestion. 62:(Suppl 1):2000;27-32.
7. Bodenant C., Leroux P., Vaudry H. Localization of somatostatin receptors in subcortical visual centres of the rat during development effect of neonatal enucleation on the expression of somatostatin receptors. Neuroscience. 53:1993;1097-1102.
8. Bologna E., Leroux P. Identification of multiple somatostatin receptors in the rat somatosensory cortex during development. J Comp Neurol. 420:2000;466-480.
9. Bugnon C., Fellmann D., Bloch B. Immunocytochemical study of the ontogenesis of the hypothalamic somatostatin-containing neurons in the human fetus. Cell Tissue Res. 183:1977;319-328.
10. Bulloch A.G. Somatostatin enhances neurite outgrowth and electrical coupling of regenerating neurons in Helisoma. Brain Res. 412:1987;6-17.
11. Cacciari E., Cicognani A., Pirazoli P., Dallacasa P., Mazzaracchio M.A., Tassoni P., Bernardi F., Salardi S., Zappulla F. GH, ACTH, LH and FSH behaviour in the first seven days of life. Acta Paediatr Scand. 65:1976;337-341.
12. Charnay Y., Chayvialle J.A., Pradayrol L., Bouvier R., Paulin C., Dubois P.M. Ontogeny of somatostatin-like immunoreactivity in the human fetus and infant spinal cord. Brain Res. 433:1987;63-73.
13. Charnay Y., Leroux P., Epelbaum J., Enjalbert A., Vaudry H., Dubois P.M. Displaceable somatostatin binding sites in the gray matter and pyramidal paths of the human developing spinal cord. Neurosci Lett. 84:1988;245-250.
14. Chayvialle J.A., Paulin C., Dubois P.M., Descos F., Dubois M.P. Ontogeny of somatostatin in the human gastro-intestinal tract, endocrine pancreas and hypothalamus. Acta Endocrinol (Copenh). 94:1980;1-10.
15. Chun J.J., Nakamura M.J., Shatz C.J. Transient cells of the developing mammalian telencephalon are peptide-immunoreactive neurons. Nature. 325:1987;617-620.
16. Cooper P.E., Fernstrom M.H., Rorstad O.P., Leeman S.E., Martin J.B. The regional distribution of somatostatin, substance P and neurotensin in human brain. Brain Res. 218:1981;219-232.
17. Csaba Z., Dournaud P. Cellular biology of somatostatin receptors. Neuropeptides. 35:2001;1-23.
18. Day R., Dong W., Panetta R., Kraicer J., Greenwood M.T., Patel Y.C. Expression of mRNA for somatostatin receptor (sstr) types 2 and 5 in individual rat pituitary cells a double labeling in situ hybridization analysis. Endocrinology. 136:1995;5232-5235.
19. Delitala G., Meloni T., Masala A., Alagna S., Devilla L., Costa R. Action of somatostatin, levodopa and pyridoxine on growth hormone (GH) secretion in newborn infants. Biomedicine. 29:1978;13-15.
20. Dournaud P., Gu Y.Z., Schonbrunn A., Mazella J., Tannenbaum G.S., Beaudet A. Localization of the somatostatin receptor SST2A in rat brain using a specific anti-peptide antibody. J Neurosci. 16:1996;4468-4478.
21. Dutour A., Kumar U., Panetta R., Ouafik L., Fina F., Sasi R., Patel Y.C. Expression of somatostatin receptor subtypes in human brain tumors. Int J Cancer. 76:1998;620-627.
22. Eshet R., Assa S., Laron Z. Heterogeneity of pituitary and endogenous plasma human growth hormone from fetuses, premature and full-term newborns. Biol Neonate. 29:1976;354-359.
23. Fehlmann D., Langenegger D., Schuepbach E., Siehler S., Feuerbach D., Hoyer D. Distribution and characterisation of somatostatin receptor mRNA and binding sites in the brain and periphery. J Physiol. 94:2000;265-281.
24. Ferrandez M.A., Carrascosa A., Audi L., Ballabriga A. Somatostatin effects on cultured human fetal epiphyseal chondrocytes. Pediatr Res. 32:1992;571-573.
25. Ferriero D.M., Sheldon R.A., Messing R.O. Somatostatin enhances nerve growth factor-induced neurite outgrowth in PC12 cells. Brain Res Dev Brain Res. 80:1994;13-18.
26. Finkelstein J.W., Anders T.F., Sacher E.J., Roffwarg H.P., Hellman L.D. Behavioral state, sleep stage and growth hormone levels in human infants. J Clin Endocrinol Metab. 32:1971;368-371.
27. Furuhashi N., Takahashi T., Fukaya T., Kono H., Shinkawa O., Tachibana Y., Wada Y., Suzuki M. Plasma somatostatin and growth hormone in the human fetus and its mother at delivery. Gynecol Obstet Invest. 16:1983;59-62.
28. Geola F.L., Yamada T., Warwick R.J., Tourtelotte W.W., Hershman J.M. Regional distribution of somatostatin-like immunoreactivity in the human brain. Brain Res. 229:1981;35-42.
29. Gonzalez B., Leroux P., Lamacz M., Bodenant C., Balazs R., Vaudry H. Somatostatin receptors are expressed by immature cerebellar granule cells evidence for a direct inhibitory effect of somatostatin on neuroblast activity. Proc Natl Acad Sci USA. 89:1992;9627-9631.
30. Goodyer C.G. Development of the anterior pituitary. Timiras P.S. Handbook of human growth and development. 1989;21-48 CRC Press, Boca Raton.
31. Goodyer C.G., Branchaud C.L., Lefbvre Y. Effects of growth hormone (GH)-releasing factor and somatostatin on GH secretion from early to midgestation human fetal pituitaries. J Clin Endocrinol Metab. 76:1993;1259-1264.
32. 2+ channels. J Clin Endocrinol Metab. 76:1993;1265-1270.
33. Goodyer C.G., Hall C.S., Guyda H., Robert F., Giroud C.J. Human fetal pituitary in culture hormone secretion and response to somatostatin, luteinizing hormone releasing factor, thyrotropin releasing factor and dibutyryl cyclic AMP. J Clin Endocrinol Metab. 45:1977;73-85.
34. Greenman Y., Melmed S. Expression of three somatostatin receptor subtypes in pituitary adenomas evidence for preferential SSTR5 expression in the mammosomatotroph lineage. J Clin Endocrinol Metab. 79:1994;724-729.
35. Handel M., Schulz S., Stanarius A., Schreff M., Erdtmann-Vourliotis M., Schmidt H., Wolf G., Hollt V. Selective targeting of somatostatin receptor 3 to neuronal cilia. Neuroscience. 89:1999;909-926.
36. Helboe L., Stidsen C.E., Moller M. Immunohistochemical and cytochemical localization of the somatostatin receptor subtype sst1 in the somatostatinergic parvocellular neuronal system of the rat hypothalamus. J Neurosci. 18:1998;4938-4945.
37. Hervieu G., Emson P.C. The localization of somatostatin receptor 1 (sst1) immunoreactivity in the rat brain using an N-terminal specific antibody. Neuroscience. 85:1998;1263-1284.
38. Ho R.H., Wu W., Elde R. Pre-pro-somatostatin mRNA in the developing rat spinal cord with special reference to ventral horn motoneurons. Neurosci Lett. 163:1993;125-128.
39. Jaquet P., Saveanu A., Gunz G., Fina F., Zamora A.J., Grino M., Culler M.D., Moreau J.P., Enjalbert A., Ouafik L.H. Human somatostatin receptor subtypes in acromegaly distinct patterns of messenger ribonucleic acid expression and hormone suppression identify different tumoral phenotypes. J Clin Endocrinol Metab. 85:2000;781-792.
40. Kaplan S.L., Grumbach M.M., Shepard T.H. The ontogenesis of human fetal hormones I. Growth hormone and insulin. J Clin Invest. 51:1972;3080-3093.
41. Kar S., Quirion R. Neuropeptide receptors in developing and adult rat spinal cord an in vitro quantitative autoradiography study of calcitonin gene-related peptide, neurokinins, mu-opioid, galanin, somatostatin, neurotensin and vasoactive intestinal polypeptide receptors. J Comp Neurol. 354:1995;253-281.
42. Kentroti S., Vernadakis A. Growth hormone-releasing hormone and somatostatin influence neuronal expression in developing chick brain III. GABAergic neurons. Brain Res. 562:1991;34-38.
43. Kong H., DePaoli A.M., Breder C.D., Yasuda K., Bell G.I., Reisine T. Differential expression of messenger RNAs for somatostatin receptor subtypes SSTR1, SSTR2 and SSTR3 in adult rat brain analysis by RNA blotting and in situ hybridization histochemistry. Neuroscience. 59:1994;175-184.
44. Kumar U., Laird D., Srikant C.B., Escher E., Patel Y.C. Expression of the five somatostatin receptor (SSTR1-5) subtypes in rat pituitary somatotrophes quantitative analysis by double-layer immunofluorescence confocal microscopy. Endocrinology. 138:1997;4473-4476.
45. Lanneau C., Bluet-Pajot M.T., Zizzari P., Csaba Z., Dournaud P., Helboe L., Hoyer D., Pellegrini E., Tannenbaum G.S., Epelbaum J., Gardette R. Involvement of the Sst1 somatostatin receptor subtype in the intrahypothalamic neuronal network regulating growth hormone secretion an in vitro and in vivo antisense study. Endocrinology. 141:2000;967-979.
46. Matsuzaki F., Irie M., Shizume K. Growth hormone in human fetal pituitary glands and cord blood. J Clin Endocrinol Metab. 33:1971;908-911.
47. Mezey E., Hunyady B., Mitra S., Hayes E., Liu Q., Schaeffer J., Schonbrunn A. Cell specific expression of the sst2A and sst5 somatostatin receptors in the rat anterior pituitary. Endocrinology. 139:1998;414-419.
48. Miller J.D., Wright N.M., Esparza A., Jansons R., Yang H.C., Hahn H., Mosier H.D. Jr. Spontaneous pulsatile growth hormone release in male and female premature infants. J Clin Endocrinol Metab. 75:1992;1508-1513.
49. Munsick R.A. Human fetal extremity lengths in the interval from 9 to 21 menstrual weeks of pregnancy. Am J Obstet Gynecol. 149:1984;883-887.
50. Nagashima K., Yagi H., Suzuki S., Noji T., Yunoki H., Kuroume T. Levels of growth hormone and growth-hormone-releasing factor in cord blood. Biol Neonate. 49:1986;307-310.
51. Panetta R., Patel Y.C. Expression of mRNA for all five human somatostatin receptors (hSSTR1-5) in pituitary tumors. Life Sci. 56:1995;333-342.
52. Patel Y.C. Somatostatin and its receptor family. Front Neuroendocrinol. 20:1999;157-198.
53. Patel Y.C., Greenwood M., Kent G., Panetta R., Srikant C.B. Multiple gene transcripts of the somatostatin receptor SSTR2 tissue selective distribution and cAMP regulation. Biochem Biophys Res Commun. 192:1993;288-294.
54. Pfeiffer M., Koch T., Schroder H., Klutzny M., Kirscht S., Kreienkamp H.J., Hollt V., Schulz S. Homo- and heterodimerization of somatostatin receptor subtypes inactivation of sst(3) receptor function by heterodimerization with sst(2A). J Biol Chem. 276:2001;14027-14036.
55. Reed D.K., Korytko A.I., Hipkin R.W., Wehrenberg W.B., Schonbrunn A., Cuttler L. Pituitary somatostatin receptor (sst)1-5 expression during rat development age-dependent expression of sst2. Endocrinology. 140:1999;4739-4744.
56. Reisine T., Bell G.I. Molecular biology of somatostatin receptors. Endocr Rev. 16:1995;427-442.
57. Ren S.G., Taylor J., Dong J., Yu R., Culler M.D., Melmed S. Functional association of somatostatin receptor subtypes 2 and 5 in inhibiting human growth hormone secretion. J Clin Endocrinol Metab. 88:2003;4239-4245.
58. Reubi J.C., Cortes R., Maurer R., Probst A., Palacios J.M. Distribution of somatostatin receptors in the human brain an autoradiographic study. Neuroscience. 18:1986;329-346.
59. Rieutort M. Ontogenetic development of the inhibition of growth hormone release by somatostatin in the rat in-vivo and in-vitro (perifusion) study. J Endocrinol. 89:1981;355-363.
60. Rocheville M., Lange D.C., Kumar U., Patel S.C., Patel R.C., Patel Y.C. Receptors for dopamine and somatostatin formation of hetero-oligomers with enhanced functional activity. Science. 288:2000;154-157.
61. Rocheville M., Lange D.C., Kumar U., Sasi R., Patel R.C., Patel Y.C. Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers. J Biol Chem. 275:2000;7862-7869.
62. Roti E., Gnudi A., Robuschi G., Emanuele R., Benassi L., Braverman L.E. Response of growth hormone to thyrotropin-releasing hormone during fetal life. J Clin Endocrinol Metab. 54:1982;1255-1257.
63. Sack J., Fisher D.A., Wang C.C. Serum thyrotropin, prolactin, and growth hormone levels during the early neonatal period in the human infant. J Pediatr. 89:1976;298-300.
64. Saveanu A., Gunz G., Dufour H., Caron P., Fina F., Ouafik L., Culler M.D., Moreau J.P., Enjalbert A., Jaquet P. Bim-23244, a somatostatin receptor subtype 2- and 5-selective analog with enhanced efficacy in suppressing growth hormone (GH) from octreotide-resistant human GH-secreting adenomas. J Clin Endocrinol Metab. 86:2001;140-145.
65. Schindler M., Harrington K.A., Humphrey P.P., Emson P.C. Cellular localisation and co-expression of somatostatin receptor messenger RNAs in the human brain. Brain Res Mol Brain Res. 34:1995;321-326.
66. Schindler M., Holloway S., Hathway G., Woolf C.J., Humphrey P.P., Emson P.C. Identification of somatostatin sst2(a) receptor expressing neurones in central regions involved in nociception. Brain Res. 798:1998;25-35.
67. Schindler M., Holloway S., Humphrey P.P., Waldvogel H., Faull R.L., Berger W., Emson P.C. Localization of the somatostatin sst2(a) receptor in human cerebral cortex, hippocampus and cerebellum. Neuroreport. 9:1998;521-525.
68. Schindler M., Humphrey P.P., Lohrke S., Friauf E. Immunohistochemical localization of the somatostatin sst2(b) receptor splice variant in the rat central nervous system. Neuroscience. 90:1999;859-874.
69. Schindler M., Sellers L.A., Humphrey P.P., Emson P.C. Immunohistochemical localization of the somatostatin SST2(A) receptor in the rat brain and spinal cord. Neuroscience. 76:1997;225-240.
70. Schoenen J., Lotstra F., Vierendeels G., Reznik M., Vanderhaeghen J.J. Substance P, enkephalins, somatostatin, cholecystokinin, oxytocin, and vasopressin in human spinal cord. Neurology. 35:1985;881-890.
71. Schulz S., Handel M., Schreff M., Schmidt H., Hollt V. Localization of five somatostatin receptors in the rat central nervous system using subtype-specific antibodies. J Physiol. 94:2000;259-264.
72. Segond V.B., Schindler M., Hervieu G.J., Beckmann B., Emson P.C., Heppelmann B. Distribution of somatostatin receptor subtypes in rat lumbar spinal cord examined with gold-labelled somatostatin and anti-receptor antibodies. Brain Res. 816:1999;254-257.
73. Selmer I., Schindler M., Allen J.P., Humphrey P.P., Emson P.C. Advances in understanding neuronal somatostatin receptors. Regul Pept. 90:2000;1-18.
74. Selmer I.S., Schindler M., Humphrey P.P., Waldvogel H.J., Faull R.L., Emson P.C. First localisation of somatostatin sst(4) receptor protein in selected human brain areas an immunohistochemical study. Brain Res Mol Brain Res. 82:2000;114-125.
75. Shimon I. Somatostatin receptors in pituitary and development of somatostatin receptor subtype-selective analogs. Endocrine. 20:2003;265-270.
76. Shimon I., Taylor J.E., Dong J.Z., Bitonte R.A., Kim S., Morgan B., Coy D.H., Culler M.D., Melmed S. Somatostatin receptor subtype specificity in human fetal pituitary cultures differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation. J Clin Invest. 99:1997;789-798.
77. Shimon I., Yan X., Taylor J.E., Weiss M.H., Culler M.D., Melmed S. Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas novel potential therapy for functional pituitary tumors. J Clin Invest. 100:1997;2386-2392.
78. Srikant C.B. Cell cycle dependent induction of apoptosis by somatostatin analog SMS 201-995 in AtT-20 mouse pituitary cells. Biochem Biophys Res Commun. 209:1995;400-406.
79. Tannenbaum G.S., Zhang W.H., Lapointe M., Zeitler P., Beaudet A. Growth hormone-releasing hormone neurons in the arcuate nucleus express both Sst1 and Sst2 somatostatin receptor genes. Endocrinology. 139:1998;1450-1453.
80. Thoss V.S., Perez J., Duc D., Hoyer D. Embryonic and postnatal mRNA distribution of five somatostatin receptor subtypes in the rat brain. Neuropharmacology. 34:1995;1673-1688.
81. Thoss V.S., Perez J., Probst A., Hoyer D. Expression of five somatostatin receptor mRNAs in the human brain and pituitary. Naunyn Schmiedebergs Arch Pharmacol. 354:1996;411-419.
82. Thoss V.S., Piwko C., Probst A., Hoyer D. Autoradiographic analysis of somatostatin SRIF1 and SRIF2 receptors in the human brain and pituitary. Naunyn Schmiedebergs Arch Pharmacol. 355:1997;168-176.
83. Todd A.J., Spike R.C., Polgar E. A quantitative study of neurons which express neurokinin-1 or somatostatin sst2a receptor in rat spinal dorsal horn. Neuroscience. 85:1998;459-473.
84. Toni, R, Briganti, F, Lechan, RM, Vezzadini, P (1996) Immunocytochemical distribution of somatostatin in the hypothalamus of the human fetus. Endocrine Society Meeting 1996. Abstract.
85. Viollet C., Videau C., Epelbaum J. Somatostatin and behaviour the need for genetically engineered models. J Physiol. 94:2000;179-183.
86. Weill C.L. Somatostatin (SRIF) prevents natural motoneuron cell death in embryonic chick spinal cord. Dev Neurosci. 13:1991;377-381.
87. Wulfsen I., Meyerhof W., Fehr S., Richter D. Expression patterns of rat somatostatin receptor genes in pre- and postnatal brain and pituitary. J Neurochem. 61:1993;1549-1552.
88. Zatelli M.C., Piccin D., Tagliati F., Ambrosio M.R., Margutti A., Padovani R., Scanarini M., Culler M.D., degli Uberti E.C. Somatostatin receptor subtype 1 selective activation in human growth hormone (GH)- and prolactin (PRL)-secreting pituitary adenomas effects on cell viability, GH, and PRL secretion. J Clin Endocrinol Metab. 88:2003;2797-2802.
89. Zhang W.H., Beaudet A., Tannenbaum G.S. Sexually dimorphic expression of sst1 and sst2 somatostatin receptor subtypes in the arcuate nucleus and anterior pituitary of adult rats. J Neuroendocrinol. 11:1999;129-136.