Cafeteria diet-induced obese rats have an increased somatostatin protein content and gene expression in the periventricular nucleus

Journal of Endocrinological Investigation

Volumn 20, Issue 5, 1997, Pages 264-269

  Zhou, X ^a   De Schepper, J ^a   Vergeylen, A ^a   Luis, O ^a   Delhase, M ^a   Hooghe Peters, E L ^a  

^a FREE UNIVERSITY OF BRUSSELS   (Belgium)

Author keywords

Cafeteria diet; Hypothalamus; Obesity; Periventricular nucleus; Somatostatin

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; MESSENGER RNA; SOMATOSTATIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; GENE EXPRESSION; GROWTH HORMONE RELEASE; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; IMAGE ANALYSIS; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; MALE; NONHUMAN; OBESITY; OPTICAL DENSITY; PROTEIN BLOOD LEVEL; RAT;

EID: 0030853530     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03350298     Document Type: Article

References (27)

1. Brazeau P., Rivier J., Vale W., Guillemin R. Inhibition of growth hormone secretion in the rat by synthetic somatostatin. Endocrinology 94: 184, 1974.
2. Wehrenberg W.B., Ling N., Bohlen P., Esch F., Brazeau P., Guillemin R. Physiological roles of somatocrinin and somatostatin in the regulation of growth hormone secretion. Biochim. Biophys. Res. Commun. 109: 562, 1982.
3. Williams T., Berelowitz M., Joffe S.N., Thorner M.O., Rivier J., Bale W., Frohman L.A Impaired growth hormone responses to growth hormone-releasing factor in obesity. N. Engl. J. Med. 311: 1403, 1984.
4. Sheppard M.C., Shapiro B., Hudson A., Dimstone B.L. Tissue and serum somatostatin-like immunoreactivity in lean and obese Zucker rats. Horm. Metab. Res. 12: 236, 1980.
5. Renier G., Gaudreau P., Hajjad H., Deslauriers N., Houde-Nadeau M., Brazeau P. Decreased pituitary growth hormone response to growth hormone-releasing factor in cafeteria-fed rats: dietary and obesity effects. Neuroendocrinology 52: 284, 1990.
6. Van Vliet G., Bosson D., Rummens E. Evidence against growth hormone-releasing factor deficiency in children with idiopathic obesity. Acta Endocrinol. (Copenh.) (suppl.) 279: 403, 1986.
7. Casto R., Bieira J., Chacra A. Pyridostigmine enhances, but does not normalize the GH response to GH-releasing hormone in obese subjects. Acta Endocrinol. (Copenh.) 122: 385, 1990.
8. Finley J.C.W., Maderdrut J.L., Roger L.J., Petrusz P. The immunocytochemical localization of somatostatincontaining neurons in the rat central nervous system. Neuroscience 6: 2173, 1981.
9. Horvath S., Palkovits M. Synaptic interconnections among growth hormone-releasing hormone (GHRH)-containing neurons in the arcuate nucleus of the rat hypothalamus. Neuroendocrinology 48: 471, 1988.
10. Epelbaum J., Tapia-Arancibia L., Alonso G., Astier H., Kordon C. The anterior periventricular hypothalamus is the site of somatostatin inhibition on its own release: an in vitro and immunocytochemical study. Neuroendocrinology 44: 255, 1986.
11. Burton K.A., Kabigting E.B., Clifton O.K., Steiner R.A. Growth hormone receptor messenger ribonucleic acid distribution in the adult male rat brain and its colocalization in hypothalamic somatostatin neurons. Endocrinology 130: 958, 1992.
12. Paxinos G., Watson C. The rat brain in stereotaxic coordinates, ed 2. Academic Press, Sydney, 1986.
13. Fang G., Mark S., Majid L, Gordon D. Analysis of ODC and c-myc gene expression in hepatocellular carcinoma by in situ hybridization and immunohistochemistry. J. Histoche. and Cytoche. 41: 1185, 1993.
14. Larsson L.I., Traasdahl B., Hougaard D.M. Quantitative non-radioactive in situ hybridization. Model studies and studies on pituitary proopiomelanocortin cells after adrenalictomy. Histochemistry. 95: 209, 1991.
15. Larsson L.I., Hougaard D.M. Optimization of non-radioactive in situ hybridization: image analysis of varying pretreatment, hybridization and probe labelling conditions. Histochemistry. 93: 347, 1990.
16. Rahier J., Stevens M., Menten Y.D., Henquin J.C. Determination of antigen concentration in tissue sections by immunodensitometry. Laboratory Investigation. 61: 357, 1989.
17. Childs G.V., Lloyd J.M., Unabia G., Gharib S.D., Wierman M.E., Chin W.W. Detection of luteinizing hormone B messenger ribonucleic acid (RNA) in individual gonadotropes after castration: use of a new in situ hybridization method with a photobiotinylated complementary RNA probe. Mol. Endocrinol. 1: 926, 1987.
18. Bestetti G.D., Abramo F., Guillaume-Gentil C., Rohner-Jeanrenaud F., Jeanrenaud B., Rossi G.L. Changes in the hypothalamo-Pituitary-Adrenal Axis of genetically obese fa/fa rats: a structural, immunocytochemical, and morphometrical study. Endocrinology. 126: 1880, 1990.
19. Stephens T.W., Basinski M., Bristow P.K., BueValleskey J.M., Burgett S.G., Craft L., Hale J., Hoffmann J., Jsiung H.M., Kriauciunas A., Mackellar W., Rosteck Jr P.R., Schoner B., Smith D., Tinsley FC., Zhang X., Heiman M. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature. 377: 530, 1995.
20. Childs G.W., Yamauchi K., Unabia G. Localization and quantification of hormones, ligands and mRNA with affinity-gold probes. Am. J. Anat. 155: 223, 1989.
21. Berelowitz M., Firestone S.L., Frohman L.A. Effects of growth hormone excess and deficiency on hypothalamic somatostatin content and release and on tissue somatostatin distribution. Endocrinology. 109: 714, 1981.
22. Renier G., Gaudreau P., Deslauriers N., Petitclerc D., Brazeau P. Dynamic of the GRF-induced GH response in genetically obese Zucker rats: influence of central and peripheral factors. Regul. Peptides. 28: 95, 1990.
23. York D.A. Neural activity in hypothalamic and genetic obesity. Proc. Nutr. Soc. 46: 105, 1987.
24. Fletcher J.M., Haggarty P., Wahle K.W.J., Reeds P.J. Hormonal studies of young lean and obese Zucker rats. Horm. Metab. Res. 18: 290, 1986.
25. Argente J., Chowen-Breed J., Steiner R., Clifton D. Somatostatin messenger RNA in hypothalamic neurons is increased by testosterone through activation of androgen receptors and not by aromatization to estradiol. Neuroendocrinology. 52: 342, 1990.
26. Zeitler P., Vician L., Chowen-Breed J.A., Argente J., Tannenbaum G.S., Clifton O.K., Steiner R.A. Regulation of somatostatin and growth hormone-releasing hormone gene expression in the rat brain. Metabolism. 39 (suppl 2): 46, 1990.
27. Kamegai J., Minami S., Sugihara H., Higuchi H., Wakabayashi I. Growth hormone induces expression of the c-fos gene on hypothalamic neuropeptide-y and somatostatin neurons in hypophysectomized rats. Endocrinology. 135: 2765, 1994.