Localization of the insulin-like growth factor I receptor in the cerebellum and hypothalamus of adult rats: An electron microscopic study

Journal of Neurocytology

Volumn 26, Issue 7, 1997, Pages 479-490

  Garcia Segura, L M ^a   Rodriguez, J R ^a   Torres Aleman, I ^a  

^a INSTITUTO CAJAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN C RECEPTOR;

ANIMAL TISSUE; ARTICLE; BRAIN REGION; CELLULAR DISTRIBUTION; CEREBELLUM; DENDRITE; ELECTRON MICROSCOPY; HYPOTHALAMUS; IMMUNOCYTOCHEMISTRY; MALE; MOSSY FIBER; NONHUMAN; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PURKINJE CELL; RAT;

AGE FACTORS; ANIMALS; ANTIBODY SPECIFICITY; ARCUATE NUCLEUS; CEREBELLAR CORTEX; MALE; MICROSCOPY, ELECTRON; NEUROGLIA; NEURONS; RATS; RATS, WISTAR; RECEPTOR, IGF TYPE 1;

ANIMALIA;

EID: 0030779032     PISSN: 03004864     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018581407804     Document Type: Article

References (60)

1. AGUADO, F., SANCHEZ-FRANCO, F., CACICEDO, L., FERNANDEZ, T., RODRIGO, J. & MARTINEZ-MURILLO, R. (1992) Subcellular localization of insulin-like growth factor I (IGF-I) in Purkinje cells of the adult rat: an immunocytochemical study. Neuroscience Letters 135, 171-4.
2. AGUADO, F., RODRIGO, J., CACICEDO, L. & MELLSTROM, B. (1993) Distribution of insulin-like growth factor-I receptor mRNA in rat brain. Regulation in the hypothalamo-neurohypophysial system. Journal of Molecular Endocrinology 11, 231-9.
3. ANDERSSON, I. K., EDWALL, D., NORSTEDT, G., ROZELL, B., SKOTTNER, A. & HANSSON, H. A. (1988) Differing expression of insulin-like growth factor I in the developing and in the adult rat cerebellum. Acta Physiologica Scandinavica 132, 167-73.
4. ARAUJO, D. M., LAPCHAK, P. A., COLLIER, B., CHABOT, J. G. & QUIRION, R. (1989) Insulin-like growth factor-I (somatomedin-C) receptors in the rat brain: Distribution and interaction with the hippocampal cholinergic systems. Brain Research 484, 130-8.
5. AULETTA, M., NIELSEN, F. C. & GAMMELTOFT, S. (1992) Receptor-mediated endocytosis and degradation of insulin-like growth factor I and II in neonatal rat astrocytes. Journal of Neurosciencc Research 31, 14-20.
6. BACH, M. A., SHEN-ORR, Z., LOWE, W. L., ROBERTS, C. T. & LeROITH, D. (1991) Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain. Molecular Brain Research 10, 43-8.
7. BARTLETT, W. P., LI, X. S., WILLIAMS, M. & BENKOVIC, S. (1991) Localization of insulin-like growth factor-I mRNA in murine central nervous system during postnatal development. Developmental Biology 147, 239-50.
8. BECK, K. D., POWELL-BRAXTON, L., WIDMER, H. R., VALVERDE, J. & HEFTI, F. (1995) Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons. Neuron 14, 717-30.
9. BECKER, K., STEGENGA, S. & CONWAY, S. (1995) Role of insulin-like growth factor I in regulating growth hormone release and feedback in the male rate. Neuroendocrinology 61, 573-83.
10. BERELOWITZ, M., SZABO, M., FROHMAN, L. A., FIRESTONE, S., CHU, L. & HINTZ, R. L. (1981) Somatomedin C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary. Science 212, 1279-81.
11. BONDY, C. A. (1991) Transient IGF-I gene expression during the maturation of functionally related central projecting neurons. Journal of Neuroscience 11, 3442-55.
12. BONDY, C. & LEE, W. H. (1993) Correlation between insulin-like growth factor (IGF)-binding protein 5 and IGF-I gene expression during brain development. Journal of Neuroscience 13, 5092-104.
13. BONDY, C., WERNER, H., ROBERTS, C. T. & LeROITH, D. (1992) Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: Comparison with insulin-like growth factors I and II. Neuroscience 46, 909-23.
14. BOURGUIGNON, J. P., GERARD, A., ALVAREZ GONZALEZ M. L. & FRANCHIMONT, P. (1993) Acute suppression of gonadotrophin-releasing hormone secretion by insulin-like growth factor I and subproducts: an age-dependent endocrine effect. Neuroendocrinology 58, 525-30.
15. CASTRO-ALAMANCOS, M. A. & TORRES-ALEMAN, I. (1993) Long-term depression of glutamate-induced gamma-aminobutyric acid release in cerebellum by insulin-like growth factor I. Proceedings of the National Academy of Sciences (USA) 90, 7386-90.
16. CASTRO-ALAMANCOS, M. A. & TORRES-ALEMAN, I. (1994) Learning of the conditioned eye-blink response is impaired by an antisense insulin-like growth factor I oligonucleotide. Proceedings of the National Academy of Sciences (USA) 91, 10203-7.
17. DeFELIPE, J. & FAIRÉN, A. (1993) A simple and reliable method for correlative light and electron microscopic studies. Journal of Histochemistry and Cytochemistry 41, 769-72.
18. De PABLO, F. & De la ROSA, E. J. (1995) The developing CNS: a scenario for the action of proinsulin, insulin and insulin-like growth factors. Trends in Neuroscience 18, 143-50.
19. DUEÑAS, M., LUQUIN, S., CHOWEN, J. A., TORRESALEMAN, I., NAFTOLIN, F. & GARCIA-SEGURA, L. M. (1994) Gonadal hormone regulation of insulin-like growth factor-I-like immunoreactivity in hypothalamic astroglia of developing and adult rats. Neuroendocrinology 59, 528-38.
20. DUEÑAS, M., TORRES-ALEMAN, I., NAFTOLIN, F. & GARCIA-SEGURA, L. M. (1996) Interaction of insulin-like growth factor-I and estradiol signaling pathways on hypothalamic neuronal differentiation. Neuroscience 74, 531-9.
21. FERNANDEZ-GALAZ, M. C., TORRES-ALEMAN, I. & GARCIA-SEGURA, L. M. (1996) Endocrine-dependent accumulation of IGF-I by hypothalamic glia. Neuro-Report 8, 373-7.
22. GARCIA-SEGURA, L. M., PEREZ, J., PONS, S., REJAS, M. T. & TORRES-ALEMAN, I. (1991) Localization of insulin-like growth factor I (IGF-I)-like immunoreactivity in the rat brain. Brain Research 560, 167-74.
23. GARCIA-SEGURA, L. M., CHOWEN, J. A. & NAFTOLIN, F. (1996) Endocrine glia: Roles of glial cells in the brain actions of steroid and thyroid hormones and in the regulation of hormone secretion. Frontiers in Neuroendocrinology 17, 180-211.
24. HAWKER, J. R. & GRANGER, H. J. (1992) Internalized basic fibroblast growth factor translocates to nuclei of venular endothelial cells. American Journal of Physiology 262, H1525-37.
25. HINEY, J. J., OJEDA, S. R. & LES DEES, W. (1991) Insulin-like growth factor I: A possible metabolic signal involved in the regulation of female puberty. Neuroendocrinology 54, 420-3.
26. HINEY, J. K., SRIVASTAVA, V., NYBERG, C. L., OJEDA, S. R. & LES DEES, W. (1996) Insulin-like growth factor I of peripheral origin acts centrally to accelerate the initiation of female puberty. Endocrinology 137, 3717-28.
27. HÖKFELT, T. (1991) Neuropeptides in perspective: the last ten years. Neuron 7, 867-79.
28. JANS, D. A. (1994) Nuclear signaling pathways for polypeptide ligands and their membrane receptors? FASEB Journal 8, 841-7.
29. 125I]insulin receptor binding sites in developing and adult rat brain. Journal of Comparative Neurology 333, 375-97.
30. KIM, S. J. & KAHN, C. R. (1993) Insulin induces rapid accumulation of insulin receptors and increases tyrosine kinase activity in the nucleus of cultured adipocytes. Journal of Cell Physiology 157, 217-28.
31. KOMOLY, S., HUDSON, L. D., WEBSTER, H. D. & BONDY, C. A. (1992) Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination. Proceedings of the National Academy of Sciences (USA) 89, 1894-8.
32. LAUDRON, P. M. (1994) From receptor internalization to nuclear translocation. New targets for long-term pharmacology. Biochemical Pharmacology 13, 3-13.
33. LEE, W. H., JAVEDAN, S. & BONDY, C. A. (1992) Coordinate expression of insulin-like growth factor system components by neurons and neuroglia during retinal and cerebellar development. Journal of Neuroscience 12, 4737-44.
34. LERANTH, C., SHANABROUGH, M. & NAFTOLIN, F. (1991) Estrogen induces ultrastructural changes in progesterone receptor-containing GABA neurons of the primate hypothalamus. Neuroendocrinology 54, 571-9.
35. LESNIAK, M. A., HILL, J. M., KIESS, W., ROJESKI, M., PERT, C. B. & ROTH, J. (1988) Receptors for insulin-like growth factors I and II: Autoradiographic localization in rat brain and comparison to receptors for insulin. Endocrinology 123, 2089-99.
36. LLANO, I., LERESCHE, N. & MARTY, A. (1991) Calcium entry increases the sensitivity of cerebellar Purkinje cells to applied GABA and decreases inhibitory synaptic currents. Neuron 6, 565-74.
37. LOBIE, P. E., MERTANI, H., MOREL, G., MORALESBUSTOS, O., NORSTEDT, G. & WATERS, M. J. (1994) Receptor-mediated nuclear translocation of growth hormone. Journal of Biological Chemistry 269, 21330-9.
38. MA, Y. J., JUNIER, M. P., COSTA, M. E. & OJEDA, S. R. (1992) Transforming growth factor-α gene expression in the hypothalamus is developmentally regulated and linked to sexual maturation. Neuron 9, 657-70.
39. MARKS, J. K., PORTE, D. & BASKIN, D. G. (1991) Localization of type I insulin-like growth factor receptor messenger RNA in the adult rat brain by in situ hybridization. Molecular Endocrinology 5, 1158-68.
40. MASTERS, B. A., WERNER, H., ROBERTS, C. T., LeROITH, D. & RAIZADA, M. K. (1991) Insulin-like growth factor I (IGF-I) receptors and IGF-I action in oligodendrocytes from rat brains. Regulatory Peptides 25, 117-31.
41. MOSS, A. M. & LIVINGSTON, J. N. (1993) Distinct beta-subunits are present in hybrid insulin-like-growth-factor-1 receptors in the central nervous system. Biochemical Journal 294, 685-92.
42. MOZELL, R. L. & McMORRIS, F. A. (1991) Insulin-like growth factor I stimulates oligodendrocyte development and myelination in rat brain aggregate cultures. Journal of Neuroscience Research 30, 382-90.
43. NIETO-BONA, M. P., BUSIGUINA, S. & TORRES-ALEMAN, I. (1995) Insulin-like growth factor I is an afferent trophic signal that modulates calbindin-28kD in adult Purkinje cells. Journal of Neuroscience Research 42, 371-6.
44. NILSSON, L., SARA, V. R. & NORDBERG, A. (1988) Insulin-like growth factor I stimulates the release of acetylcholine from rat cortical slices. Neuroscience Letters 88, 221-6.
45. OCRANT, I., FAY, C. T. & PARMELEE, J. T. (1990) Characterization of insulin-like growth factor binding proteins produced in the rat central nervous system. Endocrinology 127, 1260-7.
46. PONS, S., REJAS, M. T. & TORRES-ALEMAN, I. (1991) Ontogeny of insulin-like growth factor I, its receptor, and its binding proteins in the rat hypothalamus. Developmental Brain Research 62, 169-75.
47. QUIROGA, S., GAROFALO, R. S. & PFENNINGER, K. H. (1995) Insulin-like growth factor 1 receptors of fetal brain are enriched in nerve growth cones and contain a β-subunit variant. Proceedings of the National Academy of Sciences (USA) 92, 4309-12.
48. RAO, Y. P., OLSON, M. D., BUCKLEY, D. J &. BUCKLEY, A. R. (1993) Nuclear co-localization of prolactin and the prolactin receptor in rat Nb2 node lymphoma cells. Endocrinology 133, 3062-5.
49. RAO, Y. P., BUCKLEY, D. J., OLSON, M. D. & BUCKLEY, A. R. (1995) Nuclear translocation of prolactin: collaboration of tyrosine kinase and protein kinase C activation in rat Nb2 node lymphoma cells. Journal of Cell Physiology 163, 266-76.
50. REINHARDT, R. R. & BONDY, C. A. (1994) Insulin-like growth factors cross the blood-brain barrier. Endocrinology 135, 1753-61.
51. ROTWEIN, P., BURGESS, S. K., MILBRANDT, J. D. & KRAUSE, J. E. (1988) Differential expression of insulin-like growth factor genes in rat central nervous system. Proceedings of the National Academy of Sciences (USA) 85, 265-9.
52. SHAH, N. ZHANG, S., HARADA, S., SMITH, R. M. & JARETT, L. (1995) Electron microscopic visualization of insulin translocation into the cytoplasm and nuclei of intact H35 hepatoma cells using covalently linked nanogold-insulin. Endocrinology 136, 2825-35.
53. SHEMER, J., RAIZADA, M. K., MASTERS, B. A., OTA, A. & LeROITH, D. (1987) Insulin-like growth factor I receptors in neuronal and glial cells. Journal of Biological Chemistry 262, 7693-99.
54. SOLARI, R., SMITHERS, N., KENNARD, N., RAY, K. & GRENFELL, S. (1994) Receptor mediated endocytosis and intracellular fate of interleukin 1. Biochemical Pharmacology 13, 93-101.
55. TANNENBAUM, G. S., GUYDA, H. J. & POSNER, B. I. (1983) Insulin-like growth factors: A role in growth hormone negative feedback and body weight regulation via brain. Science 220, 77-9.
56. TORRES-ALEMAN, I., PONS, S. & AREVALO, M. A. (1994) The insulin-like growth factor I system in the rat cerebellum: developmental regulation and role in neuronal survival and differentiation. Journal of Neuroscience Research 39, 117-26.
57. UCHIYAMA, T., KAJI, H., ABE, H. & CHIHARA, K. (1994) Negative regulation of hypothalamic growth hormone-releasing factor messenger ribonucleic acid by growth hormone and insulin-like growth factor I. Neuroendocrinology 59, 441-50.
58. VINCENT, P. & MARTY, A. (1993) Neighboring cerebellar Purkinje cells communicate via retrograde inhibition of common presynaptic interneurons. Neuron 11, 885-93.
59. WALICKE, P. A. & BAIRD, A. (1991) Internalization and processing of basic fibroblast growth factor by neurons and astrocytes. Journal of Neuroscience 11, 2249-58.
60. WERTHER, G. A., ABATE, M., HOGG, A., CHEESMAN, H., OLDFIELD, B., HARDS, D., HUDSON, P., POWER, B., FREED, K. & HERINGTON, A. C. (1990) Localization of insulin-like growth factor-I mRNA in rat brain by HI situ hybridization - relationship to IGF-I receptors. Molecular Endocrinology 4, 773-8.