메뉴 건너뛰기




Volumn 57, Issue 4, 2008, Pages 259-265

Antiangiogenic effects of flavonoids and chalcones

Author keywords

Chalcones; Flavonoids; Tumour angiogenesis

Indexed keywords

2 CHLORO 2',5' DIHYDROXYCHALCONE; 2' HYDROXY 4' METHOXYCHALCONE; 2',4' DIHYDROXY 6' METHOXY 3',5' DIMETHYLCHALCONE; ANTHOCYANIN; APIGENIN; CHALCONE DERIVATIVE; CHRYSIN; CYANIDIN; DELPHINIDIN; EPICATECHIN; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; FISETIN; FLAVONOID; GENISTEIN; ISOXANTHOHUMOL; KAEMPFEROL; LICOCHALCONE E; LUTEOLIN; MALVIDIN CHLORIDE; MATRIX METALLOPROTEINASE; PELARGONIDIN; PEONIDIN; PETUNIDIN CHLORIDE; POLYPHENOL; QUERCETIN; SILIBININ; UNINDEXED DRUG; WOGONIN; XANTHOHUMOL;

EID: 43049127754     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2008.02.005     Document Type: Review
Times cited : (214)

References (107)
  • 1
    • 30744432619 scopus 로고    scopus 로고
    • Endothelial cells and VEGF in vascular development
    • Coultas L., Chawengsaksophak K., and Rossant J. Endothelial cells and VEGF in vascular development. Nature 438 (2005) 937-945
    • (2005) Nature , vol.438 , pp. 937-945
    • Coultas, L.1    Chawengsaksophak, K.2    Rossant, J.3
  • 2
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. Angiogenesis in health and disease. Nat Med 9 (2003) 653-660
    • (2003) Nat Med , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 3
    • 0033179470 scopus 로고    scopus 로고
    • Molecular angiogenesis
    • Klagsbrun M., and Moses M.A. Molecular angiogenesis. Chem Biol 6 (1999) 217-224
    • (1999) Chem Biol , vol.6 , pp. 217-224
    • Klagsbrun, M.1    Moses, M.A.2
  • 4
    • 0035721955 scopus 로고    scopus 로고
    • Role of matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis
    • Pepper M.S. Role of matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis. Arterioscler Thromb Vasc Biol 21 (2001) 1104-1117
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1104-1117
    • Pepper, M.S.1
  • 6
    • 0026053146 scopus 로고
    • The plasminogen activator/plasmin system
    • Vassalli J.-D., Sappino A.P., and Belin D. The plasminogen activator/plasmin system. J Clin Invest 88 (1991) 1067-1072
    • (1991) J Clin Invest , vol.88 , pp. 1067-1072
    • Vassalli, J.-D.1    Sappino, A.P.2    Belin, D.3
  • 7
    • 0030271595 scopus 로고    scopus 로고
    • Focalized proteolysis: spatial and temporal regulation of extracellular matrix degradation at the cell surface
    • Basbaum C.B., and Werb Z. Focalized proteolysis: spatial and temporal regulation of extracellular matrix degradation at the cell surface. Curr Opin Cell Biol 8 (1996) 731-738
    • (1996) Curr Opin Cell Biol , vol.8 , pp. 731-738
    • Basbaum, C.B.1    Werb, Z.2
  • 8
    • 0026903364 scopus 로고
    • The matrix metalloproteinases and their inhibitors
    • Murphy G., and Docherty A.J.P. The matrix metalloproteinases and their inhibitors. Am J Resp Cell Mol Biol 7 (1992) 120-125
    • (1992) Am J Resp Cell Mol Biol , vol.7 , pp. 120-125
    • Murphy, G.1    Docherty, A.J.P.2
  • 9
    • 0032582686 scopus 로고    scopus 로고
    • Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins
    • Hiraoka N., Allen E., Apel I.J., Gyetko M.R., and Weiss S.J. Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins. Cell 95 (1998) 365-377
    • (1998) Cell , vol.95 , pp. 365-377
    • Hiraoka, N.1    Allen, E.2    Apel, I.J.3    Gyetko, M.R.4    Weiss, S.J.5
  • 10
    • 0030957218 scopus 로고    scopus 로고
    • Activation mechanism of matrix metalloproteinases
    • Nagase H. Activation mechanism of matrix metalloproteinases. Biol Chem 378 (1997) 151-160
    • (1997) Biol Chem , vol.378 , pp. 151-160
    • Nagase, H.1
  • 11
    • 0034615550 scopus 로고    scopus 로고
    • Tissue inhibitors of metalloproteinases: evolution, structure and function
    • Brew K., Dinakarpandian D., and Nagase H. Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochem Biophys Acta 1477 (2000) 267-283
    • (2000) Biochem Biophys Acta , vol.1477 , pp. 267-283
    • Brew, K.1    Dinakarpandian, D.2    Nagase, H.3
  • 12
    • 0034074887 scopus 로고    scopus 로고
    • Atherosclerotic arterial remodelling and the localization of macrophages and matrix metalloproteinases 1, 2 and 9 in the human coronary artery
    • Pasterkamp G., Schoneveld A.D., Hijnen D.J., de Kleijn D.P., Teepen H., van der Wal A.C., and Borst C. Atherosclerotic arterial remodelling and the localization of macrophages and matrix metalloproteinases 1, 2 and 9 in the human coronary artery. Atherosclerosis 150 (2000) 245-253
    • (2000) Atherosclerosis , vol.150 , pp. 245-253
    • Pasterkamp, G.1    Schoneveld, A.D.2    Hijnen, D.J.3    de Kleijn, D.P.4    Teepen, H.5    van der Wal, A.C.6    Borst, C.7
  • 13
    • 0037693895 scopus 로고    scopus 로고
    • Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases: structure, function, and biochemistry
    • Visse R., and Nagase H. Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases: structure, function, and biochemistry. Circ Res 92 (2003) 827-839
    • (2003) Circ Res , vol.92 , pp. 827-839
    • Visse, R.1    Nagase, H.2
  • 14
    • 29344440476 scopus 로고    scopus 로고
    • A review on pro- and anti-angiogenic factors as targets of clinical intervention
    • Bouïs D., Kusumanto Y., Meijer C., Mulder N.H., and Hospers G.A.P. A review on pro- and anti-angiogenic factors as targets of clinical intervention. Pharmacol Res 53 (2006) 89-103
    • (2006) Pharmacol Res , vol.53 , pp. 89-103
    • Bouïs, D.1    Kusumanto, Y.2    Meijer, C.3    Mulder, N.H.4    Hospers, G.A.P.5
  • 15
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G., and Benjamin L.E. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3 (2003) 401-410
    • (2003) Nat Rev Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 16
    • 85013312416 scopus 로고
    • Tumour angiogenesis: therapeutic implications
    • Folkman J. Tumour angiogenesis: therapeutic implications. N Engl J Med 285 (1971) 1182-1186
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 17
    • 16844381577 scopus 로고    scopus 로고
    • A new perspective on tumor endothelial cells: unexpected chromosome and centrosome abnormalities
    • Hida K., and Klagsbrun M. A new perspective on tumor endothelial cells: unexpected chromosome and centrosome abnormalities. Cancer Res 65 (2005) 2507-2510
    • (2005) Cancer Res , vol.65 , pp. 2507-2510
    • Hida, K.1    Klagsbrun, M.2
  • 18
    • 0038143145 scopus 로고    scopus 로고
    • Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma
    • Hendrix M.J., Seftor E.A., Hess A.R., and Seftor R.E. Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma. Nat Rev Cancer 3 (2003) 411-421
    • (2003) Nat Rev Cancer , vol.3 , pp. 411-421
    • Hendrix, M.J.1    Seftor, E.A.2    Hess, A.R.3    Seftor, R.E.4
  • 20
    • 0027437920 scopus 로고
    • The combination of antiangiogenic agents to inhibit primary tumour growth and metastasis
    • Brem H., Gresser I., Grosfeld J., and Folkman J. The combination of antiangiogenic agents to inhibit primary tumour growth and metastasis. J Pediatr Surg 28 (1993) 1253-1257
    • (1993) J Pediatr Surg , vol.28 , pp. 1253-1257
    • Brem, H.1    Gresser, I.2    Grosfeld, J.3    Folkman, J.4
  • 22
    • 33646201477 scopus 로고    scopus 로고
    • The use of thalidomide in androgen-independent prostate cancer
    • Cox M.C., Dahut W.L., and Figg W.D. The use of thalidomide in androgen-independent prostate cancer. Urol Oncol 24 (2006) 246-249
    • (2006) Urol Oncol , vol.24 , pp. 246-249
    • Cox, M.C.1    Dahut, W.L.2    Figg, W.D.3
  • 24
    • 33845961014 scopus 로고    scopus 로고
    • Bevacizumab: an angiogenesis inhibitor for the treatment of solid malignancies
    • Shih T., and Lindley C. Bevacizumab: an angiogenesis inhibitor for the treatment of solid malignancies. Clin Ther 28 (2006) 1779-1802
    • (2006) Clin Ther , vol.28 , pp. 1779-1802
    • Shih, T.1    Lindley, C.2
  • 25
    • 1442305186 scopus 로고    scopus 로고
    • Emerging roles of targeted small molecule protein-tyrosine kinase inhibitors in cancer therapy
    • Smith J.K., Mamoon N.M., and Duhe R.J. Emerging roles of targeted small molecule protein-tyrosine kinase inhibitors in cancer therapy. Oncol Res 14 (2004) 175-225
    • (2004) Oncol Res , vol.14 , pp. 175-225
    • Smith, J.K.1    Mamoon, N.M.2    Duhe, R.J.3
  • 26
    • 33745534542 scopus 로고    scopus 로고
    • The roles of polyphenols in cancer chemoprevention
    • Lee K.W., and Lee H.J. The roles of polyphenols in cancer chemoprevention. Biofactors 26 (2006) 105-121
    • (2006) Biofactors , vol.26 , pp. 105-121
    • Lee, K.W.1    Lee, H.J.2
  • 27
    • 0034736046 scopus 로고    scopus 로고
    • Advances in flavonoid research since 1992
    • Harborne J.B., and Williams C. Advances in flavonoid research since 1992. Phytochemistry 55 (2000) 481-504
    • (2000) Phytochemistry , vol.55 , pp. 481-504
    • Harborne, J.B.1    Williams, C.2
  • 28
    • 0037438947 scopus 로고    scopus 로고
    • Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers
    • Moridani M.Y., Pourahmad J., Bui H., Siraki A., and O'Brien P.J. Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers. Free Radic Biol Med 34 (2003) 243-253
    • (2003) Free Radic Biol Med , vol.34 , pp. 243-253
    • Moridani, M.Y.1    Pourahmad, J.2    Bui, H.3    Siraki, A.4    O'Brien, P.J.5
  • 30
    • 32644462034 scopus 로고    scopus 로고
    • Chemical structure of flavonols in relation to modulation of angiogenesis and immune-endothelial cell adhesion
    • Kim J.D., Liu L., Guo W., and Meydani M. Chemical structure of flavonols in relation to modulation of angiogenesis and immune-endothelial cell adhesion. J Nutr Biochem 17 (2006) 165-176
    • (2006) J Nutr Biochem , vol.17 , pp. 165-176
    • Kim, J.D.1    Liu, L.2    Guo, W.3    Meydani, M.4
  • 31
    • 33646483676 scopus 로고    scopus 로고
    • Protection of peroxynitrite-induced DNA damage by dietary antioxidants
    • Moon H.K., Yang E.S., and Park J.W. Protection of peroxynitrite-induced DNA damage by dietary antioxidants. Arch Pharm Res 29 (2006) 213-217
    • (2006) Arch Pharm Res , vol.29 , pp. 213-217
    • Moon, H.K.1    Yang, E.S.2    Park, J.W.3
  • 33
    • 0034759867 scopus 로고    scopus 로고
    • Protective effect of quercetin on ischemia/reperfusion-induced gastric mucosal injury in rats
    • Mojžiš J., Hviščová K., Germanová D., Bukovičová D., and Mirossay L. Protective effect of quercetin on ischemia/reperfusion-induced gastric mucosal injury in rats. Physiol Res 50 (2001) 501-506
    • (2001) Physiol Res , vol.50 , pp. 501-506
    • Mojžiš, J.1    Hviščová, K.2    Germanová, D.3    Bukovičová, D.4    Mirossay, L.5
  • 34
    • 0035691944 scopus 로고    scopus 로고
    • Dietary flavonoids and risk of coronary heart disease
    • Mojžišová G., and Kuchta M. Dietary flavonoids and risk of coronary heart disease. Physiol Res 50 (2001) 529-535
    • (2001) Physiol Res , vol.50 , pp. 529-535
    • Mojžišová, G.1    Kuchta, M.2
  • 35
    • 23244433350 scopus 로고    scopus 로고
    • Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress
    • Zern T.L., Wood R.J., Greene C., West K.L., Liu Y., Aggarwal D., Shachter N.S., and Fernandez M.L. Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J Nutr 135 (2005) 1911-1917
    • (2005) J Nutr , vol.135 , pp. 1911-1917
    • Zern, T.L.1    Wood, R.J.2    Greene, C.3    West, K.L.4    Liu, Y.5    Aggarwal, D.6    Shachter, N.S.7    Fernandez, M.L.8
  • 36
    • 0038807711 scopus 로고    scopus 로고
    • Flavonoids: promising anticancer agents
    • Ren W., Qiao Z., Wang H., Zhu L., and Zhang L. Flavonoids: promising anticancer agents. Med Res Rev 23 (2003) 519-534
    • (2003) Med Res Rev , vol.23 , pp. 519-534
    • Ren, W.1    Qiao, Z.2    Wang, H.3    Zhu, L.4    Zhang, L.5
  • 37
    • 11144237662 scopus 로고    scopus 로고
    • Antiangiogenic properties of natural polyphenols from red wine and green tea
    • Oak M.H., El Bedoui J., and Schini-Kerth V.B. Antiangiogenic properties of natural polyphenols from red wine and green tea. J Nutr Biochem 16 (2005) 1-8
    • (2005) J Nutr Biochem , vol.16 , pp. 1-8
    • Oak, M.H.1    El Bedoui, J.2    Schini-Kerth, V.B.3
  • 38
    • 0038120889 scopus 로고    scopus 로고
    • Red wine polyphenolic compounds inhibit vascular endothelial growth factor expression in vascular smooth muscle cells by preventing the activation of the p38 mitogen-activated protein kinase pathway
    • Oak M.H., Chataigneau M., Keravis T., Chataigneau T., Beretz A., Andriantsitohaina R., Stoclet J.C., Chang S.J., and Schini-Kerth V.B. Red wine polyphenolic compounds inhibit vascular endothelial growth factor expression in vascular smooth muscle cells by preventing the activation of the p38 mitogen-activated protein kinase pathway. Arterioscler Thromb Vasc Biol 23 (2003) 1001-1007
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1001-1007
    • Oak, M.H.1    Chataigneau, M.2    Keravis, T.3    Chataigneau, T.4    Beretz, A.5    Andriantsitohaina, R.6    Stoclet, J.C.7    Chang, S.J.8    Schini-Kerth, V.B.9
  • 39
    • 4644287416 scopus 로고    scopus 로고
    • Red wine polyphenolic compounds strongly inhibit pro-matrix metalloproteinase-2 expression and its activation in response to thrombin via direct inhibition of membrane type 1-matrix metalloproteinase in vascular smooth muscle cells
    • Oak M.H., El Bedoui J., Anglard P., and Schini-Kerth V.B. Red wine polyphenolic compounds strongly inhibit pro-matrix metalloproteinase-2 expression and its activation in response to thrombin via direct inhibition of membrane type 1-matrix metalloproteinase in vascular smooth muscle cells. Circulation 110 (2004) 1861-1867
    • (2004) Circulation , vol.110 , pp. 1861-1867
    • Oak, M.H.1    El Bedoui, J.2    Anglard, P.3    Schini-Kerth, V.B.4
  • 40
    • 33749032411 scopus 로고    scopus 로고
    • Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK
    • Oak M.H., Bedoui J.E., Madeira S.V., Chalupsky K., and Schini-Kerth V.B. Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK. Br J Pharmacol 149 (2006) 283-290
    • (2006) Br J Pharmacol , vol.149 , pp. 283-290
    • Oak, M.H.1    Bedoui, J.E.2    Madeira, S.V.3    Chalupsky, K.4    Schini-Kerth, V.B.5
  • 42
    • 0037196553 scopus 로고    scopus 로고
    • Green tea polyphenol (-)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells
    • Annabi B., Lachambre M.P., Bousquet-Gagnon N., Page M., Gingras D., and Beliveau R. Green tea polyphenol (-)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells. Biochim Biophys Acta 1542 (2002) 209-220
    • (2002) Biochim Biophys Acta , vol.1542 , pp. 209-220
    • Annabi, B.1    Lachambre, M.P.2    Bousquet-Gagnon, N.3    Page, M.4    Gingras, D.5    Beliveau, R.6
  • 45
    • 0033118504 scopus 로고    scopus 로고
    • Angiogenesis inhibited by drinking tea
    • Cao Y., and Cao R. Angiogenesis inhibited by drinking tea. Nature 398 (1999) 381
    • (1999) Nature , vol.398 , pp. 381
    • Cao, Y.1    Cao, R.2
  • 46
    • 0035937335 scopus 로고    scopus 로고
    • EGCG a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells
    • Jung Y.D., Kim M.S., Shin B.A., Chay K.O., Ahn B.W., Liu W., Bucana C.D., Gallick G.E., and Ellis L.M. EGCG a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells. Br J Cancer 84 (2001) 844-850
    • (2001) Br J Cancer , vol.84 , pp. 844-850
    • Jung, Y.D.1    Kim, M.S.2    Shin, B.A.3    Chay, K.O.4    Ahn, B.W.5    Liu, W.6    Bucana, C.D.7    Gallick, G.E.8    Ellis, L.M.9
  • 47
    • 0036842094 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transduction
    • Masuda M., Suzui M., Lim J.T., Deguchi A., Soh J.W., and Weinstein I.B. Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transduction. J Exp Ther Oncol 2 (2002) 350-359
    • (2002) J Exp Ther Oncol , vol.2 , pp. 350-359
    • Masuda, M.1    Suzui, M.2    Lim, J.T.3    Deguchi, A.4    Soh, J.W.5    Weinstein, I.B.6
  • 48
    • 33745058978 scopus 로고    scopus 로고
    • Green tea extract and (-)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1α protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells
    • Zhang Q., Tang X., Lu Q., Zhang Z., Rao J., and Le A.D. Green tea extract and (-)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1α protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells. Mol Cancer Ther 5 (2006) 1227-1238
    • (2006) Mol Cancer Ther , vol.5 , pp. 1227-1238
    • Zhang, Q.1    Tang, X.2    Lu, Q.3    Zhang, Z.4    Rao, J.5    Le, A.D.6
  • 50
    • 51649092812 scopus 로고    scopus 로고
    • Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 2
    • Sagar S.M., Yance D., and Wong R.K. Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 2. Curr Oncol 13 (2006) 99-107
    • (2006) Curr Oncol , vol.13 , pp. 99-107
    • Sagar, S.M.1    Yance, D.2    Wong, R.K.3
  • 51
    • 0038000122 scopus 로고    scopus 로고
    • Molecular targets for green tea in prostate cancer prevention
    • Adhami V.M., Ahmad N., and Mukhtar H. Molecular targets for green tea in prostate cancer prevention. J Nutr 133 (2003) 2417S-2424S
    • (2003) J Nutr , vol.133
    • Adhami, V.M.1    Ahmad, N.2    Mukhtar, H.3
  • 52
    • 31544447710 scopus 로고    scopus 로고
    • Orally administered green tea polyphenols prevent ultraviolet radiation-induced skin cancer in mice through activation of cytotoxic T cells and inhibition of angiogenesis in tumors
    • Mantena S.K., Meeran S.M., Elmets C.A., and Katiyar S.K. Orally administered green tea polyphenols prevent ultraviolet radiation-induced skin cancer in mice through activation of cytotoxic T cells and inhibition of angiogenesis in tumors. J Nutr 135 (2005) 2871-2877
    • (2005) J Nutr , vol.135 , pp. 2871-2877
    • Mantena, S.K.1    Meeran, S.M.2    Elmets, C.A.3    Katiyar, S.K.4
  • 53
    • 27544437494 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate inhibits photocarcinogenesis through inhibition of angiogenic factors and activation of CD8+ T cells in tumors
    • Mantena S.K., Roy A.M., and Katiyar S.K. Epigallocatechin-3-gallate inhibits photocarcinogenesis through inhibition of angiogenic factors and activation of CD8+ T cells in tumors. Photochem Photobiol 81 (2005) 1174-1179
    • (2005) Photochem Photobiol , vol.81 , pp. 1174-1179
    • Mantena, S.K.1    Roy, A.M.2    Katiyar, S.K.3
  • 55
    • 14644410403 scopus 로고    scopus 로고
    • Silibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and down-regulation of survivin, Akt and NF-kappaB: implications for angioprevention and antiangiogenic therapy
    • Singh R.P., Dhanalakshmi S., Agarwal C., and Agarwal R. Silibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and down-regulation of survivin, Akt and NF-kappaB: implications for angioprevention and antiangiogenic therapy. Oncogene 24 (2005) 1188-1202
    • (2005) Oncogene , vol.24 , pp. 1188-1202
    • Singh, R.P.1    Dhanalakshmi, S.2    Agarwal, C.3    Agarwal, R.4
  • 57
    • 28844499127 scopus 로고    scopus 로고
    • Cytoprotective effect of green tea extract and quercetin against hydrogen peroxide-induced oxidative stress
    • Jeong Y.M., Choi Y.G., Kim D.S., Park S.H., Yoon J.A., Kwon S.B., Park E.S., and Park K.C. Cytoprotective effect of green tea extract and quercetin against hydrogen peroxide-induced oxidative stress. Arch Pharm Res 28 (2005) 1251-1256
    • (2005) Arch Pharm Res , vol.28 , pp. 1251-1256
    • Jeong, Y.M.1    Choi, Y.G.2    Kim, D.S.3    Park, S.H.4    Yoon, J.A.5    Kwon, S.B.6    Park, E.S.7    Park, K.C.8
  • 59
    • 33846531384 scopus 로고    scopus 로고
    • Distinctive antioxidant and antiinflammatory effects of flavonols
    • Wang L., Tu Y.C., Lian T.W., Hung J.T., Yen J.H., and Wu M.J. Distinctive antioxidant and antiinflammatory effects of flavonols. J Agric Food Chem 54 (2006) 9798-9804
    • (2006) J Agric Food Chem , vol.54 , pp. 9798-9804
    • Wang, L.1    Tu, Y.C.2    Lian, T.W.3    Hung, J.T.4    Yen, J.H.5    Wu, M.J.6
  • 61
    • 33645836334 scopus 로고    scopus 로고
    • The antiproliferative effect of quercetin in cancer cells is mediated via inhibition of the PI3K-Akt/PKB pathway
    • Gulati N., Laudet B., Zohrabian V.M., Murali R., and Jhanwar-Uniyal M. The antiproliferative effect of quercetin in cancer cells is mediated via inhibition of the PI3K-Akt/PKB pathway. Anticancer Res 26 (2006) 1177-1181
    • (2006) Anticancer Res , vol.26 , pp. 1177-1181
    • Gulati, N.1    Laudet, B.2    Zohrabian, V.M.3    Murali, R.4    Jhanwar-Uniyal, M.5
  • 63
    • 0035964450 scopus 로고    scopus 로고
    • Resveratrol and quercetin inhibit angiogenesis in vitro
    • Igura K., Ohta T., Kuroda Y., and Kaji K. Resveratrol and quercetin inhibit angiogenesis in vitro. Cancer Lett 171 (2001) 11-16
    • (2001) Cancer Lett , vol.171 , pp. 11-16
    • Igura, K.1    Ohta, T.2    Kuroda, Y.3    Kaji, K.4
  • 65
    • 33646392442 scopus 로고    scopus 로고
    • Quercetin inhibits eNOS, microtubule polymerization, and mitotic progression in bovine aortic endothelial cells
    • Jackson S.J., and Venema R.C. Quercetin inhibits eNOS, microtubule polymerization, and mitotic progression in bovine aortic endothelial cells. J Nutr 136 (2006) 1178-1184
    • (2006) J Nutr , vol.136 , pp. 1178-1184
    • Jackson, S.J.1    Venema, R.C.2
  • 66
    • 34548329748 scopus 로고    scopus 로고
    • Genistein-induced apoptosis of human breast cancer MCF-7 cells involves calpain-caspase and apoptosis signaling kinase 1-p38 mitogen-activated protein kinase activation cascades
    • Shim H.Y., Park J.H., Paik H.D., Nah S.Y., Kim D.S., and Han Y.S. Genistein-induced apoptosis of human breast cancer MCF-7 cells involves calpain-caspase and apoptosis signaling kinase 1-p38 mitogen-activated protein kinase activation cascades. Anticancer Drugs 18 (2007) 649-657
    • (2007) Anticancer Drugs , vol.18 , pp. 649-657
    • Shim, H.Y.1    Park, J.H.2    Paik, H.D.3    Nah, S.Y.4    Kim, D.S.5    Han, Y.S.6
  • 67
    • 35348823188 scopus 로고    scopus 로고
    • Genistein-induced neuronal apoptosis and G2/M cell cycle arrest is associated with MDC1 up-regulation and PLK1 down-regulation
    • Ismail I.A., Kang K.S., Lee H.A., Kim J.W., and Sohn Y.K. Genistein-induced neuronal apoptosis and G2/M cell cycle arrest is associated with MDC1 up-regulation and PLK1 down-regulation. Eur J Pharmacol 575 (2007) 12-20
    • (2007) Eur J Pharmacol , vol.575 , pp. 12-20
    • Ismail, I.A.1    Kang, K.S.2    Lee, H.A.3    Kim, J.W.4    Sohn, Y.K.5
  • 68
    • 33847688864 scopus 로고    scopus 로고
    • Pro-apoptotic effect and cytotoxicity of genistein and genistin in human ovarian cancer SK-OV-3 cells
    • Choi E.J., Kim T., and Lee M.S. Pro-apoptotic effect and cytotoxicity of genistein and genistin in human ovarian cancer SK-OV-3 cells. Life Sci 80 (2007) 1403-1408
    • (2007) Life Sci , vol.80 , pp. 1403-1408
    • Choi, E.J.1    Kim, T.2    Lee, M.S.3
  • 69
    • 34248139001 scopus 로고    scopus 로고
    • Suppression of VEGF-mediated autocrine and paracrine interactions between prostate cancer cells and vascular endothelial cells by soy isoflavones
    • Guo Y., Wang S., Hoot D.R., and Clinton S.K. Suppression of VEGF-mediated autocrine and paracrine interactions between prostate cancer cells and vascular endothelial cells by soy isoflavones. J Nutr Biochem 18 (2007) 408-417
    • (2007) J Nutr Biochem , vol.18 , pp. 408-417
    • Guo, Y.1    Wang, S.2    Hoot, D.R.3    Clinton, S.K.4
  • 70
    • 34250213433 scopus 로고    scopus 로고
    • Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer
    • Farina H.G., Pomies M., Alonso D.F., and Gomez D.E. Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer. Oncol Rep 16 (2006) 885-891
    • (2006) Oncol Rep , vol.16 , pp. 885-891
    • Farina, H.G.1    Pomies, M.2    Alonso, D.F.3    Gomez, D.E.4
  • 72
    • 31344441221 scopus 로고    scopus 로고
    • Genistein inhibits invasive potential of human hepatocellular carcinoma by altering cell cycle, apoptosis, and angiogenesis
    • Gu Y., Zhu C.F., Iwamoto H., and Chen J.S. Genistein inhibits invasive potential of human hepatocellular carcinoma by altering cell cycle, apoptosis, and angiogenesis. World J Gastroenterol 11 (2005) 6512-6517
    • (2005) World J Gastroenterol , vol.11 , pp. 6512-6517
    • Gu, Y.1    Zhu, C.F.2    Iwamoto, H.3    Chen, J.S.4
  • 74
    • 33749056928 scopus 로고    scopus 로고
    • Inhibition of endothelial cell proliferation, in vitro angiogenesis, and the down-regulation of cell adhesion-related genes by genistein. Combined with a cDNA microarray analysis
    • Piao M., Mori D., Satoh T., Sugita Y., and Tokunaga O. Inhibition of endothelial cell proliferation, in vitro angiogenesis, and the down-regulation of cell adhesion-related genes by genistein. Combined with a cDNA microarray analysis. Endothelium 13 (2006) 249-266
    • (2006) Endothelium , vol.13 , pp. 249-266
    • Piao, M.1    Mori, D.2    Satoh, T.3    Sugita, Y.4    Tokunaga, O.5
  • 75
    • 34248157606 scopus 로고    scopus 로고
    • Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells
    • Shukla S., and Gupta S. Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells. Cell Cycle 6 (2007) 1102-1114
    • (2007) Cell Cycle , vol.6 , pp. 1102-1114
    • Shukla, S.1    Gupta, S.2
  • 76
    • 33750720916 scopus 로고    scopus 로고
    • Apigenin suppresses cancer cell growth through ERbeta
    • Mak P., Leung Y.K., Tang W.Y., Harwood C., and Ho S.M. Apigenin suppresses cancer cell growth through ERbeta. Neoplasia 8 (2006) 896-904
    • (2006) Neoplasia , vol.8 , pp. 896-904
    • Mak, P.1    Leung, Y.K.2    Tang, W.Y.3    Harwood, C.4    Ho, S.M.5
  • 78
    • 34047132303 scopus 로고    scopus 로고
    • Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression
    • Fang J., Zhou Q., Liu L.Z., Xia C., Hu X., Shi X., and Jiang B.H. Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression. Carcinogenesis 28 (2007) 858-864
    • (2007) Carcinogenesis , vol.28 , pp. 858-864
    • Fang, J.1    Zhou, Q.2    Liu, L.Z.3    Xia, C.4    Hu, X.5    Shi, X.6    Jiang, B.H.7
  • 79
    • 23944521126 scopus 로고    scopus 로고
    • Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer
    • Liu L.Z., Fang J., Zhou Q., Hu X., Shi X., and Jiang B.H. Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer. Mol Pharmacol 68 (2005) 635-643
    • (2005) Mol Pharmacol , vol.68 , pp. 635-643
    • Liu, L.Z.1    Fang, J.2    Zhou, Q.3    Hu, X.4    Shi, X.5    Jiang, B.H.6
  • 80
    • 14644432362 scopus 로고    scopus 로고
    • Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways
    • Fang J., Xia C., Cao Z., Zheng J.Z., Reed E., and Jiang B.H. Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. FASEB J 19 (2005) 342-353
    • (2005) FASEB J , vol.19 , pp. 342-353
    • Fang, J.1    Xia, C.2    Cao, Z.3    Zheng, J.Z.4    Reed, E.5    Jiang, B.H.6
  • 81
    • 33846842258 scopus 로고    scopus 로고
    • Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis
    • Fu B., Xue J., Li Z., Shi X., Jiang B.H., and Fang J. Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis. Mol Cancer Ther 6 (2007) 220-226
    • (2007) Mol Cancer Ther , vol.6 , pp. 220-226
    • Fu, B.1    Xue, J.2    Li, Z.3    Shi, X.4    Jiang, B.H.5    Fang, J.6
  • 82
    • 33746075933 scopus 로고    scopus 로고
    • Chrysin inhibits lipopolysaccharide-induced angiogenesis via down-regulation of VEGF/VEGFR-2(KDR) and IL-6/IL-6R pathways
    • Lin C.M., Chang H., Li S.Y., Wu I.H., and Chiu J.H. Chrysin inhibits lipopolysaccharide-induced angiogenesis via down-regulation of VEGF/VEGFR-2(KDR) and IL-6/IL-6R pathways. Planta Med 72 (2006) 708-714
    • (2006) Planta Med , vol.72 , pp. 708-714
    • Lin, C.M.1    Chang, H.2    Li, S.Y.3    Wu, I.H.4    Chiu, J.H.5
  • 83
    • 33646812944 scopus 로고    scopus 로고
    • Flavonoids and vitamin E reduce the release of the angiogenic peptide vascular endothelial growth factor from human tumor cells
    • Schindler R., and Mentlein R. Flavonoids and vitamin E reduce the release of the angiogenic peptide vascular endothelial growth factor from human tumor cells. J Nutr 136 (2006) 1477-1482
    • (2006) J Nutr , vol.136 , pp. 1477-1482
    • Schindler, R.1    Mentlein, R.2
  • 84
    • 33745209876 scopus 로고    scopus 로고
    • Antioxidative effects of quercetin-glycosides isolated from the flower buds of Tussilago farfara L
    • Kim M.R., Lee J.Y., Lee H.H., Aryal D.K., Kim Y.G., Kim S.K., Woo E.R., and Kang K.W. Antioxidative effects of quercetin-glycosides isolated from the flower buds of Tussilago farfara L. Food Chem Toxicol 44 (2006) 1299-1307
    • (2006) Food Chem Toxicol , vol.44 , pp. 1299-1307
    • Kim, M.R.1    Lee, J.Y.2    Lee, H.H.3    Aryal, D.K.4    Kim, Y.G.5    Kim, S.K.6    Woo, E.R.7    Kang, K.W.8
  • 85
    • 34347361698 scopus 로고    scopus 로고
    • Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalpha kinase activation
    • Sung B., Pandey M.K., Aggarwal B.B., Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, and antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalpha kinase activation. Mol Pharmacol 71 (2007) 1703-1714
    • (2007) Mol Pharmacol , vol.71 , pp. 1703-1714
    • Sung, B.1    Pandey, M.K.2    Aggarwal, B.B.3
  • 86
    • 0033711459 scopus 로고    scopus 로고
    • Treatment of corneal neovascularization with dietary isoflavonoids and flavonoids
    • Joussen A.M., Rohrschneider K., Reichling J., Kirchhof B., and Kruse F.E. Treatment of corneal neovascularization with dietary isoflavonoids and flavonoids. Exp Eye Res 71 (2000) 483-487
    • (2000) Exp Eye Res , vol.71 , pp. 483-487
    • Joussen, A.M.1    Rohrschneider, K.2    Reichling, J.3    Kirchhof, B.4    Kruse, F.E.5
  • 87
    • 33845248255 scopus 로고    scopus 로고
    • Wogonin inhibits IL-6-induced angiogenesis via down-regulation of VEGF and VEGFR-1, not VEGFR-2
    • Lin C.M., Chang H., Chen Y.H., Wu I.H., and Chiu J.H. Wogonin inhibits IL-6-induced angiogenesis via down-regulation of VEGF and VEGFR-1, not VEGFR-2. Planta Med 72 (2006) 1305-1310
    • (2006) Planta Med , vol.72 , pp. 1305-1310
    • Lin, C.M.1    Chang, H.2    Chen, Y.H.3    Wu, I.H.4    Chiu, J.H.5
  • 88
    • 33748421494 scopus 로고    scopus 로고
    • Protective role of wogonin against lipopolysaccharide-induced angiogenesis via VEGFR-2, not VEGFR-1
    • Lin C.M., Chang H., Chen Y.H., Li S.Y., Wu I.H., and Chiu J.H. Protective role of wogonin against lipopolysaccharide-induced angiogenesis via VEGFR-2, not VEGFR-1. Int Immunopharmacol 6 (2006) 1690-1698
    • (2006) Int Immunopharmacol , vol.6 , pp. 1690-1698
    • Lin, C.M.1    Chang, H.2    Chen, Y.H.3    Li, S.Y.4    Wu, I.H.5    Chiu, J.H.6
  • 89
    • 7444272077 scopus 로고    scopus 로고
    • Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3′-kinase activity
    • Bagli E., Stefaniotou M., Morbidelli L., Ziche M., Psillas K., Murphy C., and Fotsis T. Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3′-kinase activity. Cancer Res 64 (2004) 7936-7946
    • (2004) Cancer Res , vol.64 , pp. 7936-7946
    • Bagli, E.1    Stefaniotou, M.2    Morbidelli, L.3    Ziche, M.4    Psillas, K.5    Murphy, C.6    Fotsis, T.7
  • 90
    • 1542541381 scopus 로고    scopus 로고
    • Specific inhibition of hypoxia-inducible factor (HIF)-1 alpha activation and of vascular endothelial growth factor (VEGF) production by flavonoids
    • Hasebe Y., Egawa K., Yamazaki Y., Kunimoto S., Hirai Y., Ida Y., and Nose K. Specific inhibition of hypoxia-inducible factor (HIF)-1 alpha activation and of vascular endothelial growth factor (VEGF) production by flavonoids. Biol Pharm Bull 26 (2003) 1379-1383
    • (2003) Biol Pharm Bull , vol.26 , pp. 1379-1383
    • Hasebe, Y.1    Egawa, K.2    Yamazaki, Y.3    Kunimoto, S.4    Hirai, Y.5    Ida, Y.6    Nose, K.7
  • 91
    • 33847265733 scopus 로고    scopus 로고
    • Silybin and silymarin-new and emerging applications in medicine
    • Gazák R., Walterová D., and Kren V. Silybin and silymarin-new and emerging applications in medicine. Curr Med Chem 14 (2007) 315-338
    • (2007) Curr Med Chem , vol.14 , pp. 315-338
    • Gazák, R.1    Walterová, D.2    Kren, V.3
  • 93
    • 23944519382 scopus 로고    scopus 로고
    • Silibinin inhibits angiogenesis via Flt-1, but not KDR, receptor up-regulation
    • Yang S.H., Lin J.K., Huang C.J., Chen W.S., Li S.Y., and Chiu J.H. Silibinin inhibits angiogenesis via Flt-1, but not KDR, receptor up-regulation. J Surg Res 128 (2005) 140-146
    • (2005) J Surg Res , vol.128 , pp. 140-146
    • Yang, S.H.1    Lin, J.K.2    Huang, C.J.3    Chen, W.S.4    Li, S.Y.5    Chiu, J.H.6
  • 94
    • 0038217415 scopus 로고    scopus 로고
    • Flavanones, chalcones and dihydrochalcones: nature, occurrence and dietary burden
    • Tomas-Barberen F.A., and Clifford M.N. Flavanones, chalcones and dihydrochalcones: nature, occurrence and dietary burden. J Sci Food Agric 80 (2000) 1073-1080
    • (2000) J Sci Food Agric , vol.80 , pp. 1073-1080
    • Tomas-Barberen, F.A.1    Clifford, M.N.2
  • 95
    • 3843137373 scopus 로고    scopus 로고
    • Isoliquiritigenin inhibits the proliferation and induces the apoptosis of human non-small cell lung cancer A549 cells
    • Hsu Y.L., Kuo P.L., Chiang L.C., and Lin C.C. Isoliquiritigenin inhibits the proliferation and induces the apoptosis of human non-small cell lung cancer A549 cells. Clin Exp Pharmacol Physiol 31 (2004) 414-418
    • (2004) Clin Exp Pharmacol Physiol , vol.31 , pp. 414-418
    • Hsu, Y.L.1    Kuo, P.L.2    Chiang, L.C.3    Lin, C.C.4
  • 96
    • 27744559989 scopus 로고    scopus 로고
    • Antiproliferative properties of piperidinylchalcones
    • Liu X., and Go M.L. Antiproliferative properties of piperidinylchalcones. Bioorg Med Chem 14 (2006) 153-163
    • (2006) Bioorg Med Chem , vol.14 , pp. 153-163
    • Liu, X.1    Go, M.L.2
  • 98
    • 0037294729 scopus 로고    scopus 로고
    • Cytotoxic 2′,5′-dihydroxychalcones with unexpected antiangiogenic activity
    • Nam N.H., Kim Y., You Y.J., Hong D.H., Kim H.M., and Ahn B.Z. Cytotoxic 2′,5′-dihydroxychalcones with unexpected antiangiogenic activity. Eur J Med Chem 38 (2003) 179-187
    • (2003) Eur J Med Chem , vol.38 , pp. 179-187
    • Nam, N.H.1    Kim, Y.2    You, Y.J.3    Hong, D.H.4    Kim, H.M.5    Ahn, B.Z.6
  • 100
    • 26244450830 scopus 로고    scopus 로고
    • Beer constituents as potential cancer chemopreventive agents
    • Gerhauser C. Beer constituents as potential cancer chemopreventive agents. Eur J Cancer 41 (2005) 1941-1954
    • (2005) Eur J Cancer , vol.41 , pp. 1941-1954
    • Gerhauser, C.1
  • 101
    • 33645814383 scopus 로고    scopus 로고
    • Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets
    • Albini A., Dell'Eva R., Vene R., Ferrari N., Buhler D.R., Noonan D.M., and Fassina G. Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets. FASEB J 20 (2006) 20527-20529
    • (2006) FASEB J , vol.20 , pp. 20527-20529
    • Albini, A.1    Dell'Eva, R.2    Vene, R.3    Ferrari, N.4    Buhler, D.R.5    Noonan, D.M.6    Fassina, G.7
  • 102
    • 35648974809 scopus 로고    scopus 로고
    • AKT/NF-kappaB inhibitor xanthohumol targets cell growth and angiogenesis in hematologic malignancies
    • Dell'Eva R., Ambrosini C., Vannini N., Piaggio G., Albini A., and Ferrari N. AKT/NF-kappaB inhibitor xanthohumol targets cell growth and angiogenesis in hematologic malignancies. Cancer 110 (2007) 2007-2011
    • (2007) Cancer , vol.110 , pp. 2007-2011
    • Dell'Eva, R.1    Ambrosini, C.2    Vannini, N.3    Piaggio, G.4    Albini, A.5    Ferrari, N.6
  • 104
    • 33646440301 scopus 로고    scopus 로고
    • Anti-angiogenic and anti-tumor activities of 2′-hydroxy-4′-methoxychalcone
    • Lee Y.S., Lim S.S., Shin K.H., Kim Y.S., Ohuchi K., and Jung S.H. Anti-angiogenic and anti-tumor activities of 2′-hydroxy-4′-methoxychalcone. Biol Pharm Bull 29 (2006) 1028-1031
    • (2006) Biol Pharm Bull , vol.29 , pp. 1028-1031
    • Lee, Y.S.1    Lim, S.S.2    Shin, K.H.3    Kim, Y.S.4    Ohuchi, K.5    Jung, S.H.6
  • 105
    • 17844405853 scopus 로고    scopus 로고
    • Blockade of vascular endothelial growth factor receptor signal pathway and antitumor activity of ON-III (2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethyl chalcone), a component from Chinese herbal medicine
    • Zhu X.F., Xie B.F., Zhou J.M., Feng G.K., Liu Z.C., Wei X.Y., Zhang F.X., Liu M.F., and Zeng Y.X. Blockade of vascular endothelial growth factor receptor signal pathway and antitumor activity of ON-III (2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethyl chalcone), a component from Chinese herbal medicine. Mol Pharmacol 67 (2005) 1444-1450
    • (2005) Mol Pharmacol , vol.67 , pp. 1444-1450
    • Zhu, X.F.1    Xie, B.F.2    Zhou, J.M.3    Feng, G.K.4    Liu, Z.C.5    Wei, X.Y.6    Zhang, F.X.7    Liu, M.F.8    Zeng, Y.X.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.