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Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 24, 2004, Pages 6049-6052

3-(2-Methoxytetrahydrofuran-2-yl)pyrazoles: A novel class of potent, selective cyclooxygenase-2 (COX-2) inhibitors

(11) Ranatunge, Ramani R a Earl, Richard A a Garvey, David S a Janero, David R a Letts, L Gordon a Martino, Allison M a Murty, Madhavi G a Richardson, Stewart K a Schwalb, David J a Young, Delano V a Zemtseva, Irina S a

a NitroMed Inc (United States)

Author keywords

Cyclooxygenase 2 (COX 2); Pyrazole; Tetrahydrofuran 2 yl

Indexed keywords

1 (4 BROMOPHENYL) 5 (4 METHANESULFONYLPHENYL) 3 (2 METHOXYTETRAHYDROFURAN 2 YL) 1H PYRAZOLE; 1 (4 CHLOROPHENYL) 5 (4 METHANESULFONYLPHENYL) 3 (2 METHOXYTETRAHYDROFURAN 2 YL) 1H PYRAZOLE; 1 (4 FLUOROPHENYL) 5 (4 METHANESULFONYLPHENYL) 3 (2 METHOXYTETRAHYDROFURAN 2 YL) 1H PYRAZOLE; 4 [5 (4 METHANESULFONYLPHENYL) 3 (2 METHOXYTETRAHYDROFURAN 2 YL)PYRAZOL 1 YL]BENZENECARBONITRILE; 5 (4 METHANESULFONYLPHENYL) 3 (2 METHOXYTETRAHYDROFURAN 2 YL) 1 (4 TRIFLUOROMETHYLPHENYL) 1H PYRAZOLE; 5 (4 METHANESULFONYLPHENYL) 3 (2 METHOXYTETRAHYDROFURAN 2 YL) 1 PHENYL 1H PYRAZOLE; 5 (4 METHANESULFONYLPHENYL) 3 (2 METHOXYTETRAHYDROFURAN 2 YL) 1,4 TOLYL 1H PYRAZOLE; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; PYRAZOLE DERIVATIVE; ROFECOXIB; UNCLASSIFIED DRUG;

ARTICLE; BLOOD; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN;

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; MOLECULAR STRUCTURE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 8844244872 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2004.09.073 Document Type: Article

Times cited : (51)

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