Defective hypothalamic growth hormone (GH)-releasing hormone activity may contribute to declining GH secretion with age in man

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 9, 1997, Pages 2885-2888

  Degli Uberti, Ettore C ^a   Ambrosio, Maria R ^a   Cella, Silvano G ^b   Margutti, Angelo R ^a   Trasforini, Giorgio ^a   Rigamonti, Antonello E ^b   Petrone, Emilio ^a   Müller, Eugenio E ^b  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; GROWTH HORMONE RELEASING FACTOR; SEX HORMONE; SOMATOMEDIN C; SOMATOSTATIN; TESTOSTERONE;

ADULT; AGED; AGING; ARTICLE; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; FEMALE; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE RELEASE; HORMONE ACTION; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; TESTOSTERONE BLOOD LEVEL;

ADOLESCENT; ADULT; AGED; AGING; ESTRADIOL; FEMALE; GROWTH HORMONE-RELEASING HORMONE; HUMAN GROWTH HORMONE; HUMANS; HYPOTHALAMUS; INSULIN-LIKE GROWTH FACTOR I; MALE; SEX CHARACTERISTICS; SINGLE-BLIND METHOD; TESTOSTERONE;

EID: 0005517324     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.9.2885     Document Type: Article

References (31)

1. Corpas E, Harman SM, Blackman MR. 1993 Human growth hormone and human aging. Endocr Rev. 14:20-39.
2. Finkelstein J, Roffwarg H, Boyar P, Kream J, Hellman L. 1972 Age related changes in the twenty-four hour spontaneous secretion of growth hormone in normal individuals. J Clin Endocrinol Metab. 35:665-670.
3. Zadik Z, Chalew SA, McCarter RJ, Meistas M, Kowarski AA. 1985 The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. J Clin Endocrinol Metab. 60:513-516.
4. Ho KY, Evans WS, Blizzard RM, et al. 1987 Effects of sex and age on 24-hour profile of growth hormone secretion in men: importance of endogenous estradiol concentrations. J Clin Endocrinol Metab. 64:51-58.
5. Corpas E, Harman SM, Pineyro MA, Roberson R, Blackman MR. 1992 GHRH-1-29 twice daily reverses the decreased GH and IGF-I levels in old men. J Clin Endocrinol Metab. 75:530-535.
6. Iranmanesh A, Lizarralde G, Veldhuis JD. 1991 Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrinol Metab. 73:1081-1088.
7. Ghigo E, Goffi S, Nicolosi M, et al. 1990 Growth hormone (GH) responsiveness to combined administration of arginine and GH-releasing hormone does not vary with age in man. J Clin Endocrinol Metab. 71:481-485.
8. Penalva A, Burguera B, Casabiell X, Tresguerres JA, Dieguez C, Casanueva FF. 1989 Activation of cholinergic neurotransmission by pyridostigmine reverses the inhibitory effect of hyperglycemia on growth hormone (GH) releasing hormone-induced GH secretion in man: does acute hyperglycemia act through hypothalamic releasing of somatostatin? Neuroendocrinology. 49:551-554.
9. Shibasaki T, Shizume K, Nakahara M, et al. 1984 Age-related changes in plasma growth hormone response to growth hormone-releasing factor in man. J Clin Endocrinol Metab. 58:212-214.
10. Lang I, Schernthaner G, Pietschmann P, Kurz R, Stephenson JM, Templ H. 1987 Effects of sex and age on growth hormone response to growth hormone-releasing hormone in healthy individuals. J Clin Endocrinol Metab. 65:535-540.
11. Bellantoni MF, Harman SM, Cho DE, Blackman MR. 1991 Effects of progestin-opposed transdermal estrogen administration on growth hormone and insulin-like growth factor-1 in postmenopausal women of different ages. J Clin Endocrinol Metab. 72:172-178.
12. Pavlov EP, Harman SM, Merriam GR, Gelato MC, Blackman MR. 1986 Responses of growth hormone (GH) and somatomedin-C to GH-releasing hormone in healthy aging men. J Clin Endocrinol Metab. 62:595-600.
13. De Gennaro Colonna V, Zoli M, Cocchi D, et al. 1989 Reduced growth hormone releasing factor (GHRF) a like immunoreactivity and GHRF gene expression in the hypothalamus of aged rats. Peptides. 10:705-708.
14. Morimoto N, Kawakami F, Makino S, Chihara K, Hasegawa M, Ibata Y. 1988 Age-related changes in growth hormone releasing factor and somatostatin in the rat hypothalamus. Neuroendocrinology. 47:459-464.
15. Müller EE. 1987 Neural control of somatotropic function. Physiol Rev. 67:962-1053.
16. Plotsky PM, Vale W. 1985 Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat. Science. 230:461-463.
17. Frohman LA, Downs TR, Clarke IJ, Thomas GB. 1990 Measurement of growth hormone-releasing hormone and somatostatin in hypothalamic-portal plasma of unanesthesized sheep. Spontaneous secretion and response to insulin-induced hypoglycemia. J Clin Invest. 86:17-24.
18. Lumpkin MD, Mulroney SE, Haramati A. 1989 Inhibition of pulsatile growth hormone (GH) secretion and somatic growth in immature rats with a synthetic GH-releasing factor antagonist. Endocrinology. 124:1154-1159.
19. Tannenbaum GS, Ling N. 1984 The interrelationship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultradian rhythm of GH secretion. Endocrinology. 115:1952-1957.
20. Miki N, Ono M, Shizume K. 1988 Withdrawal of endogenous somatostatin induces secretion of growth hormone releasing factor in rats. J Endocrinol. 117:245-252.
21. Robinson IC, Jeffery S, Clark RG. 1990 Somatostatin and its physiological significance in regulating the episodic secretion of growth hormone in the rat. Acta Paediatr Scand. 367(Suppl):87-92.
22. Hindmarsh PC, Brain CE, Robinson IC, Matthews DR, Brook CG. 1991 The interaction of growth hormone releasing hormone and somatostatin in the generation of a GH pulse in man. Clin Endocrinol (Oxf). 35:353-360.
23. Cella SG, Luceri M, Cattaneo L, Torsello A, Müller EE. 1996 Somatostatin withdrawal as generator of pulsatile GH release in the dog: a possible tool to evaluate the endogenous GHRH tone? Neuroendocrinology. 63:481-488.
24. Tait PG. 1963 The use of isotopic steroids for measurement of production rates in vivo. J Clin Endocrinol Metab. 23:1287-1297.
25. Rudman D. 1985 Growth hormone, body composition and aging. J Am Geriatr Soc. 33:800-807.
26. Müller EE, Cella SG, De Gennaro Colonna V, Parenti M, Cocchi D, Locatelli V. 1993 Aspects of the neuroendocrine control of growth hormone secretion in ageing mammals. J Reprod Fertil. 46(Suppl):99-114.
27. Peter F, Szentistvanyi S. 1983 Changes of the growth hormone level after a single small dose of somatostatin. Acta Paediatr Hung. 24:63-65.
28. Ho PJ, Kletter GB, Hopwood NJ, DeMott Friberg R, Barkkan AL. 1993 Somatostatin withdrawal alone is an ineffective generator of pulsatile growth hormone release in man. Acta Endocrinol (Copenh). 129:414-418.
29. Cella SG, Moiraghi V, Minuto F, et al. 1989 Prolonged fasting or clonidine can restore the defective growth hormone secretion in old dogs. Acta Endocrinol (Copenh). 121:177-184.
30. Hartman ML, Pezzoli SS, Hellmann PJ, Suratt PM, Thorner MO. 1996 Pulsatile grouwth hormone secretion in older persons is enhanced by fasting without relationship to sleep stages. J Clin Endocrinol Metab. 81:2694-2701.
31. Veldhuis JD. 1995 The neuroendocrine regulation and implications of pulsatile GH secretion: gender effects. Endocrinologist. 5:198-213.