메뉴 건너뛰기




Volumn 181, Issue 3, 2008, Pages 447-460

Telomere dysfunction and cell survival: Roles for distinct TIN2-containing complexes

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; PROTEIN TIN2; RAP1 PROTEIN; TELOMERIC REPEAT BINDING FACTOR 1; TELOMERIC REPEAT BINDING FACTOR 2;

EID: 43149085538     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200710028     Document Type: Article
Times cited : (47)

References (51)
  • 2
    • 0035844082 scopus 로고    scopus 로고
    • Pot1, the putative telomere end-binding protein in fission yeast and humans
    • Baumann, P., and T.R. Cech. 2001. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science. 292:1171-1175.
    • (2001) Science , vol.292 , pp. 1171-1175
    • Baumann, P.1    Cech, T.R.2
  • 3
    • 0036840361 scopus 로고    scopus 로고
    • Human Pot1 (protection of telomeres) protein: Cytolocalization, gene structure, and alternative splicing
    • Baumann, P., E. Podell, and T.R. Cech. 2002. Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing. Mol. Cell. Biol. 22:8079-8087.
    • (2002) Mol. Cell. Biol , vol.22 , pp. 8079-8087
    • Baumann, P.1    Podell, E.2    Cech, T.R.3
  • 6
    • 0034597794 scopus 로고    scopus 로고
    • Telomere states and cell fates
    • Blackburn, E.H. 2000. Telomere states and cell fates. Nature. 408:53-56.
    • (2000) Nature , vol.408 , pp. 53-56
    • Blackburn, E.H.1
  • 7
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • Brummelkamp, T.R., R. Bernards, and R. Agami. 2002. A system for stable expression of short interfering RNAs in mammalian cells. Science. 296:550-553.
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 8
    • 22144490491 scopus 로고    scopus 로고
    • DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
    • Celli, G.B., and T. de Lange. 2005. DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat. Cell Biol. 7:712-718.
    • (2005) Nat. Cell Biol , vol.7 , pp. 712-718
    • Celli, G.B.1    de Lange, T.2
  • 9
    • 0037610123 scopus 로고    scopus 로고
    • TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres
    • Chang, W., J.N. Dynek, and S. Smith. 2003. TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres. Genes Dev. 17:1328-1333.
    • (2003) Genes Dev , vol.17 , pp. 1328-1333
    • Chang, W.1    Dynek, J.N.2    Smith, S.3
  • 10
    • 3242709415 scopus 로고    scopus 로고
    • Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway
    • Chiang, Y.J., S.H. Kim, L. Tessarollo, J. Campisi, and R.J. Hodes. 2004. Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway. Mol. Cell. Biol. 24:6631-6634.
    • (2004) Mol. Cell. Biol , vol.24 , pp. 6631-6634
    • Chiang, Y.J.1    Kim, S.H.2    Tessarollo, L.3    Campisi, J.4    Hodes, R.J.5
  • 11
    • 0033553516 scopus 로고    scopus 로고
    • p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
    • Chin, L., S.E. Artandi, Q. Shen, A. Tam, S.L. Lee, G.J. Gottlieb, C.W. Greider, and R.A. DePinho. 1999. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell. 97:527-538.
    • (1999) Cell , vol.97 , pp. 527-538
    • Chin, L.1    Artandi, S.E.2    Shen, Q.3    Tam, A.4    Lee, S.L.5    Gottlieb, G.J.6    Greider, C.W.7    DePinho, R.A.8
  • 13
    • 0141864666 scopus 로고    scopus 로고
    • Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks
    • Davalos, A.R., and J. Campisi. 2003. Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks. J. Cell Biol. 162:1197-1209.
    • (2003) J. Cell Biol , vol.162 , pp. 1197-1209
    • Davalos, A.R.1    Campisi, J.2
  • 14
    • 24944460598 scopus 로고    scopus 로고
    • Shelterin: The protein complex that shapes and safeguards human telomeres
    • de Lange, T. 2005. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 19:2100-2110.
    • (2005) Genes Dev , vol.19 , pp. 2100-2110
    • de Lange, T.1
  • 15
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam, J.D., R.M. Lebovitz, and R.G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489.
    • (1983) Nucleic Acids Res , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 18
    • 26944433834 scopus 로고    scopus 로고
    • Caspase-independent cytochrome c release is a sensitive measure of low-level apoptosis in cell culture models
    • Goldstein, J.C., F. Rodier, J.C. Garbe, M.R. Stampfer, and J. Campisi. 2005. Caspase-independent cytochrome c release is a sensitive measure of low-level apoptosis in cell culture models. Aging Cell. 4:217-222.
    • (2005) Aging Cell , vol.4 , pp. 217-222
    • Goldstein, J.C.1    Rodier, F.2    Garbe, J.C.3    Stampfer, M.R.4    Campisi, J.5
  • 20
    • 0027506274 scopus 로고
    • Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA
    • Gudkov, A.V., C.R. Zelnick, A.R. Kazarov, R. Thimmapaya, D.P. Suttle, W.T. Beck, and I.B. Roninson. 1993. Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA. Proc. Natl. Acad. Sci. USA. 90:3231-3235.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3231-3235
    • Gudkov, A.V.1    Zelnick, C.R.2    Kazarov, A.R.3    Thimmapaya, R.4    Suttle, D.P.5    Beck, W.T.6    Roninson, I.B.7
  • 21
    • 0035825601 scopus 로고    scopus 로고
    • Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability
    • Guiducci, C., M.A. Cerone, and S. Bacchetti. 2001. Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability. Oncogene. 20:714-725.
    • (2001) Oncogene , vol.20 , pp. 714-725
    • Guiducci, C.1    Cerone, M.A.2    Bacchetti, S.3
  • 23
    • 2442511752 scopus 로고    scopus 로고
    • Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
    • Herbig, U., W.A. Jobling, B.P. Chen, D.J. Chen, and J.M. Sedivy. 2004. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell. 14:501-513.
    • (2004) Mol. Cell , vol.14 , pp. 501-513
    • Herbig, U.1    Jobling, W.A.2    Chen, B.P.3    Chen, D.J.4    Sedivy, J.M.5
  • 24
    • 23044500389 scopus 로고    scopus 로고
    • 2 005. POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end
    • Hockemeyer, D., A.J. Sfeir, J.W. S hay, W.E. Wright, and T. de Lange. 2 005. POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J. 24:2667-2678.
    • EMBO J , vol.24 , pp. 2667-2678
    • Hockemeyer, D.1    Sfeir, A.J.2    hay, J.W.S.3    Wright, W.E.4    de Lange, T.5
  • 25
    • 33745685066 scopus 로고    scopus 로고
    • Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres
    • Hockemeyer, D., J.P. Daniels, H. Takai, and T. de Lange. 2006. Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell. 126:63-77.
    • (2006) Cell , vol.126 , pp. 63-77
    • Hockemeyer, D.1    Daniels, J.P.2    Takai, H.3    de Lange, T.4
  • 26
    • 4544258775 scopus 로고    scopus 로고
    • A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2
    • Houghtaling, B.R., L. Cuttonaro, W. Chang, and S. Smith. 2004. A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2. Curr. Biol. 14:1621-1631.
    • (2004) Curr. Biol , vol.14 , pp. 1621-1631
    • Houghtaling, B.R.1    Cuttonaro, L.2    Chang, W.3    Smith, S.4
  • 28
    • 0347723876 scopus 로고    scopus 로고
    • Importance of TRF1 for functional telomere structure
    • Iwano, T., M. Tachibana, M. Reth, and Y. Shinkai. 2004. Importance of TRF1 for functional telomere structure. J. Biol. Chem. 279:1442-1448.
    • (2004) J. Biol. Chem , vol.279 , pp. 1442-1448
    • Iwano, T.1    Tachibana, M.2    Reth, M.3    Shinkai, Y.4
  • 29
    • 0033605145 scopus 로고    scopus 로고
    • p53-and ATM-dependent apoptosis induced by telomeres lacking TRF2
    • Karlseder, J., D. Broccoli, Y. Dai, S. Hardy, and T. de Lange. 1999. p53-and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science. 283:1321-1325.
    • (1999) Science , vol.283 , pp. 1321-1325
    • Karlseder, J.1    Broccoli, D.2    Dai, Y.3    Hardy, S.4    de Lange, T.5
  • 30
    • 0032727616 scopus 로고    scopus 로고
    • TIN2, a new regulator of telomere length in human cells
    • Kim, S.H., P. Kaminker, and J. Campisi. 1999. TIN2, a new regulator of telomere length in human cells. Nat. Genet. 23:405-412.
    • (1999) Nat. Genet , vol.23 , pp. 405-412
    • Kim, S.H.1    Kaminker, P.2    Campisi, J.3
  • 31
    • 0043066727 scopus 로고    scopus 로고
    • The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro
    • 4:685-691
    • Kim, S.H., S. Han, Y.H. You, D.J. Chen, and J. Campisi. 2003. The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro. EMBO Rep. 4:685-691.
    • (2003) EMBO Rep
    • Kim, S.H.1    Han, S.2    You, Y.H.3    Chen, D.J.4    Campisi, J.5
  • 33
    • 3142661809 scopus 로고    scopus 로고
    • Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA
    • Li, S., J.E. Rosenberg, A.A. Donjacour, I.L. Botchkina, Y.K. Hom, G.R. Cunha, and E.H. Blackburn. 2004. Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA. Cancer Res. 64:4833-4840.
    • (2004) Cancer Res , vol.64 , pp. 4833-4840
    • Li, S.1    Rosenberg, J.E.2    Donjacour, A.A.3    Botchkina, I.L.4    Hom, Y.K.5    Cunha, G.R.6    Blackburn, E.H.7
  • 34
    • 10944240539 scopus 로고    scopus 로고
    • Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins
    • Liu, D., M.S. O'Connor, J. Qin, and Z. Songyang. 2004a. Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J. Biol. Chem. 279:51338-51342.
    • (2004) J. Biol. Chem , vol.279 , pp. 51338-51342
    • Liu, D.1    O'Connor, M.S.2    Qin, J.3    Songyang, Z.4
  • 36
    • 0038451396 scopus 로고    scopus 로고
    • POT1 as a terminal transducer of TRF1 telomere length control
    • Loayza, D., and T. De Lange. 2003. POT1 as a terminal transducer of TRF1 telomere length control. Nature. 423:1013-1018.
    • (2003) Nature , vol.423 , pp. 1013-1018
    • Loayza, D.1    De Lange, T.2
  • 37
    • 25144475030 scopus 로고    scopus 로고
    • Inhibition of p53 by lentiviral mediated shRNA abrogates G1 arrest and apoptosis in retinal pigmented epithelial cell line
    • Nair, A.R., M. Schliekelman, M.B. Thomas, J. Wakefield, S. Jurgensen, and R. Ramabhadran. 2005. Inhibition of p53 by lentiviral mediated shRNA abrogates G1 arrest and apoptosis in retinal pigmented epithelial cell line. Cell Cycle. 4:697-703.
    • (2005) Cell Cycle , vol.4 , pp. 697-703
    • Nair, A.R.1    Schliekelman, M.2    Thomas, M.B.3    Wakefield, J.4    Jurgensen, S.5    Ramabhadran, R.6
  • 38
    • 33747051742 scopus 로고    scopus 로고
    • A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly
    • O'Connor, M.S., A. Safari, H. Xin, D. Liu, and Z. Songyang. 2006. A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. Proc. Natl. Acad. Sci. USA. 103:11874-11879.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 11874-11879
    • O'Connor, M.S.1    Safari, A.2    Xin, H.3    Liu, D.4    Songyang, Z.5
  • 39
    • 1042291970 scopus 로고    scopus 로고
    • Limited capacity of the nuclear matrix to bind telomere repeat binding factor TRF1 may restrict the proliferation of mortal human fibroblasts
    • Okabe, J., A. Eguchi, R. Wadhwa, R. Rakwal, R. Tsukinoki, T. Hayakawa, and M. Nakanishi. 2004. Limited capacity of the nuclear matrix to bind telomere repeat binding factor TRF1 may restrict the proliferation of mortal human fibroblasts. Hum. Mol. Genet. 13:285-293.
    • (2004) Hum. Mol. Genet , vol.13 , pp. 285-293
    • Okabe, J.1    Eguchi, A.2    Wadhwa, R.3    Rakwal, R.4    Tsukinoki, R.5    Hayakawa, T.6    Nakanishi, M.7
  • 41
    • 0037102234 scopus 로고    scopus 로고
    • Different telomere damage signaling pathways in human and mouse cells
    • Smogorzewska, A., and T. De Lange. 2002. Different telomere damage signaling pathways in human and mouse cells. EMBO J. 21:4338-4348.
    • (2002) EMBO J , vol.21 , pp. 4338-4348
    • Smogorzewska, A.1    De Lange, T.2
  • 42
    • 2042429168 scopus 로고    scopus 로고
    • Regulation of telomerase by telomeric proteins
    • Smogorzewska, A., and T. de Lange. 2004. Regulation of telomerase by telomeric proteins. Annu. Rev. Biochem. 73:177-208.
    • (2004) Annu. Rev. Biochem , vol.73 , pp. 177-208
    • Smogorzewska, A.1    de Lange, T.2
  • 43
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • Takai, H., A. Smogorzewska, and T. de Lange. 2003. DNA damage foci at dysfunctional telomeres. Curr. Biol. 13:1549-1556.
    • (2003) Curr. Biol , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    de Lange, T.3
  • 44
    • 0031027618 scopus 로고    scopus 로고
    • Control of telomere length by the human telomeric protein TRF1
    • van Steensel, B., and T. de Lange. 1997. Control of telomere length by the human telomeric protein TRF1. Nature. 385:740-743.
    • (1997) Nature , vol.385 , pp. 740-743
    • van Steensel, B.1    de Lange, T.2
  • 45
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel, B., A. Smogorzewska, and T. de Lange. 1998. TRF2 protects human telomeres from end-to-end fusions. Cell. 92:401-413.
    • (1998) Cell , vol.92 , pp. 401-413
    • van Steensel, B.1    Smogorzewska, A.2    de Lange, T.3
  • 47
    • 33846692105 scopus 로고    scopus 로고
    • TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase
    • Xin, H., D. Liu, M. Wan, A. Safari, H. Kim, W. Sun, M.S. O'Connor, and Z. Songyang. 2007. TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature. 445:559-562.
    • (2007) Nature , vol.445 , pp. 559-562
    • Xin, H.1    Liu, D.2    Wan, M.3    Safari, A.4    Kim, H.5    Sun, W.6    O'Connor, M.S.7    Songyang, Z.8
  • 48
    • 12844254472 scopus 로고    scopus 로고
    • POT1 and TRF2 cooperate to maintain telomeric integrity
    • Yang, Q., Y.L. Zheng, and C.C. Harris. 2005. POT1 and TRF2 cooperate to maintain telomeric integrity. Mol. Cell. Biol. 25:1070-1080.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 1070-1080
    • Yang, Q.1    Zheng, Y.L.2    Harris, C.C.3
  • 49
    • 6944232071 scopus 로고    scopus 로고
    • Chait, and T. d e Lange. 2 004a. TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres
    • Ye, J.Z., J.R. Donigian, M. van Overbeek, D. Loayza, Y. Luo, A.N. Krutchinsky, B.T. Chait, and T. d e Lange. 2 004a. TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J. Biol. Chem. 279:47264-47271.
    • J. Biol. Chem , vol.279 , pp. 47264-47271
    • Ye, J.Z.J.R.1    Donigian, M.2    van Overbeek, D.3    Loayza, Y.4    Luo, A.N.5    Krutchinsky, B.T.6
  • 50
    • 3142679378 scopus 로고    scopus 로고
    • POT1-interacting protein PIP1: A telomere length regulator that recruits POT1 to the TIN2/TRF1 complex
    • Ye, J.Z., D. Hockemeyer, A.N. Krutchinsky, D. Loayza, S.M. Hooper, B.T. Chait, and T. de Lange. 2004b. POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes Dev. 18:1649-1654.
    • (2004) Genes Dev , vol.18 , pp. 1649-1654
    • Ye, J.Z.1    Hockemeyer, D.2    Krutchinsky, A.N.3    Loayza, D.4    Hooper, S.M.5    Chait, B.T.6    de Lange, T.7
  • 51
    • 3342972121 scopus 로고    scopus 로고
    • Does a sentinel or a subset of short telomeres determine replicative senescence?
    • Zou, Y., A. Sfeir, S.M. Gryaznov, J.W. Shay, and W.E. Wright. 2004. Does a sentinel or a subset of short telomeres determine replicative senescence? Mol. Biol. Cell. 15:3709-3718
    • (2004) Mol. Biol. Cell , vol.15 , pp. 3709-3718
    • Zou, Y.1    Sfeir, A.2    Gryaznov, S.M.3    Shay, J.W.4    Wright, W.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.