Chrysin inhibits expression of hypoxia-inducible factor 1-α through reducing hypoxia-inducible factor-1α stability and inhibiting its protein synthesis

Molecular Cancer Therapeutics

Volumn 6, Issue 1, 2007, Pages 220-226

  Fu, Beibei ^a   Xue, Jing ^a   Li, Zhaodong ^a   Shi, Xianglin ^a   Jiang, Bing Hua ^a,b   Fang, Jing ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHRYSIN; FLAVONOID; HEAT SHOCK PROTEIN 90; HEMOGLOBIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; HUMAN; HUMAN CELL; HYDROXYLATION; INHIBITION KINETICS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; UBIQUITINATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL HYPOXIA; COLLAGEN; DRUG COMBINATIONS; FLAVONOIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LAMININ; MALE; MICE; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; PROTEIN BIOSYNTHESIS; PROTEOGLYCANS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; THERMODYNAMICS; TRANS-ACTIVATION (GENETICS); VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 33846842258     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-06-0526     Document Type: Article

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