Wogonin inhibits IL-6-induced angiogenesis via down-regulation of VEGF and VEGFR-1, not VEGFR-2

Planta Medica

Volumn 72, Issue 14, 2006, Pages 1305-1310

  Lin, Chiu Mei ^a,b   Chang, Hang ^c,d   Chen, Yeh Hsu ^f   Wu, I Hsing ^b   Chiu, Jen Hwey ^a,e  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^c TAIPEI CITY HOSPITAL   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^f KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Angiogenesis; IL 6; IL 6R; VEGF; VEGFR 1; Wogonin

Indexed keywords

INTERLEUKIN 6; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; WOGONIN;

ANGIOGENESIS; ARTICLE; CELL CULTURE; CELL MIGRATION; CHORIOALLANTOIS; DOWN REGULATION; DRUG INHIBITION; HUMAN; HUMAN CELL; IC 50; NEOVASCULARIZATION (PATHOLOGY); PROTEIN BINDING;

ANGIOGENESIS INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUGS, CHINESE HERBAL; ENDOTHELIUM, VASCULAR; FLAVANONES; HUMANS; INTERLEUKIN-6; PHYTOTHERAPY; PLANTS, MEDICINAL; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33845248255     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-951692     Document Type: Article

References (30)

1. Tsuda H, Ohshima Y, Nomoto H, Fujita K, Matsuda E, Iigo M et al. Cancer prevention by natural compounds. 2004; 19: 245-63
2. Kanadaswami C, Lee LT, Lee PP, Hwang JJ, Ke FC, Huang YT et al. The antitumor activities of flavonoids. 2005; 19: 895-909
3. Lee, Kim YO, Kim H, Kim SY, Noh HS, Kang SS et al. Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. FASEB J 2003; 17: 1943-4
4. Gao Z, Huang K, Yang X, Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochem Biophys Acta 1999; 1472: 643-50
5. Chang YL, Shen JJ, Wung BS, Cheng JJ, Wang DL. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. Mol Pharmacol 2001; 60: 507-13
6. Augustin HG. Antiangiogenic tumor therapies - will it work. Trends Pharmacol Sci 1998; 19: 216-22
7. Feghali CA, Wright TM. Cytokines in acute and chronic inflammation. Bioscience 1997; 2: 12-26
8. Nian M, Lee P, Khaper N, Liu P. Inflammatory cytokines and postmyocardial infarction modeling. Circ Res 2004; 94: 1543-53
9. Bachelot T, Ray-Coquard I, Menetrier-Caux C, Rastkha M, Duc A, Blay JY. Prognostic value of serum levels of interleukin 6 and serum and plasma levels of vascular endothelial growth factor in hormone-refractory metastatic breast cancer patients. Br J Cancer 2003; 88: 1721-6
10. Kofler S, Nickel T, Weis M. Role of cytokines in cardiovascular diseases: a focus on endothelial responses to inflammation. Clin Sci (Lond) 2005; 108: 205-13
11. Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res 2004; 24: 2783-840
12. Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 1973; 52: 2745-56
13. Hernandez-Rodriguez J, Sergarra M, Vilardell C, Sanchez M, Garcia-Martinez A, Esteban MJ et al. Elevated production of interleukin-6 as associated with a lower incidence of disease-related ischemic events in patients with giant-cell arteritis. Circulation 2003; 107: 2428-34
14. Lay IS, Chiu JH, Shiao MS, Lui WY, Wu CW. Crude extract of Salvia mitiorrhiza and salvianolic acid B enhance in vitro angiogenesis in murine SVR endothelial cell line. Planta Med 2003; 69: 26-32
15. Nicosia RF, Ottinetti A. Growth of microvessels in serum-free matrix culture of rat aorta. A quantitative assay of angiogenesis in vitro. Lab Invest 1990; 63: 15-22
16. Lin SK, Tsai SC, Lee CC, Wang BW, Liou JY, Shyu KG. Berberine inhibits HIF-1 expression via enhanced proteolysis. Mol Pharmacol 2004; 66: 612-9
17. Taga T, Kishimoto T. Cytokine receptors and signal transduction. FASEB J 1992; 6: 3387-96
18. Yang SH, Lin JK, Huang CJ, Chen WS, Li SY, Chiu JH. Silibinin inhibits angiogenesis via Flt-1, but not KDR, receptor upregulation. J Surg Res 2005; 128: 140-6
19. Nakamura N, Hayasaka S, Zhang XY, Nagaki Y, Matsumoto M, Hayasaka Y et al. Effects of baicalin, baicalein, and wogonin on interleukin-6 and interleukin-8 expression, and nuclear factor-kappa b binding activities induced by interleukin-1 beta in human retinal pigment epithelial cell line. Exp Eye Res 2003; 77: 195-202
20. Park BK, Heo MY, Park H, Kim HP. Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix. Eur J Pharmacol 2001; 425: 153-7
21. Ravindranath MH, Muthugounder S, Presser N, Viswannthan S. Anticancer therapeutic potential of soy isoflavone, genistein. Adv Exp Med Biol 2004; 546: 121-65
22. Fang J, Xia C, Cao Z, Zheng JZ, Reed E, Jiang BH. Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. FASEB J 2005; 19: 342-53
23. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995; 1: 27-31
24. Zachary I, Gliki G. Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc Res 2001; 49: 568-81
25. Jackson MW, Roberts JS, Heckford SE, Ricciardelli C, Stahl J, Horsfall DJ et al. A potential autocrine role for vascular endothelial growth factor in prostate cancer. Cancer Res 2002; 62: 854-9
26. Fong GH, Rossant J, Gertsenstein M, Breitman ML. Role of the Flt-1 receptor tyrosine kinase in regulation the assembly of vascular endothelium. Nature 1995; 376: 66-70
27. Ferrara N. Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol 2001; 280: C1358-66
28. Heinrich PC, Behrmann I, Haan S, Hermanns HM, Muller-Newen G, Schaper F. Principles of interleukin (IL)-6- type cytokine signaling and its regulation. Biochem J 2003; 374: 1-20
29. Marin V, Montero-Julian FA, Gres S, Boulay V, Bongrand P, Farnarier C et al. The IL-6-soluble IL-6Ralpha autocrine loop of endothelial activation as an intermediate between acute and chronic inflammation: an experimental model involving thrombin. J Immunol 2001; 167: 3435-42
30. Molostvov G, Morris A, Rose P, Basu S, Muller G. The effects of selective cytokines inhibiting drugs (CC-10 004 and CC-1088) on VEGF and IL-6 expression and apoptosis in myeloma and endothelial cell co-cultures. Br J Haematol 2004; 124: 366-75