Synthesis and discovery of a novel pyrazole derivative as an inhibitor of apoptosis through modulating integrin β4, ROS, and p53 levels in vascular endothelial cells

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 9, 2008, Pages 5171-5180

  Zhao, Bao Xiang ^a   Zhang, Lu ^a,b   Zhu, Xing Shang ^a,b   Wan, Mao Sheng ^c   Zhao, Jing ^a,b   Zhang, Yun ^b   Zhang, Shang Li ^a,b   Miao, Jun Ying ^a,b  

^a SHANDONG UNIVERSITY   (China)

^b BEIJING HOSPITAL   (China)

^c Shandong Drug and Food Vocational College   (China)

Author keywords

Apoptosis; Integrin 4; p53; Pyrazole derivative; ROS; Vascular endothelial cell

Indexed keywords

3 (2 CHLOROPHENYL) 5 METHYL 1 PHENYL 1H PYRAZOLE 4 CARBOXYLIC ACID; 3 (2 NITROPHENYL) 1 PHENYL 1H PYRAZOL 5 OL; 3 PARA TOLYL 1H PYRAZOL 5 OL; APOPTOSIS INHIBITOR; BETA4 INTEGRIN; ETHYL 3 (2 CHLOROPHENYL) 5 METHYL 1 PHENYL 1H PYRAZOLE 4 CARBOXYLIC ACID; ETHYL 3 (2 CHLOROPHENYL) 5 METHYL 1H PYRAZOLE 4 CARBOXYLIC ACID; ETHYL 5 METHYL 3 (2 NITROPHENYL) 1H PYRAZOLE 4 CARBOXYLIC ACID; ETHYL 5 METHYL 3 (4 NITROPHENYL) 1H PYRAZOLE 4 CARBOXYLIC ACID; FIBROBLAST GROWTH FACTOR 2; PROTEIN P53; PYRAZOLE DERIVATIVE; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; BIOASSAY; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG SYNTHESIS; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; VASCULAR ENDOTHELIUM;

APOPTOSIS; CELL NUCLEUS; CELLS, CULTURED; DNA; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; HUMANS; INTEGRIN BETA4; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR STRUCTURE; PYRAZOLES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEIN P53;

EID: 43049115718     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.03.011     Document Type: Article

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